Bharat B Aggarwal

Summary

Affiliation: The University of Texas
Country: USA

Publications

  1. ncbi request reprint Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
    Anjana Bhardwaj
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 109:2293-302. 2007
  2. doi request reprint Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:3306-17. 2008
  3. ncbi request reprint Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment
    Noor Hasima
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States
    Curr Med Chem 21:1583-94. 2014
  4. pmc Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Br J Pharmacol 169:1672-92. 2013
  5. doi request reprint Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mol Nutr Food Res 57:1529-42. 2013
  6. pmc NF-κB in cancer: a matter of life and death
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Discov 1:469-71. 2011
  7. pmc Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, 77054, USA
    Blood 119:651-65. 2012
  8. pmc Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling
    Bokyung Sung
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 11:350-9. 2012
  9. pmc Cancer is a preventable disease that requires major lifestyle changes
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Pharm Res 25:2097-116. 2008
  10. doi request reprint The past, present and future of multi-targeted cancer treatment "naturally": food for thought
    Bharat B Aggarwal
    Department of Experimental Therapeutics, University of Texas, Houston, TX, USA
    Cancer Lett 269:187-8. 2008

Detail Information

Publications123 found, 100 shown here

  1. ncbi request reprint Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-kappaB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
    Anjana Bhardwaj
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 109:2293-302. 2007
    ..These mechanistic findings suggest that resveratrol may have a potential in the treatment of multiple myeloma...
  2. doi request reprint Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-kappa B pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:3306-17. 2008
    ..Overall, our results show that coronarin D inhibited NF-kappaB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis...
  3. ncbi request reprint Targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment
    Noor Hasima
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, United States
    Curr Med Chem 21:1583-94. 2014
    ..In this review, we discuss in detail how modulation of these targets by curcumin is linked to prevention and treatment of cancer. ..
  4. pmc Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Br J Pharmacol 169:1672-92. 2013
    ..With health-care costs and safety being major issues today, this golden spice may help provide the solution...
  5. doi request reprint Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA
    Mol Nutr Food Res 57:1529-42. 2013
    ....
  6. pmc NF-κB in cancer: a matter of life and death
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Discov 1:469-71. 2011
    ..Thus, inhibition of NF-κB has therapeutic potential in sensitization of tumors to chemotherapeutic agents; however, generalized suppression of NF-κB can result in serious host toxicity with minimum effect on the tumor...
  7. pmc Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, 77054, USA
    Blood 119:651-65. 2012
    ..In this review, we summarize the initial discovery of TNF-α, and the insights gained regarding the roles of this molecule and its related family members in normal physiology and disease...
  8. pmc Plumbagin inhibits osteoclastogenesis and reduces human breast cancer-induced osteolytic bone metastasis in mice through suppression of RANKL signaling
    Bokyung Sung
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 11:350-9. 2012
    ..Overall, our results indicate that plumbagin, a vitamin K analogue, is a potent inhibitor of osteoclastogenesis induced by tumor cells and of breast cancer-induced osteolytic metastasis through suppression of RANKL signaling...
  9. pmc Cancer is a preventable disease that requires major lifestyle changes
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Pharm Res 25:2097-116. 2008
    ..In addition, we provide evidence that cancer is a preventable disease that requires major lifestyle changes...
  10. doi request reprint The past, present and future of multi-targeted cancer treatment "naturally": food for thought
    Bharat B Aggarwal
    Department of Experimental Therapeutics, University of Texas, Houston, TX, USA
    Cancer Lett 269:187-8. 2008
  11. ncbi request reprint From chemoprevention to chemotherapy: common targets and common goals
    Bharat B Aggarwal
    The University of Texas M D Anderson Cancer Center, Cytokine Research Section, Department of Experimental Therapeutics, PO Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Expert Opin Investig Drugs 13:1327-38. 2004
    ..Because of their pharmacological safety, these agents can be used alone to prevent cancer and in combination with chemotherapy to treat cancer...
  12. doi request reprint Potential of spice-derived phytochemicals for cancer prevention
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Planta Med 74:1560-9. 2008
    ..The current review describes the active components of some of the major spices, their mechanisms of action and their potential in cancer prevention...
  13. ncbi request reprint Nuclear factor-kappaB: the enemy within
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Cell 6:203-8. 2004
    ..Furthermore, there exists genetic evidence that NF-kappaB mediates tumorigenesis. Thus, suppression of NF-kappaB activation should be effective in the prevention and treatment of cancer...
  14. pmc Molecular targets of nutraceuticals derived from dietary spices: potential role in suppression of inflammation and tumorigenesis
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Box 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Exp Biol Med (Maywood) 234:825-49. 2009
    ..Overall our review suggests "adding spice to your life" may serve as a healthy and delicious way to ward off cancer and other chronic diseases...
  15. ncbi request reprint Targeting cell signaling pathways for drug discovery: an old lock needs a new key
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Cell Biochem 102:580-92. 2007
    ..This review analyzes the shortcomings of rationally designed target-specific drugs against cancer cell signaling pathways and evaluates the available options for future drug development...
  16. ncbi request reprint Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann N Y Acad Sci 1030:434-41. 2004
    ..For the first time, therefore, research provides "reasoning for seasoning."..
  17. ncbi request reprint Curcumin: the Indian solid gold
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Adv Exp Med Biol 595:1-75. 2007
    ..g., HERCEPTIN). Considering the recent scientific bandwagon that multitargeted therapy is better than monotargeted therapy for most diseases, curcumin can be considered an ideal "Spice for Life"...
  18. ncbi request reprint Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Ann N Y Acad Sci 1091:151-69. 2006
    ..g., curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, EGCG, and cucurbitacin). This article discusses these aspects of STAT3 in more detail...
  19. ncbi request reprint Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Biochem Pharmacol 73:1024-32. 2007
    ..Overall, our results suggest that proteasome-mediated down-regulation of cyclin E and up-regulation of CDK inhibitors may contribute to the antiproliferative effects of curcumin against various tumors...
  20. ncbi request reprint Inflammation and cancer: how hot is the link?
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biochem Pharmacol 72:1605-21. 2006
    ..The current review describes in detail the critical link between inflammation and cancer...
  21. ncbi request reprint Molecular targets and anticancer potential of indole-3-carbinol and its derivatives
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cell Cycle 4:1201-15. 2005
    ..Numerous studies have indicated that I3C also has a strong hepatoprotective activity against various carcinogens. Initial clinical trials in women have shown that I3C is a promising agent against breast and cervical cancers...
  22. ncbi request reprint Molecular targets of dietary agents for prevention and therapy of cancer
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biochem Pharmacol 71:1397-421. 2006
    ..This work reaffirms what Hippocrates said 25 centuries ago, let food be thy medicine and medicine be thy food...
  23. ncbi request reprint From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas, MD Anderson Cancer Center, Box 143, Houston, Texas 77030, USA
    Expert Opin Ther Targets 10:87-118. 2006
    ..The focus of this review is to elucidate the Ayurvedic concept of cancer, including its classification, causes, pathogenesis and prevention; surgical removal of tumours; herbal remedies; dietary modifications; and spiritual treatments...
  24. ncbi request reprint Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice
    Bharat B Aggarwal
    Cytokine Research Laboratory and Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, Texas, 77030, USA
    Clin Cancer Res 11:7490-8. 2005
    ..Overall, our results indicate that curcumin, which is a pharmacologically safe compound, has a therapeutic potential in preventing breast cancer metastasis possibly through suppression of NF-kappaB and NF-kappaB-regulated gene products...
  25. pmc Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Biochem Cell Biol 41:40-59. 2009
    ..These features, combined with the pharmacological safety and negligible cost, render curcumin an attractive agent to explore further...
  26. doi request reprint Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Trends Pharmacol Sci 30:85-94. 2009
    ..The pharmacodynamics and pharmacokinetics of curcumin have been examined in animals and in humans. Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail here...
  27. ncbi request reprint Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling
    Sita Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotheraphy, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Int J Cancer 111:679-92. 2004
    ..Our results indicate that curcumin is a potent inhibitor of cell proliferation and an inducer of apoptosis in HNSCC through suppression of IKK-mediated NF-kappaB activation and of NF-kappaB-regulated gene expression...
  28. ncbi request reprint Anticancer potential of curcumin: preclinical and clinical studies
    Bharat B Aggarwal
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX, USA
    Anticancer Res 23:363-98. 2003
    ..All of these studies suggest that curcumin has enormous potential in the prevention and therapy of cancer. The current review describes in detail the data supporting these studies...
  29. pmc Multitargeting by curcumin as revealed by molecular interaction studies
    Subash C Gupta
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Nat Prod Rep 28:1937-55. 2011
    ..We will also discuss various analogues of curcumin designed to bind selective targets with increased affinity...
  30. pmc Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Curr Drug Targets 12:1595-653. 2011
    ..The current review is an attempt to provide description of various Ayurvedic plants currently used for treatment, their active chemical components, and the inflammatory pathways that they inhibit...
  31. pmc A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways
    Kanokkarn Phromnoi
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Anticancer Res 30:3599-610. 2010
    ..Overall, our results demonstrate that DH-PMF induces suppression of cell proliferation through modulation of AKT-GSK3β pathways and induction of cyclin-dependent kinase (CDK) inhibitors...
  32. pmc Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Biochem Pharmacol 80:1613-31. 2010
    ..As disappointment with the therapeutic value of the tocopherols grows, the potential of these novel vitamin E analogues awaits further investigation...
  33. ncbi request reprint Signalling pathways of the TNF superfamily: a double-edged sword
    Bharat B Aggarwal
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, Texas, USA
    Nat Rev Immunol 3:745-56. 2003
    ..These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. Blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases in the United States and other countries...
  34. pmc Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Annu Rev Nutr 30:173-99. 2010
    ..Other structurally homologous nutraceuticals, derived from red chili, cinnamon, cloves, black pepper, and ginger, also exhibit effects against obesity and insulin resistance...
  35. ncbi request reprint The role of TNF and its family members in inflammation and cancer: lessons from gene deletion
    Bharat B Aggarwal
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX, USA
    Curr Drug Targets Inflamm Allergy 1:327-41. 2002
    ..Our current understanding of the signaling pathways for TNF and other family members could serve as a target for the development of therapeutics...
  36. pmc Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship?
    Bharat B Aggarwal
    Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Ann N Y Acad Sci 1171:59-76. 2009
    ..Several of these small molecules are chemopreventive agents derived from plants. This review discusses the intimate relationship between STAT-3, inflammation, and cancer in more detail...
  37. pmc Inflammation and cancer: how friendly is the relationship for cancer patients?
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, United States
    Curr Opin Pharmacol 9:351-69. 2009
    ..We present evidence that inhibitors of inflammatory biomarkers may have a role in both prevention and treatment of cancer...
  38. ncbi request reprint Nuclear transcription factor NF-kappa B: role in biology and medicine
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Indian J Exp Biol 42:341-53. 2004
    ..In this review we summarize our current understanding of the NF-kappaB signaling pathways, their role in various cellular responses and the potential of using NF-kappaB as a therapeutic target in modern medicine...
  39. pmc Models for prevention and treatment of cancer: problems vs promises
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Biochem Pharmacol 78:1083-94. 2009
    ....
  40. doi request reprint Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 15:425-30. 2009
    ..Thus, suppression of these proinflammatory pathways may provide opportunities for both prevention and treatment of cancer...
  41. ncbi request reprint Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, Texas 77030, USA
    Anticancer Res 24:2783-840. 2004
    ..Limited data in humans have revealed that resveratrol is pharmacologically quite safe. Currently, structural analogues of resveratrol with improved bioavailability are being pursued as potential therapeutic agents for cancer...
  42. ncbi request reprint Protein farnesyltransferase inhibitor (SCH 66336) abolishes NF-kappaB activation induced by various carcinogens and inflammatory stimuli leading to suppression of NF-kappaB-regulated gene expression and up-regulation of apoptosis
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:26287-99. 2004
    ....
  43. ncbi request reprint Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, and Imgenex, San Diego, California 92121, USA
    J Biol Chem 279:15096-104. 2004
    ..Overall, our results demonstrate the identification of a p65 peptide that can selectively inhibit NF-kappaB activation induced by various inflammatory stimuli, down-regulate NF-kappaB-mediated gene expression, and up-regulate apoptosis...
  44. ncbi request reprint Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism
    Alok C Bharti
    Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:6065-76. 2004
    ..Thus, overall, our studies indicate that RANKL can inhibit cell proliferation and induce apoptosis through a TRAF-6-dependent but NF-kappaB-independent mechanism...
  45. ncbi request reprint Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion
    Yasunari Takada
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:17203-12. 2005
    ....
  46. pmc Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer
    Kuzhuvelil B Harikumar
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 127:257-68. 2010
    ..Overall our results demonstrate that resveratrol can potentiate the effects of gemcitabine through suppression of markers of proliferation, invasion, angiogenesis and metastasis...
  47. ncbi request reprint Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis
    Shishir Shishodia
    Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 173:2011-22. 2004
    ....
  48. ncbi request reprint Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:39541-54. 2004
    ....
  49. pmc {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment
    Ajaikumar B Kunnumakkara
    Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 70:8695-705. 2010
    ..Overall, our findings suggest that γ-T3 can inhibit the growth of human pancreatic tumors and sensitize them to gemcitabine by suppressing NF-κB-mediated inflammatory pathways linked to tumorigenesis...
  50. doi request reprint Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model
    Ajaikumar B Kunnumakkara
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Cancer 125:2187-97. 2009
    ..Overall, our results suggest that curcumin sensitizes CRC to the antitumor and antimetastatic effects of capecitabine by suppressing NF-kappaB cell signaling pathway...
  51. ncbi request reprint Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation
    Kazuhiro Ashikawa
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    J Immunol 169:6490-7. 2002
    ....
  52. doi request reprint Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosi
    Yasunari Takada
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Pharmacol 73:1549-57. 2008
    ..Overall, our results clearly suggest that flavopiridol interferes with the TNF cell-signaling pathway, leading to suppression of antiapoptotic mechanisms and enhancement of apoptosis...
  53. ncbi request reprint Melanoma differentiation-associated gene-7/IL-24 gene enhances NF-kappa B activation and suppresses apoptosis induced by TNF
    Sita Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 173:4368-76. 2004
    ..Potentiation of NF-kappaB survival signaling by MDA-7 inhibits TNF-mediated apoptosis...
  54. ncbi request reprint Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis
    Shishir Shishodia
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 279:47148-58. 2004
    ..Overall, our results indicate that guggulsterone suppresses NF-kappaB and NF-kappaB-regulated gene products, which may explain its anti-inflammatory activities...
  55. doi request reprint Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis
    Manoj K Pandey
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 68:5370-9. 2008
    ..This may provide the molecular basis for the ability of berberine to act as an anticancer and anti-inflammatory agent...
  56. ncbi request reprint Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9
    Yasunari Takada
    Cytokine Research Laboratory, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Immunol 171:3278-86. 2003
    ..This may provide a molecular basis for the ability of BA to mediate apoptosis, suppress inflammation, and modulate the immune response...
  57. pmc Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cells
    Kuzhuvelil B Harikumar
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 113:2003-13. 2009
    ..Thus, our results show that modification of cysteine residues of IKK and p65 by XN leads to inhibition of the NF-kappaB activation pathway, suppression of antiapoptotic gene products, and potentiation of apoptosis in leukemia cells...
  58. doi request reprint Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB
    Bokyung Sung
    Cytokine Research Section, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:191-201. 2008
    ..Together, our results indicate that DBL inhibits NF-kappaB activation and NF-kappaB-regulated gene expression, which may explain the ability of DBL to enhance apoptosis and inhibit invasion...
  59. pmc Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane)
    Santosh K Sandur
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Box 143, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Free Radic Biol Med 43:568-80. 2007
    ..Further, N-acetylcysteine partially reversed the effect of curcumin. Based on these results we conclude that curcumin mediates its apoptotic and anti-inflammatory activities through modulation of the redox status of the cell...
  60. ncbi request reprint Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation
    Manisha Bhutani
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 13:3024-32. 2007
    ..Because the transcription factor signal transducer and activator of transcription 3 (STAT3) has been closely linked with tumorigenesis, we investigated the effect of this vanilloid on the STAT3 pathway in human multiple myeloma cells...
  61. pmc Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model
    Bokyung Sung
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 8:959-70. 2009
    ..Collectively, our results suggest that curcumin overcomes chemoresistance and sensitizes multiple myeloma cells to thalidomide and bortezomib by down-regulating NF-kappaB and NF-kappaB-regulated gene products...
  62. ncbi request reprint Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression
    Haruyo Ichikawa
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:5910-8. 2006
    ....
  63. pmc Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents
    Subash C Gupta
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:35406-17. 2010
    ..Overall, our results indicate that nimbolide can sensitize tumor cells to chemotherapeutic agents through interaction with IKK, leading to inhibition of NF-κB-regulated proteins...
  64. pmc Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    Tingfang Yi
    Center for Cancer and Stem Cell Biology, Institute for Bioscience and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:1789-96. 2008
    ..Overall, our results indicate that thymoquinone inhibits tumor angiogenesis and tumor growth and could be used as a potential drug candidate for cancer therapy...
  65. pmc Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine
    Sahdeo Prasad
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Cancer Res 18:4942-53. 2012
    ..The effect of ursolic acid on the growth and chemosensitization was also examined in orthotopically implanted CRC in nude mice...
  66. pmc Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells
    Manoj K Pandey
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Cancer 127:282-92. 2010
    ..Overall, our results suggest that betulinic acid downregulates STAT3 activation through upregulation of SHP-1, and this may have potential in sensitization of STAT3 overexpressing tumors to chemotherapeutic agents...
  67. pmc Salinosporamide A (NPI-0052) potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through down-modulation of NF-kappaB regulated gene products
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 110:2286-95. 2007
    ..Thus, overall, our results indicate that salinosporamide A enhances apoptosis, suppresses osteoclastogenesis, and inhibits invasion through suppression of the NF-kappaB pathway...
  68. ncbi request reprint Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types
    Sekhar Majumdar
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas, TX 77030, USA
    Oncogene 22:1206-18. 2003
    ..Overall, our results clearly demonstrate that adenosine selectively suppresses TNF-induced NF-kappaB activation, which may contribute to its role in suppression of inflammation and of the immune system...
  69. pmc Turmeric (Curcuma longa) inhibits inflammatory nuclear factor (NF)-κB and NF-κB-regulated gene products and induces death receptors leading to suppressed proliferation, induced chemosensitization, and suppressed osteoclastogenesis
    Ji H Kim
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Mol Nutr Food Res 56:454-65. 2012
    ..Whether lower cancer incidence is due to turmeric was investigated by examining its effects on tumor cell proliferation, on pro-inflammatory transcription factors NF-κB and STAT3, and on associated gene products...
  70. ncbi request reprint Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1
    Shishir Shishodia
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 63:4375-83. 2003
    ..These actions of ursolic acid may mediate its antitumorigenic and chemosensitizing effects...
  71. doi request reprint Pinitol targets nuclear factor-kappaB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 7:1604-14. 2008
    ..Our results show that pinitol inhibits the NF-kappaB activation pathway, which may explain its ability to suppress inflammatory cellular responses...
  72. pmc Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity
    Santosh K Sandur
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 75:534-42. 2009
    ..Simultaneous inhibition of these pathways can sensitize these tumors to radiation therapy...
  73. ncbi request reprint Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue
    Manoj K Pandey
    Department of Experimental Therapeutics, Cytokine Research Laboratory, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 282:17340-50. 2007
    ..Overall, our results indicated that antitumor and anti-inflammatory activities previously assigned to butein may be mediated in part through the direct inhibition of IKK, leading to the suppression of the NF-kappaB activation pathway...
  74. ncbi request reprint Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cell
    Ashish M Kamat
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Unit 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 6:1022-30. 2007
    ..Cigarette smoke-induced expression of the NF-kappaB-regulated gene products cyclooxygenase-2 and vascular endothelial growth factor, linked with proliferation and angiogenesis, respectively, was also down-regulated by curcumin...
  75. ncbi request reprint Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptors
    Bei Zheng
    Departments of Lymphoma Myeloma, Bioimmunotherapy, and Cancer Biology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 10:3207-15. 2004
    ..Cell cycle analysis was determined by flow cytometry. Intracellular protein levels were determined by Western blot...
  76. ncbi request reprint Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9
    Sanjeev Banerjee
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 62:4945-54. 2002
    ..Overall, our results suggest that resveratrol suppresses DMBA-induced mammary carcinogenesis, which correlates with down-regulation of NF-kappaB, cyclooxygenase-2, and matrix metalloprotease-9 expression...
  77. pmc NF-kappaB and cancer: how intimate is this relationship
    Sahdeo Prasad
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, TX, 77030, USA
    Mol Cell Biochem 336:25-37. 2010
    ....
  78. pmc Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells
    Yasunari Takada
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Section of Molecular Hematology and Therapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Blood 106:641-9. 2005
    ..Overall, our results indicated that indole-3-carbinol inhibits NF-kappaB and NF-kappaB-regulated gene expression and that this mechanism may provide the molecular basis for its ability to suppress tumorigenesis...
  79. ncbi request reprint Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 109:2727-35. 2007
    ..Overall, our results suggest that celastrol potentiates TNF-induced apoptosis and inhibits invasion through suppression of the NF-kappaB pathway...
  80. pmc Morin (3,5,7,2',4'-Pentahydroxyflavone) abolishes nuclear factor-kappaB activation induced by various carcinogens and inflammatory stimuli, leading to suppression of nuclear factor-kappaB-regulated gene expression and up-regulation of apoptosis
    Sunil K Manna
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Cente, Houston, TX 77030, USA
    Clin Cancer Res 13:2290-7. 2007
    ....
  81. ncbi request reprint Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products
    Ajaikumar B Kunnumakkara
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 67:3853-61. 2007
    ..018 versus control). Overall, our results suggest that curcumin potentiates the antitumor effects of gemcitabine in pancreatic cancer by suppressing proliferation, angiogenesis, NF-kappaB, and NF-kappaB-regulated gene products...
  82. ncbi request reprint Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl
    Ruby John Anto
    Cytokine Research Section, Department of Bioimmunotherapy, Box 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Carcinogenesis 23:143-50. 2002
    ..Our results also suggest that Bcl-2 and Bcl-xl are critical negative regulators of curcumin-induced apoptosis...
  83. ncbi request reprint Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression
    Haruyo Ichikawa
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:1434-45. 2006
    ..Overall, our results indicate that withanolides inhibit activation of NF-kappaB and NF-kappaB-regulated gene expression, which may explain the ability of withanolides to enhance apoptosis and inhibit invasion and osteoclastogenesis...
  84. ncbi request reprint N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products
    Shishir Shishodia
    Cytokine Research Laboratory, Department of Experimental Therapeutics and Thoracic Head and Neck Medical Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:9555-65. 2005
    ..This correlated with potentiation of apoptosis induced by TNF and chemotherapeutic agents...
  85. doi request reprint Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 269:199-225. 2008
    ..Several phase I and phase II clinical trials indicate that curcumin is quite safe and may exhibit therapeutic efficacy. These aspects of curcumin are discussed further in detail in this review...
  86. ncbi request reprint Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation
    Sita Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030 4009, USA
    Mol Pharmacol 69:195-206. 2006
    ..Overall, our results indicated that curcumin inhibits NF-kappaB activation and NF-kappaB-regulated gene expression through inhibition of IKK and Akt activation...
  87. ncbi request reprint Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-kappaB activation through inhibition of IkappaBalpha kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1
    Shishir Shishodia
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Carcinogenesis 24:1269-79. 2003
    ..Overall our results indicate that CS-induced NF-kappaB activation and NF-kappaB-regulated gene expression in human non-small cell lung carcinoma cells is suppressed by curcumin through suppression of IkappaBalpha kinase...
  88. ncbi request reprint Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer
    Shishir Shishodia
    Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, USA
    Cancer Treat Res 119:139-73. 2004
  89. doi request reprint Targeting inflammatory pathways by flavonoids for prevention and treatment of cancer
    Sahdeo Prasad
    Department of Experimental Therapeutics, The University of Texas, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Planta Med 76:1044-63. 2010
    ....
  90. ncbi request reprint Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kina
    Bokyung Sung
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Pharmacol 71:1703-14. 2007
    ..This correlated with potentiation of apoptosis induced by TNF, doxorubicin, and cisplatin. Thus, overall, our results indicate that fisetin mediates antitumor and anti-inflammatory effects through modulation of NF-kappaB pathways...
  91. pmc The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo
    Mi Ae Lyu
    Immunopharmacology and Targeted Therapy Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Neoplasia 12:366-75. 2010
    ..05) in a DLBCL xenograft model. Thus, our results indicate that rGel/BLyS is an excellent candidate for the treatment of aggressive NHLs that are both dependent on NF-kappaB and are resistant to conventional chemotherapeutic regimens...
  92. doi request reprint Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products
    Ajaikumar B Kunnumakkara
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2128-36. 2008
    ..Because curcumin, a component of turmeric (Curcuma longa), has been shown to suppress NF-kappaB activation, whether it can sensitize the colorectal cancer to gamma-radiation was investigated in colorectal cancer xenografts in nude mice...
  93. ncbi request reprint Nuclear factor-kappa B and cancer: its role in prevention and therapy
    Alok C Bharti
    Cytokine Research Section, Department of Bioimmunotherapy, M D Anderson Cancer Center, University of Texas, Box 143, 1515 Holcomb Boulevard, Houston, TX 77030, USA
    Biochem Pharmacol 64:883-8. 2002
    ..Overall, these observations suggest that NF-kappaB is an ideal target for chemoprevention and chemosensitization. This article reviews evidence supporting this hypothesis...
  94. doi request reprint Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 6:1059-70. 2008
    ....
  95. ncbi request reprint Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
    Yasunari Takada
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Oncogene 24:6957-69. 2005
    ....
  96. pmc Sesamin manifests chemopreventive effects through the suppression of NF-kappa B-regulated cell survival, proliferation, invasion, and angiogenic gene products
    Kuzhuvelil B Harikumar
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Res 8:751-61. 2010
    ..Overall, our results showed that sesamin may have potential against cancer and other chronic diseases through the suppression of a pathway linked to the NF-kappaB signaling...
  97. ncbi request reprint Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2
    Shishir Shishodia
    Cytokine Research Laboratory, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 64:5004-12. 2004
    ....
  98. ncbi request reprint Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products
    Haruyo Ichikawa
    Cytokine Research Section, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    J Immunol 174:7383-92. 2005
    ..Overall, our results indicate that ACA inhibits activation of NF-kappaB and NF-kappaB-regulated gene expression, which may explain the ability of ACA to enhance apoptosis and inhibit invasion...
  99. ncbi request reprint Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
    Alok C Bharti
    Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 101:1053-62. 2003
    ....
  100. ncbi request reprint Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-kappaB (NF-kappaB) signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Mol Pharmacol 71:209-19. 2007
    ..This down-regulation was associated with enhanced apoptosis by cytokine and chemotherapeutic agents. Together, our results indicate that embelin is a novel NF-kappaB blocker and potential suppressor of tumorigenesis...
  101. ncbi request reprint Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway
    Gautam Sethi
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 281:23425-35. 2006
    ..Overall, our results indicate that anti-cancer and anti-inflammatory activities previously assigned to indirubin may be mediated in part through the suppression of the NF-kappaB activation pathway...