C David Allis

Summary

Affiliation: The Rockefeller University
Country: USA

Publications

  1. doi Spreading chromatin into chemical biology
    C David Allis
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Chembiochem 12:264-79. 2011
  2. pmc The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation
    Jaehoon Kim
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 49:1121-33. 2013
  3. pmc Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
    Alexander J Ruthenburg
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA
    Cell 145:692-706. 2011
  4. pmc Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes
    Debabrata Biswas
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:15751-6. 2011
  5. pmc Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
    Peter W Lewis
    Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:14075-80. 2010
  6. pmc Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
    Gang G Wang
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    Nature 459:847-51. 2009
  7. ncbi Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 28:677-91. 2007
  8. pmc WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
    Andrew Xiao
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 457:57-62. 2009
  9. pmc The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress
    Lindsey A Baker
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York, USA
    Mol Cell Biol 33:3735-48. 2013
  10. doi DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition
    Simon J Elsässer
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    Nature 491:560-5. 2012

Collaborators

Detail Information

Publications69

  1. doi Spreading chromatin into chemical biology
    C David Allis
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Chembiochem 12:264-79. 2011
    ..The primary objective of this article is to serve as a "call to arms" for chemists to contribute to the development of the precision tools needed to answer pressing molecular problems in this rapidly moving field...
  2. pmc The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation
    Jaehoon Kim
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 49:1121-33. 2013
    ..As not all members of the H3K4 methyltransferase family contain n-SET domains, our studies draw attention to the n-SET domain as a predictor of an H2B ubiquitylation-sensing mechanism that leads to downstream H3K4 methylation...
  3. pmc Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
    Alexander J Ruthenburg
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA
    Cell 145:692-706. 2011
    ..Together, our data call attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations...
  4. pmc Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes
    Debabrata Biswas
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 108:15751-6. 2011
    ..Thus, our study provides direct mechanistic insight into the role of fusion partners in MLL fusion-mediated leukemogenesis...
  5. pmc Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres
    Peter W Lewis
    Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, 1230 York Ave, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:14075-80. 2010
    ..These data demonstrate that Daxx functions as an H3.3-specific chaperone and facilitates the deposition of H3.3 at heterochromatin loci in the context of the ATRX-Daxx complex...
  6. pmc Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger
    Gang G Wang
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    Nature 459:847-51. 2009
    ....
  7. ncbi Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 28:677-91. 2007
    ....
  8. pmc WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
    Andrew Xiao
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    Nature 457:57-62. 2009
    ..Our work demonstrates a new mechanism that regulates the DNA damage response and expands our knowledge of domains that contain intrinsic tyrosine kinase activity...
  9. pmc The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress
    Lindsey A Baker
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York, USA
    Mol Cell Biol 33:3735-48. 2013
    ..Our results establish a function for Snt2 in regulating transcription in response to oxidative stress and suggest Snt2 may also function in multiple stress pathways. ..
  10. doi DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition
    Simon J Elsässer
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    Nature 491:560-5. 2012
    ..3-specific residues, and functional studies address the contributions of Gly 90 in H3.3 and Glu 225 in DAXX to chaperone-mediated H3.3 variant recognition specificity...
  11. doi Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression
    Zhanxin Wang
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 141:1183-94. 2010
    ..Our results highlight the role of PHD3-Bromo cassette as a regulatory platform, orchestrating MLL1 binding of H3K4me3/2 marks and cyclophilin-mediated repression through HDAC recruitment...
  12. ncbi How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
    Sean D Taverna
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nat Struct Mol Biol 14:1025-40. 2007
    ..Changes in these interactions may have far-reaching implications for human biology and disease, notably cancer...
  13. ncbi Dynamic regulation of effector protein binding to histone modifications: the biology of HP1 switching
    Holger L Dormann
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York, USA
    Cell Cycle 5:2842-51. 2006
    ....
  14. pmc RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena
    Yifan Liu
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 21:1530-45. 2007
    ..These studies provide a framework for an RNAi-dependent, Polycomb group protein-mediated heterochromatin formation pathway in Tetrahymena and underscore the connection between the two highly conserved machineries in eukaryotes...
  15. pmc Hira-dependent histone H3.3 deposition facilitates PRC2 recruitment at developmental loci in ES cells
    Laura A Banaszynski
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Cell 155:107-20. 2013
    ..Moreover, our findings support the emerging notion that H3.3 has multiple functions in distinct genomic locations that are not always correlated with an "active" chromatin state. ..
  16. pmc Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2
    Sarah J Whitcomb
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 287:23718-25. 2012
    ..Taken together, these results highlight how the position of nucleosome monoubiquitylation affects the specificity and direction of cross-talk with enzymatic activities on chromatin...
  17. pmc H3R42me2a is a histone modification with positive transcriptional effects
    Fabio Casadio
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065
    Proc Natl Acad Sci U S A 110:14894-9. 2013
    ..We propose that methylation of basic histone residues at the DNA interface may disrupt histone:DNA interactions, with effects on downstream processes, notably transcription. ..
  18. pmc DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA
    Steen K T Ooi
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Nature 448:714-7. 2007
    ..These data indicate that DNMT3L recognizes histone H3 tails that are unmethylated at lysine 4 and induces de novo DNA methylation by recruitment or activation of DNMT3A2...
  19. pmc Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini
    Sean D Taverna
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:2086-91. 2007
    ..This methodology is applicable to other histones and larger polypeptides and will likely be a valuable tool in understanding the roles of combinatorial patterns of PTMs...
  20. pmc Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation
    Elizabeth M Duncan
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Cell 135:284-94. 2008
    ..Our studies underscore the intriguing possibility that histone proteolysis, brought about by Cathepsin L and potentially other family members, plays a role in development and differentiation that was not previously recognized...
  21. pmc Analysis of histones and chromatin in Xenopus laevis egg and oocyte extracts
    Laura A Banaszynski
    The Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Methods 51:3-10. 2010
    ..We expect that these methods will be of use in promoting further understanding of embryonic chromatin in a unique experimental system...
  22. pmc Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis
    Thomas A Milne
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Mol Cell 38:853-63. 2010
    ..Since wild-type MLL1 and oncogenic MLL1 fusion proteins have overlapping yet distinct recruitment mechanisms, this creates a window of opportunity that could be exploited for the development of targeted therapies...
  23. doi Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    Peter W Lewis
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Science 340:857-61. 2013
    ..We propose that K-to-M substitutions may represent a mechanism to alter epigenetic states in a variety of pathologies...
  24. pmc Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity
    Xinyang Zhao
    Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Genes Dev 22:640-53. 2008
    ..These arginine methylation sites and the dynamic regulation of corepressor binding are lost in the leukemia-associated RUNX1-ETO fusion protein, which likely contributes to its dominant inhibitory activity...
  25. pmc A phosphorylated subpopulation of the histone variant macroH2A1 is excluded from the inactive X chromosome and enriched during mitosis
    Emily Bernstein
    Laboratory of Chromatin Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 105:1533-8. 2008
    ..We provide evidence that S137ph is enriched in mitosis, suggestive of a role in the regulation of mH2A posttranslational modifications throughout the cell cycle...
  26. pmc Analysis of histones in Xenopus laevis. I. A distinct index of enriched variants and modifications exists in each cell type and is remodeled during developmental transitions
    David Shechter
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 284:1064-74. 2009
    ..Overall, our observations suggest that each metazoan cell type may have a unique histone modification signature correlated with its differentiation status...
  27. ncbi Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF
    Haitao Li
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 442:91-5. 2006
    ..Our findings call attention to the PHD finger as a previously uncharacterized chromatin-binding module found in a large number of chromatin-associated proteins...
  28. ncbi Expression patterns and post-translational modifications associated with mammalian histone H3 variants
    Sandra B Hake
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    J Biol Chem 281:559-68. 2006
    ..1 and H3.2 in mammalian cells should not be treated as equivalent proteins...
  29. pmc Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin
    Emily Bernstein
    Laboratory of Chromatin Biology, The Rockefeller University, 1230 York Ave, New York, New York 10021, USA
    Mol Cell Biol 26:2560-9. 2006
    ....
  30. pmc New functions for an old variant: no substitute for histone H3.3
    Simon J Elsaesser
    The Rockefeller University, New York, NY 10065, USA
    Curr Opin Genet Dev 20:110-7. 2010
    ..3 in the germline. With strikingly little amino acid sequence difference to the canonical H3, H3.3 therefore accomplishes a surprising variety of cellular and developmental processes...
  31. pmc A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint
    David Shechter
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:749-54. 2009
    ..We propose that this isoform may be involved in modulating the cellular response to the rapid early cell cycles in externally developing species...
  32. ncbi Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs
    Sean D Taverna
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Mol Cell 24:785-96. 2006
    ..Our data support a general mechanism of transcriptional control through which histone acetylation upstream of gene activation is promoted partially through availability of H3K4me3, "read" by binding modules in select subunits...
  33. pmc ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours
    Ping Chi
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Nature 467:849-53. 2010
    ..It also represents a novel mechanism of oncogenic transcription factor activation...
  34. pmc Analysis of histones in Xenopus laevis. II. mass spectrometry reveals an index of cell type-specific modifications on H3 and H4
    Joshua J Nicklay
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10065, USA
    J Biol Chem 284:1075-85. 2009
    ..Our results are consistent with a histone code index for each cell type and uncover potential cross-talk between modifications on a single tail...
  35. pmc Histone variants in metazoan development
    Laura A Banaszynski
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Dev Cell 19:662-74. 2010
    ..Here, we review the role of histone variants in the embryo with particular emphasis on early mammalian development...
  36. ncbi Chromatin remodeling and cancer, Part II: ATP-dependent chromatin remodeling
    Gang G Wang
    Laboratory of Chromatin Biology, The Rockefeller University, and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Mol Med 13:373-80. 2007
    ..In part II of this series, we focus on connections between ATP-dependent chromatin-remodeling complexes and oncogenesis and discuss the potential clinical implications of chromatin remodeling and cancer...
  37. ncbi Multivalent engagement of chromatin modifications by linked binding modules
    Alexander J Ruthenburg
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10065, USA
    Nat Rev Mol Cell Biol 8:983-94. 2007
    ..We propose that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions...
  38. ncbi Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark
    Alexander J Ruthenburg
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell 25:15-30. 2007
    ..Finally, we hypothesize how the unique properties of the polyvalent chromatin fiber and associated effectors may amplify small differences in methyl-lysine recognition, simultaneously allowing for a dynamic chromatin architecture...
  39. pmc Proteome-wide prediction of acetylation substrates
    Amrita Basu
    Laboratory of Chromatin Biology, Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 106:13785-90. 2009
    ..Our approach, combined with more traditional experimental methods, may be useful for identifying acetylated substrates proteome-wide...
  40. pmc Ubiquitylation of histone H2B controls RNA polymerase II transcription elongation independently of histone H3 methylation
    Jason C Tanny
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 21:835-47. 2007
    ..We propose that ubiquitylation of H2B impacts transcription elongation and nuclear architecture through its effects on chromatin dynamics...
  41. ncbi Regulation of MLL1 H3K4 methyltransferase activity by its core components
    Yali Dou
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Nat Struct Mol Biol 13:713-9. 2006
    ..Mechanistic insights gained from this study can be generalized to the whole family of SET1-like histone methyltransferases in mammals...
  42. pmc PHD fingers in human diseases: disorders arising from misinterpreting epigenetic marks
    Lindsey A Baker
    The Rockefeller University, Laboratory of Chromatin Biology and Epigenetics, New York, NY 10065, USA
    Mutat Res 647:3-12. 2008
    ....
  43. ncbi Histone H2B deacetylation at lysine 11 is required for yeast apoptosis induced by phosphorylation of H2B at serine 10
    Sung Hee Ahn
    Laboratory of Chromatin Biology, The Rockefeller University, Box 78, New York, New York 10021, USA
    Mol Cell 24:211-20. 2006
    ..Together, these studies underscore a concerted series of enzyme reactions governing histone modifications that promote a switch from cell proliferation to cell death...
  44. ncbi Extraction, purification and analysis of histones
    David Shechter
    The Laboratory of Chromatin Biology, The Rockefeller University, New York, NY, USA
    Nat Protoc 2:1445-57. 2007
    ....
  45. ncbi Epigenetics: a landscape takes shape
    Aaron D Goldberg
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY 10021, USA
    Cell 128:635-8. 2007
    ..In this Essay, we examine the epistemology of epigenetics, provide a brief overview of underlying molecular mechanisms, and suggest future challenges for the field...
  46. pmc Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers
    Ping Chi
    Laboratory of Chromatin Biology and Epigenetics, 1230 York Avenue, The Rockefeller University, Box 78, New York, NY 10065, USA
    Nat Rev Cancer 10:457-69. 2010
    ..These observations provide us with a greater mechanistic understanding of epigenetic alterations in human cancers and might also help direct new therapeutic interventions in the future...
  47. pmc Histone regulation in the CNS: basic principles of epigenetic plasticity
    Ian Maze
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 38:3-22. 2013
    ..Understanding the functions of chromatin in the context of the CNS will aid in the future development of pharmacological therapeutics aimed at alleviating devastating neurological disorders...
  48. pmc Mutagenesis of pairwise combinations of histone amino-terminal tails reveals functional redundancy in budding yeast
    Jung Ae Kim
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:5779-84. 2012
    ..Altogether, these data suggest that the N-tails of core histones share previously unrecognized, potentially redundant functions that, in some cases are different from those of the widely accepted H2A/H2B and H3/H4 dimer pairs...
  49. pmc Distinct factors control histone variant H3.3 localization at specific genomic regions
    Aaron D Goldberg
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Cell 140:678-91. 2010
    ..3 at telomeres and for the repression of telomeric RNA. Our data demonstrate that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells...
  50. pmc Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells
    Sonja C Stadler
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 110:11851-6. 2013
    ..We demonstrate a dynamic and previously unappreciated interplay between histone-modifying enzymes, citrullination of nonhistone proteins, and epithelial-to-mesenchymal transition. ..
  51. pmc Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia
    Huimin Geng
    Department of Medicine Hematology Oncology Division, Weill Medical College of Cornell University, New York, NY 10065, USA
    Cancer Discov 2:1004-23. 2012
    ..Notably, BCL6 blockade or loss of function suppressed proliferation and survival of MLLr leukemia cells, suggesting BCL6-targeted therapy as a new therapeutic strategy for MLLr B-ALLs...
  52. ncbi Histone arginine methylation and its dynamic regulation
    Joanna Wysocka
    Laboratory of Chromatin Biology, Rockefeller University, New York, NY 10021, USA
    Front Biosci 11:344-55. 2006
    ..Given the surge of interest in histone arginine methylation, this review article will focus on recent progress in this area...
  53. pmc Genome-wide "re"-modeling of nucleosome positions
    Ronen Sadeh
    Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY 10065, USA
    Cell 147:263-6. 2011
    ..These data suggest two emerging models: chromatin remodelers position nucleosomes around transcriptional start sites in yeast, and a few "locked" nucleosomes may serve as barriers from which nucleosome arrays emanate in human genomes...
  54. ncbi Taking LSD 1 to a new high
    Joanna Wysocka
    Laboratory of Chromatin Biology, The Rockerfeller University, New York, NY 10021, USA
    Cell 122:654-8. 2005
    ..Now, a new study from published in a recent issue of Molecular Cell, together with two studies recently published by and in Nature, reveal that LSD 1's specificity and activity is in fact regulated by associated protein cofactors...
  55. ncbi Chromatin remodeling and cancer, Part I: Covalent histone modifications
    Gang G Wang
    Laboratory of Chromatin Biology, The Rockefeller University, and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Trends Mol Med 13:363-72. 2007
    ..Where possible, we discuss the implications of these advances for disease-management strategies...
  56. ncbi Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nature 438:1116-22. 2005
    ..These findings establish a regulatory mechanism of protein-protein interactions, through a combinatorial readout of two adjacent post-translational modifications: a stable methylation and a dynamic phosphorylation mark...
  57. pmc Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia
    Altuna Akalin
    Department of Physiology and Biophysics and the HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, New York, United States of America
    PLoS Genet 8:e1002781. 2012
    ..Therefore, aberrant DNA methylation patterns in AML do not occur in a stereotypical manner but rather are highly specific and associated with specific driving genetic lesions...
  58. ncbi Polycomb Group proteins: an evolutionary perspective
    Sarah J Whitcomb
    Lab of Chromatin Biology, The Rockefeller University, 1230 York Ave, Box 78, New York, NY 10065, USA
    Trends Genet 23:494-502. 2007
    ..We propose that PcG gene expansion and diversification contributed significantly to the complexity of heritable gene repression mechanisms in extant multicellular organisms...
  59. pmc Histone H3 variants and their potential role in indexing mammalian genomes: the "H3 barcode hypothesis"
    Sandra B Hake
    Laboratory of Chromatin Biology, The Rockefeller University, Box 78, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:6428-35. 2006
    ..Although we restrict our comments to H3 variants in mammals, we expect that the more general concepts presented here will apply to other histone variant families in organisms that employ them...
  60. ncbi Sterile 20 kinase phosphorylates histone H2B at serine 10 during hydrogen peroxide-induced apoptosis in S. cerevisiae
    Sung Hee Ahn
    Laboratory of Chromatin Biology, The Rockefeller University, Box 78, New York, NY 10021, USA
    Cell 120:25-36. 2005
    ....
  61. ncbi Beyond the double helix: writing and reading the histone code
    Yanming Wang
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Novartis Found Symp 259:3-17; discussion 17-21, 163-9. 2004
    ..As this modification is not found during mitotic chromosome condensation, these findings suggest the intriguing possibility that a unique 'death' mark exists for chromatin condensation during apoptosis...
  62. ncbi Binary switches and modification cassettes in histone biology and beyond
    Wolfgang Fischle
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Nature 425:475-9. 2003
    ..Our ideas might also apply to non-histone proteins and are open to direct experimental examination...
  63. ncbi WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development
    Joanna Wysocka
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 121:859-72. 2005
    ..Our results are the first demonstration that a WD40-repeat protein acts as a module for recognition of a specific histone modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation...
  64. ncbi A protozoan pays off
    C David Allis
    Laboratory of Chromatin Biology, The Rockefeller University, New York, NY, USA
    Biotechniques 42:19. 2007
  65. ncbi RNA meets chromatin
    Emily Bernstein
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 19:1635-55. 2005
    ..The role of potential RNA-binding chromatin-associated proteins will be discussed as one possible link between RNA and chromatin...
  66. ncbi Human PAD4 regulates histone arginine methylation levels via demethylimination
    Yanming Wang
    Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Science 306:279-83. 2004
    ..Moreover, PAD4 activity is linked with the transcriptional regulation of estrogen-responsive genes in MCF-7 cells. These data suggest that PAD4 mediates gene expression by regulating Arg methylation and citrullination in histones...
  67. pmc Serine 31 phosphorylation of histone variant H3.3 is specific to regions bordering centromeres in metaphase chromosomes
    Sandra B Hake
    Laboratory of Chromatin Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:6344-9. 2005
    ..3 S31P is localized in distinct chromosomal regions immediately adjacent to centromeres. These findings argue for a unique function for the phosphorylated isoform of H3.3 that is distinct from its suspected role in gene activation...
  68. ncbi Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
    Yali Dou
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, New York 10021, USA
    Cell 121:873-85. 2005
    ....
  69. ncbi H2B (Ser10) phosphorylation is induced during apoptosis and meiosis in S. cerevisiae
    Sung Hee Ahn
    Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, USA
    Cell Cycle 4:780-3. 2005
    ..How phosphorylation marks are translated into meaningful downstream events during processes as diverse as apoptosis and meiosis remain a challenge for future studies...