CHARLES ALLIS

..Although we restrict our comments to H3 variants in mammals, we expect that the more general concepts presented here will apply to other histone variant families in organisms that employ them...

..X, with oncogenesis provides strong support for an emerging view that covalent modification of histones plays a vital role in the regulation of chromatin dynamics with far-reaching implications for human biology and disease. ..

..Understanding these mechanisms in normal development is essential if we are to understand cases of abnormal development, some congenital diseases and certain pathological situations such as neoplastic transformation. ..

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..Knowing how to control which genes to turn on or off, using therapy, could reduce the risk of certain diseases. The implications of this research for human biology and human health are far-reaching. ..

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..Whether any of the 'rules' that emerge from these studies will also apply to heterochromatin-induced gene inactivation in other organisms is not known, but remains an exciting possibility. ..

..Understanding these mechanisms in normal cells is essential if the investigator is to understand abnormal development and tumorigenesis. ..

..Knowing how to control which genes to turn on or off, using therapy, could reduce the risk of certain diseases. The implications of this research for human biology and human health are far-reaching. ..