Birgit E Alber

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. pmc Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria
    Jan Zarzycki
    Mikrobiologie, Fakultat fur Biologie, Universitat Freiburg, Germany
    J Bacteriol 190:1366-74. 2008
  2. doi request reprint Biotechnological potential of the ethylmalonyl-CoA pathway
    Birgit E Alber
    The Department of Microbiology, Ohio State University, 484 West 12th Ave, Room 417, Columbus, OH, USA
    Appl Microbiol Biotechnol 89:17-25. 2011
  3. pmc 3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation
    Birgit E Alber
    Mikrobiologie, Institut fur Biologie II, Albert Ludwigs Universitat Freiburg, Germany
    J Bacteriol 190:1383-9. 2008
  4. pmc Properties of succinyl-coenzyme A:D-citramalate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus
    Silke Friedmann
    Mikrobiologie, Institut Biologie II, Schänzlestr 1, D 79104 Freiburg, Germany
    J Bacteriol 188:6460-8. 2006
  5. doi request reprint Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases
    Tobias J Erb
    Mikrobiologie, Institut fur Biologie II, Albert Ludwigs Universitat Freiburg, Schanzlestrasse 1, 79104 Freiburg im Breisgau, Germany
    J Biol Chem 283:32283-93. 2008
  6. pmc The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase
    Tobias J Erb
    Department of Microbiology, Ohio State University, 484 West 12th Ave, Room 417, Columbus, OH 43210, USA
    J Bacteriol 192:1249-58. 2010
  7. doi request reprint (2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
    Tobias J Erb
    Mikrobiologie, Institut fur Biologie II, Schänzlestr 1, Albert Ludwigs Universitat Freiburg, Freiburg i Br, Germany
    Mol Microbiol 73:992-1008. 2009
  8. pmc 3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales
    Robin Teufel
    Mikrobiologie, Fakultat Biologie, Freiburg, Germany
    J Bacteriol 191:4572-81. 2009
  9. doi request reprint Autotrophic carbon fixation in archaea
    Ivan A Berg
    Mikrobiologie, Fakultat Biologie, Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Nat Rev Microbiol 8:447-60. 2010
  10. pmc Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus
    Silke Friedmann
    Mikrobiologie, Institut Biologie II, Schänzlestr 1, D 79104 Freiburg, Germany
    J Bacteriol 189:2906-14. 2007

Collaborators

Detail Information

Publications19

  1. pmc Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria
    Jan Zarzycki
    Mikrobiologie, Fakultat fur Biologie, Universitat Freiburg, Germany
    J Bacteriol 190:1366-74. 2008
    ..A similar yet distinct class of enzymes containing only one hydratase domain was found in various other bacteria, such as Streptomyces species. The role of this widely distributed new enzyme is discussed...
  2. doi request reprint Biotechnological potential of the ethylmalonyl-CoA pathway
    Birgit E Alber
    The Department of Microbiology, Ohio State University, 484 West 12th Ave, Room 417, Columbus, OH, USA
    Appl Microbiol Biotechnol 89:17-25. 2011
    ..The biotechnological implications of the ethylmalonyl-CoA pathway are tremendous as one looks to tap into the potential of using these new intermediates and catalysts to produce value-added products...
  3. pmc 3-Hydroxypropionyl-coenzyme A synthetase from Metallosphaera sedula, an enzyme involved in autotrophic CO2 fixation
    Birgit E Alber
    Mikrobiologie, Institut fur Biologie II, Albert Ludwigs Universitat Freiburg, Germany
    J Bacteriol 190:1383-9. 2008
    ..sedula, supporting its proposed role during CO2 fixation in this archaeon and possibly other members of the Sulfolobaceae family...
  4. pmc Properties of succinyl-coenzyme A:D-citramalate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus
    Silke Friedmann
    Mikrobiologie, Institut Biologie II, Schänzlestr 1, D 79104 Freiburg, Germany
    J Bacteriol 188:6460-8. 2006
    ..It is proposed that the CoA transferase and the lyase catalyze the last two steps in the glyoxylate assimilation route...
  5. doi request reprint Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases
    Tobias J Erb
    Mikrobiologie, Institut fur Biologie II, Albert Ludwigs Universitat Freiburg, Schanzlestrasse 1, 79104 Freiburg im Breisgau, Germany
    J Biol Chem 283:32283-93. 2008
    ..In combination with molecular modeling, two signature sequences were identified that presumably contribute to the substrate specificity of these enzymes...
  6. pmc The apparent malate synthase activity of Rhodobacter sphaeroides is due to two paralogous enzymes, (3S)-Malyl-coenzyme A (CoA)/{beta}-methylmalyl-CoA lyase and (3S)- Malyl-CoA thioesterase
    Tobias J Erb
    Department of Microbiology, Ohio State University, 484 West 12th Ave, Room 417, Columbus, OH 43210, USA
    J Bacteriol 192:1249-58. 2010
    ..Mcl1 and Mcl2 are both related to malate synthase, an enzyme which catalyzes both a Claisen condensation and thioester hydrolysis reaction...
  7. doi request reprint (2S)-Methylsuccinyl-CoA dehydrogenase closes the ethylmalonyl-CoA pathway for acetyl-CoA assimilation
    Tobias J Erb
    Mikrobiologie, Institut fur Biologie II, Schänzlestr 1, Albert Ludwigs Universitat Freiburg, Freiburg i Br, Germany
    Mol Microbiol 73:992-1008. 2009
    ..This allowed defining the minimum set of enzymes necessary for its operation and to screen for further organisms following this acetyl-CoA assimilation strategy...
  8. pmc 3-hydroxypropionyl-coenzyme A dehydratase and acryloyl-coenzyme A reductase, enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in the Sulfolobales
    Robin Teufel
    Mikrobiologie, Fakultat Biologie, Freiburg, Germany
    J Bacteriol 191:4572-81. 2009
    ..This indicates that the autotrophic carbon fixation cycles in Chloroflexus and in the Sulfolobales evolved independently and that different genes/enzymes have been recruited in the two lineages that catalyze the same kinds of reactions...
  9. doi request reprint Autotrophic carbon fixation in archaea
    Ivan A Berg
    Mikrobiologie, Fakultat Biologie, Universitat Freiburg, Schanzlestrasse 1, D 79104 Freiburg, Germany
    Nat Rev Microbiol 8:447-60. 2010
    ..These reactions differ fundamentally from those of the well-known Calvin cycle, and their distribution mirrors the phylogenetic positions of the archaeal lineages and the needs of the ecological niches that they occupy...
  10. pmc Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus
    Silke Friedmann
    Mikrobiologie, Institut Biologie II, Schänzlestr 1, D 79104 Freiburg, Germany
    J Bacteriol 189:2906-14. 2007
    ..Incomplete sets of genes were found in aerobic phototrophic bacteria and in the gamma-proteobacterium Congregibacter litoralis. This may indicate that part of the reactions may be involved in a different metabolic process...
  11. pmc Acrylyl-coenzyme A reductase, an enzyme involved in the assimilation of 3-hydroxypropionate by Rhodobacter sphaeroides
    Marie Asao
    Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
    J Bacteriol 195:4716-25. 2013
    ..Complementation of the ΔacuI::kan mutant phenotype by crotonyl-CoA carboxylase/reductase from R. sphaeroides was attributed to the fact that the enzyme also uses acrylyl-CoA as a substrate. ..
  12. pmc Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase
    Tobias J Erb
    Mikrobiologie, Institut fur Biologie II, Schanzlestrasse 1, Albertstrasse 25, Albert Ludwigs Universitat Freiburg, 79104 Freiburg im Breisgau, Germany
    Proc Natl Acad Sci U S A 106:8871-6. 2009
    ..This may be useful for protein engineering of enoyl reductases and their application in biocatalysis...
  13. pmc Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway
    Tobias J Erb
    Mikrobiologie, Institut fur Biologie II, Fakultat fur Chemie, Pharmazie und Geowissenschaften, Albert Ludwigs Universitat Freiburg, Schanzlestrasse 1, 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 104:10631-6. 2007
    ..For methylotrophic bacteria such as Methylobacterium extorquens, extension of the serine cycle with reactions of the ethylmalonyl-CoA pathway leads to a simplified scheme for isocitrate lyase-independent C1 assimilation...
  14. ncbi request reprint Study of an alternate glyoxylate cycle for acetate assimilation by Rhodobacter sphaeroides
    Birgit E Alber
    Mikrobiologie, Fakultat fur Biologie, Albert Ludwigs Universitat Freiburg, Germany
    Mol Microbiol 61:297-309. 2006
    ..In a second part glyoxylate and propionyl-CoA are converted with another molecule of acetyl-CoA and CO(2) to l-malyl-CoA and succinyl-CoA...
  15. pmc Rhodobacter sphaeroides uses a reductive route via propionyl coenzyme A to assimilate 3-hydroxypropionate
    Kathrin Schneider
    Department of Microbiology, The Ohio State University, Columbus, Ohio, USA
    J Bacteriol 194:225-32. 2012
    ....
  16. doi request reprint Acetate-dependent photoheterotrophic growth and the differential requirement for the Calvin-Benson-Bassham reductive pentose phosphate cycle in Rhodobacter sphaeroides and Rhodopseudomonas palustris
    Rick Laguna
    Department of Microbiology, The Ohio State University, 484 West 12th Avenue, Columbus, OH 43210, USA
    Arch Microbiol 193:151-4. 2011
    ..Each pathway, therefore, also dictates at what point, CO(2) and reductant are consumed, thereby determining the requirement for the Calvin-Benson-Bassham reductive pentose phosphate cycle...
  17. pmc Properties of succinyl-coenzyme A:L-malate coenzyme A transferase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus
    Silke Friedmann
    Mikrobiologie, Institut Biologie II, Schänzlestr 1, D 79104 Freiburg, Germany
    J Bacteriol 188:2646-55. 2006
    ..The enzyme is a member of the class III of the CoA transferase family. The demonstration of the missing CoA transferase closes the last gap in the proposed 3-hydroxypropionate cycle...
  18. pmc L-malyl-coenzyme A/beta-methylmalyl-coenzyme A lyase is involved in acetate assimilation of the isocitrate lyase-negative bacterium Rhodobacter capsulatus
    Michael Meister
    Mikrobiologie, Institut Biologie II, Schänzlestr 1, D 79104 Freiburg, Germany
    J Bacteriol 187:1415-25. 2005
    ..We therefore propose that L-malyl-CoA/beta-methylmalyl-CoA lyase encoded by mcl1 is involved in acetate assimilation by R. capsulatus and possibly other glyoxylate cycle-negative bacteria...
  19. ncbi request reprint Propionyl-coenzyme A synthase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO2 fixation
    Birgit E Alber
    Institut Biologie II, Mikrobiologie, Universitat Freiburg, Schanzlestrasse 1, Freiburg D 79104, Germany
    J Biol Chem 277:12137-43. 2002
    ..g. polyketide synthases) but rare in primary metabolism (e.g. eukaryotic type I fatty acid synthase). These results lend strong support to the operation of the proposed pathway in autotrophic CO(2) fixation...