Research Topics
| M G AngelosSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
O2 delivery and redox state are determinants of compartment-specific reactive O2 species in myocardial reperfusionJason D Stoner
Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 292:H109-16. 2007..The redox state that develops during ischemia appears to be an important precursor for reperfusion ROS production...- Inhibition of peroxynitrite precursors, NO and O2, at the onset of reperfusion improves myocardial recoveryJessica A Falk
Department of Emergency Medicine, Ohio State University, Columbus, OH, United States
Resuscitation 74:508-15. 2007..We tested the hypothesis that inhibition of *NO or ROS production at the time of reperfusion improves recovery of post-ischemic myocardial function... 
Post-cardiac arrest hyperoxia and mitochondrial functionMark G Angelos
Department of Emergency Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Resuscitation 82:S48-51. 2011..We hypothesized that arterial hyper-oxygenation following ROSC would result in greater impairment of heart mitochondrial function...- Hypoxic reperfusion of the ischemic heart and oxygen radical generationMark G Angelos
Dept of Emergency Medicine, The Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 290:H341-7. 2006..Recovery of LV function during reperfusion is inversely related to this oxygen radical burst, highlighting the importance of myocardial oxygen tension during initial reperfusion... - Cardiovascular response to epinephrine varies with increasing duration of cardiac arrestMark G Angelos
Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, United States
Resuscitation 77:101-10. 2008..Epinephrine is also associated with significant myocardial dysfunction in the post-resuscitation period. We tested the hypothesis that the cardiac effects of epinephrine vary according to the duration of cardiac arrest... - Postischemic inotropic support of the dysfunctional heartMark G Angelos
Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210 1270, USA
Crit Care Med 30:410-6. 2002..However, the relative effectiveness and associated bioenergetic changes associated with these agents in the postischemic heart are unclear... - Bench to bedside: resuscitation from prolonged ventricular fibrillationM G Angelos
Department of Emergency Medicine, Ohio State University, Columbus, OH 43210 1270, USA
Acad Emerg Med 8:909-24. 2001..This review focuses first on the initial resuscitation (achieving ROSC) and then on the reperfusion issues affecting the heart and brain... - Left ventricular myocardial adenosine triphosphate changes during reperfusion of ventricular fibrillation: the influence of flow and epinephrineM G Angelos
Department of Emergency Medicine, Ohio State University, Columbus 43210, USA
Crit Care Med 28:1503-8. 2000..To determine whether epinephrine in combination with high flow worsens left ventricular (LV) myocardial high-energy phosphate stores during reperfusion of ischemic ventricular fibrillation (VF)... - Flow requirements in ventricular fibrillation: An in vivo nuclear magnetic resonance analysis of the left ventricular high-energy phosphate poolM G Angelos
Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
Ann Emerg Med 34:583-8. 1999..We sought to determine whether flow rates of approximately 60% of normal values are sufficient to preserve the left ventricular myocardial high-energy phosphate pool during ventricular fibrillation (VF)... - In-vivo myocardial substrate alteration during perfused ventricular fibrillationM G Angelos
Department of Emergency Medicine, The Ohio State University, Columbus 43210 1270, USA
Acad Emerg Med 6:581-7. 1999..The authors hypothesized that myocardial substrate utilization during VF with perfusion is similar to the normal beating heart under conditions of increased workload... - Glucose, insulin and potassium (GIK) during reperfusion mediates improved myocardial bioenergeticsMark G Angelos
Department of Emergency Medicine, The Ohio State University, 016 Prior Health Sciences Library, 376 West Tenth Avenue, Columbus 43210 1270, USA
Resuscitation 55:329-36. 2002..GIK may be a viable adjunctive reperfusion therapy following the global ischemia of cardiac arrest to improve post-resuscitation cardiac dysfunction... - Organ blood flow following cardiac arrest in a swine low-flow cardiopulmonary bypass modelM G Angelos
Department of Emergency Medicine, Ohio State University, Columbus 43210
Resuscitation 27:245-54. 1994..Early post-resuscitation organ blood flow is characterized by a selective hyperemia involving the cerebral, myocardial and adrenal vascular beds, in contrast to hypoperfusion of the pulmonary and mesenteric vascular beds... - Low flow after global ischemia to improve postischemic myocardial function and bioenergeticsPaul F Klawitter
Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
Crit Care Med 30:2542-7. 2002..Very low flow may further reduce bioenergetic recovery without improvement in postischemic function, compared with continuous global ischemia... - Reactive oxygen species generated during myocardial ischemia enable energetic recovery during reperfusionPaul F Klawitter
Department of Emergency Medicine, The Ohio State University, Columbus 43210, USA
Am J Physiol Heart Circ Physiol 283:H1656-61. 2002..This suggests that reactive oxygen species, which are generated during ischemia, enhance bioenergetic recovery by increasing the efficiency of contraction... - Global ischemic duration and reperfusion function in the isolated perfused rat heartBrian S Palmer
Department of Emergency Medicine, The Ohio State University, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
Resuscitation 62:97-106. 2004..This data suggests a period of transition from reversible to irreversible injury occurring at approximately 20 min of normothermic global ischemia in the isolated perfused rat heart... - Oxygen requirement during cardiopulmonary resuscitation (CPR) to effect return of spontaneous circulationSteve T Yeh
Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA
Resuscitation 80:951-5. 2009..We tested the hypothesis that initial ventilation during CPR without oxygen improves resuscitation success... - Role of oxygen in postischemic myocardial injuryVijay Kumar Kutala
Department of Internal Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio 43210, USA
Antioxid Redox Signal 9:1193-206. 2007..In this review, we discuss the role of oxygenation during reperfusion and subsequent biochemical and pathologic alterations in reperfused myocardium and recovery of heart function... - Myocardial contractile function during postischemic low-flow reperfusion: critical thresholds of NADH and O2 deliveryJason D Stoner
Dept. of Emergency Medicine, Ohio State Univ, 146 Means Hall, 1654 Upham Dr, Columbus, OH 43210, USA
Am J Physiol Heart Circ Physiol 286:H375-80. 2004..Although oxygen is utilized at very low flow rates, as indicated by changes in NADH, a critical threshold of approximately 25% of baseline Do2 is necessary to restore contractile function after short-term global ischemia... - Degradation of rat cardiac troponin I during ischemia independent of reperfusionBrian S Palmer
Department of Emergency Medicine, The Ohio State University, Columbus, Ohio 43210, USA
Am J Physiol Heart Circ Physiol 287:H1269-75. 2004..cTnI breakdown during ischemia is further increased in the presence of antioxidants, suggesting ROS generated during ischemia may play a cTnI protective role... 
Preservation of mitochondrial function with cardiopulmonary resuscitation in prolonged cardiac arrest in ratsSteve T Yeh
Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, USA Department of Emergency Medicine, The Ohio State University, Columbus, OH 43210, USA Biophysics Graduate Program, The Ohio State University, Columbus, OH 43210, USA
J Mol Cell Cardiol 47:789-97. 2009..Preservation of complex I activity and mitochondrial function during cardiac arrest may be an important mechanism underlying the beneficial effects of CPR which have been shown in clinical studies...- Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortalityJ Hope Kilgannon
Department of Emergency Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
JAMA 303:2165-71. 2010..Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking... - Compared to angiotensin II, epinephrine is associated with high myocardial blood flow following return of spontaneous circulation after cardiac arrestCharles M Little
Division of Emergency Medicine, Department of Surgery, Health Sciences Center, University of Colorado, 4200 E. Ninth Avenue, Denver, CO 80262, USA
Resuscitation 59:353-9. 2003..05). CONCLUSIONS: The combination of ANG and EPI did not improve MBF during cardiac arrest. Epinephrine may increase MBF compared with angiotensin II post-reperfusion... - Cardiopulmonary resuscitation, ventilation, defibrillation: in what order?Mark G Angelos
Ann Emerg Med 40:571-4. 2002