Daniel P Ankeny
Affiliation: The Ohio State University
- Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in ratsDaniel P Ankeny
Department of Physiology and Cell Biology, The Ohio State University, 333 West 10th Avenue, Columbus, OH 43210, USA
Exp Neurol 190:17-31. 2004..Together, these studies support further investigation of marrow stromal cells as a potential SCI repair strategy...
- Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cordKristina A Kigerl
Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
J Neurosci 29:13435-44. 2009....
- System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivoKristina A Kigerl
Center for Brain and Spinal Cord Repair, College of Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Exp Neurol 233:333-41. 2012..Together, these data indicate that modulation of redox balance in CNS macrophages, perhaps through regulating system x(c)(-), could be a novel approach for attenuating injurious neuroinflammatory cascades...
- B cells produce pathogenic antibodies and impair recovery after spinal cord injury in miceDaniel P Ankeny
Center for Brain and Spinal Cord Repair, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Medical Center, 460 West 12th Avenue, Columbus, OH 43210 1239, USA
J Clin Invest 119:2990-9. 2009..One or more components of this pathologic immune response could be considered as novel therapeutic targets for minimizing tissue injury and/or promoting repair after SCI...
- An efficient and reproducible method for quantifying macrophages in different experimental models of central nervous system pathologyDustin J Donnelly
The Integrated Biomedical Graduate Studies Program, The Ohio State University College of Medicine, Columbus, OH, USA
J Neurosci Methods 181:36-44. 2009....
- Macrophages promote axon regeneration with concurrent neurotoxicityJohn C Gensel
Center for Brain and Spinal Cord Repair, Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
J Neurosci 29:3956-68. 2009..Together, these data show that a single mode of activation endows macrophages with the ability to simultaneously promote axon regeneration and cell killing...
- A mouse model of ischemic spinal cord injury with delayed paralysis caused by aortic cross-clampingHamdy Awad
Department of Anesthesiology, The Ohio State University College of Medicine, Columbus, Ohio, USA
Anesthesiology 113:880-91. 2010..Here, we report on the development of a new mouse model of spinal cord ischemia with delayed paralysis induced by cross-clamping the descending aorta...
- Central nervous system and non-central nervous system antigen vaccines exacerbate neuropathology caused by nerve injuryDaniel P Ankeny
Department of Molecular Virology, Immunology and Medical Genetics, The Center for Brain and Spinal Cord Repair and The Institute for Behavioral Medicine Research, The Ohio State University College of Medicine, Columbus, OH, USA
Eur J Neurosci 25:2053-64. 2007..These data have important implications for therapeutic vaccination in clinical neurotrauma and neurodegeneration...
- B cells and autoantibodies: complex roles in CNS injuryDaniel P Ankeny
Center for Brain and Spinal Cord Repair, Department of Neuroscience, The Ohio State University Medical Center, 460W 12th Avenue, Columbus, OH 43210, USA
Trends Immunol 31:332-8. 2010..On the basis of recent data, we hypothesize that a subset of autoimmune B cell responses initiated by CNS injury are pathogenic and that targeted inhibition of B cells could improve recovery in cases of brain and spinal cord injury...
- Characterization and modeling of monocyte-derived macrophages after spinal cord injuryErin E Longbrake
Integrated Biomedical Science Graduate Studies Program, The Ohio State University College of Medicine, Columbus, Ohio, USA
J Neurochem 102:1083-94. 2007..Thus, peripheral macrophages should not be used interchangeably in vitro to model the functional consequences of the MDM response elicited by SCI...
- Spinal cord injury triggers systemic autoimmunity: evidence for chronic B lymphocyte activation and lupus-like autoantibody synthesisDaniel P Ankeny
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
J Neurochem 99:1073-87. 2006..We show a similar pathologic potential for the autoantibodies produced after SCI. Thus, mammalian SCI produces marked dysregulation of B cell function (i.e. autoimmunity) with pathological potential...
- Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in ratsT Bucky Jones
The Neuroscience Graduate Studies Program, Division of Physical Therapy, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA
J Neurosci 24:3752-61. 2004..These data are consistent with the conventional view of myelin-reactive T-cells as pathological effector cells...
- Functional effects of B cells activated by spinal cord injury in miceDANIEL ANKENY; Fiscal Year: 2007..If so, then manipulating (specifically, inhibiting) B cell function may be useful as an acute and chronic therapy for these patients. ..