M G Angelos

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint O2 delivery and redox state are determinants of compartment-specific reactive O2 species in myocardial reperfusion
    Jason D Stoner
    Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H109-16. 2007
  2. ncbi request reprint Inhibition of peroxynitrite precursors, NO and O2, at the onset of reperfusion improves myocardial recovery
    Jessica A Falk
    Department of Emergency Medicine, Ohio State University, Columbus, OH, United States
    Resuscitation 74:508-15. 2007
  3. doi request reprint Post-cardiac arrest hyperoxia and mitochondrial function
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Resuscitation 82:S48-51. 2011
  4. ncbi request reprint Hypoxic reperfusion of the ischemic heart and oxygen radical generation
    Mark G Angelos
    Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 290:H341-7. 2006
  5. doi request reprint Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, United States
    Resuscitation 77:101-10. 2008
  6. ncbi request reprint Postischemic inotropic support of the dysfunctional heart
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210 1270, USA
    Crit Care Med 30:410-6. 2002
  7. ncbi request reprint Bench to bedside: resuscitation from prolonged ventricular fibrillation
    M G Angelos
    Department of Emergency Medicine, Ohio State University, Columbus, OH 43210 1270, USA
    Acad Emerg Med 8:909-24. 2001
  8. ncbi request reprint Left ventricular myocardial adenosine triphosphate changes during reperfusion of ventricular fibrillation: the influence of flow and epinephrine
    M G Angelos
    Department of Emergency Medicine, Ohio State University, Columbus 43210, USA
    Crit Care Med 28:1503-8. 2000
  9. ncbi request reprint Flow requirements in ventricular fibrillation: An in vivo nuclear magnetic resonance analysis of the left ventricular high-energy phosphate pool
    M G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
    Ann Emerg Med 34:583-8. 1999
  10. ncbi request reprint In-vivo myocardial substrate alteration during perfused ventricular fibrillation
    M G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus 43210 1270, USA
    Acad Emerg Med 6:581-7. 1999

Collaborators

Detail Information

Publications23

  1. ncbi request reprint O2 delivery and redox state are determinants of compartment-specific reactive O2 species in myocardial reperfusion
    Jason D Stoner
    Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 292:H109-16. 2007
    ..The redox state that develops during ischemia appears to be an important precursor for reperfusion ROS production...
  2. ncbi request reprint Inhibition of peroxynitrite precursors, NO and O2, at the onset of reperfusion improves myocardial recovery
    Jessica A Falk
    Department of Emergency Medicine, Ohio State University, Columbus, OH, United States
    Resuscitation 74:508-15. 2007
    ..We tested the hypothesis that inhibition of *NO or ROS production at the time of reperfusion improves recovery of post-ischemic myocardial function...
  3. doi request reprint Post-cardiac arrest hyperoxia and mitochondrial function
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Resuscitation 82:S48-51. 2011
    ..We hypothesized that arterial hyper-oxygenation following ROSC would result in greater impairment of heart mitochondrial function...
  4. ncbi request reprint Hypoxic reperfusion of the ischemic heart and oxygen radical generation
    Mark G Angelos
    Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 290:H341-7. 2006
    ..Recovery of LV function during reperfusion is inversely related to this oxygen radical burst, highlighting the importance of myocardial oxygen tension during initial reperfusion...
  5. doi request reprint Cardiovascular response to epinephrine varies with increasing duration of cardiac arrest
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, United States
    Resuscitation 77:101-10. 2008
    ..Epinephrine is also associated with significant myocardial dysfunction in the post-resuscitation period. We tested the hypothesis that the cardiac effects of epinephrine vary according to the duration of cardiac arrest...
  6. ncbi request reprint Postischemic inotropic support of the dysfunctional heart
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210 1270, USA
    Crit Care Med 30:410-6. 2002
    ..However, the relative effectiveness and associated bioenergetic changes associated with these agents in the postischemic heart are unclear...
  7. ncbi request reprint Bench to bedside: resuscitation from prolonged ventricular fibrillation
    M G Angelos
    Department of Emergency Medicine, Ohio State University, Columbus, OH 43210 1270, USA
    Acad Emerg Med 8:909-24. 2001
    ..This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain...
  8. ncbi request reprint Left ventricular myocardial adenosine triphosphate changes during reperfusion of ventricular fibrillation: the influence of flow and epinephrine
    M G Angelos
    Department of Emergency Medicine, Ohio State University, Columbus 43210, USA
    Crit Care Med 28:1503-8. 2000
    ..To determine whether epinephrine in combination with high flow worsens left ventricular (LV) myocardial high-energy phosphate stores during reperfusion of ischemic ventricular fibrillation (VF)...
  9. ncbi request reprint Flow requirements in ventricular fibrillation: An in vivo nuclear magnetic resonance analysis of the left ventricular high-energy phosphate pool
    M G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
    Ann Emerg Med 34:583-8. 1999
    ..We sought to determine whether flow rates of approximately 60% of normal values are sufficient to preserve the left ventricular myocardial high-energy phosphate pool during ventricular fibrillation (VF)...
  10. ncbi request reprint In-vivo myocardial substrate alteration during perfused ventricular fibrillation
    M G Angelos
    Department of Emergency Medicine, The Ohio State University, Columbus 43210 1270, USA
    Acad Emerg Med 6:581-7. 1999
    ..The authors hypothesized that myocardial substrate utilization during VF with perfusion is similar to the normal beating heart under conditions of increased workload...
  11. ncbi request reprint Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergetics
    Mark G Angelos
    Department of Emergency Medicine, The Ohio State University, 016 Prior Health Sciences Library, 376 West Tenth Avenue, Columbus 43210 1270, USA
    Resuscitation 55:329-36. 2002
    ..GIK may be a viable adjunctive reperfusion therapy following the global ischemia of cardiac arrest to improve post-resuscitation cardiac dysfunction...
  12. ncbi request reprint Organ blood flow following cardiac arrest in a swine low-flow cardiopulmonary bypass model
    M G Angelos
    Department of Emergency Medicine, Ohio State University, Columbus 43210
    Resuscitation 27:245-54. 1994
    ..Early post-resuscitation organ blood flow is characterized by a selective hyperemia involving the cerebral, myocardial and adrenal vascular beds, in contrast to hypoperfusion of the pulmonary and mesenteric vascular beds...
  13. ncbi request reprint Low flow after global ischemia to improve postischemic myocardial function and bioenergetics
    Paul F Klawitter
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
    Crit Care Med 30:2542-7. 2002
    ..In this study, we test the hypothesis that a period of low flow perfusion before full reperfusion improves ventricular function and bioenergetics...
  14. ncbi request reprint Reactive oxygen species generated during myocardial ischemia enable energetic recovery during reperfusion
    Paul F Klawitter
    Department of Emergency Medicine, The Ohio State University, Columbus 43210, USA
    Am J Physiol Heart Circ Physiol 283:H1656-61. 2002
    ..This suggests that reactive oxygen species, which are generated during ischemia, enhance bioenergetic recovery by increasing the efficiency of contraction...
  15. ncbi request reprint Global ischemic duration and reperfusion function in the isolated perfused rat heart
    Brian S Palmer
    Department of Emergency Medicine, The Ohio State University, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Resuscitation 62:97-106. 2004
    ..This data suggests a period of transition from reversible to irreversible injury occurring at approximately 20 min of normothermic global ischemia in the isolated perfused rat heart...
  16. doi request reprint Oxygen requirement during cardiopulmonary resuscitation (CPR) to effect return of spontaneous circulation
    Steve T Yeh
    Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
    Resuscitation 80:951-5. 2009
    ..We tested the hypothesis that initial ventilation during CPR without oxygen improves resuscitation success...
  17. ncbi request reprint Role of oxygen in postischemic myocardial injury
    Vijay Kumar Kutala
    Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
    Antioxid Redox Signal 9:1193-206. 2007
    ..In this review, we discuss the role of oxygenation during reperfusion and subsequent biochemical and pathologic alterations in reperfused myocardium and recovery of heart function...
  18. ncbi request reprint Myocardial contractile function during postischemic low-flow reperfusion: critical thresholds of NADH and O2 delivery
    Jason D Stoner
    Dept of Emergency Medicine, Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
    Am J Physiol Heart Circ Physiol 286:H375-80. 2004
    ..Although oxygen is utilized at very low flow rates, as indicated by changes in NADH, a critical threshold of approximately 25% of baseline Do2 is necessary to restore contractile function after short-term global ischemia...
  19. ncbi request reprint Degradation of rat cardiac troponin I during ischemia independent of reperfusion
    Brian S Palmer
    Department of Emergency Medicine, The Ohio State University, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 287:H1269-75. 2004
    ..cTnI breakdown during ischemia is further increased in the presence of antioxidants, suggesting ROS generated during ischemia may play a cTnI protective role...
  20. pmc Preservation of mitochondrial function with cardiopulmonary resuscitation in prolonged cardiac arrest in rats
    Steve T Yeh
    Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA
    J Mol Cell Cardiol 47:789-97. 2009
    ..Preservation of complex I activity and mitochondrial function during cardiac arrest may be an important mechanism underlying the beneficial effects of CPR which have been shown in clinical studies...
  21. doi request reprint Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality
    J Hope Kilgannon
    Department of Emergency Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
    JAMA 303:2165-71. 2010
    ..Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking...
  22. ncbi request reprint Compared to angiotensin II, epinephrine is associated with high myocardial blood flow following return of spontaneous circulation after cardiac arrest
    Charles M Little
    Division of Emergency Medicine, Department of Surgery, Health Sciences Center, University of Colorado, 4200 E Ninth Avenue, Denver, CO 80262, USA
    Resuscitation 59:353-9. 2003
    ..We explored the effects of angiotensin II or epinephrine alone, and the combination of angiotensin with epinephrine, on myocardial and cerebral blood flows in a swine model of cardiac arrest...
  23. ncbi request reprint Cardiopulmonary resuscitation, ventilation, defibrillation: in what order?
    Mark G Angelos
    Ann Emerg Med 40:571-4. 2002