Ken Aldape

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi The prognostic value of neurologic function in astrocytic spinal cord glioma
    Hoon K Lee
    Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Neuro Oncol 5:208-13. 2003
  2. ncbi Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    Kenneth D Aldape
    Department of Pathology and Brain Tumor Center, UT-MD Anderson Cancer Center, Houston, Texas, USA
    J Neuropathol Exp Neurol 63:700-7. 2004
  3. ncbi Aggregation of cancer in first-degree relatives of patients with glioma
    Michael E Scheurer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1439, USA
    Cancer Epidemiol Biomarkers Prev 16:2491-5. 2007
  4. ncbi Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival
    Yanhong Liu
    Departments of Epidemiology, Neuro Oncology, and Pathology, TheUniversity of Texas MD Anderson CancerCente, Houston, TX 77030, USA
    J Clin Oncol 28:2467-74. 2010
  5. ncbi Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors
    Christopher A Miller
    Graduate Program in Structural and Computational Biology and Molecular Biophysics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    BMC Med Genomics 4:34. 2011
  6. ncbi Attenuated expression of DFFB is a hallmark of oligodendrogliomas with 1p-allelic loss
    J Matthew McDonald
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer 4:35. 2005
  7. ncbi Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays
    Hannah C Cheung
    Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    BMC Genomics 9:216. 2008
  8. ncbi Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA 94143, USA
    BMC Cancer 6:97. 2006
  9. ncbi Real-time quantitative polymerase chain reaction: a potential tool for genetic analysis in neuropathology
    Kenneth Aldape
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Brain Pathol 12:54-66. 2002
  10. ncbi Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma
    Kenneth Aldape
    M D Anderson Cancer Center, Department of Pathology and Brain Tumor Center, 1515 Holcombe Blvd, Houston, TX 60153, USA
    Arch Pathol Lab Med 131:242-51. 2007

Detail Information

Publications70

  1. ncbi The prognostic value of neurologic function in astrocytic spinal cord glioma
    Hoon K Lee
    Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Neuro Oncol 5:208-13. 2003
    ..We conclude that favorable NF may be associated with improved outcome in patients with astrocytic spinal cord glioma...
  2. ncbi Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
    Kenneth D Aldape
    Department of Pathology and Brain Tumor Center, UT-MD Anderson Cancer Center, Houston, Texas, USA
    J Neuropathol Exp Neurol 63:700-7. 2004
    ....
  3. ncbi Aggregation of cancer in first-degree relatives of patients with glioma
    Michael E Scheurer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030 1439, USA
    Cancer Epidemiol Biomarkers Prev 16:2491-5. 2007
    ..Previous studies have been inconclusive in estimating the risk of different cancer sites among close relatives of glioma patients; however, malignant melanoma has consistently been described...
  4. ncbi Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival
    Yanhong Liu
    Departments of Epidemiology, Neuro Oncology, and Pathology, TheUniversity of Texas MD Anderson CancerCente, Houston, TX 77030, USA
    J Clin Oncol 28:2467-74. 2010
    ..Therefore, identifying the genetic variants that influence this small number of unusually long-term survivors may provide important insight into tumor biology and treatment...
  5. ncbi Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors
    Christopher A Miller
    Graduate Program in Structural and Computational Biology and Molecular Biophysics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA
    BMC Med Genomics 4:34. 2011
    ..Analyses that extend beyond single genes are often restricted to examining pathways, interactions and functional modules that are already known...
  6. ncbi Attenuated expression of DFFB is a hallmark of oligodendrogliomas with 1p-allelic loss
    J Matthew McDonald
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer 4:35. 2005
    ..Mutational analysis did not reveal DFFB mutations in 12 tested samples. However, it is possible that DFFB haploinsufficiency from 1p allelic loss is a contributing factor in oligodendroglioma development...
  7. ncbi Global analysis of aberrant pre-mRNA splicing in glioblastoma using exon expression arrays
    Hannah C Cheung
    Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas M, d, Anderson Cancer Center, Houston, TX 77030, USA
    BMC Genomics 9:216. 2008
    ..Validation studies were performed using RT-PCR on glioma cell lines, patient tumor and nontumor brain samples...
  8. ncbi Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma
    Yu Liang
    Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, CA 94143, USA
    BMC Cancer 6:97. 2006
    ....
  9. ncbi Real-time quantitative polymerase chain reaction: a potential tool for genetic analysis in neuropathology
    Kenneth Aldape
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston 77030, USA
    Brain Pathol 12:54-66. 2002
    ..In this overview, we will highlight the uses of real-time quantitative PCR as a potential diagnostic tool in neuropathology, focusing on the analysis of CNS tumors...
  10. ncbi Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma
    Kenneth Aldape
    M D Anderson Cancer Center, Department of Pathology and Brain Tumor Center, 1515 Holcombe Blvd, Houston, TX 60153, USA
    Arch Pathol Lab Med 131:242-51. 2007
    ..These findings raise questions as to the role of 1p/19q testing in clinical practice, both as a prognostic marker and as a potential diagnostic marker among infiltrating glial neoplasms...
  11. ncbi Molecular epidemiology of glioblastoma
    Kenneth D Aldape
    Department of Pathology, Neuropathology Section, UT MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer J 9:99-106. 2003
    ..This review highlights current insights into the molecular epidemiology of GBM...
  12. ncbi A multigene predictor of outcome in glioblastoma
    Howard Colman
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77401, USA
    Neuro Oncol 12:49-57. 2010
    ..The profile has potential clinical application both for optimization of therapy in GBM and for the identification of novel therapies targeting tumors refractory to standard therapy...
  13. ncbi Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas
    Howard Colman
    Department of Neuro Oncology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Am J Surg Pathol 30:657-64. 2006
    ..These results also suggest that pHH3 staining may be a useful method in other neoplasms in which accurate determination of proliferation potential is relevant to tumor grading or clinical treatment decision-making...
  14. ncbi MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
    Stephen Yip
    Pathology Service, Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
    Clin Cancer Res 15:4622-9. 2009
    ..This study aimed to clarify the timing and role of MSH6 mutations in mediating glioblastoma temozolomide resistance...
  15. ncbi The use of global profiling in biomarker development for gliomas
    Erik P Sulman
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Tex, USA
    Brain Pathol 21:88-95. 2011
    ..Identification of biomarkers, especially when coupled to clinical trials of newer targeted therapies, will enable better patient stratification and individualization of treatment...
  16. ncbi The prognostic impact of histology and 1p/19q status in anaplastic oligodendroglial tumors
    J Matthew McDonald
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 104:1468-77. 2005
    ..Loss of 1p and 19q appeared to be a prognostic marker only in the subset of patients who had AO tumors with classic histologic features...
  17. ncbi Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results
    Frederick F Lang
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    J Clin Oncol 21:2508-18. 2003
    ..Advances in brain tumor biology indicate that transfer of p53 is an alternative therapy for human gliomas. Consequently, we undertook a phase I clinical trial of p53 gene therapy using an adenovirus vector (Ad-p53, INGN 201)...
  18. ncbi Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma
    David Cogdell
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Chin J Cancer 30:247-53. 2011
    ..Thus, both genetic (gene deletion) and epigenetic alterations (promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas, which contributes to poor prognosis...
  19. ncbi Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients
    Amy B Heimberger
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Unit 442, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:1462-6. 2005
    ..We sought to determine whether glioblastoma multiforme expression of either overexpressed wild-type EGFR or the mutant EGFRvIII is an independent predictor of overall patient survival...
  20. ncbi A prognostic gene expression signature in infratentorial ependymoma
    Khalida Wani
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Acta Neuropathol 123:727-38. 2012
    ..Taken together, the results indicate a link between clinical outcome and biologically identified subsets of infratentorial ependymoma and offer the potential for prognostic testing to estimate clinical aggressiveness in these tumors...
  21. ncbi Beyond grade: molecular pathology of malignant gliomas
    Erik P Sulman
    Department of Radiation Oncology, The University of Texas, M D Anderson Cancer Center, Houston, TX 77030, USA
    Semin Radiat Oncol 19:142-9. 2009
    ..It also focuses on the molecular signatures defined by large-scale gene expression profiling experiments because these studies are at the forefront in developing new biomarkers and identifying new therapeutic targets...
  22. ncbi Brain tumor stem cells
    Erik Sulman
    Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Curr Probl Cancer 32:124-42. 2008
  23. ncbi Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung
    J Matthew McDonald
    Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:7832-7. 2008
    ..The primary objective of this study was to determine whether markers of differentiation and activation of the Akt pathway are associated with metastasis in adenocarcinoma of the lung...
  24. ncbi Molecular predictors in glioblastoma: toward personalized therapy
    Howard Colman
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 431, Houston, TX 77030, USA
    Arch Neurol 65:877-83. 2008
    ....
  25. ncbi Immunological responses in a patient with glioblastoma multiforme treated with sequential courses of temozolomide and immunotherapy: case study
    Amy B Heimberger
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Neuro Oncol 10:98-103. 2008
    ..In fact, the temozolomide-induced lymphopenia may prove to be synergistic with a peptide vaccine secondary to inhibition of regulatory T cells or their delayed recovery...
  26. ncbi Molecular tools: biology, prognosis, and therapeutic triage
    Ingeborg Fischer
    Department of Pathology, Unit 085, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Neuroimaging Clin N Am 20:273-82. 2010
    ..This content gives an overview of the current knowledge about the pathogenesis of adult diffuse gliomas, emphasizing new targeted treatment approaches...
  27. ncbi The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses
    S Farzana Hussain
    Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, P.O. Box 301402, Houston, TX 77230-1402, USA
    Neuro Oncol 8:261-79. 2006
    ..Furthermore, the presence of regulatory T cells may also contribute to the lack of effective immune activation against malignant human gliomas...
  28. ncbi High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors
    Adam Wu
    The Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 442, Houston, TX 77030, USA
    J Neurooncol 99:57-64. 2010
    ..In contradistinction to previous reports, loss of 1p/19q occurs commonly in insular oligodendroglial tumors. With respect to 1p/19q, insular gliomas do not appear to be distinct from gliomas arising elsewhere in the brain...
  29. ncbi Polymorphisms of DNA repair genes and risk of glioma
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:5560-3. 2004
    ..13-2.93). These results suggest that the T allele may be a risk allele, and this XRCC7 polymorphism may be a marker for the susceptibility to glioma. Larger studies are needed to confirm our findings and unravel the underlying mechanisms...
  30. ncbi Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Clin Oncol 25:2288-94. 2007
    ..We sought to evaluate the clinical significance of GBM subtypes as defined by EGFRvIII status...
  31. ncbi The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration
    J Matthew McDonald
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Biol Ther 5:300-4. 2006
    ..Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors...
  32. ncbi Utility of chromogenic in situ hybridization (CISH) for detection of EGFR amplification in glioblastoma: comparison with fluorescence in situ hybridization (FISH)
    Ingeborg Fischer
    Department of Pathology, Division of Neuropathology, New York University Medical Center, New York, NY, USA
    Diagn Mol Pathol 17:227-30. 2008
    ..Detectable EGFR expression by IHC can occur in the absence of gene amplification, but is uncommon...
  33. ncbi EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin
    Haitao Ji
    Brain Tumor Center and Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Mol Cell 36:547-59. 2009
    ..This EGFR-ERK-CK2-mediated phosphorylation of alpha-catenin promotes beta-catenin transactivation and tumor cell invasion. These findings highlight the importance of the crosstalk between EGFR and Wnt pathways in tumor development...
  34. ncbi Pathway alterations during glioma progression revealed by reverse phase protein lysate arrays
    Rongcai Jiang
    Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proteomics 6:2964-71. 2006
    ..The marked association of phosphorylation of AKT at Thr308, but not Ser473, with glioblastoma suggests a specific event of PI3K pathway activation in glioma progression...
  35. ncbi Abnormal expression of REST/NRSF and Myc in neural stem/progenitor cells causes cerebellar tumors by blocking neuronal differentiation
    Xiaohua Su
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Mail 1006, Room S13 8136C, Houston, TX 77030, USA
    Mol Cell Biol 26:1666-78. 2006
    ..Furthermore, these results suggest that such a mechanism plays a role in the formation of human medulloblastoma...
  36. ncbi Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 4:467-75. 2008
    ..Anti-LC3B antibody provides a useful tool for monitoring the induction of autophagy in cancer cells and tissues...
  37. ncbi Progression-free survival: an important end point in evaluating therapy for recurrent high-grade gliomas
    Kathleen R Lamborn
    Department of Neurological Surgery, University of California San Francisco, 400 Parnassus Avenue, UC Clinics 808, San Francisco, CA 94143 0372, USA
    Neuro Oncol 10:162-70. 2008
    ..Earlier assessments of progression status also predicted survival and may be incorporated in the design of future clinical trials...
  38. ncbi Detection of human cytomegalovirus in different histological types of gliomas
    Michael E Scheurer
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1155 Pressler St, Unit 1340, P O Box 301439, Houston, TX, 77030 1439, USA
    Acta Neuropathol 116:79-86. 2008
    ..This will allow for detection of low-level latent infections that may play an important role in the initiation and/or promotion of malignant gliomas...
  39. ncbi Aberrant NF-kappaB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor
    Tong Xin Xie
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Oncol 33:5-15. 2008
    ....
  40. ncbi YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, Neuro Oncology, and Pathology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 11:3326-34. 2005
    ..Here we test these findings in a larger series of patients with glioblastoma, and in particular, determine if tumor YKL-40 expression is associated with radiation response...
  41. ncbi Phase I study of temozolomide and irinotecan for recurrent malignant gliomas in patients receiving enzyme-inducing antiepileptic drugs: a north american brain tumor consortium study
    Monica E Loghin
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:7133-8. 2007
    ..The study was also intended to assess whether temozolomide affects the conversion of irinotecan to SN-38...
  42. ncbi Long-term anti-inflammatory and antihistamine medication use and adult glioma risk
    Michael E Scheurer
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, PO Box 301439, Houston, TX 77230 1439, USA
    Cancer Epidemiol Biomarkers Prev 17:1277-81. 2008
    ..Our results lend additional support for an important but unknown link between malignant brain tumors and immune mediators...
  43. ncbi Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma
    Hiroshi Aoki
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 13:6603-9. 2007
    ..Thus, we examined patterns of Pak1 expression in glioblastoma and sought to determine whether the level of phosphorylated Pak1 in glioblastoma cells is associated with patient survival time...
  44. ncbi Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2
    Krishna P Bhat
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    FEBS Lett 582:3193-200. 2008
    ..This study presents a paradigm for NF-kappaB regulation of one of its targets in a strict cell type specific manner...
  45. ncbi Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance
    Marta M Alonso
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1589-600. 2005
    ..Several tumor suppressor pathways have been identified as modulators of telomerase function. We examined the functional role of the retinoblastoma-E2F1 pathway in regulating telomerase activity in malignant gliomas...
  46. ncbi Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma
    Janice M Nigro
    Department of Neurological Surgery (Brain Tumor Research Center, University of California, School of Medicine, San Francisco, California, USA
    Cancer Res 65:1678-86. 2005
    ....
  47. ncbi Expression of activated signal transducer and activator of transcription 3 predicts expression of vascular endothelial growth factor in and angiogenic phenotype of human gastric cancer
    Weida Gong
    Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 11:1386-93. 2005
    ..CONCLUSION: Dysregulated Stat3 activation may play an important role in VEGF overexpression and elevated angiogenic phenotype in gastric cancer and contribute to gastric cancer development and progression...
  48. ncbi FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells
    Mingguang Liu
    Department of Neurosurgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 66:3593-602. 2006
    ..These results showed that FoxM1 is overexpressed in human glioblastomas and contributes to glioma tumorigenicity. Therefore, FoxM1 might be a new potential target of therapy for human malignant gliomas...
  49. ncbi Phase II trial of temozolomide plus marimastat for recurrent anaplastic gliomas: a relationship among efficacy, joint toxicity and anticonvulsant status
    Morris D Groves
    Department of Neuro Oncology, Unit 431, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Neurooncol 80:83-90. 2006
    ....
  50. ncbi Sustained angiopoietin-2 expression disrupts vessel formation and inhibits glioma growth
    Ok Hee Lee
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Neoplasia 8:419-28. 2006
    ..We therefore conclude that deregulated Ang2 expression during gliomagenesis hindered successful angiogenesis and that therapies that sustain Ang2 expression might be effective against malignant gliomas...
  51. ncbi Prognostic associations of activated mitogen-activated protein kinase and Akt pathways in glioblastoma
    Christopher E Pelloski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 12:3935-41. 2006
    ..This study was conducted to determine whether any of these markers are associated with survival time and response to radiation in glioblastoma...
  52. ncbi Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: implications for therapy
    Kelly N Blehm
    Department of Cancer Biology, Brain Tumor Center, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Clin Cancer Res 12:4671-7. 2006
    ..The focus of this study was to determine if these alterations are present within the tyrosine kinase and ligand-binding domain of EGFR in urothelial carcinoma...
  53. ncbi Relationship between ornithine decarboxylase levels in anaplastic gliomas and progression-free survival in patients treated with DFMO-PCV chemotherapy
    Victor A Levin
    Department of Neuro Oncology and M D Anderson Clinical Oncology Program, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 121:2279-83. 2007
    ..3 nmol/30 min/mug protein. This study shows that Ab-ODC-Alexa 647 fluorescence intensity can be used as a surrogate marker of ODC biochemical activity in AGs and can predict PFS to DFMO-based chemotherapy...
  54. ncbi A model of molecular interactions on short oligonucleotide microarrays
    Li Zhang
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd 447, Houston, Texas 77030, USA
    Nat Biotechnol 21:818-21. 2003
    ..The model indicates that the amount of nonspecific binding can be estimated from a simple rule. Using this model, we have developed an improved measure of gene expression for use in data analysis...
  55. ncbi Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma
    Arie Perry
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Cancer 101:2318-26. 2004
    ..Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma...
  56. ncbi Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR
    Ajay Pandita
    The Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario
    Genes Chromosomes Cancer 39:29-36. 2004
    ....
  57. ncbi The mitosis-specific antibody anti-phosphohistone-H3 (PHH3) facilitates rapid reliable grading of meningiomas according to WHO 2000 criteria
    Teresa Ribalta
    Department of Pathology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg Pathol 28:1532-6. 2004
    ..PHH3 immunostaining facilitates the rapid reliable grading of meningiomas by focusing attention on the most mitotically active areas and by allowing easy and objective differentiation of MFs from apoptotic nuclei...
  58. ncbi Grade II astrocytomas are subgrouped by chromosome aberrations
    Yuichi Hirose
    Department of Neurological Surgery, University of California, San Francisco, CA 94115, USA
    Cancer Genet Cytogenet 142:1-7. 2003
    ..The comparatively large number of cases in this study allows us to suggest that these tumors are genetically subgrouped...
  59. ncbi Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth
    Chibo Hong
    Department of Neurological Surgery and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 104:10974-9. 2007
    ..Thus, our integrated genetic and epigenetic approach might be useful to identify genes that are widely relevant to cancer, even when genetic alterations of the locus are infrequent...
  60. ncbi Conversion of myoblasts to physiologically active neuronal phenotype
    Yumi Watanabe
    Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:889-900. 2004
    ....
  61. ncbi The molecular epidemiology of gliomas in adults
    Margaret Wrensch
    Department of Neurological Surgery, University of California, San Francisco, California 94102, USA
    Neurosurg Focus 19:E5. 2005
    ..Improving survival rates for patients harboring astrocytic tumors will probably require many randomized clinical trials of novel treatment strategies...
  62. ncbi Expression of the receptor tyrosine kinase Tie2 in neoplastic glial cells is associated with integrin beta1-dependent adhesion to the extracellular matrix
    Ok-Hee Lee
    Department of Neuro-Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 4:915-26. 2006
    ....
  63. ncbi Transgenic E2F1 expression in the mouse brain induces a human-like bimodal pattern of tumors
    Melissa V Olson
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 67:4005-9. 2007
    ..Thus, this study offers the first evidence for a global role of E2F1 in the formation and maintenance of multilineage brain tumors, irrefutably establishing E2F1 as an oncogene in the brain...
  64. ncbi Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group
    Sandeep Kunwar
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, 94143 0350, USA
    J Clin Oncol 25:837-44. 2007
    ..We assessed the use of intracerebral CED to deliver CB in patients with recurrent malignant glioma (MG)...
  65. ncbi Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin
    Mukesh K Sharma
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:890-900. 2007
    ..These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated...
  66. ncbi Proteomic investigation of glioblastoma cell lines treated with wild-type p53 and cytotoxic chemotherapy demonstrates an association between galectin-1 and p53 expression
    Maja Puchades
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, Goteborg University, SU Mölndal, SE 43180 Molndal, Sweden
    J Proteome Res 6:869-75. 2007
    ..These results demonstrate the utility of using proteomic approaches to interrogate and identify potential useful targets for cancer therapy by evaluating specific tumor responses, either positive or negative, to various therapies...
  67. ncbi Epidemiology and molecular pathology of glioma
    Judith A Schwartzbaum
    Ohio State University, Columbus, OH 432 10, USA
    Nat Clin Pract Neurol 2:494-503; quiz 1 p following 516. 2006
    ..The Brain Tumor Epidemiology Consortium has been formed to co-ordinate these studies...
  68. ncbi Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation
    Luo Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    J Clin Oncol 24:1627-32. 2006
    ..We investigated whether hTERT MNS16A variant genotype predicted survival in GBM patients...
  69. ncbi Activation of stat3 in human melanoma promotes brain metastasis
    Tong-Xin Xie
    Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 66:3188-96. 2006
    ..Therefore, Stat3 activation might be a new potential target for therapy of human melanoma brain metastases...
  70. ncbi CC chemokine receptor 8 in the central nervous system is associated with phagocytic macrophages
    Corinna Trebst
    Department of Neurosciences, The Lerner Research Institute, Cleveland, Ohio 44195, USA
    Am J Pathol 162:427-38. 2003
    ..CCR8 expression may also indicate a selective program of mononuclear phagocyte gene expression...