William T Abraham

Summary

Affiliation: The Ohio State University
Country: USA

Publications

  1. ncbi request reprint Intrathoracic impedance monitoring for early detection of impending heart failure decompensation
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Congest Heart Fail 13:113-5. 2007
  2. doi request reprint Disease management: remote monitoring in heart failure patients with implantable defibrillators, resynchronization devices, and haemodynamic monitors
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, 473 West 12th Avenue, Columbus, OH 43210 1252, USA
    Europace 15:i40-i46. 2013
  3. doi request reprint Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia
    William T Abraham
    Division of Cardiovascular Medicine, Ohio State University, Columbus, Ohio 43210 1252, USA
    Kidney Int 82:1215-22. 2012
  4. doi request reprint Lixivaptan safely and effectively corrects serum sodium concentrations in hospitalized patients with euvolemic hyponatremia
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio 43210 1252, USA
    Kidney Int 82:1223-30. 2012
  5. pmc Devices in the management of advanced, chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, 473 West 12th Avenue, Room 110P, Columbus, OH 43210 1252, USA
    Nat Rev Cardiol 10:98-110. 2013
  6. doi request reprint Randomized controlled trial of ventricular elastic support therapy in the treatment of symptomatic heart failure: rationale and design
    William T Abraham
    The Ohio State University Heart Center, Columbus, OH 43210 1252, USA
    Am Heart J 164:638-45. 2012
  7. doi request reprint Randomized controlled trial comparing simultaneous versus optimized sequential interventricular stimulation during cardiac resynchronization therapy
    William T Abraham
    The Ohio State University Heart Center, Columbus, OH 43210 1252, USA
    Am Heart J 164:735-41. 2012
  8. ncbi request reprint Cardiac resynchronization therapy is important for all patients with congestive heart failure and ventricular dyssynchrony
    William T Abraham
    Department Internal Medicine, Division of Cardiovascular Medicine, and The Davis Heart and Lung Research Institute, Ohio State University, Columbus, USA
    Circulation 114:2692-8; discussion 2698. 2006
  9. doi request reprint Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University Heart Center, Columbus, USA
    Clin Transl Sci 3:249-53. 2010
  10. doi request reprint Intrathoracic impedance vs daily weight monitoring for predicting worsening heart failure events: results of the Fluid Accumulation Status Trial (FAST)
    William T Abraham
    Division of Cardiovascular Medicine, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210 1252, USA
    Congest Heart Fail 17:51-5. 2011

Detail Information

Publications114 found, 100 shown here

  1. ncbi request reprint Intrathoracic impedance monitoring for early detection of impending heart failure decompensation
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA
    Congest Heart Fail 13:113-5. 2007
    ..This review discusses the basic concepts underlying intrathoracic impedance monitoring, the clinical evidence supporting its use, and some common pitfalls to avoid when interpreting intrathoracic impedance data...
  2. doi request reprint Disease management: remote monitoring in heart failure patients with implantable defibrillators, resynchronization devices, and haemodynamic monitors
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, 473 West 12th Avenue, Columbus, OH 43210 1252, USA
    Europace 15:i40-i46. 2013
    ..All these devices depend upon high-intensity remote monitoring for successful detection of parameter deviations and for directing and following therapy...
  3. doi request reprint Oral lixivaptan effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia
    William T Abraham
    Division of Cardiovascular Medicine, Ohio State University, Columbus, Ohio 43210 1252, USA
    Kidney Int 82:1215-22. 2012
    ..2%). Overall, lixivaptan was considered safe and well-tolerated. Thus, oral lixivaptan can be safely initiated in the outpatient setting and effectively increases serum sodium concentrations in outpatients with euvolemic hyponatremia...
  4. doi request reprint Lixivaptan safely and effectively corrects serum sodium concentrations in hospitalized patients with euvolemic hyponatremia
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio 43210 1252, USA
    Kidney Int 82:1223-30. 2012
    ..After drug discontinuation, serum sodium concentrations decreased to near-baseline levels within 7 days. Thus, lixivaptan safely and effectively corrects serum sodium concentrations in patients with euvolemic hyponatremia...
  5. pmc Devices in the management of advanced, chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, 473 West 12th Avenue, Room 110P, Columbus, OH 43210 1252, USA
    Nat Rev Cardiol 10:98-110. 2013
    ....
  6. doi request reprint Randomized controlled trial of ventricular elastic support therapy in the treatment of symptomatic heart failure: rationale and design
    William T Abraham
    The Ohio State University Heart Center, Columbus, OH 43210 1252, USA
    Am Heart J 164:638-45. 2012
    ..The Prospective Evaluation of Elastic Restraint to LESSen the effects of Heart Failure (PEERLESS-HF) trial was designed to further evaluate the safety and efficacy of one such device, the HeartNet (Paracor Medical, Sunnyvale, CA)...
  7. doi request reprint Randomized controlled trial comparing simultaneous versus optimized sequential interventricular stimulation during cardiac resynchronization therapy
    William T Abraham
    The Ohio State University Heart Center, Columbus, OH 43210 1252, USA
    Am Heart J 164:735-41. 2012
    ..This randomized, double-blind, controlled study evaluated whether optimizing the interventricular stimulating interval (V-V) to sequentially activate the ventricles is clinically better than simultaneous V-V stimulation during CRT...
  8. ncbi request reprint Cardiac resynchronization therapy is important for all patients with congestive heart failure and ventricular dyssynchrony
    William T Abraham
    Department Internal Medicine, Division of Cardiovascular Medicine, and The Davis Heart and Lung Research Institute, Ohio State University, Columbus, USA
    Circulation 114:2692-8; discussion 2698. 2006
  9. doi request reprint Rationale and design of the treatment of hyponatremia based on lixivaptan in NYHA class III/IV cardiac patient evaluation (THE BALANCE) study
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University Heart Center, Columbus, USA
    Clin Transl Sci 3:249-53. 2010
    ..BALANCE seeks to address unmet questions regarding the use of vasopressin antagonists including their effects on cognitive function and clinical outcomes in patients with hyponatremia and worsening heart failure...
  10. doi request reprint Intrathoracic impedance vs daily weight monitoring for predicting worsening heart failure events: results of the Fluid Accumulation Status Trial (FAST)
    William T Abraham
    Division of Cardiovascular Medicine, Ohio State University, 473 West 12th Avenue, Columbus, OH 43210 1252, USA
    Congest Heart Fail 17:51-5. 2011
    ..Intrathoracic impedance monitoring represents a useful adjunctive clinical tool for managing HF in patients with implanted devices...
  11. doi request reprint Safety and accuracy of a wireless pulmonary artery pressure monitoring system in patients with heart failure
    William T Abraham
    The Ohio State University Heart Center, Columbus, USA
    Am Heart J 161:558-66. 2011
    ..The goal of this investigation was to evaluate the safety and technical performance of a novel wireless pulmonary artery pressure monitoring system in 17 patients with symptomatic HF...
  12. ncbi request reprint Nesiritide in acute decompensated heart failure: a pooled analysis of randomized controlled trials
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    Clin Cardiol 33:484-9. 2010
    ..This study used relevant data from all RCTs of nesiritide in ADHF completed as of June 2006 to independently estimate the effect of nesiritide on 30- and 180-day mortality...
  13. doi request reprint Subgroup analysis of a randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure
    William T Abraham
    Ohio State University Heart Center, Columbus, Ohio, USA
    J Card Fail 17:710-7. 2011
    ..In the present analysis, we sought to identify if there was a subgroup of patients who showed a response to CCM...
  14. doi request reprint Predictors of in-hospital mortality in patients hospitalized for heart failure: insights from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF)
    William T Abraham
    Division of Cardiology, The Ohio State University, Columbus, Ohio, USA
    J Am Coll Cardiol 52:347-56. 2008
    ..The aim of this study was to develop a clinical model predictive of in-hospital mortality in a broad hospitalized heart failure (HF) patient population...
  15. ncbi request reprint Pharmacologic therapies across the continuum of left ventricular dysfunction
    William T Abraham
    Division of Cardiovascular Medicine, Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Am J Cardiol 102:21G-28G. 2008
    ..This review illustrates the impact of these therapies on post-MI LVD patients using evidence from multiple clinical trials. In addition, current and emerging treatments for acute decompensated HF will be outlined...
  16. ncbi request reprint Treatment of anemia with darbepoetin alfa in heart failure
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University Medical Center, Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Congest Heart Fail 16:87-95. 2010
    ..These results suggest that DA is well tolerated, corrects HF-associated anemia, and may have favorable effects on clinical outcomes...
  17. ncbi request reprint Validation and clinical utility of a simple in-home testing tool for sleep-disordered breathing and arrhythmias in heart failure: results of the Sleep Events, Arrhythmias, and Respiratory Analysis in Congestive Heart Failure (SEARCH) study
    William T Abraham
    The Ohio State University Heart Center, Davis Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210 1252, USA
    Congest Heart Fail 12:241-7; quiz 248-9. 2006
    ..The device was judged by 80% of patients to be easy or very easy to use, and 74% of patients expressed a preference for the in-home system. Therefore, this system represents a reasonable home testing device in these patients...
  18. ncbi request reprint A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation in patients with systolic heart failure: rationale, design, and baseline patient characteristics
    William T Abraham
    The Ohio State University Heart Center, Division of Cardiovascular Medicine, Columbus, OH 43210 1252, USA
    Am Heart J 156:641-648.e1. 2008
    ..Baseline characteristics for patients randomized in this trial are also presented...
  19. doi request reprint Rationale and design of a randomized clinical trial to assess the safety and efficacy of frequent optimization of cardiac resynchronization therapy: the Frequent Optimization Study Using the QuickOpt Method (FREEDOM) trial
    William T Abraham
    The Ohio State University, Columbus, OH 43017, USA
    Am Heart J 159:944-948.e1. 2010
    ....
  20. ncbi request reprint Systolic blood pressure at admission, clinical characteristics, and outcomes in patients hospitalized with acute heart failure
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 296:2217-26. 2006
    ..The association between systolic blood pressure (SBP) at admission, clinical characteristics, and outcomes in patients hospitalized for heart failure who have reduced or relatively preserved systolic function has not been well studied...
  21. ncbi request reprint Effect of cardiac resynchronization therapy on left ventricular size and function in chronic heart failure
    Martin G St John Sutton
    Division of Cardiology, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Circulation 107:1985-90. 2003
    ..The purpose of the present study was to determine whether improvements in left ventricular (LV) size and function were associated with CRT...
  22. ncbi request reprint Beta-blocker dosing in community-based treatment of heart failure
    Michael B Fowler
    Division of Cardiovascular Medicine, Stanford University Medical Center, Palo Alto, CA, USA
    Am Heart J 153:1029-36. 2007
    ..Community patients with heart failure (HF) are older, less often treated by HF specialists, and have more comorbidity than those in randomized clinical trials. These differences might affect beta-blocker prescribing in HF...
  23. doi request reprint Does preoperative hyponatremia potentiate the effects of left ventricular dysfunction on mortality after cardiac surgery?
    Juan A Crestanello
    Division of Cardiac Surgery, The Ohio State University Medical Center, Columbus, Ohio, USA
    J Thorac Cardiovasc Surg 145:1589-94, 1594.e1-2. 2013
    ..Thus, we evaluated the interaction of low left ventricular ejection fraction (<40%) and preoperative hyponatremia (Na <135 mEq/L) with morbidity and mortality after cardiac surgery...
  24. doi request reprint Postoperative hyponatremia predicts an increase in mortality and in-hospital complications after cardiac surgery
    Juan A Crestanello
    Division of Cardiac Surgery, Wexner Medical Center, The Ohio State University, Columbus, OH, USA
    J Am Coll Surg 216:1135-43, 1143.e1. 2013
    ..The association between postoperative hyponatremia (Na < 135 mEq/L) and outcomes after cardiac surgery has not been established. We studied the prevalence of postoperative hyponatremia and its effects on outcomes after cardiac surgery...
  25. ncbi request reprint Cardiac resynchronization therapy for the management of chronic heart failure
    William T Abraham
    Department of Internal Medicine, Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    Am Heart Hosp J 1:55-61. 2003
    ..Thus, cardiac resynchronization therapy should be routinely considered in eligible NYHA class III and IV heart failure patients with ventricular dyssynchrony...
  26. ncbi request reprint Relationship between admission serum sodium concentration and clinical outcomes in patients hospitalized for heart failure: an analysis from the OPTIMIZE-HF registry
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Galter 10 240, 201 E Huron Street, Chicago, IL 60611, USA
    Eur Heart J 28:980-8. 2007
    ..The predictive value of hyponatraemia has not been evaluated in unselected patients hospitalized with heart failure...
  27. doi request reprint Relation of low hemoglobin and anemia to morbidity and mortality in patients hospitalized with heart failure (insight from the OPTIMIZE-HF registry)
    James B Young
    Department of Cardiovascular Medicine, Heart Failure Section, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    Am J Cardiol 101:223-30. 2008
    ..Lower hemoglobin is associated with higher morbidity and mortality in hospitalized patients with HF...
  28. ncbi request reprint Effects of cardiac resynchronization on disease progression in patients with left ventricular systolic dysfunction, an indication for an implantable cardioverter-defibrillator, and mildly symptomatic chronic heart failure
    William T Abraham
    Ohio State University Heart Center, Division of Cardiovascular Medicine, 473 W 12th Ave, Room 110P DHLRI, Columbus, OH 43210 1252
    Circulation 110:2864-8. 2004
    ..The effects of cardiac resynchronization therapy (CRT) in patients with mildly symptomatic heart failure have not been fully elucidated...
  29. doi request reprint Application of implantable hemodynamic monitoring in the management of patients with diastolic heart failure: a subgroup analysis of the COMPASS-HF trial
    Michael R Zile
    Division of Cardiology, Departmentof Medicine, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    J Card Fail 14:816-23. 2008
    ..However, appropriate management of DHF patients remains a difficult and uncertain challenge...
  30. doi request reprint Hemodynamic factors associated with acute decompensated heart failure: part 1--insights into pathophysiology
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina, 25 Courtenay Drive, Charleston, SC 29425, USA
    J Card Fail 17:282-91. 2011
    ..The purpose of this study was to determine which pressure-based hemodynamic factor was most closely associated with the transition from chronic compensated to acute decompensated heart failure...
  31. doi request reprint Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial
    William T Abraham
    Ohio State University Heart and Vascular Center, Columbus, OH, USA
    Lancet 377:658-66. 2011
    ..Results of previous studies support the hypothesis that implantable haemodynamic monitoring systems might reduce rates of hospitalisation in patients with heart failure. We undertook a single-blind trial to assess this approach...
  32. ncbi request reprint In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE)
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA
    J Am Coll Cardiol 46:57-64. 2005
    ..We sought to compare the in-hospital mortality of patients with acute decompensated heart failure (ADHF) who were receiving parenteral treatment with one of four intravenous vasoactive medications...
  33. ncbi request reprint Heart failure with normal ejection fraction: consideration of mechanisms other than diastolic dysfunction
    Travis Bench
    Division of Cardiology, Columbia University, 177 Fort Washington Avenue, New York, NY 10032, USA
    Curr Heart Fail Rep 6:57-64. 2009
    ..In this article, we review the current understanding of nondiastolic mechanisms that may contribute to the HF with normal EF syndrome to highlight potential pathways for research that may lead to new targets for therapy...
  34. ncbi request reprint Congestion is an important diagnostic and therapeutic target in heart failure
    Mihai Gheorghiade
    Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Rev Cardiovasc Med 7:S12-24. 2006
    ..Identification of hemodynamic congestion, before the clinical manifestations appear, may potentially prevent hospitalization and slow the progression of HF by allowing life-saving interventions to be implemented sooner...
  35. doi request reprint Percutaneous left ventricular partitioning in patients with chronic heart failure and a prior anterior myocardial infarction: Results of the PercutAneous Ventricular RestorAtion in Chronic Heart failUre PaTiEnts Trial
    Ernest L Mazzaferri
    Division of Cardiovascular Medicine, The Ohio State University Heart and Vascular Center, 473 West 12th Ave, Columbus, OH 43210 1252, USA
    Am Heart J 163:812-820.e1. 2012
    ..The aim of this study was to assess the feasibility, safety, and preliminary efficacy of a novel percutaneous left ventricular partitioning device (VPD) in patients with chronic heart failure (HF) and a prior anterior myocardial infarction...
  36. ncbi request reprint Cardiac resynchronization therapy
    William T Abraham
    Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210 1252, USA
    Prog Cardiovasc Dis 48:232-8. 2006
    ..Cardiac resynchronization therapy has been shown to significantly improve LV structure and function, New York Heart Association functional class, exercise tolerance, quality of life, and morbidity and mortality...
  37. ncbi request reprint Canine nonischemic left ventricular dysfunction: a model of chronic human cardiomyopathy
    Yoshinori Nishijima
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    J Card Fail 11:638-44. 2005
    ..The mechanisms of cardiac remodeling during chronic heart failure remain poorly defined. We sought to advance a chronic canine model of nonischemic cardiomyopathy...
  38. doi request reprint Effects of exercise on left ventricular systolic and diastolic properties in patients with heart failure and a preserved ejection fraction versus heart failure and a reduced ejection fraction
    Michael R Zile
    Division of Cardiology, Medical University of South Carolina and RHJ Department of Veterans Affairs Medical Center, Charleston, SC 29425, USA
    Circ Heart Fail 6:508-16. 2013
    ....
  39. ncbi request reprint Effect of treatment with continuous positive airway pressure or oxygen on sleep-disordered breathing in patients with heart failure: results of the Sleep Events, Arrhythmias, and Respiratory Analysis in Chronic Heart Failure (SEARCH) study
    William T Abraham
    The Ohio State University Heart Center, Columbus, OH 43210, USA
    Congest Heart Fail 14:197-201. 2008
    ..5%) experienced a 16.7-events/h mean reduction in AHI. Thus, the Clear Path system appears to be a useful device to monitor response to SDB-directed treatment for apnea in patients with heart failure...
  40. pmc Cardiac effects of continuous and bilevel positive airway pressure for patients with heart failure and obstructive sleep apnea: a pilot study
    Rami N Khayat
    Sleep Heart Program, Ohio State University, Columbus, OH 43210, USA
    Chest 134:1162-8. 2008
    ..The intermediate-term effect of bilevel PAP on left ventricular ejection fraction (LVEF) in patients with stable heart failure and OSA has not been compared to the effect of CPAP...
  41. doi request reprint Effect of QRS duration and morphology on cardiac resynchronization therapy outcomes in mild heart failure: results from the Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction (REVERSE) study
    Michael R Gold
    Division of Cardiology, Medical University of South Carolina, 25 Courtenay Dr, ART 7031, Charleston, SC 29425 5920, USA
    Circulation 126:822-9. 2012
    ..We aimed to assess the impact of baseline QRS duration and morphology and the change in QRS duration with pacing on CRT outcomes in mild heart failure...
  42. doi request reprint Reproducibility of peak oxygen uptake and other cardiopulmonary exercise parameters: implications for clinical trials and clinical practice
    Steven J Keteyian
    Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
    Chest 138:950-5. 2010
    ....
  43. ncbi request reprint Effect of cardiac resynchronization therapy on myocardial gene expression in patients with nonischemic dilated cardiomyopathy
    Srinivas Iyengar
    Division of Cardiovascular Medicine and the Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210 1252, USA
    J Card Fail 13:304-11. 2007
    ....
  44. doi request reprint Transition from chronic compensated to acute decompensated heart failure: pathophysiological insights obtained from continuous monitoring of intracardiac pressures
    Michael R Zile
    Department of Medicine, Division of Cardiology, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 118:1433-41. 2008
    ..The purpose of this study was to use echocardiographic and implantable hemodynamic monitor data to examine the pathophysiology of chronic compensated and acute decompensated HF in SHF versus DHF patients...
  45. ncbi request reprint Cardiac resynchronization therapy for heart failure: biventricular pacing and beyond
    William T Abraham
    Division of Cardiovascular Medicine, Gill Heart Institute, Heart Failure and Cardiac Transplantation Program, University of Kentucky College of Medicine, Lexington, Kentucky 49536, USA
    Curr Opin Cardiol 17:346-52. 2002
    ..In addition, the results of recently completed clinical trials, as well as the status of ongoing clinical trials, are reviewed...
  46. ncbi request reprint Biventricular and novel pacing mechanisms in heart failure
    Christina Salazar
    Ohio State University, 473 West 12th Avenue, Columbus, OH 43210, USA
    Curr Heart Fail Rep 6:14-8. 2009
    ..In this article, we review CRT's effects on reverse remodeling in an expanding patient population and as a novel pacing mechanism, its cardiac contractility modulation, and its benefits in patients with heart failure...
  47. ncbi request reprint Noninvasive calibration of cardiac pressure transducers in patients with heart failure: an aid to implantable hemodynamic monitoring and therapeutic guidance
    Dougal McClean
    Division of Cardiology, Department of Medicine, and the Research Institute at Cedars Sinai Medical Center, Los Angeles, California, USA
    J Card Fail 12:568-76. 2006
    ..Implantable cardiac pressure monitors require assurance of calibration. This study evaluated if airway pressure responses during Valsalva maneuver (VM) can be used for calibrating intracardiac pressure transducers...
  48. ncbi request reprint Optimization of cardiac resynchronization devices using acoustic cardiography: a comparison to echocardiography
    Ayesha Hasan
    Division of Cardiology, The Ohio State University, Columbus, OH 43210, USA
    Congest Heart Fail 12:25-31. 2006
    ..7%). In addition, it took less time for the acoustic cardiogram to collect sufficient information to make a recommendation, and it was found that the acoustic cardiogram data trend is easier to interpret...
  49. ncbi request reprint Predictors of remodeling in the CRT era: influence of mitral regurgitation, BNP, and gender
    Thomas P Cappola
    Division of Cardiovascular Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    J Card Fail 12:182-8. 2006
    ..We analyzed quantitative echocardiographic data from a large heart failure cohort receiving medical and cardiac resynchronization therapy (CRT) to determine baseline predictors of progressive left ventricular (LV) enlargement...
  50. ncbi request reprint Beyond diuretics: management of volume overload in acute heart failure syndromes
    James A Hill
    Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA
    Am J Med 119:S37-44. 2006
    ....
  51. doi request reprint Cardiac contractility modulation in patients with advanced heart failure
    Rami Kahwash
    Davis Heart and Lung Research Institute, 473 W 12th Ave, Columbus, OH 43210, USA
    Expert Rev Cardiovasc Ther 11:635-45. 2013
    ..The device is currently available for the treatment of heart failure in Europe. Approval in the USA is pending additional testing currently underway using a protocol approved by the US FDA...
  52. ncbi request reprint "Responder analysis" for assessing effectiveness of heart failure therapies based on measures of exercise tolerance
    Daniel Burkhoff
    Division of Cardiology, Columbia University, New York, New York 10032, USA
    J Card Fail 15:108-15. 2009
    ..Here, we review the principles of a "responder analysis."..
  53. ncbi request reprint Cardiac resynchronization in chronic heart failure
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington 40536 0284, USA
    N Engl J Med 346:1845-53. 2002
    ..We conducted a double-blind trial to evaluate this therapeutic approach...
  54. ncbi request reprint Prevalence of sleep disordered breathing in a heart failure program
    Robin J Trupp
    Davis Heart and Lung Research Institute, Ohio State University, 473 W 12th Avenue, Columbus, OH 43210 1252, USA
    Congest Heart Fail 10:217-20. 2004
    ..Forty-two percent of patients with stable heart failure presenting to a heart failure clinic screened positive for SDB, despite receiving optimal standard of care...
  55. ncbi request reprint Diuretics for the treatment of acute decompensated heart failure
    Srinivas Iyengar
    Division of Cardiovascular Medicine, The Ohio State University, 473 West 12th Avenue, Rm 110P DHLRI, Columbus, Ohio 43210 1252, USA
    Heart Fail Rev 12:125-30. 2007
    ..Given this reality and until further information is available about the most ideal utilization of these medications, diuretics will continue to represent a double-edged sword for physicians treating this disease process...
  56. ncbi request reprint Clinical and hemodynamic effects of nesiritide (B-type natriuretic peptide) in patients with decompensated heart failure receiving beta blockers
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH 43210 1252, USA
    Congest Heart Fail 11:59-64. 2005
    ..Thus, the clinical and hemodynamic benefits and safety of nesiritide are preserved in decompensated congestive heart failure patients receiving chronic beta blockade...
  57. ncbi request reprint Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function as measured by iodine 123 metaiodobenzylguanidine
    Myron C Gerson
    Division of Cardiology, Department of Internal Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Nucl Cardiol 9:608-15. 2002
    ..The goal of this study was to determine the effect of chronic carvedilol treatment in patients with cardiac sympathetic nerve dysfunction of varying severity...
  58. ncbi request reprint New approaches to monitoring heart failure before symptoms appear
    William T Abraham
    Division of Cardiovascular Medicine, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, Ohio, USA
    Rev Cardiovasc Med 7:S33-41. 2006
    ..IHM systems may extend such monitoring capabilities. Both emerging approaches for monitoring patients with heart failure may alert clinicians (and possibly patients) to impending decompensation before symptoms appear...
  59. pmc In-hospital testing for sleep-disordered breathing in hospitalized patients with decompensated heart failure: report of prevalence and patient characteristics
    Rami N Khayat
    Division of Pulmonary Critical Care and Sleep, Ohio State University, Columbus, OH, USA
    J Card Fail 15:739-46. 2009
    ..Sleep-disordered breathing (SDB) is present in more than 50% of ambulatory patients with chronic heart failure. The prevalence and type of SDB in hospitalized patients with acutely decompensated heart failure (ADHF) are not known...
  60. ncbi request reprint Clinical predictors and timing of New York Heart Association class improvement with cardiac resynchronization therapy in patients with advanced chronic heart failure: results from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) and Multice
    Luis A Pires
    The Heart Rhythm Center, Division of Cardiology, St John Hospital and Medical Center, Detroit, MI 48236, USA
    Am Heart J 151:837-43. 2006
    ..The purpose of this analysis is to identify predictors and characterize the timing of response to CRT in patients with advanced heart failure...
  61. pmc Sleep-disordered breathing in heart failure: identifying and treating an important but often unrecognized comorbidity in heart failure patients
    Rami Khayat
    Ohio State University, Division of Pulmonary, Critical Care and Sleep, Columbus, OH 43210, USA
    J Card Fail 19:431-44. 2013
    ..This article provides an overview of SDB in HF and proposes a clinical care pathway to help clinicians to better recognize and treat SDB in their HF patients...
  62. ncbi request reprint Future therapies for heart failure
    Robin J Trupp
    The Heart and Lung Research Institute, The Ohio State University 473 West 12th Avenue, Columbus, OH 43210, USA
    Crit Care Nurs Clin North Am 15:525-30, x. 2003
    ..This article discusses recently approved drugs and devices and clinical trials that may affect the management of this challenging disease...
  63. ncbi request reprint Tolerability, safety, and efficacy of beta-blockade in black patients with heart failure in the community setting: insights from a large prospective beta-blocker registry
    William T Abraham
    Division of Cardiovascular Medicine, The Ohio State University School of Medicine, Columbus, OH, USA
    Congest Heart Fail 13:16-21. 2007
    ..9% vs 7.5%, hazard ratio 1.2 vs 1.0, P=.276). Thus carvedilol was similarly effective in blacks and whites with HF in the community setting, consistent with carvedilol clinical trials...
  64. ncbi request reprint Mechanisms of disease: beta-adrenergic receptors--alterations in signal transduction and pharmacogenomics in heart failure
    David S Feldman
    Davis Heart and Lung Research Institute, Division of Cardiology Medicine, Ohio State University, Columbus, OH 43210, USA
    Nat Clin Pract Cardiovasc Med 2:475-83. 2005
    ..In this review, we summarize current insights into beta-adrenergic signal-transduction pathways, the best-described beta-AR polymorphisms, and therapies that target the beta-AR pathway in HF...
  65. ncbi request reprint Cardiac resynchronization therapy for heart failure
    William T Abraham
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA
    Circulation 108:2596-603. 2003
  66. ncbi request reprint Nesiritide for the treatment of congestive heart failure
    Srinivas Iyengar
    Division of Cardiovascular Medicine, The Ohio State University Heart Center, Columbus, OH 43210 1252, USA
    Expert Opin Pharmacother 5:901-7. 2004
    ..Overall, nesiritide represents an effective and safe therapeutic option for the treatment of decompensated CHF...
  67. ncbi request reprint Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)
    Kirkwood F Adams
    Division of Cardiology, University of North Carolina, Chapel Hill, NC, USA
    Am Heart J 149:209-16. 2005
    ..Most available data on these patients are limited by patient selection criteria and study design of clinical trials and single-center studies...
  68. ncbi request reprint Electrophysiological aids in congestive heart failure: supporting and synchronizing systole
    William T Abraham
    Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210 1252, USA
    Med Clin North Am 87:509-21. 2003
    ..Ongoing and future clinical trials should help to further validate the role of cardiac resynchronization in the treatment of patients with systolic HF...
  69. ncbi request reprint Safety and efficacy of nesiritide for acute decompensated heart failure: recent literature and upcoming trials
    Brian Hiestand
    Department of Emergency Medicine, The Ohio State University, 149 Means Hall, 1654 Upham Drive, Columbus, OH 43210, USA
    Curr Cardiol Rep 9:182-6. 2007
    ..We review the recent evidence regarding the efficacy and safety profile of nesiritide, and discuss upcoming trials designed to address concerns regarding safety and the comparative efficacy of nesiritide...
  70. ncbi request reprint Practical considerations for switching beta-blockers in heart failure patients
    William T Abraham
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University Heart Center, Columbus, Ohio, USA
    Rev Cardiovasc Med 5:S36-44. 2004
    ....
  71. ncbi request reprint Cardiac resynchronization treatment of heart failure
    Ayesha Hasan
    Division of Cardiovascular Medicine, The Ohio State University College of Medicine, Columbus, Ohio 43210 1252, USA
    Annu Rev Med 58:63-74. 2007
    ..With the exponential rise in implants, new issues have emerged, such as optimal device programming, identifying appropriate candidates, and accounting for cases without clinical benefit from CRT...
  72. ncbi request reprint Highlights of Heart Rhythm 2004, the Annual Scientific Sessions of the Heart Rhythm Society: May 19 to 22, 2004, in San Francisco, California
    Anne B Curtis
    Division of Cardiovascular Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Am Coll Cardiol 44:1550-6. 2004
    ....
  73. ncbi request reprint Implications of heart failure drug trials: COMET, CHARM, EPHESUS
    Brian Hiestand
    Department of Emergency Medicine, Ohio State University, Columbus, Ohio, USA
    Rev Cardiovasc Med 6:S4-11. 2005
    ..These trials established that it is feasible to design and execute heart failure studies of sufficient scale to assess improvement in rates of mortality and morbidity...
  74. ncbi request reprint Cardiology patient page. Cardiac resynchronization therapy: a better and longer life for patients with advanced heart failure
    Srinivas Iyengar
    Division of Cardiovascular Medicine, Ohio State University, Columbus, OH 43210 1252, USA
    Circulation 112:e236-7. 2005
  75. ncbi request reprint Diuretic resistance in heart failure
    Srinivas Iyengar
    The Ohio State University, 473 West 12th Avenue, Rm 110P DHLRI, Columbus, OH 43210 1252, USA
    Curr Heart Fail Rep 3:41-5. 2006
    ..The methods for overcoming this resistance are varied and require a focused approach with emphasis on relieving the congestive symptoms related to HF while attempting to preserve renal function and minimize any untoward systemic effects...
  76. ncbi request reprint Neutral endopeptidase inhibitors and endothelin antagonists
    Srinivas Iyengar
    Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA
    Cardiol Clin 26:41-8, vi. 2008
    ..The reasons for these shortcomings are varied and require analysis of the design of the studies as well as the intrinsic functions of these agents...
  77. ncbi request reprint Nonpharmacologic options for the management of heart failure
    Robin J Trupp
    The Ohio State University, Heart and Lung Research Institute, 473 West 12th Avenue, Columbus, OH 43210 1252, USA
    Curr Cardiol Rep 5:243-6. 2003
    ..A variety of nonpharmacologic approaches compliment drug therapy of heart failure, and many have been shown to improve patient quality of life and functional capacity, while reducing morbidity and mortality...
  78. doi request reprint Epidemiology of sudden cardiac death in patients with heart failure
    Mahmoud Houmsse
    Division of Cardiovascular Medicine, Department of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Suite 200, 473 West 12th Avenue, Columbus, OH 43210, USA
    Heart Fail Clin 7:147-55, vii. 2011
    ..This article discusses the incidence, prediction, and prevention of SCD in CHF due to ischemic and nonischemic cardiomyopathy...
  79. doi request reprint Device therapy in advanced heart failure: what to put in and what to turn off: remote telemonitoring and implantable hemodynamic devices for advanced heart failure monitoring in the ambulatory setting and the evolving role of cardiac resynchronization the
    Sakima A Smith
    Division of Cardiovascular Medicine, The Ohio State University Medical Center, Davis Heart and Lung Research Institute, Columbus, OH 43210, USA
    Congest Heart Fail 17:220-6. 2011
    ..We also explore the growth of cardiac resynchronization therapy and how it has evolved into another tool in our armamentarium for hemodynamic monitoring...
  80. pmc In-hospital treatment of obstructive sleep apnea during decompensation of heart failure
    Rami N Khayat
    Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Internal Medicine, Ohio State University, 201 DHLRI, 473 West 12th Ave, Columbus, OH 43210, USA
    Chest 136:991-7. 2009
    ..We evaluated the impact of immediate inpatient diagnosis and treatment of OSA in hospitalized patients with acutely decompensated heart failure (ADHF) on in-hospital cardiac outcomes...
  81. ncbi request reprint Higher expectations for management of heart failure: current recommendations
    William T Abraham
    Division of Cardiovascular Medicine, University of Kentucky Medical Center, Lexington, USA
    J Am Board Fam Pract 15:39-49. 2002
    ..Each year 260,000 patients die as a direct or indirect result of the disorder, with annual costs estimated between $21 billion to $40 billion...
  82. doi request reprint Switching to evidence-based once-daily beta-blockers for improved adherence to medication across the continuum of post-myocardial infarction left ventricular dysfunction and heart failure
    William T Abraham
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210 1252, USA
    Congest Heart Fail 14:272-80. 2008
    ..Algorithms are provided for switching patients with heart failure or post-MI LVD from another beta-blocker to carvedilol CR...
  83. ncbi request reprint Ultrafiltration for volume control in decompensated heart failure
    Garrie J Haas
    The Ohio State University Medical Center, Columbus, OH, USA
    Heart Fail Clin 4:519-34. 2008
    ..This approach, however, will require further investigation with specific emphasis on safety and costs...
  84. pmc Management strategies for stage-D patients with acute heart failure
    David Feldman
    Department of Physiology and Cell Biology, Ohio State University, Columbus, Ohio, USA
    Clin Cardiol 31:297-301. 2008
    ..Newer surgical options such as surgical ventricular restoration may be considered in select patients...
  85. ncbi request reprint OptiVol fluid status monitoring with an implantable cardiac device: a heart failure management system
    Laura M Yamokoski
    Heart Failure Program, The Ohio State University, OSU Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, 473 W 12th Ave Suite 105, Columbus, OH 43210, USA
    Expert Rev Med Devices 4:775-80. 2007
    ..9% sensitivity. Intrathoracic impedance monitoring is not intended to replace careful frequent clinical evaluation of the heart failure patient, but instead aims to complement traditional heart failure management practices...
  86. ncbi request reprint Cardiac resynchronization therapy: a review of clinical trials and criteria for identifying the appropriate patient
    William T Abraham
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, OH, USA
    Rev Cardiovasc Med 4:S30-7. 2003
    ..Given these findings, cardiac resynchronization therapy should be routinely considered in eligible NYHA Class III and IV heart failure patients with ventricular dyssynchrony...
  87. ncbi request reprint Diabetes, hypertension, and renal insufficiency in post-myocardial infarction cardiovascular risk
    William T Abraham
    Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, Ohio State University, Columbus, Ohio, USA
    Rev Cardiovasc Med 4:S30-6. 2003
    ..Results from 1 recent study of the beta-blocker, carvedilol, have shown further that these benefits extend to high-risk patients with either diabetes or hypertension...
  88. ncbi request reprint Aquaretic effect of lixivaptan, an oral, non-peptide, selective V2 receptor vasopressin antagonist, in New York Heart Association functional class II and III chronic heart failure patients
    William T Abraham
    The Ohio State University Heart Center, Division of Cardiovascular Medicine, Columbus, Ohio 43210 1252, USA
    J Am Coll Cardiol 47:1615-21. 2006
    ..The purpose of this study was to examine the renal effects of a V2 receptor arginine vasopressin (AVP) antagonist in heart failure...
  89. ncbi request reprint Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF): rationale and design
    Gregg C Fonarow
    Department of Medicine, UCLA Medical Center, Los Angeles, Calif, USA
    Am Heart J 148:43-51. 2004
    ..The ultimate aim of this program is to improve the standard of HF care in the hospital and outpatient settings and increase the use of evidence-based therapeutic strategies to save lives...
  90. ncbi request reprint B-type natriuretic peptide and renal function in the diagnosis of heart failure: an analysis from the Breathing Not Properly Multinational Study
    Peter A McCullough
    University of California, San Diego Veteran s Affairs Medical Center, San Diego, CA, USA
    Am J Kidney Dis 41:571-9. 2003
    ..However, relationships between BNP, renal function, and heart failure as an emergency diagnosis are unknown...
  91. ncbi request reprint Does quality of life evidence assist in the selection of patients for resynchronization therapy?
    Peter A McCullough
    Department of Basic Science, Cardiology Section, University of Missouri Kansas City School of Medicine, Truman Medical Center, Kansas City, MO, USA
    Card Electrophysiol Rev 7:71-6. 2003
    ..In conclusion, assessment of quality of life before device implantation is necessary in order to select those individuals who are most likely to benefit from cardiac resynchronization therapy...
  92. ncbi request reprint Rapid measurement of B-type natriuretic peptide in the emergency diagnosis of heart failure
    Alan S Maisel
    University of California, San Diego, Veterans Affairs Medical Center, San Diego 92161, USA
    N Engl J Med 347:161-7. 2002
    ..B-type natriuretic peptide is released from the cardiac ventricles in response to increased wall tension...
  93. ncbi request reprint Relationship between heart failure treatment and development of worsening renal function among hospitalized patients
    Javed Butler
    Vanderbilt University, Nashville, Tenn, USA
    Am Heart J 147:331-8. 2004
    ..Whether treatment for HF contributes to WRF is unknown. In this study, we sought to assess whether acute treatment for patients who were hospitalized with HF contributes to WRF...
  94. ncbi request reprint Role of beta-blocker therapy in the post-myocardial infarction patient with and without left ventricular dysfunction
    Gregg C Fonarow
    Rev Cardiovasc Med 4:S54-9. 2003
  95. ncbi request reprint Effect of nesiritide versus milrinone in the treatment of acute decompensated heart failure
    Daniel A Lewis
    College of Pharmacy, University of Kentucky Chandler Medical Center, Lexington, USA
    Am J Health Syst Pharm 60:S16-20. 2003
    ..Total cost of therapy was lower in the nesiritide group as compared to those patients treated with milrinone...
  96. ncbi request reprint Bedside B-Type natriuretic peptide in the emergency diagnosis of heart failure with reduced or preserved ejection fraction. Results from the Breathing Not Properly Multinational Study
    Alan S Maisel
    Cardiology 111 A, San Diego VA Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
    J Am Coll Cardiol 41:2010-7. 2003
    ..This study examines B-type natriuretic peptide (BNP) levels in patients with systolic versus non-systolic dysfunction presenting with shortness of breath...
  97. ncbi request reprint Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial
    James B Young
    Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    JAMA 289:2685-94. 2003
    ....
  98. ncbi request reprint Baseline characteristics of patients randomized in The Resynchronization Reverses Remodeling In Systolic Left Ventricular Dysfunction (REVERSE) study
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Congest Heart Fail 14:66-74. 2008
    ..1% of patients. Compared with previous randomized cardiac resynchronization therapy trials, REVERSE patients are on better pharmacologic treatment, are younger, and have a narrower QRS width despite similar LV dysfunction...
  99. ncbi request reprint Continuous autonomic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device
    Philip B Adamson
    Department of Medicine, Cardiovascular Disease and Physiology, University of Oklahoma Health Sciences Center, 920 SL Young Blvd, WP3120, Oklahoma City, OK 73104, USA
    Circulation 110:2389-94. 2004
    ..Long-term continuous HRV can be measured from an implantable device, but the clinical value of these measurements is unknown...
  100. ncbi request reprint Beta-blocker therapy for heart failure outside the clinical trial setting: findings of a community-based registry
    Joseph A Franciosa
    Mount Sinai School of Medicine and Weill Medical College, Cornell University, New York, NY, USA
    Am Heart J 148:718-26. 2004
    ..beta-Blockers reduce morbidity and mortality rates in heart failure (HF) clinical trials, but it is unknown whether these findings persist in the community setting...
  101. ncbi request reprint Rationale and design of a randomized controlled trial to assess the safety and efficacy of cardiac resynchronization therapy in patients with asymptomatic left ventricular dysfunction with previous symptoms or mild heart failure--the REsynchronization reV
    Cecilia Linde
    Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
    Am Heart J 151:288-94. 2006
    ..The effects of CRT on HF outcomes in patients with asymptomatic left ventricular dysfunction (ALVD) or mild HF remain to be determined...