Christopher Amos

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population
    J Shawn Jones
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:5845-9. 2004
  2. pmc Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians
    Jinyun Chen
    Department of Epidemiology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 13:3100-4. 2007
  3. pmc Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations
    Shenying Fang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 5:e10813. 2010
  4. pmc Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy
    Musaffe Tuna
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    BMC Med Genomics 5:60. 2012
  5. pmc Genome-wide association study identifies novel loci predisposing to cutaneous melanoma
    Christopher I Amos
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 20:5012-23. 2011
  6. pmc Seeking gene relationships in gene expression data using support vector machine regression
    Robert Yu
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, Texas 77030, USA
    BMC Proc 1:S51. 2007
  7. pmc Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families
    Wei V Chen
    Department of Epidemiology, Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Proc 1:S97. 2007
  8. pmc Genome-wide single-nucleotide polymorphism linkage analyses of quantitative rheumatoid arthritis phenotypes in Caucasian NARAC families
    Kimberly E Taylor
    University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, 374 Parnassus Avenue, Box 0500, San Francisco, California 94143, USA
    BMC Proc 1:S105. 2007
  9. pmc Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data
    Xiaojun Zhou
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX, 77030, USA
    BMC Proc 1:S53. 2007
  10. pmc A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests
    Lianfu Chen
    Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843, USA
    BMC Proc 3:S6. 2009

Research Grants

  1. High Density Association Analysis of Lung Cancer
    Christopher Amos; Fiscal Year: 2009
  2. High Density Association Analysis of Lung Cancer
    Christopher I Amos; Fiscal Year: 2010
  3. Genetic Susceptibility for Lung Cancer in African Americans
    Christopher Amos; Fiscal Year: 2009
  4. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2004
  5. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2002
  6. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2003
  7. High Density Association Analysis of Lung Cancer
    Christopher Amos; Fiscal Year: 2009
  8. Statistical Methods for Gene Environment Interactions In Lung Cancer
    Christopher Amos; Fiscal Year: 2009
  9. High Density Association Analysis of Lung Cancer
    Christopher Amos; Fiscal Year: 2009
  10. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2006

Detail Information

Publications109 found, 100 shown here

  1. ncbi p53 polymorphism and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population
    J Shawn Jones
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 10:5845-9. 2004
    ..We studied the influence of this p53 polymorphism on HNPCC age of onset...
  2. pmc Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians
    Jinyun Chen
    Department of Epidemiology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 13:3100-4. 2007
    ..The purpose of this study was to investigate the association of the Aurora-A (T91A), and p16 (C540G and C580T) polymorphisms with age at diagnosis of pancreatic cancer...
  3. pmc Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations
    Shenying Fang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 5:e10813. 2010
    ..The impact of MDM4 polymorphism on tumor onset in germline mutation carriers has not previously been studied...
  4. pmc Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy
    Musaffe Tuna
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    BMC Med Genomics 5:60. 2012
    ..STS can be classified into two main categories according to the type of genomic alteration: recurrent translocation driven STS, and non-recurrent translocations. However, little has known about acquired uniparental disomy in STS...
  5. pmc Genome-wide association study identifies novel loci predisposing to cutaneous melanoma
    Christopher I Amos
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 20:5012-23. 2011
    ..3 rs7412746 (P = 6 × 10(-10)). Together, these data identified several candidate genes for additional studies to identify causal variants predisposing to increased risk for developing melanoma...
  6. pmc Seeking gene relationships in gene expression data using support vector machine regression
    Robert Yu
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, Texas 77030, USA
    BMC Proc 1:S51. 2007
    ..The model was subsequently used to search for and capture similarly related genes. SVMR shows promising capability in modeling and seeking gene relationships through expression data...
  7. pmc Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families
    Wei V Chen
    Department of Epidemiology, Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Proc 1:S97. 2007
    ..A larger sample size of the Hispanic group is needed to identify linkage regions...
  8. pmc Genome-wide single-nucleotide polymorphism linkage analyses of quantitative rheumatoid arthritis phenotypes in Caucasian NARAC families
    Kimberly E Taylor
    University of California, San Francisco, Rosalind Russell Medical Research Center for Arthritis, 374 Parnassus Avenue, Box 0500, San Francisco, California 94143, USA
    BMC Proc 1:S105. 2007
    ....
  9. pmc Joint linkage and imprinting analyses of GAW15 rheumatoid arthritis and gene expression data
    Xiaojun Zhou
    Department of Epidemiology, Unit 1340, The University of Texas M, Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX, 77030, USA
    BMC Proc 1:S53. 2007
    ..03 for imprinting, but increase in the LOD score did not meet the required threshold to reliably identify imprinting as the correct mode of inheritance in genome-wide linkage scans...
  10. pmc A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests
    Lianfu Chen
    Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843, USA
    BMC Proc 3:S6. 2009
    ..In addition, SNPs with the largest TH score on each chromosome were identified. These SNPs may be located in the regions of genes that have modest effects on rheumatoid arthritis. These regions deserve further investigation...
  11. pmc Normalizing a large number of quantitative traits using empirical normal quantile transformation
    Bo Peng
    Department of Epidemiology, The University of Texas, Anderson Cancer Center, 1155 Pressler Boulevard, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S156. 2007
    ..To investigate the impact of such a transformation on real data sets, we apply variance-components and variance-regression methods to the expression data of GAW15 and compare the results before and after transformation...
  12. pmc Design considerations in a sib-pair study of linkage for susceptibility loci in cancer
    Richard A Kerber
    Population Sciences Program, Hunstman Cancer Institute, Salt Lake City, UT, USA
    BMC Med Genet 9:64. 2008
    ..However, the sibpair design is still valuable because it requires few assumptions other than acceptably high penetrance to identify genetic loci...
  13. pmc Relative effects of mutability and selection on single nucleotide polymorphisms in transcribed regions of the human genome
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Genomics 9:292. 2008
    ..The goal of this study was to estimate the relative effects of mutability and selection on SNP density in transcribed regions of human genes. It is important for prediction of the regions that harbor functional polymorphisms...
  14. pmc Examining the effect of linkage disequilibrium on multipoint linkage analysis
    Qiqing Huang
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 6:S83. 2005
    ..Bias can be eliminated with parental data and can be reduced when additional markers not in LD are included in the analyses...
  15. pmc Genome-wide algorithm for detecting CNV associations with diseases
    Yaji Xu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1155 Pressler St, Houston, Texas 77030, USA
    BMC Bioinformatics 12:331. 2011
    ..An alternative procedure called PennCNV uses information from both the marker intensities as well as the genotypes and therefore has increased sensitivity...
  16. pmc Forward-time simulation of realistic samples for genome-wide association studies
    Bo Peng
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    BMC Bioinformatics 11:442. 2010
    ..However, a number of methodological and computational constraints have prevented the power of this simulation method from being fully explored in existing forward-time simulation methods...
  17. ncbi Least squares estimation of variance components for linkage
    C I Amos
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Genet Epidemiol 19:S1-7. 2000
    ..The LS method was computationally rapid, over 4,000 times faster than ML estimation for bivariate data. Because ML estimation is time consuming, LS methods are suggested for initial interval mapping with multivariate data...
  18. pmc Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
    ....
  19. pmc Genotype-phenotype correlations in Peutz-Jeghers syndrome
    C I Amos
    Department of Epidemiology, U T M D Anderson Cancer Center HMB, Houston 77030, USA
    J Med Genet 41:327-33. 2004
    ..Time to onset of symptoms was characterised for a large collection of individuals with PJS who had been tested for STK11 mutations and genotype-phenotype correlations were evaluated...
  20. ncbi Assessing BRCA carrier probabilities in extended families
    Carlos H Barcenas
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Clin Oncol 24:354-60. 2006
    ..We also studied the effect of extended family information on risk estimation using BOADICEA...
  21. pmc Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    Christopher I Amos
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nat Genet 40:616-22. 2008
    ..Haplotype analysis was consistent with there being a single risk variant in this region. We conclude that variation in a region of 15q25.1 containing nicotinic acetylcholine receptors genes contributes to lung cancer risk...
  22. pmc A susceptibility locus on chromosome 6q greatly increases lung cancer risk among light and never smokers
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas 77005, USA
    Cancer Res 70:2359-67. 2010
    ..These results identify a region of chromosome 6q that increases risk for lung cancer and that confers particularly higher risks to never and light smokers...
  23. doi Chipping away at the genetics of smoking behavior
    Christopher I Amos
    Departments of Epidemiology and Behavioral Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Genet 42:366-8. 2010
    ..Three large consortia present comprehensive analyses that identify genetic factors influencing smoking initiation, intensity and cessation. The genetic architecture of these three phases of smoking behavior appears to be largely distinct...
  24. pmc Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study
    Christopher I Amos
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 102:1199-205. 2010
    ..Thus, among African American persons, multiple loci in the region of chromosome 15q25.1 appear to be strongly associated with lung cancer risk...
  25. pmc Data for Genetic Analysis Workshop 16 Problem 1, association analysis of rheumatoid arthritis data
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, MD Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    BMC Proc 3:S2. 2009
    ..Several questions could be addressed using the data, including analysis of genetic associations using single SNPs or haplotypes, as well as gene-gene and genetic analysis of SNPs for qualitative and quantitative factors...
  26. pmc Mitochondrial DNA content: its genetic heritability and association with renal cell carcinoma
    Jinliang Xing
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    J Natl Cancer Inst 100:1104-12. 2008
    ..Renal cell carcinoma accounts for 85% of all renal cancers. No studies have investigated the association between mtDNA content and the risk of renal cell carcinoma...
  27. ncbi In vitro sensitivity to ultraviolet B light and skin cancer risk: a case-control analysis
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1822-31. 2005
    ..However, an association between UV-induced chromosomal aberrations and risk of skin cancer in the general population has not been established...
  28. doi Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation
    Jinyun Chen
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Ann Surg Oncol 16:431-9. 2009
    ..13 (1.04-4.36), 3.18 (1.37-7.39), and 10.09 (3.17-32.05), respectively. These findings suggest these polymorphisms in the cell cycle genes are promising prognostic markers for patients with pancreatic cancer...
  29. ncbi Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation
    Jie Lin
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Hermann Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:2065-71. 2007
    ..As risk assessment for cancer risk is moving toward a multigenic pathway-based approach, future genotype-phenotype correlation studies should also investigate the combined effects of multiple genetic variants...
  30. ncbi Association of a p73 exon 2 G4C14-to-A4T14 polymorphism with risk of squamous cell carcinoma of the head and neck
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 25:1911-6. 2004
    ..70; 95% CI, 1.19-2.43), women (1.61; 1.09-2.37), current smokers (1.77; 1.25-2.51) and patients with oral cancer (1.54; 1.15-2.07). Our results suggest that this p73 polymorphism may be a risk marker for genetic susceptibility to SCCHN...
  31. ncbi An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:2251-7. 2004
    ..Using such a molecular evolutionary approach may hold great promise for prioritizing SNPs to be genotyped in future molecular epidemiological studies...
  32. ncbi DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Unit 189, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 15:886-91. 2006
    ....
  33. ncbi Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries
    Annie O Chan
    Department of Pathology, Division of Pathology and Laboratory Medicine, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 11:8281-7. 2005
    ..International differences in molecular pathology have not been studied extensively but have implications for the management of patients in different countries and of immigrant patients...
  34. pmc Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study
    Jinyun Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Pancreas 39:1-4. 2010
    ..We hypothesized that genetic variants in p21 and p27 may modify individual susceptibility to pancreatic cancer...
  35. ncbi Ascertainment correction for Markov chain Monte Carlo segregation and linkage analysis of a quantitative trait
    Jianzhong Ma
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77005, USA
    Genet Epidemiol 31:594-604. 2007
    ..Ascertainment correction greatly reduced biases in parameter estimates. Our method is designed for multiple, but a fixed number of trait loci...
  36. pmc Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome
    Mala Pande
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 17:2393-401. 2008
    ..Our results suggest that the I462V and Msp1 polymorphisms in CYP1A1 may be an additional susceptibility factor for disease expression in Lynch syndrome because they modify the age of colorectal cancer onset by up to 4 years...
  37. ncbi IGF1 gene polymorphism and risk for hereditary nonpolyposis colorectal cancer
    Maja Zecevic
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 98:139-43. 2006
    ..This is the first report, to our knowledge, to show that IGF1 variant genotypes modify risk of a hereditary form of cancer...
  38. pmc Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer
    Jinyun Chen
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Lett 272:32-9. 2008
    ..004; HR=2.91; 95%CI, 1.49-5.67). Our findings suggest that the p21 polymorphism independently and p21 and p27 polymorphisms jointly contribute to a significantly earlier age at diagnosis of pancreatic cancer...
  39. ncbi Influence of methylenetetrahydrofolate reductase gene polymorphisms C677T and A1298C on age-associated risk for colorectal cancer in a caucasian lynch syndrome population
    Mala Pande
    Department of Epidemiology, Unit 1365, The University of Texas M D Anderson Cancer Center, 1155 Hermann P Pressler Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 16:1753-9. 2007
    ..This is the first report to our knowledge to provide evidence that the C677T polymorphism modifies the age at onset of colorectal cancer in Caucasian Lynch syndrome subjects with the 677T allele having a protective effect...
  40. pmc Missense mutations in hMLH1 and hMSH2 are associated with exonic splicing enhancers
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 73:1157-61. 2003
    ..Similarly, pathogenic effects of >/=16% of missense mutations in the hMLH1 gene are ESE related. The colocalization of pathogenic missense mutations with ESE sites strongly suggests that their pathogenic effects are splicing related...
  41. ncbi ATM polymorphism and hereditary nonpolyposis colorectal cancer (HNPCC) age of onset (United States)
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Causes Control 16:749-53. 2005
    ..ATM germline mutations have been associated with breast and digestive cancers. In a smaller European study, the G-to-A polymorphism was associated with an increased risk of developing an HNPCC-related cancer within HNPCC families...
  42. pmc Building a statistical model for predicting cancer genes
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    PLoS ONE 7:e49175. 2012
    ..We provide the list of the top 200 predicted PCa genes, which can be used as candidates for experimental validation. The model may be modified to predict genes for other cancer sites...
  43. doi Accuracy of the BRCAPRO model among women with bilateral breast cancer
    Kaylene J Ready
    University of Texas M D Anderson Cancer Center, Department of Breast Medical Oncology, Unit 1354, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer 115:725-30. 2009
    ..The objectives of this study were to determine the accuracy of the BRCAPRO model among women with bilateral breast cancer and to determine whether their mutation status was dependent on their age at first diagnosis...
  44. ncbi Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population
    Jinyun Chen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 46:249-56. 2007
    ..The169G-to-A polymorphism did not have a significant influence on risk for HNPCC. However, when we did haplotype analysis for these two polymorphisms, the 91A-169G haplotype was associated with protection from HNPCC at an earlier age...
  45. ncbi p73 G4C14-to-A4T14 polymorphism and risk of lung cancer
    Guojun Li
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:6863-6. 2004
    ..61, 95% CI, 1.26-2.06), light smokers (OR = 1.58, 95% CI, 1.17-2.14), and squamous cell lung carcinoma (OR = 1.79, 95% CI, 1.32-2.42). These results suggest that this p73 polymorphism may be a marker for susceptibility to lung cancer...
  46. pmc Shifting paradigm of association studies: value of rare single-nucleotide polymorphisms
    Ivan P Gorlov
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 82:100-12. 2008
    ..Our analysis suggests that including rare SNPs in genotyping platforms will advance identification of causal SNPs in case-control association studies, particularly as sample sizes increase...
  47. ncbi A case-control analysis of lymphocytic chromosome 9 aberrations in lung cancer
    Yong Zhu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 102:536-40. 2002
    ..67 [0.84, 3.32]) and lung cancer (OR = 2.49 [0.81, 7.67]). Our findings suggest that chromosome 9 aberrations in PBLs might be considered a marker of lung cancer predisposition and may be associated with familial aggregation of cancer...
  48. pmc Mediating effects of smoking and chronic obstructive pulmonary disease on the relation between the CHRNA5-A3 genetic locus and lung cancer risk
    Jian Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas
    Cancer 116:3458-62. 2010
    ..However, it has not been established whether the association between genetic variants and lung cancer risk is a direct one or one mediated by nicotine dependence...
  49. ncbi GSTM1 polymorphism does not affect hereditary nonpolyposis colorectal cancer age of onset
    J Shawn Jones
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 13:676-8. 2004
  50. ncbi Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck
    Zhengdong Zhang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:5596-602. 2006
    ....
  51. pmc Interactions between cigarette smoking and selected polymorphisms in xenobiotic metabolizing enzymes in risk for colorectal cancer: A case-only analysis
    Mala Pande
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Carcinog 49:974-80. 2010
    ..Thus, the study of gene-environment and gene-gene interactions may help to identify high-risk subgroups that can be targeted for intensive smoking cessation and CRC screening interventions...
  52. ncbi The worldwide distribution of the VHL 598C>T mutation indicates a single founding event
    Enli Liu
    Baylor College of Medicine and Veterans Affairs Medical Center, Houston, TX, USA
    Blood 103:1937-40. 2004
    ..Haplotype analysis indicated a founder effect. We conclude that the VHL 598C>T mutation, the most common defect of congenital polycythemia yet found, was spread from a single founder 1,000 to 62,000 years ago...
  53. ncbi Dietary folate intake and lung cancer risk in former smokers: a case-control analysis
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 12:980-6. 2003
    ..Our data suggest that there is a possible protective role of dietary folate in lung carcinogenesis, a finding which may have implications in public health and cancer prevention...
  54. ncbi Smoking, DNA repair capacity and risk of nonsmall cell lung cancer
    Hongbing Shen
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 107:84-8. 2003
    ..The results suggest that suboptimal DRC is associated with increased risk of NSCLC and DRC may modulate the risk of lung cancer associated with smoking but the latter needs to be verified in larger studies...
  55. ncbi Genetic susceptibility for lung cancer: interactions with gender and smoking history and impact on early detection policies
    Olga Y Gorlova
    University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Hum Hered 56:139-45. 2003
    ....
  56. pmc Forward-time simulations of non-random mating populations using simuPOP
    Bo Peng
    Department of Epidemiology, The University of Texas, M D Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    Bioinformatics 24:1408-9. 2008
    ....
  57. ncbi Telomere dysfunction: a potential cancer predisposition factor
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Natl Cancer Inst 95:1211-8. 2003
    ..Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between telomere length and cancer risk in four ongoing case-control studies...
  58. ncbi Interplay between mutagen sensitivity and epidemiological factors in modulatinglung cancer risk
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 120:2687-95. 2007
    ..This new integrative approach should facilitate identification of high-risk subgroups and has important implications in LC prevention...
  59. ncbi Projecting individualized probabilities of developing bladder cancer in white individuals
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:4974-81. 2007
    ..There has been no risk assessment model for bladder cancer (BC). We developed the first model incorporating mutagen sensitivity and epidemiologic factors to predict BC risk...
  60. ncbi XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Carcinogenesis 24:505-9. 2003
    ..Our data suggest that the XPA 5' non-coding region polymorphism modulates NER capacity and is associated with decreased lung cancer risk, especially in the presence of exposure to tobacco carcinogens...
  61. pmc Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk
    Shih Jen Hwang
    Section of Clinical Cancer Genetics, Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 72:975-83. 2003
    ..These results quantitatively illustrated the spectrum of cancer risk in germline p53 mutation carriers and will provide valuable reference for the evaluation and treatment of patients with cancer...
  62. pmc An expanded risk prediction model for lung cancer
    Margaret R Spitz
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, P O Box 301439, Houston, TX 77230 1439, USA
    Cancer Prev Res (Phila) 1:250-4. 2008
    ..Addition of biomarker assays improved the sensitivity of the expanded models...
  63. pmc Individual-specific liability groups in genetic linkage, with applications to kindreds with Li-Fraumeni syndrome
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 70:813-7. 2002
    ..Application of our method to these families yielded significantly higher LOD scores and more-accurate recombination fractions than did analysis that did not account for individual-specific covariate information...
  64. ncbi Predicting the oncogenicity of missense mutations reported in the International Agency for Cancer Research (IARC) mutation database on p53
    Ivan P Gorlov
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Hum Mutat 26:446-54. 2005
    ..We estimated the relative oncogenicity of all missense mutations reported in the IARC p53 mutation database, and constructed a profile of oncogenicity of the missense mutations along the DNA-binding region of p53...
  65. pmc Testing for genetic linkage in families by a variance-components approach in the presence of genomic imprinting
    Sanjay Shete
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Hum Genet 70:751-7. 2002
    ..Optimal strategies for a genome scan of potentially imprinted traits are discussed...
  66. pmc Bladder cancer predisposition: a multigenic approach to DNA-repair and cell-cycle-control genes
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Am J Hum Genet 78:464-79. 2006
    ....
  67. ncbi Genome-wide meta-analysis for rheumatoid arthritis
    Carol J Etzel
    Department of Epidemiology, UT MD Anderson Cancer Center, 1155 Pressler Street Unit 1340, Houston, TX 77030, USA
    Hum Genet 119:634-41. 2006
    ..This procedure provided marginal evidence (P<0.05) of linkage on chromosome 1, 2, 5 and 18, strong evidence (P<0.01) on chromosomes 8 and 16, and overwhelming evidence in the HLA region of chromosome 6...
  68. ncbi Effect of winsorization on power and type 1 error of variance components and related methods of QTL detection
    Sanjay Shete
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Behav Genet 34:153-9. 2004
    ..A robust version of the LRT that adjusts for sample kurtosis showed the best power for nonnormal data. Finally, phenotype winsorization of nonnormal data reduces the bias in estimation of the major gene variance component...
  69. pmc A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer
    Jian Gu
    Department of Epidemiology, Unit 1340, The University of Texas MD Anderson Cancer Center, 1155 Pressler Blvd, Houston, TX 77030, USA
    Cancer Prev Res (Phila) 4:514-21. 2011
    ..In conclusion, we found that the SNP rs398652 on 14q21 was associated with longer telomere length and a reduced risk of bladder cancer and that a portion of the effect of this SNP on bladder cancer risk was mediated by telomere length...
  70. ncbi Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer
    Xifeng Wu
    Department of Epidemiology, Experimental Therapeutics, GI Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 24:3789-98. 2006
    ..Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy...
  71. ncbi p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity
    Xifeng Wu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Natl Cancer Inst 94:681-90. 2002
    ..We also examined the functionality of the p53 variants in apoptosis and DNA repair...
  72. ncbi Repair of UV light-induced DNA damage and risk of cutaneous malignant melanoma
    Qingyi Wei
    Department of Epidemiology, Unit 189, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Natl Cancer Inst 95:308-15. 2003
    ....
  73. ncbi Imprinting detection by extending a regression-based QTL analysis method
    Olga Y Gorlova
    Department of Epidemiology, MD Anderson Cancer Center, University of Texas, Unit 1340, 1155 Pressler Street, Houston, TX 77030, USA
    Hum Genet 122:159-74. 2007
    ..A parent-of-origin effect consistent with maternal imprinting was suggested at 99.67-111.26 Mb for body mass index, bioelectrical impedance analysis, waist circumference, and leptin concentration...
  74. pmc Detection of disease-associated deletions in case-control studies using SNP genotypes with application to rheumatoid arthritis
    Chih Chieh Wu
    Unit 1340, Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Genet 126:303-15. 2009
    ..We detected disease-associated deletions within the region of human leukocyte antigen in which genomic deletions were previously discovered in rheumatoid arthritis patients...
  75. pmc A modified forward multiple regression in high-density genome-wide association studies for complex traits
    Xiangjun Gu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Genet Epidemiol 33:518-25. 2009
    ....
  76. ncbi Statistical methods for anomalous discrete time series based on minimum cell count
    Chih Chieh Wu
    Department of Epidemiology, Unit 1340, The University of Texas M D Anderson Cancer Center, 1155 Pressler Street, Houston, Texas 77030, USA
    Biom J 50:86-96. 2008
    ..Data on a temporal series of adolescent suicide from the US National Center for Health Statistics were analyzed using these methods...
  77. pmc A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians
    Qian Liu
    Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 51:433-8. 2012
    ..In addition, this SNP may serve as a prognostic marker in PDA patients who undergo the same or similar treatment as the clinical trials...
  78. ncbi How to get the most from microarray data: advice from reverse genomics
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, Unit 1374, The University of Texas MD Anderson Cancer Center, 1155 Pressler Street, Houston, TX 77030 3721, USA
    BMC Genomics 15:223. 2014
    ..The goal of this study was to identify the best microarray data-derived predictor of known cancer associated genes...
  79. pmc GWAS meets microarray: are the results of genome-wide association studies and gene-expression profiling consistent? Prostate cancer as an example
    Ivan P Gorlov
    Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    PLoS ONE 4:e6511. 2009
    ..It is not obvious whether there is a consistency between the candidate genes identified by GWAS (GWAS genes) and those identified by profiling gene expression (microarray genes)...
  80. pmc Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q
    Shenying Fang
    Department of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Epidemiol Biomarkers Prev 19:3157-66. 2010
    ..Genetic susceptibility for cancer can differ substantially among families. We use trait-related covariates to identify a genetically homogeneous subset of families with the best evidence for linkage in the presence of heterogeneity...
  81. ncbi Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23
    Linda L Bachinski
    Section of Cancer Genetics, Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:427-31. 2005
    ..Identification ofa third predisposing gene and its underlying mutation(s) should provide insight into other genetic events that predispose to the genesis of the diverse tumor types associated with LFS and its variants...
  82. ncbi Dissecting the heterogeneity of rheumatoid arthritis through linkage analysis of quantitative traits
    Lindsey A Criswell
    University of California, San Francisco, CA 94143, USA
    Arthritis Rheum 56:58-68. 2007
    ..To dissect the heterogeneity of rheumatoid arthritis (RA) through linkage analysis of quantitative traits, specifically, IgM rheumatoid factor (IgM-RF) and anti-cyclic citrullinated peptide (anti-CCP) autoantibody titers...
  83. ncbi Extension of variance components approach to incorporate temporal trends and longitudinal pedigree data analysis
    Mariza de Andrade
    Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA
    Genet Epidemiol 22:221-32. 2002
    ..The results of our analysis show that the apolipoprotein E locus has no effect on interindividual variability in systolic blood pressure. We found that the longitudinal measure of heritability of systolic blood pressure is 0.32...
  84. ncbi Stochastic search gene suggestion: a Bayesian hierarchical model for gene mapping
    Michael D Swartz
    Department of Statistics, Texas A and M University, 3143 TAMU, College Station, Texas 77843, USA
    Biometrics 62:495-503. 2006
    ..Our software is available on the website http://www.epigenetic.org/Linkage/ssgs-public/...
  85. pmc Common deletion of SMAD4 in juvenile polyposis is a mutational hotspot
    James R Howe
    Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242 1086, USA
    Am J Hum Genet 70:1357-62. 2002
    ....
  86. pmc A genome-wide screen for nicotine dependence susceptibility loci
    Gary E Swan
    Center for Health Sciences, SRI International, Menlo Park, California, USA
    Am J Med Genet B Neuropsychiatr Genet 141:354-60. 2006
    ..Several of the corresponding support intervals were near putative loci reported previously (on chromosomes 6, 7, and 8) while others appear to be novel (on chromosomes 5, 16, and 19)...
  87. ncbi Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations
    Mark Van Oene
    Ellipsis Biotherapeutics Corporation, Toronto, Ontario, Canada
    Arthritis Rheum 52:1993-8. 2005
    ....
  88. pmc Characterization of BRCA1 and BRCA2 mutations in a large United States sample
    Sining Chen
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    J Clin Oncol 24:863-71. 2006
    ..Existing studies have focused on Ashkenazi Jews (AJ) or on families from outside the United States. In this article, we consider the US population using the largest US-based cohort to date of both AJ and non-AJ families...
  89. ncbi Empirical bayes method for incorporating data from multiple genome scans
    T Mark Beasley
    Department of Biostatistics, Section of Statistical Genetics, The University of Alabama at Birmingham, 35294, USA
    Hum Hered 60:36-42. 2005
    ..This EB method for incorporating data from multiple studies into genome scan analyses seems promising...
  90. pmc Bias in estimates of quantitative-trait-locus effect in genome scans: demonstration of the phenomenon and a method-of-moments procedure for reducing bias
    David B Allison
    Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, 35294 0022, USA
    Am J Hum Genet 70:575-85. 2002
    ..Finally, limitations of the MOM approach are noted, and we discuss some alternative procedures that may also reduce bias...
  91. ncbi Support for previously identified alcoholism susceptibility Loci in a cohort selected for smoking behavior
    Kirk C Wilhelmsen
    Department of Neurology, Gallo Institute, Center for Health Sciences, SRI International, Menlo Park, California, USA
    Alcohol Clin Exp Res 29:2108-15. 2005
    ..In this paper we use, for the first time, linkage analysis to search for alcoholism-related phenotypes in a family sample selected for smoking behavior...
  92. ncbi Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins
    Tom W J Huizinga
    Department of Rheumatology C4R, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Arthritis Rheum 52:3433-8. 2005
    ..We undertook this study to make the first comparison of SE allele frequencies in the healthy population with those in RA patients who do or do not harbor anti-CCP antibodies...
  93. pmc Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis
    Damini Jawaheer
    Center for Genomics and Human Genetics, North Shore Long Island Jewish Research Institute, Manhasset, NY, 11030, USA
    Am J Hum Genet 71:585-94. 2002
    ....
  94. ncbi A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease
    Bill Newman
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Gastroenterology 128:260-9. 2005
    ..Here we examine the contribution of this susceptibility haplotype alone and in combination with CARD15 variants to CD subphenotypes and to susceptibility to ulcerative colitis (UC)...
  95. pmc Possible genomic imprinting of three human obesity-related genetic loci
    Chuanhui Dong
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104 6140, USA
    Am J Hum Genet 76:427-37. 2005
    ..79; multipoint LOD of 3.72 for BMI) in region 13q32, in the European American sample. The results suggest that parent-of-origin effects, perhaps including genomic imprinting, may play a role in human obesity...
  96. ncbi Functional variants of OCTN cation transporter genes are associated with Crohn disease
    Vanya D Peltekova
    Department of Medicine, University of Toronto, and Department of Immunology, Mount Sinai Hospital Samuel Lunenfeld Research Institute, Ontario, Canada
    Nat Genet 36:471-5. 2004
    ..These results suggest that SLC22A4, SLC22A5 and CARD15 act in a common pathogenic pathway to cause Crohn disease...
  97. pmc A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q33.2
    Monica Chang
    Celera, Alameda, California, United States of America
    PLoS Genet 4:e1000107. 2008
    ..Lastly, in combination with the other two known genetic risk factors, HLA-DRB1 and PTPN22, the variants reported here generate more than a 45-fold RA-risk differential...
  98. ncbi Screening the genome for rheumatoid arthritis susceptibility genes: a replication study and combined analysis of 512 multicase families
    Damini Jawaheer
    Center for Genomics and Human Genetics, Manhasset, New York 11030, USA
    Arthritis Rheum 48:906-16. 2003
    ..A number of non-HLA loci that have shown evidence (P < 0.05) for linkage with rheumatoid arthritis (RA) have been previously identified. The present study attempts to confirm these findings...
  99. pmc Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus
    Hye Soon Lee
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, United States of America
    Mol Med 14:293-300. 2008
    ..These data emphasize that further analysis of the MHC is likely to reveal genetic risk factors for rheumatoid arthritis that are independent of the DRB1 shared epitope alleles...
  100. pmc Joint tests for quantitative trait loci in experimental crosses
    T Mark Beasley
    Department of Biostatistics, Section on Statistical Genetics, University of Alabama at Birmingham, Birmingham, AL, USA
    Genet Sel Evol 36:601-19. 2004
    ..Joint tests were generally more powerful for one-tailed selection under both backcross and F2 intercross situations. However, joint tests cannot be recommended for one-tailed selective genotyping if segregation distortion is suspected...
  101. pmc Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer
    Pengyuan Liu
    Washington University, St Louis, MO 63110, USA
    J Natl Cancer Inst 100:1326-30. 2008
    ..67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted...

Research Grants20

  1. High Density Association Analysis of Lung Cancer
    Christopher Amos; Fiscal Year: 2009
    ..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
  2. High Density Association Analysis of Lung Cancer
    Christopher I Amos; Fiscal Year: 2010
    ..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
  3. Genetic Susceptibility for Lung Cancer in African Americans
    Christopher Amos; Fiscal Year: 2009
    ..This analysis will allow us to identify groups of African-American individuals at particularly higher risks for developing lung cancer. ..
  4. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2004
    ..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
  5. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2002
    ..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
  6. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2003
    ..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
  7. High Density Association Analysis of Lung Cancer
    Christopher Amos; Fiscal Year: 2009
    ..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
  8. Statistical Methods for Gene Environment Interactions In Lung Cancer
    Christopher Amos; Fiscal Year: 2009
    ..The simulation approaches and analytical discoveries from our research will be widely distributed. (End of Abstract) ..
  9. High Density Association Analysis of Lung Cancer
    Christopher Amos; Fiscal Year: 2009
    ..We are collaborating with the International Lung Cancer Consortium so that it can further validate our findings for a variety of different populations, in future initiatives. ..
  10. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2006
    ..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
  11. Positional Gene Identification of Complex Traits
    Christopher Amos; Fiscal Year: 2005
    ..Finally, we will apply the methods that we are developing as part of existing studies of obesity, cancer-predisposition and rheumatoid arthritis. ..
  12. LINKAGE AND LINKAGE DISEQUILIBRIUM METHODS FOR TRAITS
    Christopher Amos; Fiscal Year: 2001
    ..abstract_text> ..
  13. LINKAGE AND LINKAGE DISEQUILIBRIUM METHODS FOR TRAITS
    Christopher Amos; Fiscal Year: 2000
    ..abstract_text> ..
  14. LINKAGE AND LINKAGE DISEQUILIBRIUM METHODS FOR TRAITS
    Christopher Amos; Fiscal Year: 1999
    ..abstract_text> ..
  15. LINKAGE AND LINKAGE DISEQUILIBRIUM METHODS FOR TRAITS
    Christopher Amos; Fiscal Year: 1999
    ..abstract_text> ..