N Scott Adzick

Summary

Affiliation: The Children's Hospital of Philadelphia
Country: USA

Publications

  1. doi request reprint Management of fetal lung lesions
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Perinatol 36:363-76, x. 2009
  2. pmc Fetal surgery for myelomeningocele: trials and tribulations. Isabella Forshall Lecture
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Surg 47:273-81. 2012
  3. ncbi request reprint Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome
    Holly L Hedrick
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Pediatr Surg 39:430-8; discussion 430-8. 2004
  4. doi request reprint Prospects for fetal surgery
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, United States The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States Electronic address
    Early Hum Dev 89:881-6. 2013
  5. doi request reprint Fetal surgery for spina bifida: past, present, future
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Pediatr Surg 22:10-7. 2013
  6. pmc A randomized trial of prenatal versus postnatal repair of myelomeningocele
    N Scott Adzick
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    N Engl J Med 364:993-1004. 2011
  7. pmc Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Semin Fetal Neonatal Med 15:9-14. 2010
  8. doi request reprint Open fetal surgery for life-threatening fetal anomalies
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Fetal Neonatal Med 15:1-8. 2010
  9. doi request reprint Ex utero intrapartum treatment in the management of giant cervical teratomas
    Pablo Laje
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 47:1208-16. 2012
  10. ncbi request reprint Acute cardiovascular effects of fetal surgery in the human
    Jack Rychik
    Center for Fetal Diagnosis and Treatment and the Fetal Heart Program, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Circulation 110:1549-56. 2004

Research Grants

Detail Information

Publications99

  1. doi request reprint Management of fetal lung lesions
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Clin Perinatol 36:363-76, x. 2009
    ..Serial sonographic study of fetuses with thoracic lesions has helped define the natural history of these lesions, determine the pathophysiologic features that affect clinical outcome, and formulate management based on prognosis...
  2. pmc Fetal surgery for myelomeningocele: trials and tribulations. Isabella Forshall Lecture
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Surg 47:273-81. 2012
    ..This is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC...
  3. ncbi request reprint Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcome
    Holly L Hedrick
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Pediatr Surg 39:430-8; discussion 430-8. 2004
    ..To understand the natural history and define indications for fetal intervention in sacrococcygeal teratoma (SCT), the authors reviewed all cases of fetal SCT presenting for evaluation...
  4. doi request reprint Prospects for fetal surgery
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, United States The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States Electronic address
    Early Hum Dev 89:881-6. 2013
    ....
  5. doi request reprint Fetal surgery for spina bifida: past, present, future
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Semin Pediatr Surg 22:10-7. 2013
    ..In the future, research will expand our understanding of the pathophysiology of MMC, evaluate the long-term impact of in-utero intervention, and to refine timing and technique of fetal MMC surgery using tissue engineering technology...
  6. pmc A randomized trial of prenatal versus postnatal repair of myelomeningocele
    N Scott Adzick
    Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    N Engl J Med 364:993-1004. 2011
    ..Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair...
  7. pmc Fetal myelomeningocele: natural history, pathophysiology, and in-utero intervention
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
    Semin Fetal Neonatal Med 15:9-14. 2010
    ..Further research is needed to better understand the pathophysiology of MMC, the ideal timing and technique of repair, and the long-term impact of in-utero intervention...
  8. doi request reprint Open fetal surgery for life-threatening fetal anomalies
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Fetal Neonatal Med 15:1-8. 2010
    ..Important lessons have been learned about perioperative management and maternal, fetal, and neonatal outcomes after open fetal surgery...
  9. doi request reprint Ex utero intrapartum treatment in the management of giant cervical teratomas
    Pablo Laje
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 47:1208-16. 2012
    ..The purpose of this study is to present the outcome and technical details of the Ex Utero Intrapartum Treatment (EXIT) procedure performed in the management of the fetus with a giant cervical teratoma...
  10. ncbi request reprint Acute cardiovascular effects of fetal surgery in the human
    Jack Rychik
    Center for Fetal Diagnosis and Treatment and the Fetal Heart Program, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
    Circulation 110:1549-56. 2004
    ..The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system...
  11. ncbi request reprint Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Pediatr Pulmonol 41:1188-96. 2006
    ..We hypothesize that a GC-induced reduction in lung liquid volume during TO contributes, in part, to the observed increase in AE2 cell density and SPmRNA expression...
  12. doi request reprint Early neurodevelopmental outcome of infants with high-risk fetal lung lesions
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 31:210-5. 2012
    ....
  13. ncbi request reprint The ex utero intrapartum therapy procedure for high-risk fetal lung lesions
    Holly L Hedrick
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Pediatr Surg 40:1038-43; discussion 1044. 2005
    ..Indications for the ex utero intrapartum therapy (EXIT) procedure have expanded to include any fetal anomaly in which resuscitation of the neonate may be compromised...
  14. doi request reprint Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesions
    ANTHONY Y TSAI
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 43:513-7. 2008
    ..On the other hand, malignant degeneration, pneumonia, and pneumothorax are known consequences of cystic lung lesions. This study aims to assess the safety of resection for asymptomatic lung lesions that were diagnosed before birth...
  15. doi request reprint Predicting the severity of congenital high airway obstruction syndrome
    Jessica L Roybal
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 45:1633-9. 2010
    ..In our relatively large series of CHAOS patients, we have observed a spectrum of clinical severity. The aim of this study was to identify the prenatal characteristics of CHAOS predictive of a milder postnatal course...
  16. ncbi request reprint Severe pulmonary hypoplasia associated with giant cervical teratomas
    Kenneth W Liechty
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 41:230-3. 2006
    ..The use of the ex utero intrapartum treatment (EXIT) procedure has salvaged many fetuses with giant neck masses. Despite an adequate airway, a subset of these patients die from an inability to achieve adequate gas exchange...
  17. ncbi request reprint Reproductive outcomes after pregnancy complicated by maternal-fetal surgery
    R Douglas Wilson
    Pediatric Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Obstet Gynecol 191:1430-6. 2004
    ..The reproductive outcomes for women after the pregnancy complicated by maternal-fetal surgery were evaluated to obtain evidence-based information for prenatal risk counseling...
  18. ncbi request reprint Chorioamniotic membrane separation following open fetal surgery: pregnancy outcome
    R Douglas Wilson
    Department of Surgery, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
    Fetal Diagn Ther 18:314-20. 2003
    ....
  19. doi request reprint Early delivery as an alternative management strategy for selected high-risk fetal sacrococcygeal teratomas
    Jessica L Roybal
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, PA, USA
    J Pediatr Surg 46:1325-32. 2011
    ..In our experience, even with aggressive serial imaging, many fetuses have died under a policy of "watchful waiting." We propose "early delivery" as the best option for selected cases of high-risk fetal SCT...
  20. doi request reprint Sacrococcygeal teratomas: prenatal surveillance, growth and pregnancy outcome
    R Douglas Wilson
    Fetal Heart Program, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 25:15-20. 2009
    ..Prenatal surveillance and growth characteristics are evaluated in a cohort of fetuses with sacrococcygeal teratomas (SCT) as part of risk assessment...
  21. ncbi request reprint Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic hernia
    Holly L Hedrick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Obstet Gynecol 197:422.e1-4. 2007
    ..The purpose of this study was to determine the ability of liver position and lung-to-head ratio to predict outcome in isolated left congenital diaphragmatic hernia...
  22. doi request reprint Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 31:248-53. 2012
    ..To determine the value of fetal MRI-calculated total lung volumes (TLV) in the prediction of short-term outcome in patients with giant omphalocele (GO)...
  23. ncbi request reprint Fetal myelomeningocele repair: short-term clinical outcomes
    Mark P Johnson
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
    Am J Obstet Gynecol 189:482-7. 2003
    ..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair...
  24. ncbi request reprint Right congenital diaphragmatic hernia: Prenatal assessment and outcome
    Holly L Hedrick
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    J Pediatr Surg 39:319-23; discussion 319-23. 2004
    ..To understand the natural history of right congenital diaphragmatic hernia (CDH), the authors retrospectively reviewed 27 cases of right CDH that presented for prenatal evaluation or postnatal treatment...
  25. doi request reprint Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arterioles
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 43:1767-75. 2008
    ..The aim of this study is to examine structure of lung parenchyma (Pp) and muscularization of pulmonary arterioles (PAs) in human fetuses that underwent tracheal occlusion (TO) therapy for severe congenital diaphragmatic hernia (CDH)...
  26. ncbi request reprint Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusion
    Marcus G Davey
    The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 19104, USA
    Pediatr Res 60:131-5. 2006
    ..GC or surfactant therapy alone significantly improved respiratory gas exchange, Cl, and ventilatory efficiency index. Total lung capacity was normalized only in DH/TO lambs that received both GC and S...
  27. ncbi request reprint Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism
    Olga T Hardy
    Division of Endocrinology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 92:4706-11. 2007
    ..This study evaluated the accuracy of 18F-fluoro-l-dihydroxyphenylalanine ([18F]DOPA) positron emission tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location of focal lesions...
  28. doi request reprint Congenital high airway obstruction syndrome: MR/US findings, effect on management, and outcome
    Andrew Mong
    Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Pediatr Radiol 38:1171-9. 2008
    ..Prompt airway intervention at delivery after accurate prenatal diagnosis may allow survival of this otherwise fatal condition...
  29. doi request reprint Prenatal course and postnatal management of peripheral bronchial atresia: association with congenital cystic adenomatoid malformation of the lung
    William H Peranteau
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 24:190-6. 2008
    ....
  30. doi request reprint Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findings
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Neurosurg Pediatr 2:406-13. 2008
    ..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure...
  31. doi request reprint Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomes
    Andrea T Badillo
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 43:647-53. 2008
    ..The purpose of this study was to correlate prenatal identification of additional gastrointestinal sonographic abnormalities with postnatal clinical outcome...
  32. ncbi request reprint Impact of continuous intraoperative monitoring on outcomes in open fetal surgery
    Sundeep G Keswani
    Center for Fetal Diagnosis and Treatment and Fetal Heart Program at the Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 20:316-20. 2005
    ..We have developed an intraoperative monitoring strategy to continuously assess fetal hemodynamics. We hypothesized that this approach would enhance intraoperative management and survival...
  33. doi request reprint Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgery
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 25:47-53. 2009
    ..To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure...
  34. doi request reprint Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic hernia
    Teresa Victoria
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, 19103, USA
    Prenat Diagn 32:715-23. 2012
    ....
  35. ncbi request reprint The EXIT procedure: experience and outcome in 31 cases
    Sarah Bouchard
    Division of Pediatric General, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Surg 37:418-26. 2002
    ..The EXIT (ex utero intrapartum treatment) procedure, although initially designed for reversal of tracheal occlusion in fetuses with congenital diaphragmatic hernias (CDH), has been adapted to treat a variety of fetal conditions...
  36. ncbi request reprint Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRI
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, Department of Radiology, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    AJR Am J Roentgenol 187:W350-6. 2006
    ..The purpose of this study was to determine whether prenatal MRI provides additional information about fetal sacrococcygeal teratoma compared with prenatal sonography...
  37. ncbi request reprint Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survival
    William H Peranteau
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 22:365-71. 2007
    ..To evaluate the effect of prenatal steroid treatment on the growth of congenital cystic adenomatoid malformations (CCAM) and survival in affected fetuses not amenable to other percutaneous ultrasound-guided prenatal interventions...
  38. ncbi request reprint Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?
    R Douglas Wilson
    Department of Surgery and Obstetrics and Gynecology, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
    Fetal Diagn Ther 22:348-51. 2007
    ..A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, 'Does the presence or size of an MMC sac affect postnatal leg function?'..
  39. doi request reprint Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007)
    R Douglas Wilson
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Am J Obstet Gynecol 203:209.e1-6. 2010
    ..The reproductive and gynecologic outcomes for women after the pregnancy complicated by open maternal-fetal surgery (OMFS) were evaluated...
  40. doi request reprint Preschool neurodevelopmental outcome of children following fetal myelomeningocele closure
    Enrico Danzer
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 202:450.e1-9. 2010
    ..We sought to investigate the preschool neurodevelopmental outcomes of children following fetal myelomeningocele (fMMC) surgery...
  41. ncbi request reprint Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformations
    R Douglas Wilson
    Department of Surgery, Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    Fetal Diagn Ther 19:413-20. 2004
    ....
  42. ncbi request reprint Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep
    Sarah Bouchard
    Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Pediatr Surg 38:451-8; discussion 451-8. 2003
    ..This hypothesis was tested by assessing the impact of a spinal cord myelotomy on hindbrain anatomy in fetal sheep...
  43. doi request reprint OEIS sequence--a rare congenital anomaly with prenatal evaluation and postnatal outcome in six cases
    Eleonor Tiblad
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Prenat Diagn 28:141-7. 2008
    ..To describe the outcome of children prenatally diagnosed with omphalocele, exstrophy of the cloaca, imperforate anus and spinal defects (OEIS)...
  44. ncbi request reprint Abnormal umbilical cord Doppler sonograms may predict impending demise in fetuses with sacrococcygeal teratoma. A report of two cases
    Oluyinka O Olutoye
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 19:35-9. 2004
    ..To identify factors predictive of fetal demise in fetuses with sacrococcygeal teratoma (SCT)...
  45. ncbi request reprint Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformation
    Aziz M Merchant
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, and Department of Surgery and Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
    Fetal Diagn Ther 22:435-9. 2007
    ..Large macrocystic congenital cystic adenomatoid malformations (CCAMs) can be treated with thoracoamniotic (TA) shunting to reduce CCAM volume. Two CCAM fetuses treated with TA shunt had postnatal radiographic rib deformities...
  46. ncbi request reprint Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic hernia
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Abramson 1112 D, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Pediatr Pulmonol 39:359-67. 2005
    ..Furthermore, AE2 cell density is increased in DH, suggesting that the increase in SP mRNA and protein levels is due to increases AE2 cell number. Our data further support the premise that fetal lung hypoplasia favors an AE2 phenotype...
  47. ncbi request reprint Prenatal diagnosis and postnatal management of diffuse congenital hyperinsulinism: a case report
    William H Peranteau
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 21:515-8. 2006
    ..This case highlights the benefits of the timely in utero diagnosis of hyperinsulinism by mutational analysis...
  48. ncbi request reprint Congenital high airway obstruction syndrome: natural history and management
    Foong Yen Lim
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 38:940-5. 2003
    ..Congenital high airway obstruction syndrome (CHAOS) is a life-threatening condition with a poorly understood natural history...
  49. ncbi request reprint Prenatal diagnosis and management of mainstem bronchial atresia
    Sundeep G Keswani
    Center for Fetal Diagnosis and Treatment, The Chhildren s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 20:74-8. 2005
    ..Post-mortem findings in both cases confirmed the presence of an atretic mainstem bronchus with massive enlargement of the lung. Bronchial atresia involving the mainstem bronchus is associated with a poor prognosis...
  50. doi request reprint In utero meconium passage in fetuses and newborns with myelomeningocele
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurosurg Pediatr 3:141-6. 2009
    ..The authors retrospectively investigated whether midgestational fetal myelomeningocele (fMMC) repair alters intrauterine meconium exposure...
  51. doi request reprint Preschool neurological assessment in congenital diaphragmatic hernia survivors: outcome and perinatal factors associated with neurodevelopmental impairment
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Early Hum Dev 89:393-400. 2013
    ..To evaluate the preschool neurodevelopmental outcome in CDH survivors between 2 and 5 years of age and to identify perinatal and postnatal factors that may be predictive of persistent neurological deficits...
  52. doi request reprint Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic hernia
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 47:453-61. 2012
    ..The aim of the study was to evaluate the incidence of abnormal brain maturation in survivors of severe congenital diaphragmatic hernia (CDH)...
  53. doi request reprint Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestine
    Enrico Danzer
    The Center for Fetal Research, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Pediatr Res 68:23-8. 2010
    ..The defect observed in ACLP mice closely resembles GS. Absence of ICC, NCC, EN, and immature differentiation of SMC supports an associated defect in neuromuscular development that is restricted to the EI...
  54. doi request reprint Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcome
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Pediatr Surg 45:718-23. 2010
    ..The objective of this study is to determine the short-term neurodevelopmental outcome in infants with giant omphalocele (GO)...
  55. doi request reprint Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up program
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 45:1759-66. 2010
    ..The purpose of the study was to evaluate the neurodevelopmental outcome in infants with congenital diaphragmatic hernia (CDH)...
  56. ncbi request reprint Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism
    Mariko Suchi
    Department of Pathology and Laboratory Medicine, The Childrens Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Mod Pathol 19:122-9. 2006
    ..The combined results from the immunohistochemical and molecular methods indicate that maternal 11p15 loss together with paternal K(ATP) mutation is the predominant causative mechanism of focal hyperinsulinism...
  57. doi request reprint Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury
    Enrico Danzer
    Children s Center for Fetal Research, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Am J Obstet Gynecol 204:178.e1-11. 2011
    ....
  58. ncbi request reprint Management of fetal mediastinal teratoma
    Aziz M Merchant
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
    J Pediatr Surg 40:228-31. 2005
    ..The authors present 2 cases of fetal mediastinal teratoma that illustrate successful strategies for either of these presentations...
  59. ncbi request reprint Fetal surgery for myelomeningocele
    Leslie N Sutton
    Division of Neurosurgery, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19087, USA
    Childs Nerv Syst 19:587-91. 2003
    ..Although in utero treatment of myelomeningocele shows promise in decreasing the morbidity of this disease, the risks to the fetus are significant, and the benefits are unproven...
  60. ncbi request reprint Fetal surgery for lung lesions, congenital diaphragmatic hernia, and sacrococcygeal teratoma
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Semin Pediatr Surg 12:154-67. 2003
    ..Fetal sacrococcygeal teratoma complicated with progressive high output cardiac failure may benefit from in utero resection of the tumor...
  61. doi request reprint Hepaticoduodenostomy vs hepaticojejunostomy for reconstruction after resection of choledochal cyst
    Matthew T Santore
    The Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 46:209-13. 2011
    ..Hepaticoduodenostomy (HD) has been argued to be more physiologically and technically easier but is feared to have associated complications. Here we compare outcomes of the 2 procedures...
  62. ncbi request reprint Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstruction
    Jean Marc Biard
    Center for Fetal Diagnosis and Treatment, at The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Obstet Gynecol 106:503-8. 2005
    ..Limited information is available about long-term outcomes in children treated prenatally for lower urinary tract obstruction. Our aim was to evaluate outcomes in children treated in utero with vesicoamniotic shunts...
  63. ncbi request reprint Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 cases
    Oluyinka O Olutoye
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 18:428-31. 2003
    ..To identify factors predictive of fetal demise in fetuses with sacrococcygeal teratoma (SCT)...
  64. ncbi request reprint History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experience
    Holly L Hedrick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, and Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 18:65-82. 2003
    ..Outcomes have been improved through carefully planned and coordinated perinatal management. In some cases of life-threatening or severely debilitating defects, prenatal surgery has been offered...
  65. ncbi request reprint Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningocele
    Enrico Danzer
    The Children s Center for Fetal Research, Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Abramson Research Center, Room 1116B, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    Neurosci Lett 430:157-62. 2008
    ....
  66. ncbi request reprint Pregnancy outcomes following bipolar umbilical cord cauterization for selective termination in complicated monochorionic multiple gestations
    John G Ilagan
    Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Fetal Diagn Ther 23:153-8. 2008
    ..To review pregnancy and childhood outcomes following selective termination by ultrasound guided bipolar umbilical cord cauterization (UCC) in complicated monochorionic multifetal pregnancies...
  67. ncbi request reprint Antenatal diagnosis and management of congenital cystic adenomatoid malformation
    Stephanie Mann
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood Center 5113, Philadelphia, PA 19104, USA
    Semin Fetal Neonatal Med 12:477-81. 2007
    ..Careful delivery planning by utilizing a multidisciplinary approach will optimize neonatal outcomes...
  68. ncbi request reprint Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair
    Enrico Danzer
    The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Fetal Diagn Ther 22:1-6. 2007
    ..To examine the impact of fetal myelomeningocele (MMC) repair on fetal head biometry and cerebrospinal fluid (CSF) spaces assessed by magnetic resonance imaging (MR) studies...
  69. ncbi request reprint Management of congenital lung lesions
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Semin Pediatr Surg 12:10-6. 2003
    ..The finding that fetuses with hydrops are at very high risk for fetal or neonatal death has led to successful fetal thoracoamniotic shunt placement or fetal surgical resection...
  70. ncbi request reprint Cystic adenomatoid malformation of the lung: review of genetics, prenatal diagnosis, and in utero treatment
    R Douglas Wilson
    Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
    Am J Med Genet A 140:151-5. 2006
    ..In the appropriate situation, this maternal fetal surgery approach for CCAM is life-saving for the affected fetus with acceptable maternal morbidity risks in the present and future pregnancies...
  71. ncbi request reprint Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningocele
    Enrico Danzer
    The Center for Fetal Research, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Am J Physiol Renal Physiol 292:F197-206. 2007
    ....
  72. ncbi request reprint Epinephrine inhibits tracheal occlusion induced lung growth in fetal sheep
    Yoshihiro Kitano
    The Children s Institute for Surgical Science, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
    Fetal Diagn Ther 18:333-7. 2003
    ..We hypothesized that continuous infusion of Epi would have a detrimental effect on lung growth following TO in the fetal sheep model...
  73. ncbi request reprint Management of fetal lung lesions
    N Scott Adzick
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Clin Perinatol 30:481-92. 2003
    ..Both fetuses survived and one required the use of ECMO. For hydropic fetuses of less than 32 weeks' gestation, there is now a new therapeutic option, treating the lesion before birth...
  74. doi request reprint Esophageal obstruction and intracardiac "mass" in association with omphalocele closure
    Teresa Victoria
    Radiology Department, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 44:448-50. 2009
    ..Knowledge of these less well-recognized anatomical variations is important to avoid unnecessary interventions...
  75. ncbi request reprint Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulation
    Charles A Stanley
    Division of Endocrinology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 89:288-96. 2004
    ..The combination of ASVS, careful intraoperative histologic analysis, and surgical expertise succeeded in correcting hypoglycemia in 86% of the infants with focal hyperinsulinism...
  76. doi request reprint Open fetal surgery for myelomeningocele
    Michael W Bebbington
    Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Prenat Diagn 31:689-94. 2011
    ..This will mean that not every fetus with an MMC will be a candidate for in utero surgery. The balance of risk to benefit will continue to evolve as further technological advances are evaluated and more follow-up information is obtained...
  77. ncbi request reprint Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function
    Marcus G Davey
    Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    J Appl Physiol (1985) 94:1054-62. 2003
    ..Lung compliance remained low in DH/TO+R lambs, most likely as a consequence of the persistent increase in alveolar wall thickness in these animals...
  78. ncbi request reprint Blood glucose control during selective arterial stimulation and venous sampling for localization of focal hyperinsulinism lesions in anesthetized children
    Giovanni Cucchiaro
    Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Anesth Analg 99:1044-8, table of contents. 2004
    ....
  79. ncbi request reprint Does the use of fentanyl in epidural solutions for postthoracotomy pain management in neonates affect surgical outcome?
    Phillip D Bailey
    Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, The University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
    J Pediatr Surg 40:1118-21. 2005
    ..1% and bupivacaine 0.1% with fentanyl 2 to 5 microg/mL...
  80. ncbi request reprint Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age
    Mark Paul Johnson
    The Center for Fetal Diagnosis and Treatment, Philadelphia, PA 19104, USA
    Am J Obstet Gynecol 194:1145-50; discussion 1150-2. 2006
    ..This study was undertaken to examine short-term neurodevelopmental outcomes in children with myelomeningocele (MMC) who underwent in utero neurosurgical closure...
  81. doi request reprint Efficacy of addition of fentanyl to epidural bupivacaine on postoperative analgesia after thoracotomy for lung resection in infants
    Arjunan Ganesh
    Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Anesthesiology 109:890-4. 2008
    ..The primary outcome was the total amount of rescue doses of intravenous nalbuphine in the first 24 h after surgery. Secondary outcomes included (1) time to first rescue dose of nalbuphine, (2) pain scores, and (3) behavior scores...
  82. ncbi request reprint Congenital hyperinsulinism: intraoperative biopsy interpretation can direct the extent of pancreatectomy
    Mariko Suchi
    Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, 5203 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Am J Surg Pathol 28:1326-35. 2004
    ..However, a small number of cases with unusual histology warrant caution when performing frozen section evaluation...
  83. ncbi request reprint Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan
    Olga T Hardy
    Division of Endocrinology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    J Pediatr 150:140-5. 2007
    ..To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism...
  84. ncbi request reprint A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy
    N Scott Adzick
    Department of Surgery, and The Center for Hyperinsulinism, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Pediatr Surg 39:270-5. 2004
    ..Although these 2 forms of HI are clinically identical, focal HI can be cured surgically. The authors reviewed their experience with partial pancreatectomy for focal HI...
  85. ncbi request reprint Molecular response of the bladder to obstruction
    Andrew J Kirsch
    Division of Pediatric Urology, Children s Hospital of Philadelphia, PA 19104, USA
    Adv Exp Med Biol 539:195-216. 2003
  86. ncbi request reprint Myelomeningocele: prenatal diagnosis, pathophysiology and management
    N Scott Adzick
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Semin Pediatr Surg 12:168-74. 2003
    ..A prospective, randomized clinical trial is planned comparing prenatal MMC repair with postnatal repair...
  87. ncbi request reprint A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal intervention
    Natalie E Rintoul
    Divisions of Neonatology, Philadelphia, Pennsylvania 10194, USA
    Pediatrics 109:409-13. 2002
    ..We sought to determine the distribution of postnatally repaired MMC lesions as characterized by both functional and radiologic assessment, as well as the incidence of shunting when patients were categorized according to these 2 methods...
  88. ncbi request reprint The natural history of prenatally diagnosed conjoined twins
    Tippi C MacKenzie
    Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    J Pediatr Surg 37:303-9. 2002
    ..To assess the impact of improved antenatal diagnosis in the management and outcome of conjoined twins, the authors reviewed their experience with 14 cases...
  89. ncbi request reprint Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lung
    Timothy M Crombleholme
    Division of General, The Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, USA
    J Pediatr Surg 37:331-8. 2002
    ..The authors now report the results of prospective use of the CVR both to track tumor growth and regression during gestation and confirm its predictive value in fetuses with CAM...
  90. ncbi request reprint Prenatal diagnosis of terminal myelocystocele in the fetal surgery era: case report
    Paola Midrio
    Department of Surgery, The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
    Neurosurgery 50:1152-4; discussion 1154-5. 2002
    ..This case exemplifies the importance of performing a multidisciplinary evaluation and magnetic resonance imaging in the patient with suspected meningomyelocele when fetal surgery is being considered...
  91. ncbi request reprint Influence of congenital heart disease on survival in children with congenital diaphragmatic hernia
    Meryl S Cohen
    Cardiac Center and The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    J Pediatr 141:25-30. 2002
    ..We sought to assess outcome in patients with CDH and HD to determine if LHR is also predictive of outcome in this subset of patients...
  92. ncbi request reprint Gastroschisis: growth patterns and a proposed prenatal surveillance protocol
    Denise A Netta
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Fetal Diagn Ther 22:352-7. 2007
    ..The growth assessment could be available as a prospective tool to direct an antepartum fetal surveillance protocol...
  93. ncbi request reprint The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalus
    Noel Tulipan
    Department of Neurosurgery, Vanderbilt University Medical Center, A 2219 Medical Center North, Nashville, TN 37232 2380, USA
    Pediatr Neurosurg 38:27-33. 2003
    ..However, the existing cohort of IUMR patients has not yet been systematically compared to a comparable group of conventionally treated controls...
  94. ncbi request reprint Fetal therapy: state of the art
    Beverly G Coleman
    Department of Radiology, The University of Pennsylvania Medical Center, Philadelphia 19104, USA
    J Ultrasound Med 21:1257-88. 2002
    ..To review our experience with the use of sonography in evaluating potential candidates for in utero fetal therapy performed at The Center for Fetal Diagnosis and Treatment at The Children's Hospital of Philadelphia...
  95. ncbi request reprint Prenatal diagnosis of partial trisomy 1q and monosomy X in a fetus with a congenital lung lesion and hydrops fetalis
    Tracy L Pressey
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada
    Am J Med Genet A 143:1104-7. 2007
    ..2;q25 or q31)]. The incidence of chromosomal abnormalities with CCAM lesions is estimated at 1.6%. This is the first reported case of prenatally diagnosed partial trisomy 1q and monosomy X presenting as a fetal lung lesion and hydrops...
  96. ncbi request reprint A prospective, randomized pilot trial of perfluorocarbon-induced lung growth in newborns with congenital diaphragmatic hernia
    Ronald B Hirschl
    Mott Children s Hospital, University of Michigan Health System, Ann Arbor, Michigan 48109 0245, USA
    J Pediatr Surg 38:283-9; discussion 283-9. 2003
    ..The authors, therefore, performed a prospective, randomized pilot study evaluating PLV and perfluorocarbon-induced lung growth (PILG) in newborns with CDH on extracorporeal life support (ECLS) at 6 medical centers...
  97. ncbi request reprint Fetal surgery for myelomeningocele
    Leslie N Sutton
    University of Pennsylvania School of Medicine, Children s Hospital of Philadelphia, USA
    Clin Neurosurg 51:155-62. 2004
  98. ncbi request reprint Establishing a fetal therapy center: lessons learned
    Lori J Howell
    The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Semin Pediatr Surg 12:209-17. 2003
    ..This article details the essential components of a center for fetal diagnosis and treatment and describes some of the lessons learned based on our experience at The Children's Hospital of Philadelphia (CHOP)...
  99. ncbi request reprint Prenatally diagnosed giant omphaloceles: short- and long-term outcomes
    Jean Marc Biard
    The Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, Philadelphia 19104 4399, USA
    Prenat Diagn 24:434-9. 2004
    ..To review prenatal findings, short- and long-term outcomes of giant omphaloceles (GO) managed at a single institution (1996-2001)...

Research Grants4

  1. Multicenter Trial of Fetal Myelomeningocele Repair
    N Adzick; Fiscal Year: 2006
    ..In summary, the proposed trial is expected to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..
  2. Multicenter Trial of Fetal Myelomeningocele Repair
    N Adzick; Fiscal Year: 2007
    ..In summary, the proposed trial will be able to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..