Research Topics

Juan Alfonzo


Affiliation: The Ohio State University
Country: USA


  1. Alfonzo J, Lukes J. Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors. Trends Parasitol. 2011;27:235-8 pubmed publisher
    ..Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined. ..
  2. Sample P, Kořený L, Paris Z, Gaston K, Rubio M, Fleming I, et al. A common tRNA modification at an unusual location: the discovery of wyosine biosynthesis in mitochondria. Nucleic Acids Res. 2015;43:4262-73 pubmed publisher
    ..These findings are discussed in the context of the extensive U-insertion RNA editing in trypanosome mitochondria, which may have provided selective pressure for maintenance of mitochondrial wyosine in this lineage. ..
  3. McKenney K, Alfonzo J. From Prebiotics to Probiotics: The Evolution and Functions of tRNA Modifications. Life (Basel). 2016;6: pubmed publisher
    ..In passing, we submit that the choice of tRNA is not a whimsical one but rather highlights its critical function as an essential invention for the evolution of protein enzymes. ..
  4. McKenney K, Rubio M, Alfonzo J. The Evolution of Substrate Specificity by tRNA Modification Enzymes. Enzymes. 2017;41:51-88 pubmed publisher
  5. McKenney K, Rubio M, Alfonzo J. Binding synergy as an essential step for tRNA editing and modification enzyme co-dependence in Trypanosoma brucei. RNA. 2017;: pubmed publisher