Research Topics
| N Scott AdzickSummaryAffiliation: The Children's Hospital of Philadelphia Country: USA Publications
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Publications
Management of fetal lung lesionsN Scott Adzick
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Clin Perinatol 36:363-76, x. 2009..Serial sonographic study of fetuses with thoracic lesions has helped define the natural history of these lesions, determine the pathophysiologic features that affect clinical outcome, and formulate management based on prognosis...
Fetal surgery for myelomeningocele: trials and tribulations. Isabella Forshall LectureN Scott Adzick
The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Pediatr Surg 47:273-81. 2012..This is now performed in selected patients and presents an additional therapeutic alternative for expectant mothers carrying a fetus with MMC...- Fetal surgery for spina bifida: Past, present, futureN Scott Adzick
The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
Semin Pediatr Surg 22:10-7. 2013..In the future, research will expand our understanding of the pathophysiology of MMC, evaluate the long-term impact of in-utero intervention, and to refine timing and technique of fetal MMC surgery using tissue engineering technology... - Open fetal surgery for life-threatening fetal anomaliesN Scott Adzick
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Semin Fetal Neonatal Med 15:1-8. 2010..Important lessons have been learned about perioperative management and maternal, fetal, and neonatal outcomes after open fetal surgery... - Fetal myelomeningocele: natural history, pathophysiology, and in-utero interventionN Scott Adzick
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, 34th Street and Civic Center Blvd, Philadelphia, PA 19104, USA
Semin Fetal Neonatal Med 15:9-14. 2010..Further research is needed to better understand the pathophysiology of MMC, the ideal timing and technique of repair, and the long-term impact of in-utero intervention... - A randomized trial of prenatal versus postnatal repair of myelomeningoceleN Scott Adzick
Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
N Engl J Med 364:993-1004. 2011..Prenatal repair of myelomeningocele, the most common form of spina bifida, may result in better neurologic function than repair deferred until after delivery. We compared outcomes of in utero repair with standard postnatal repair... 
Sacrococcygeal teratoma: prenatal assessment, fetal intervention, and outcomeHolly L Hedrick
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
J Pediatr Surg 39:430-8; discussion 430-8. 2004..Amnioreduction, cyst aspiration, and surgical debulking are potentially life-saving interventions...- Ex utero intrapartum treatment in the management of giant cervical teratomasPablo Laje
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 47:1208-16. 2012..The purpose of this study is to present the outcome and technical details of the Ex Utero Intrapartum Treatment (EXIT) procedure performed in the management of the fetus with a giant cervical teratoma... - Acute cardiovascular effects of fetal surgery in the humanJack Rychik
Center for Fetal Diagnosis and Treatment and the Fetal Heart Program, The Children s Hospital of Philadelphia, 34th St and Civic Center Blvd, Philadelphia, PA 19104, USA
Circulation 110:1549-56. 2004..The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system... - Prenatal glucocorticoids improve lung morphology and partially restores surfactant mRNA expression in lambs with diaphragmatic hernia undergoing fetal tracheal occlusionMarcus G Davey
The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
Pediatr Pulmonol 41:1188-96. 2006..We hypothesize that a GC-induced reduction in lung liquid volume during TO contributes, in part, to the observed increase in AE2 cell density and SPmRNA expression... - Early neurodevelopmental outcome of infants with high-risk fetal lung lesionsEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 31:210-5. 2012.... - Outcomes after postnatal resection of prenatally diagnosed asymptomatic cystic lung lesionsANTHONY Y TSAI
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 43:513-7. 2008..On the other hand, malignant degeneration, pneumonia, and pneumothorax are known consequences of cystic lung lesions. This study aims to assess the safety of resection for asymptomatic lung lesions that were diagnosed before birth... - The ex utero intrapartum therapy procedure for high-risk fetal lung lesionsHolly L Hedrick
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4399, USA
J Pediatr Surg 40:1038-43; discussion 1044. 2005..Indications for the ex utero intrapartum therapy (EXIT) procedure have expanded to include any fetal anomaly in which resuscitation of the neonate may be compromised... - Predicting the severity of congenital high airway obstruction syndromeJessica L Roybal
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, PA 19104 4318, USA
J Pediatr Surg 45:1633-9. 2010..In our relatively large series of CHAOS patients, we have observed a spectrum of clinical severity. The aim of this study was to identify the prenatal characteristics of CHAOS predictive of a milder postnatal course... - Early delivery as an alternative management strategy for selected high-risk fetal sacrococcygeal teratomasJessica L Roybal
The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, PA, USA
J Pediatr Surg 46:1325-32. 2011..In our experience, even with aggressive serial imaging, many fetuses have died under a policy of "watchful waiting." We propose "early delivery" as the best option for selected cases of high-risk fetal SCT... - Reproductive outcomes after pregnancy complicated by maternal-fetal surgeryR Douglas Wilson
Pediatric Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 191:1430-6. 2004..The uterine rupture rate is similar to the rupture rate after "classical" cesarean section (4%-9%)... - Chorioamniotic membrane separation following open fetal surgery: pregnancy outcomeR Douglas Wilson
Department of Surgery, Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA
Fetal Diagn Ther 18:314-20. 2003..3) Delivery prior to 33 weeks gestation for MMC groups was 12/43 (28%) with 3 NND (7%). (4) Elective delivery at 36-37 weeks gestation was possible for 43% of the fetal surgery population... - Sacrococcygeal teratomas: prenatal surveillance, growth and pregnancy outcomeR Douglas Wilson
Fetal Heart Program, The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 25:15-20. 2009..Prenatal surveillance and growth characteristics are evaluated in a cohort of fetuses with sacrococcygeal teratomas (SCT) as part of risk assessment... - Liver position and lung-to-head ratio for prediction of extracorporeal membrane oxygenation and survival in isolated left congenital diaphragmatic herniaHolly L Hedrick
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 197:422.e1-4. 2007..The purpose of this study was to determine the ability of liver position and lung-to-head ratio to predict outcome in isolated left congenital diaphragmatic hernia... - Fetal MRI-calculated total lung volumes in the prediction of short-term outcome in giant omphalocele: preliminary findingsEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 31:248-53. 2012..To determine the value of fetal MRI-calculated total lung volumes (TLV) in the prediction of short-term outcome in patients with giant omphalocele (GO)... - Fetal myelomeningocele repair: short-term clinical outcomesMark P Johnson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadephia, PA 19104, USA
Am J Obstet Gynecol 189:482-7. 2003..The study was undertaken to evaluate short-term clinical outcomes with antenatal myelomeningocele (MMC) repair... - Right congenital diaphragmatic hernia: Prenatal assessment and outcomeHolly L Hedrick
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
J Pediatr Surg 39:319-23; discussion 319-23. 2004.... - Prenatal glucocorticoids and exogenous surfactant therapy improve respiratory function in lambs with severe diaphragmatic hernia following fetal tracheal occlusionMarcus G Davey
The Children s Institute for Surgical Science and the Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, PA 19104, USA
Pediatr Res 60:131-5. 2006..GC or surfactant therapy alone significantly improved respiratory gas exchange, Cl, and ventilatory efficiency index. Total lung capacity was normalized only in DH/TO lambs that received both GC and S... - Fetal tracheal occlusion for severe congenital diaphragmatic hernia in humans: a morphometric study of lung parenchyma and muscularization of pulmonary arteriolesEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Pediatr Surg 43:1767-75. 2008..The aim of this study is to examine structure of lung parenchyma (Pp) and muscularization of pulmonary arterioles (PAs) in human fetuses that underwent tracheal occlusion (TO) therapy for severe congenital diaphragmatic hernia (CDH)... - Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinismOlga T Hardy
Division of Endocrinology, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 92:4706-11. 2007..This study evaluated the accuracy of 18F-fluoro-l-dihydroxyphenylalanine ([18F]DOPA) positron emission tomography (PET) scans in diagnosing focal vs. diffuse disease and identifying the location of focal lesions... - Congenital high airway obstruction syndrome: MR/US findings, effect on management, and outcomeAndrew Mong
Department of Radiology, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Pediatr Radiol 38:1171-9. 2008..Prompt airway intervention at delivery after accurate prenatal diagnosis may allow survival of this otherwise fatal condition... - Severe pulmonary hypoplasia associated with giant cervical teratomasKenneth W Liechty
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 41:230-3. 2006..Despite obtaining airway control, a subset of these patients will die because of pulmonary hypoplasia. When counseling patients with large cervical masses it is important to discuss potential pulmonary hypoplasia in these patients... - Impact of continuous intraoperative monitoring on outcomes in open fetal surgerySundeep G Keswani
Center for Fetal Diagnosis and Treatment and Fetal Heart Program at the Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 20:316-20. 2005..CONCLUSION: Continuous intraoperative fetal monitoring provides real time assessment of fetal hemodynamics which results in changes in intraoperative management. The overall outcomes in these critically ill fetuses have been improved... - Lower extremity neuromotor function and short-term ambulatory potential following in utero myelomeningocele surgeryEnrico Danzer
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 25:47-53. 2009..To evaluate lower extremity neuromotor function (LENF) and short-term ambulatory potential following fetal myelomeningocele (fMMC) closure... - Prenatal ultrasonographic gastrointestinal abnormalities in fetuses with gastroschisis do not correlate with postnatal outcomesAndrea T Badillo
The Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 43:647-53. 2008..The purpose of this study was to correlate prenatal identification of additional gastrointestinal sonographic abnormalities with postnatal clinical outcome... - Prenatal course and postnatal management of peripheral bronchial atresia: association with congenital cystic adenomatoid malformation of the lungWilliam H Peranteau
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 24:190-6. 2008.... - Intradural inclusion cysts following in utero closure of myelomeningocele: clinical implications and follow-up findingsEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Neurosurg Pediatr 2:406-13. 2008..The goal in this study was to evaluate the incidence and clinical implications of the development of cutaneously derived intradural inclusion cysts (ICs) following fetal myelomeningocele (fMMC) closure... - Use of magnetic resonance imaging in prenatal prognosis of the fetus with isolated left congenital diaphragmatic herniaTeresa Victoria
Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA, 19103, USA
Prenat Diagn 32:715-23. 2012.... - The EXIT procedure: experience and outcome in 31 casesSarah Bouchard
Division of Pediatric General, The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr Surg 37:418-26. 2002.... - Effect of maternal betamethasone administration on prenatal congenital cystic adenomatoid malformation growth and fetal survivalWilliam H Peranteau
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 22:365-71. 2007..To evaluate the effect of prenatal steroid treatment on the growth of congenital cystic adenomatoid malformations (CCAM) and survival in affected fetuses not amenable to other percutaneous ultrasound-guided prenatal interventions... - Diagnosis and characterization of fetal sacrococcygeal teratoma with prenatal MRIEnrico Danzer
The Center for Fetal Diagnosis and Treatment, Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
AJR Am J Roentgenol 187:W350-6. 2006..The additional anatomic resolution provided by MRI resulted in more accurate prenatal counseling and improved preoperative planning for surgical resection... - Reproductive outcomes in subsequent pregnancies after a pregnancy complicated by open maternal-fetal surgery (1996-2007)R Douglas Wilson
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Am J Obstet Gynecol 203:209.e1-6. 2010..The reproductive and gynecologic outcomes for women after the pregnancy complicated by open maternal-fetal surgery (OMFS) were evaluated... - Does a myelomeningocele sac compared to no sac result in decreased postnatal leg function following maternal fetal surgery for spina bifida aperta?R Douglas Wilson
Department of Surgery and Obstetrics and Gynecology, Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 22:348-51. 2007..A fetus with large sac S1 myelomeningocele (MMC) but bilateral talipes prompted the question, 'Does the presence or size of an MMC sac affect postnatal leg function?'.. - Preschool neurodevelopmental outcome of children following fetal myelomeningocele closureEnrico Danzer
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 202:450.e1-9. 2010..We sought to investigate the preschool neurodevelopmental outcomes of children following fetal myelomeningocele (fMMC) surgery... - Thoracoamniotic shunts: fetal treatment of pleural effusions and congenital cystic adenomatoid malformationsR Douglas Wilson
Department of Surgery, Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 19:413-20. 2004.... - Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheepSarah Bouchard
Division of Pediatric General, Thoracic, and Fetal Surgery, The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Pediatr Surg 38:451-8; discussion 451-8. 2003..Fetal MMC repair reverses hindbrain herniation and restores gross anatomy of the vermis... - OEIS sequence--a rare congenital anomaly with prenatal evaluation and postnatal outcome in six casesEleonor Tiblad
Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
Prenat Diagn 28:141-7. 2008..To describe the outcome of children prenatally diagnosed with omphalocele, exstrophy of the cloaca, imperforate anus and spinal defects (OEIS)... - In utero meconium passage in fetuses and newborns with myelomeningoceleEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
J Neurosurg Pediatr 3:141-6. 2009..The authors retrospectively investigated whether midgestational fetal myelomeningocele (fMMC) repair alters intrauterine meconium exposure... - Postnatal chest wall deformities after fetal thoracoamniotic shunting for congenital cystic adenomatoid malformationAziz M Merchant
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, and Department of Surgery and Obstetrics Gynecology, University of Pennsylvania, Philadelphia, PA 19104 4399, USA
Fetal Diagn Ther 22:435-9. 2007..Large macrocystic congenital cystic adenomatoid malformations (CCAMs) can be treated with thoracoamniotic (TA) shunting to reduce CCAM volume. Two CCAM fetuses treated with TA shunt had postnatal radiographic rib deformities... - Prenatal diagnosis and postnatal management of diffuse congenital hyperinsulinism: a case reportWilliam H Peranteau
The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 21:515-8. 2006..This case highlights the benefits of the timely in utero diagnosis of hyperinsulinism by mutational analysis... - Prenatal diagnosis and management of mainstem bronchial atresiaSundeep G Keswani
Center for Fetal Diagnosis and Treatment, The Chhildren's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 20:74-8. 2005..Post-mortem findings in both cases confirmed the presence of an atretic mainstem bronchus with massive enlargement of the lung. Bronchial atresia involving the mainstem bronchus is associated with a poor prognosis... - Abnormal umbilical cord Doppler sonograms may predict impending demise in fetuses with sacrococcygeal teratoma. A report of two casesOluyinka O Olutoye
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pa. 19104, USA
Fetal Diagn Ther 19:35-9. 2004..In such fetuses, depending on the gestational age, abnormalities in umbilical artery waveform should be considered indications for early delivery or in utero intervention to prevent fetal demise... - Congenital high airway obstruction syndrome: natural history and managementFoong-Yen Lim
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 38:940-5. 2003..The EXIT procedure offers the potential for salvage of this otherwise lethal condition. Hydrops may be well tolerated prenatally for weeks with potential resolution if airway fistulization is present... - Surfactant protein expression is increased in the ipsilateral but not contralateral lungs of fetal sheep with left-sided diaphragmatic herniaMarcus G Davey
Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Abramson 1112 D, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
Pediatr Pulmonol 39:359-67. 2005..Furthermore, AE2 cell density is increased in DH, suggesting that the increase in SP mRNA and protein levels is due to increases AE2 cell number. Our data further support the premise that fetal lung hypoplasia favors an AE2 phenotype... - Abnormal brain development and maturation on magnetic resonance imaging in survivors of severe congenital diaphragmatic herniaEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4318, USA
J Pediatr Surg 47:453-61. 2012..The aim of the study was to evaluate the incidence of abnormal brain maturation in survivors of severe congenital diaphragmatic hernia (CDH)... - Management of fetal mediastinal teratomaAziz M Merchant
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA
J Pediatr Surg 40:228-31. 2005..CONCLUSIONS: Massive fetal mediastinal teratoma can result in fetal or neonatal mortality by a variety of mechanisms. Optimal prenatal and perinatal management is required to salvage fetuses compromised by this lesion... - Prospective, interdisciplinary follow-up of children with prenatally diagnosed giant omphalocele: short-term neurodevelopmental outcomeEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
J Pediatr Surg 45:718-23. 2010..The objective of this study is to determine the short-term neurodevelopmental outcome in infants with giant omphalocele (GO)... - Neurodevelopmental outcome of infants with congenital diaphragmatic hernia prospectively enrolled in an interdisciplinary follow-up programEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, USA
J Pediatr Surg 45:1759-66. 2010..The purpose of the study was to evaluate the neurodevelopmental outcome in infants with congenital diaphragmatic hernia (CDH)... - Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injuryEnrico Danzer
Children s Center for Fetal Research, The Children s Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Am J Obstet Gynecol 204:178.e1-11. 2011.... - Gastroschisis in mice lacking aortic carboxypeptidase-like protein is associated with a defect in neuromuscular development of the eviscerated intestineEnrico Danzer
The Center for Fetal Research, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Pediatr Res 68:23-8. 2010..The defect observed in ACLP mice closely resembles GS. Absence of ICC, NCC, EN, and immature differentiation of SMC supports an associated defect in neuromuscular development that is restricted to the EI... - Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinismMariko Suchi
Department of Pathology and Laboratory Medicine, The Childrens Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Mod Pathol 19:122-9. 2006..The combined results from the immunohistochemical and molecular methods indicate that maternal 11p15 loss together with paternal K(ATP) mutation is the predominant causative mechanism of focal hyperinsulinism... - Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repairEnrico Danzer
The Center for Fetal Diagnosis and Treatment, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 22:1-6. 2007..To examine the impact of fetal myelomeningocele (MMC) repair on fetal head biometry and cerebrospinal fluid (CSF) spaces assessed by magnetic resonance imaging (MR) studies... - Fetal surgery for myelomeningoceleLeslie N Sutton
Division of Neurosurgery, The Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19087, USA
Childs Nerv Syst 19:587-91. 2003..TRIAL: The upcoming trial represents one of the few times that the pediatric neurosurgical community has come together to test a new procedure... - History of fetal diagnosis and therapy: Children's Hospital of Philadelphia experienceHolly L Hedrick
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, and Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Fetal Diagn Ther 18:65-82. 2003..Outcomes have been improved through carefully planned and coordinated perinatal management. In some cases of life-threatening or severely debilitating defects, prenatal surgery has been offered... - Morphologic analysis of the neuromuscular development of the anorectal unit in fetal rats with retinoic acid induced myelomeningoceleEnrico Danzer
The Children s Center for Fetal Research, Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Abramson Research Center, Room 1116B, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
Neurosci Lett 430:157-62. 2008.... - Pregnancy outcomes following bipolar umbilical cord cauterization for selective termination in complicated monochorionic multiple gestationsJohn G Ilagan
Center for Fetal Diagnosis and Treatment at the Children s Hospital of Philadelphia, Department of Surgery and Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Fetal Diagn Ther 23:153-8. 2008..To review pregnancy and childhood outcomes following selective termination by ultrasound guided bipolar umbilical cord cauterization (UCC) in complicated monochorionic multifetal pregnancies... - Antenatal diagnosis and management of congenital cystic adenomatoid malformationStephanie Mann
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Wood Center 5113, Philadelphia, PA 19104, USA
Semin Fetal Neonatal Med 12:477-81. 2007..Careful delivery planning by utilizing a multidisciplinary approach will optimize neonatal outcomes... - Abnormal umbilical cord Dopplers may predict impending demise in fetuses with sacrococcygeal teratoma. A report of 2 casesOluyinka O Olutoye
The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Fetal Diagn Ther 18:428-31. 2003..In such fetuses, depending on the gestational age, abnormalities in umbilical artery waveform should be considered indications for early delivery or in utero intervention to prevent fetal demise... - Fetal surgery for lung lesions, congenital diaphragmatic hernia, and sacrococcygeal teratomaN Scott Adzick
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Semin Pediatr Surg 12:154-67. 2003..Fetal sacrococcygeal teratoma complicated with progressive high output cardiac failure may benefit from in utero resection of the tumor... - Long-term outcomes in children treated by prenatal vesicoamniotic shunting for lower urinary tract obstructionJean-Marc Biard
Center for Fetal Diagnosis and Treatment, at The Children's Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4399, USA
Obstet Gynecol 106:503-8. 2005..Although one third of the surviving babies required dialysis and transplantation, the majority have acceptable renal and bladder function and report satisfactory quality of life. LEVEL OF EVIDENCE: III... - Hepaticoduodenostomy vs hepaticojejunostomy for reconstruction after resection of choledochal cystMatthew T Santore
The Department of Surgery, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 46:209-13. 2011..Hepaticoduodenostomy (HD) has been argued to be more physiologically and technically easier but is feared to have associated complications. Here we compare outcomes of the 2 procedures... - Management of congenital lung lesionsN Scott Adzick
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Semin Pediatr Surg 12:10-6. 2003..The finding that fetuses with hydrops are at very high risk for fetal or neonatal death has led to successful fetal thoracoamniotic shunt placement or fetal surgical resection... - Structural and functional characterization of bladder smooth muscle in fetal rats with retinoic acid-induced myelomeningoceleEnrico Danzer
The Center for Fetal Research, The Children s Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
Am J Physiol Renal Physiol 292:F197-206. 2007.... - Cystic adenomatoid malformation of the lung: review of genetics, prenatal diagnosis, and in utero treatmentR Douglas Wilson
Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4399, USA
Am J Med Genet A 140:151-5. 2006..In the appropriate situation, this maternal fetal surgery approach for CCAM is life-saving for the affected fetus with acceptable maternal morbidity risks in the present and future pregnancies... - Epinephrine inhibits tracheal occlusion induced lung growth in fetal sheepYoshihiro Kitano
The Children's Institute for Surgical Science, The Children's Hospital of Philadelphia, Philadelphia, PA 19104-4399, USA
Fetal Diagn Ther 18:333-7. 2003..Drugs affecting lung fluid secretion may have a major impact on TO-induced lung growth... - Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung functionMarcus G Davey
Children s Institute for Surgical Science and Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104 4399, USA
J Appl Physiol 94:1054-62. 2003..Lung compliance remained low in DH/TO+R lambs, most likely as a consequence of the persistent increase in alveolar wall thickness in these animals... - Open fetal surgery for myelomeningoceleMichael W Bebbington
Center for Fetal Diagnosis and Treatment, Children s Hospital of Philadelphia, Philadelphia, PA, USA
Prenat Diagn 31:689-94. 2011..This will mean that not every fetus with an MMC will be a candidate for in utero surgery. The balance of risk to benefit will continue to evolve as further technological advances are evaluated and more follow-up information is obtained... - Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calcium stimulationCharles A Stanley
Division of Endocrinology, The Children s Hospital of Philadelphia, Pennsylvania 19104, USA
J Clin Endocrinol Metab 89:288-96. 2004..The combination of ASVS, careful intraoperative histologic analysis, and surgical expertise succeeded in correcting hypoglycemia in 86% of the infants with focal hyperinsulinism... - Esophageal obstruction and intracardiac "mass" in association with omphalocele closureTeresa Victoria
Radiology Department, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 44:448-50. 2009..Knowledge of these less well-recognized anatomical variations is important to avoid unnecessary interventions... - Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of ageMark Paul Johnson
The Center for Fetal Diagnosis and Treatment, Philadelphia, PA 19104, USA
Am J Obstet Gynecol 194:1145-50; discussion 1150-2. 2006..This study was undertaken to examine short-term neurodevelopmental outcomes in children with myelomeningocele (MMC) who underwent in utero neurosurgical closure... - Management of fetal lung lesionsN Scott Adzick
Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA
Clin Perinatol 30:481-92. 2003..Both fetuses survived and one required the use of ECMO. For hydropic fetuses of less than 32 weeks' gestation, there is now a new therapeutic option, treating the lesion before birth... - Does the use of fentanyl in epidural solutions for postthoracotomy pain management in neonates affect surgical outcome?Phillip D Bailey
Department of Anesthesiology and Critical Care Medicine, Children s Hospital of Philadelphia, The University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA
J Pediatr Surg 40:1118-21. 2005..1% and bupivacaine 0.1% with fentanyl 2 to 5 microg/mL... - Efficacy of addition of fentanyl to epidural bupivacaine on postoperative analgesia after thoracotomy for lung resection in infantsArjunan Ganesh
Department of Anesthesiology and Critical Care, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Anesthesiology 109:890-4. 2008..The primary outcome was the total amount of rescue doses of intravenous nalbuphine in the first 24 h after surgery. Secondary outcomes included (1) time to first rescue dose of nalbuphine, (2) pain scores, and (3) behavior scores... - Blood glucose control during selective arterial stimulation and venous sampling for localization of focal hyperinsulinism lesions in anesthetized childrenGiovanni Cucchiaro
Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Anesth Analg 99:1044-8, table of contents. 2004.... - Congenital hyperinsulinism: intraoperative biopsy interpretation can direct the extent of pancreatectomyMariko Suchi
Department of Pathology and Laboratory Medicine, The Children s Hospital of Philadelphia and University of Pennsylvania School of Medicine, 5203 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
Am J Surg Pathol 28:1326-35. 2004..However, a small number of cases with unusual histology warrant caution when performing frozen section evaluation... - Myelomeningocele: prenatal diagnosis, pathophysiology and managementN Scott Adzick
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Semin Pediatr Surg 12:168-74. 2003..A prospective, randomized clinical trial is planned comparing prenatal MMC repair with postnatal repair... - A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomyN Scott Adzick
Department of Surgery, and The Center for Hyperinsulinism, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
J Pediatr Surg 39:270-5. 2004..CONCLUSIONS: A multidisciplinary approach to patients with the focal form of congenital hyperinsulinism can distinguish focal from diffuse disease, localize focal lesions, and permit partial pancreatectomy with cure in most patients... - Molecular response of the bladder to obstructionAndrew J Kirsch
Division of Pediatric Urology, Children 's Hospital of Philadelphia, PA 19104, USA
Adv Exp Med Biol 539:195-216. 2003 - Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scanOlga T Hardy
Division of Endocrinology, The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
J Pediatr 150:140-5. 2007..To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism... - A new look at myelomeningoceles: functional level, vertebral level, shunting, and the implications for fetal interventionNatalie E Rintoul
Divisions of Neonatology, Philadelphia, Pennsylvania 10194, USA
Pediatrics 109:409-13. 2002..The present data may serve as a comparison group and aid in the design and analysis of a prospective trial to assess the efficacy of this new procedure... - Prenatal diagnosis of terminal myelocystocele in the fetal surgery era: case reportPaola Midrio
Department of Surgery, The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4399, USA
Neurosurgery 50:1152-4; discussion 1154-5. 2002..We correlate the pathophysiology of TMC with the radiographic and amniocentesis findings. TMC must be considered in the differential diagnosis in a fetus with a dysraphic defect... - Cystic adenomatoid malformation volume ratio predicts outcome in prenatally diagnosed cystic adenomatoid malformation of the lungTimothy M Crombleholme
Division of General, The Center for Fetal Diagnosis and Treatment at The Children's Hospital of Philadelphia, USA
J Pediatr Surg 37:331-8. 2002..The CVR is a useful sonographic indicator of fetuses at risk for hydrops who require close ultrasound observation and possible fetal intervention... - Influence of congenital heart disease on survival in children with congenital diaphragmatic herniaMeryl S Cohen
Cardiac Center and The Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
J Pediatr 141:25-30. 2002..2 died; 3 of 6 with an LHR >1.2 survived (Fisher exact test, P =.04). CONCLUSION: Heart disease remains a significant risk factor for death in infants with CDH. The LHR helps predict survival in this high-risk group of patients... - The natural history of prenatally diagnosed conjoined twinsTippi C MacKenzie
Center for Fetal Diagnosis and Treatment, The Children's Hospital of Philadelphia, Philadelphia, PA, USA
J Pediatr Surg 37:303-9. 2002..CONCLUSIONS: Advances in prenatal diagnosis allow detailed, accurate evaluations of conjoined twins. Careful prenatal studies may uncover cases in which emergent separation at birth is lifesaving... - The effect of intrauterine myelomeningocele repair on the incidence of shunt-dependent hydrocephalusNoel Tulipan
Department of Neurosurgery, Vanderbilt University Medical Center, A 2219 Medical Center North, Nashville, TN 37232 2380, USA
Pediatr Neurosurg 38:27-33. 2003..However, the existing cohort of IUMR patients has not yet been systematically compared to a comparable group of conventionally treated controls... - Prenatal diagnosis of partial trisomy 1q and monosomy X in a fetus with a congenital lung lesion and hydrops fetalisTracy L Pressey
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada
Am J Med Genet A 143:1104-7. 2007..2;q25 or q31)]. The incidence of chromosomal abnormalities with CCAM lesions is estimated at 1.6%. This is the first reported case of prenatally diagnosed partial trisomy 1q and monosomy X presenting as a fetal lung lesion and hydrops... - Gastroschisis: growth patterns and a proposed prenatal surveillance protocolDenise A Netta
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ, USA
Fetal Diagn Ther 22:352-7. 2007..The growth assessment could be available as a prospective tool to direct an antepartum fetal surveillance protocol... - Fetal surgery for myelomeningoceleLeslie N Sutton
University of Pennsylvania School of Medicine, Children's Hospital of Philadelphia, USA
Clin Neurosurg 51:155-62. 2004 - A prospective, randomized pilot trial of perfluorocarbon-induced lung growth in newborns with congenital diaphragmatic herniaRonald B Hirschl
Mott Children's Hospital, University of Michigan Health System, Ann Arbor, Michigan 48109-0245, USA
J Pediatr Surg 38:283-9; discussion 283-9. 2003..The survival rate, VFD, and time on ECMO data, although not conclusive, are encouraging and indicate the need for a definitive trial of this novel intervention in these neonates with high mortality... - Fetal therapy: state of the artBeverly G Coleman
Department of Radiology, The University of Pennsylvania Medical Center, Philadelphia 19104, USA
J Ultrasound Med 21:1257-88. 2002..Technologic improvements in both sonography and magnetic resonance imaging have assisted tremendously in the many advances herein reported in the diagnosis and treatment of the above-described 4 congenital anomalies... - Prenatally diagnosed giant omphaloceles: short- and long-term outcomesJean-Marc Biard
The Center for Fetal Diagnosis and Treatment at The Children's Hospital of Philadelphia, Philadelphia 19104-4399, USA
Prenat Diagn 24:434-9. 2004..Parents need to be counseled prenatally about the probability of multiple surgeries and long hospitalization following birth... - Establishing a fetal therapy center: lessons learnedLori J Howell
The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Semin Pediatr Surg 12:209-17. 2003..This article details the essential components of a center for fetal diagnosis and treatment and describes some of the lessons learned based on our experience at The Children's Hospital of Philadelphia (CHOP)...
Research Grants
- Multicenter Trial of Fetal Myelomeningocele RepairN Adzick; Fiscal Year: 2006..In summary, the proposed trial is expected to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..
- Multicenter Trial of Fetal Myelomeningocele RepairN Adzick; Fiscal Year: 2007..In summary, the proposed trial will be able to demonstrate whether fetal intervention offers improved outcome with a reasonable quality of life for spina bifida children. ..