Research Topics
| Michael G AmanSummaryAffiliation: The Ohio State University Country: USA Publications
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Detail Information
Publications
Treatment of behavior disorders in mental retardation: report on transitioning to atypical antipsychotics, with an emphasis on risperidoneMichael G Aman
Nisonger Center, Ohio State University, Columbus 43210 1257, USA
J Clin Psychiatry 65:1197-210. 2004....- Methylphenidate treatment in children with borderline IQ and mental retardation: analysis of three aggregated studiesMichael G Aman
Department of Psychiatry, School of Medicine, University of Auckland, Auckland, New Zealand
J Child Adolesc Psychopharmacol 13:29-40. 2003..To determine response of low-IQ children with attention deficit hyperactivity disorder (ADHD) symptoms to methylphenidate (MPH)... - Four-year follow-up of children with low intelligence and ADHD: a replicationMichael G Aman
The Nisonger Center, The Ohio State University, Columbus 43210 2157, USA
Res Dev Disabil 23:119-34. 2002..Ratings on the ABC by parents and teachers showed significantly lower scores at follow-up on the Hyperactivity subscale. Relatively few associations were found between initial ratings and follow-up ratings on standardized scales... 
Evaluation of pharmacological treatment of impulsivity in children with attention deficit hyperactivity disorderNancy A Neef
College of Education, The Ohio State University, 1945 N High St, 367 Arps Hall, Columbus, Ohio 43210, USA
J Appl Behav Anal 38:135-46. 2005..Reinforcer immediacy was the most influential dimension for 3 of the students and the second most influential dimension for 1 of the students across placebo and medication conditions; medication did not affect these sensitivities...
Aripiprazole for the treatment of irritability associated with autismCristan Ann Farmer
The Ohio State University, Nisonger Center, 1581 Dodd Drive, Columbus, OH 43210, USA
Expert Opin Pharmacother 12:635-40. 2011..It seems to be effective in treating irritability associated with autism, but more research is needed...- Medication patterns in patients with autism: temporal, regional, and demographic influencesMichael G Aman
The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1257, USA
J Child Adolesc Psychopharmacol 15:116-26. 2005..Greater age and handicap, and more restrictive placements, were associated with the use of several drug classes. Knowledge of these patterns may help families and medical planners anticipate future needs... - Behavioral assessment of impulsivity: a comparison of children with and without attention deficit hyperactivity disorderNancy A Neef
The Ohio State University, College of Education, Columbus 43210, USA
J Appl Behav Anal 38:23-37. 2005..Results are discussed with respect to the implications for assessment and treatment of ADHD... - Atomoxetine for hyperactivity in autism spectrum disorders: placebo-controlled crossover pilot trialL Eugene Arnold
The authors are with Ohio State University s Nisonger Center, Columbus, OH 43210, USA
J Am Acad Child Adolesc Psychiatry 45:1196-205. 2006..To explore placebo-controlled efficacy and safety of atomoxetine (ATX) for attention-deficit/hyperactivity disorder (ADHD) symptoms in children with autism spectrum disorders (ASD)... - Acute and long-term safety and tolerability of risperidone in children with autismMichael G Aman
The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
J Child Adolesc Psychopharmacol 15:869-84. 2005..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain... - Treatment planning for patients with autism spectrum disordersMichael G Aman
The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
J Clin Psychiatry 66:38-45. 2005.... - Validity of the autism diagnostic interview-revisedLuc Lecavalier
Nisonger Center, The Ohio State University, Columbus, USA
Am J Ment Retard 111:199-215. 2006..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion... - Project MED: effects of a Medication EDucation booklet series for individuals with intellectual disabilitiesMichael G Aman
Ohio State University, Columbus, OH 43210 1296, USA
Intellect Dev Disabil 45:33-45. 2007..Female and minority respondents indicated somewhat higher satisfaction with the booklets than did their counterparts... - Treatment of inattention, overactivity, and impulsiveness in autism spectrum disordersMichael G Aman
Department of Psychology, Ohio State University, 225 Psychology Building, 1835 Neil Avenue, Columbus, OH 43210, USA
Child Adolesc Psychiatr Clin N Am 17:713-38, vii. 2008..Evidence for efficacy seems weakest for newer antidepressants, anxiolytics, and mood stabilizers... - Plasma pharmacokinetic characteristics of risperidone and their relationship to saliva concentrations in children with psychiatric or neurodevelopmental disordersMichael G Aman
The Nisonger Center, The Ohio State University, Columbus, Ohio 43210, USA
Clin Ther 29:1476-86. 2007..Risperidone is probably the most frequently used atypical antipsychotic in the pediatric population... - Medication and parent training in children with pervasive developmental disorders and serious behavior problems: results from a randomized clinical trialMichael G Aman
The Nisonger Center UCEDD, Ohio State University, Columbus, OH 43210 1257, USA
J Am Acad Child Adolesc Psychiatry 48:1143-54. 2009..We tested whether combined treatment (COMB) with risperidone and parent training (PT) in behavior management is superior to medication alone (MED) in improving severe behavioral problems in children with PDDs... - Double-blind, placebo-controlled study of risperidone for the treatment of disruptive behaviors in children with subaverage intelligenceMichael G Aman
Nisonger Center UAP, Ohio State University, Columbus 43210 1257, USA
Am J Psychiatry 159:1337-46. 2002..The short-term efficacy and safety of risperidone in the treatment of disruptive behaviors was examined in a well-characterized cohort of children with subaverage intelligence... - Psychometric properties of the Children's Scale of Hostility and Aggression: Reactive/Proactive (C-SHARP)Cristan A Farmer
Nisonger Center, Ohio State University, Columbus, OH 43210, USA
Res Dev Disabil 31:270-80. 2010..The C-SHARP appears to have fundamentally sound psychometric characteristics, although more research is needed... - Development of the Children's Scale of Hostility and Aggression: Reactive/Proactive (C-SHARP)Cristan A Farmer
Ohio State University Nisonger Center, Columbus, OH 43210, USA
Res Dev Disabil 30:1155-67. 2009..General validity was supported by expected differences between age and gender groups. Preliminary normative data were presented. The C-SHARP appears to be a promising tool for assessing aggression and hostility in children with DD... - Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trialsL Eugene Arnold
Ohio State University, 479 S Galena Road, Sunbury, OH 43074, USA
J Am Acad Child Adolesc Psychiatry 42:1443-50. 2003..A consumer-oriented efficacy assessment in clinical trials should measure changes in chief complaint and consumer request (symptoms of most concern to patient/caregiver), which may be diluted in change scores of multisymptom scales... - Line-item analysis of the Aberrant Behavior Checklist: results from two studies of aripiprazole in the treatment of irritability associated with autistic disorderMichael G Aman
The Nisonger Center, The Ohio State University, Columbus, Ohio 43210, USA
J Child Adolesc Psychopharmacol 20:415-22. 2010..The aim of this study was to evaluate the efficacy of aripiprazole in the treatment of discrete symptoms of irritability associated with autistic disorder, as well as other symptoms captured on the Aberrant Behavior Checklist (ABC)... - Reliability and validity of an assessment instrument for anxiety, depression, and mood among individuals with mental retardationAnna J Esbensen
The Ohio State University, Columbus, Ohio 43210, USA
J Autism Dev Disord 33:617-29. 2003..The ADAMS appears to be a psychometrically sound instrument for screening anxiety, depression and mood disorders among individuals with mental retardation... - Outcome measures for clinical drug trials in autismMichael G Aman
Department of Psychology, Nisonger Center, Ohio State University, Columbus 43210 1257, USA
CNS Spectr 9:36-47. 2004..It is often appropriate to include laboratory tests and assessments for continence and sleep pattern... - Risperidone and cognitive function in children with disruptive behavior disordersGahan J Pandina
Medical Affairs, Janssen Pharmaceutica, Inc, Titusville, New Jersey 08560, USA
Biol Psychiatry 62:226-34. 2007..Effects of risperidone on cognitive function in children with disruptive behavior disorders (DBDs) and subaverage intelligence quotient (IQ) were assessed... - Risperidone in the management of disruptive behavior disordersGahan J Pandina
Medical Affairs Division, Janssen Pharmaceutica Products, L P, Titusville, New Jersey, USA
J Child Adolesc Psychopharmacol 16:379-92. 2006..As with all antipsychotics, practitioners should monitor young patients' growth, weight, sexual maturation, and metabolic parameters... - The Repetitive Behavior Scale-Revised: independent validation in individuals with autism spectrum disordersKristen S L Lam
Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, CB 3367, Chapel Hill, NC 27599 3367, USA
J Autism Dev Disord 37:855-66. 2007..quot; Measures of internal consistency were high for this solution, and interrater reliability data suggested that the RBS-R performs well in outpatient settings... - A prospective open trial of guanfacine in children with pervasive developmental disordersLawrence Scahill
Yale Child Study Center, P O Box 207900, New Haven, CT 06520, USA
J Child Adolesc Psychopharmacol 16:589-98. 2006..A common complaint for children with pervasive developmental disorder (PDD) is hyperactivity. The purpose of this pilot study was to gather preliminary information on the efficacy of guanfacine in children with PDD and hyperactivity... - Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot studyRonald L Lindsay
Children s Health Center of St Joseph s Hospital and Medical Center, Arizona 85013, USA
J Intellect Dev Disabil 31:204-9. 2006..Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain... - Impact of recent findings on study design of future autism clinical trialsEric Hollander
Department of Psychiatry, Mount Sinai School of Medicine, New York City, New York 10029 6574, USA
CNS Spectr 9:49-56. 2004..The Internet System for Assessing Autistic Children system for managing multicenter clinical trials in autism and statistical issues in autism research are also described... - Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measuresDavid J Posey
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
Biol Psychiatry 61:538-44. 2007.... - Consensus report on impulsive aggression as a symptom across diagnostic categories in child psychiatry: implications for medication studiesPeter S Jensen
Center for the Advancement of Children s Mental Health, Columbia University NYSPI 1051 Riverside Drive, Unit 78, New York, NY 10032, USA
J Am Acad Child Adolesc Psychiatry 46:309-22. 2007..If so, how should IA be assessed, pharmacological studies designed, and ethical issues addressed?.. - Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioningDenis G Sukhodolsky
The Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA
J Abnorm Child Psychol 36:117-28. 2008..Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates of parent-rated anxiety symptoms in a large sample of children with PDD... - Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disordersLawrence Scahill
Yale Child Study Center, Yale University, New Haven, CT 06520, USA
J Am Acad Child Adolesc Psychiatry 45:1114-23. 2006..To examine the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scales (CYBOCS) modified for pervasive developmental disorders (PDDs)... - Factor analysis and norms for parent ratings on the Aberrant Behavior Checklist-Community for young people in special educationElaine C Brown
The Nisonger Center for Mental Retardation and Developmental Disabilities, The Ohio State University, Columbus 43210-1296, USA
Res Dev Disabil 23:45-60. 2002..With some qualifications, the ABC-C appears to be valid for assessing children in special educational settings, although further research is needed on the ABC's factor structure in this population... - Risperidone in children with autism and serious behavioral problemsJames T McCracken
University of California, Los Angeles, USA
N Engl J Med 347:314-21. 2002..The short period of this trial limits inferences about adverse effects such as tardive dyskinesia... - Prevalence and patterns of use of psychoactive medicines in individuals with autism in the Autism Society of North CarolinaKristen S Langworthy-Lam
The Nisonger Center for Mental Retardation and Developmental Disabilities, The Ohio State University, Columus, Ohio 43210, USA
J Child Adolesc Psychopharmacol 12:311-21. 2002..These findings suggest that individuals with autism are a frequently medicated group, although the empirical research support for most agents being used is still very limited... - Prevalence and patterns of use of psychoactive medicines among individuals with autism in the Autism Society of OhioMichael G Aman
The Nisonger Center for Mental Retardation and Developmental Disabilities, The Ohio State University, 1581 Dodd Drive, Columbus, OH 43210-1296, USA
J Autism Dev Disord 33:527-34. 2003..OTC autism preparations were used in substantial numbers of individuals, despite limited research support and the possibility of toxic effects... - Pharmacologic therapies aid treatment for autismRonald L Lindsay
Arizona Child Study Center, Phoenix, USA
Pediatr Ann 32:671-6. 2003..Further well-designed double-blind studies with significant numbers of subjects and defined target symptoms will provide the data that will guide therapeutic decisions in the future... - Long-term, open-label study of risperidone in children with severe disruptive behaviors and below-average IQRobert L Findling
Department of Psychiatry, Case Western Reserve University, University Hospital of Cleveland, OH 44106, USA
Am J Psychiatry 161:677-84. 2004..This study determined the long-term safety and effectiveness of risperidone in treating severe disruptive behavior in children with subaverage intelligence... - Discontinuation of risperidone and reversibility of weight gain in children with disruptive behavior disordersRonald L Lindsay
The Nisonger Center for Mental Retardation, Ohio State University, Columbus, Ohio, USA
Clin Pediatr (Phila) 43:437-44. 2004..The authors provide several recommendations for clinicians and researchers working with atypical antipsychotics... - Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQMichael G Aman
The Nisonger Center, Ohio State University, 1581 Dodd Drive, Columbus, OH 43210-1257, USA
J Child Adolesc Psychopharmacol 14:243-54. 2004..CONCLUSION: Risperidone was a safe and effective treatment, with or without a combined psychostimulant, for both disruptive behavior disorders and comorbid ADHD in children... - Empirical classification of behavioral and psychiatric problems in children and adolescents with mental retardationElaine C Brown
Sierra Regional Center, Sparks, Nevada, USA
Am J Ment Retard 109:445-55. 2004..The external data provided modest to strong support for all except one cluster (Social Withdrawal With Agitation)... - Management of hyperactivity and other acting-out problems in patients with autism spectrum disorderMichael G Aman
Nisonger Center, Ohio State University, Columbus, OH 43210-1296, USA
Semin Pediatr Neurol 11:225-8. 2004..More research is needed on the management of all of these target symptoms, both for new agents (e.g., atomoxetine) and for established psychoactive medicines... - Risperidone and adaptive behavior in children with autismSusan K Williams
Yale University, New Haven, CT 06520-7900, USA
J Am Acad Child Adolesc Psychiatry 45:431-9. 2006..Vineland age-equivalent scores appear to be most useful in assessing change with treatment over time... - Research knowledge among parents of children participating in a randomized clinical trialBenedetto Vitiello
Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
J Am Acad Child Adolesc Psychiatry 44:145-9. 2005..Parental permission is required for child research, but parents' understanding of research aims and procedures has not been well documented. Parental research knowledge was assessed during a clinical trial in autism... - Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacologyChristopher J McDougle
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
Am J Psychiatry 162:1142-8. 2005..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior... - Risperidone reduces aggression in boys with a disruptive behaviour disorder and below average intelligence quotient: analysis of two placebo-controlled randomized trialsJohn C LeBlanc
Department of Pediatrics, Psychiatry, Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
Int Clin Psychopharmacol 20:275-83. 2005..6; mean endpoint AS 8.3; 21.7% reduction). Risperidone was efficacious in reducing symptoms of aggression in boys of below average IQ with disruptive behaviour disorders... - Effects of short- and long-term risperidone treatment on prolactin levels in children with autismGeorge M Anderson
Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 61:545-50. 2007..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism... - Neurochemical correlates of autistic disorder: a review of the literatureKristen S L Lam
Neurodevelopmental Disorders Research Center, University of North Carolina at Chapel Hill, USA
Res Dev Disabil 27:254-89. 2006..In addition, research in neurochemistry must continue to work in concert with other subspecialties to form a more comprehensive and theory-based approach to the neurobiological correlates of autistic disorder... - The Aberrant Behavior Checklist and the Behavior Problems Inventory: convergent and divergent validityJohannes Rojahn
George Mason University, Center for Cognitive Development, 4400 University Drive, MSN 2C6, Fairfax, VA 22030, USA
Res Dev Disabil 24:391-404. 2003..Thus, the ABC and the BPI cross-validated one another where expected, and they diverged for subscales thought to have little relationship... - Developmental disabilities modification of the Children's Global Assessment ScaleAnn Wagner
National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 61:504-11. 2007..To measure global functioning in treatment studies, the Children's Global Assessment Scale was modified and psychometric properties of the revised version (DD-CGAS) were assessed in children with PDD... - Factor analysis of the Nisonger Child Behavior Rating Form in children with autism spectrum disordersLuc Lecavalier
Department of Psychology and Nisonger Centre, The Ohio State University, Columbus, Ohio 43210-1257, USA
J Autism Dev Disord 34:709-21. 2004..Confirmatory factor analyses indicated good fits for the social competence items and acceptable fits for the problem behavior items. Overall, results supported the construct validity of the NCBRF in children and adolescents with ASDs...