The Rockefeller University

Summary

Organization: The Rockefeller University
Country: USA

Top Publications

  1. doi A coordinated global control over cellular transcription
    Jacob Zhurinsky
    Laboratory of Yeast Genetics and Cell Biology, The Rockefeller University, 1230 York Avenue P O Box 5, New York, NY 10065, USA
    Curr Biol 20:2010-5. 2010
  2. ncbi The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock
    Pablo Meyer
    Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA
    J Biol Rhythms 22:283-90. 2007
  3. pmc Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for "dual protection" contraception
    Regine Sitruk-Ware
    Population Council, Center for Biomedical Research, New York, NY 10021, USA
    Contraception 75:454-60. 2007
  4. ncbi Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 85:199-206. 2007
  5. ncbi Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis
    Dolores D Mruk
    Population Council, Center for Biomedical Research, 1230 York Ave, New York, NY 10021, USA
    J Androl 28:742-54. 2007
  6. ncbi A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption
    Ephraim Sehayek
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
    J Lipid Res 47:2291-6. 2006
  7. pmc Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
    Anna Gazumyan
    Laboratory of Molecular Immunology and 2Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:1785-94. 2006
  8. pmc Extensive low-affinity transcriptional interactions in the yeast genome
    Amos Tanay
    Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021, USA
    Genome Res 16:962-72. 2006
  9. pmc The ABC protein turned chloride channel whose failure causes cystic fibrosis
    David C Gadsby
    Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, NY 10021, USA
    Nature 440:477-83. 2006
  10. pmc Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin
    Fionnuala McAleese
    The Rockefeller University, 1230 York Ave, New York, NY 10021
    J Bacteriol 188:1120-33. 2006

Research Grants

  1. Evaluation of a progesterone vaginal ring as a new contraceptive option in India
    REGINE SITRUK contact WARE; Fiscal Year: 2010
  2. Cooporative Contraceptive Research Center
    Regine Sitruk Ware; Fiscal Year: 2007
  3. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce S McEwen; Fiscal Year: 2010
  4. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2000
  5. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2004
  6. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2009
  7. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2007
  8. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2007
  9. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1980
  10. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1990

Scientific Experts

Detail Information

Publications62

  1. doi A coordinated global control over cellular transcription
    Jacob Zhurinsky
    Laboratory of Yeast Genetics and Cell Biology, The Rockefeller University, 1230 York Avenue P O Box 5, New York, NY 10065, USA
    Curr Biol 20:2010-5. 2010
    ..We propose that there is a coordinated, global control that determines the rate of transcription of most genes and that this control plays a role in regulating growth rate of the cell...
  2. ncbi The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clock
    Pablo Meyer
    Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA
    J Biol Rhythms 22:283-90. 2007
    ..The authors will then introduce a novel timing mechanism uncovered by a single cell-based assay, with the new ideas and prospects for future research that it has raised...
  3. pmc Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for "dual protection" contraception
    Regine Sitruk-Ware
    Population Council, Center for Biomedical Research, New York, NY 10021, USA
    Contraception 75:454-60. 2007
    ....
  4. ncbi Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamus
    Russell D Romeo
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neuroendocrinology 85:199-206. 2007
    ..Interestingly, in response to repeated restraint, neither age nor stress significantly influence CRH expression. Together, these data indicate that both age and experience with stress interact to modulate CRH expression in the PVN...
  5. ncbi Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testis
    Dolores D Mruk
    Population Council, Center for Biomedical Research, 1230 York Ave, New York, NY 10021, USA
    J Androl 28:742-54. 2007
    ..Taken collectively, these results suggest that Rab4A participates in adherens junction dynamics...
  6. ncbi A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption
    Ephraim Sehayek
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
    J Lipid Res 47:2291-6. 2006
    ....
  7. pmc Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization
    Anna Gazumyan
    Laboratory of Molecular Immunology and 2Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    J Exp Med 203:1785-94. 2006
    ..In addition, B cells with the ITAM mutant receptor showed an enhanced response to a T-independent antigen. Thus, Igbeta ITAM tyrosines help set BCR signaling threshold by regulating receptor internalization...
  8. pmc Extensive low-affinity transcriptional interactions in the yeast genome
    Amos Tanay
    Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021, USA
    Genome Res 16:962-72. 2006
    ..Low-affinity transcription factor-DNA interaction may therefore be important both evolutionarily and functionally...
  9. pmc The ABC protein turned chloride channel whose failure causes cystic fibrosis
    David C Gadsby
    Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, NY 10021, USA
    Nature 440:477-83. 2006
    ..New structural and biochemical information from prokaryotic ABC proteins and functional information from CFTR channels has led to a unifying mechanism explaining those ATP-driven conformational changes...
  10. pmc Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycin
    Fionnuala McAleese
    The Rockefeller University, 1230 York Ave, New York, NY 10021
    J Bacteriol 188:1120-33. 2006
    ..Utaida et al., Microbiology 149:2719-2732, 2003)...
  11. pmc 2005 Irving Sigal Young Investigator Award
    Tom W Muir
    Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Protein Sci 14:3140-4. 2005
  12. pmc T cell traffic signals
    Heather L Van Epps
    J Exp Med 202:460. 2005
    ....
  13. pmc Nonlinear protein degradation and the function of genetic circuits
    Nicolas E Buchler
    Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:9559-64. 2005
    ..Our results suggest that cooperative stability needs to be considered explicitly and characterized quantitatively in any systematic experimental or theoretical study of gene circuits...
  14. pmc The career of Maclyn McCarty
    Emil C Gotschlich
    Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021, USA
    J Exp Med 201:1699-707. 2005
    ..But McCarty's scientific career was long and fruitful, and his contributions to science were vast. This retrospective offers a look at some of Mac's other notable scientific achievements...
  15. ncbi Viral evasion of autophagy
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell Host Microbe 1:9-11. 2007
    ..In this issue of Cell Host & Microbe, Orvedahl et al. demonstrate for the first time that inhibition of autophagy by a viral gene product is essential for neurovirulence of herpesviruses...
  16. doi Hormonal induction of lordosis and ear wiggling in rat pups: gender and age differences
    L M Kow
    Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, Box 336, New York, NY 10021 6399, USA
    Endocrine 32:287-96. 2007
    ..These results show that ERs and their signaling systems in the VMN of rat pups are functional at least after D11 but only in females, and that the gender differences appeared to be due to differences in the molecular biology of ERalpha...
  17. doi Mechanisms underlying an ability to behave ethically
    Donald W Pfaff
    Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Am J Bioeth 8:10-9. 2008
    ..That balance results not only from genetic influences on temperament but also from environmental effects particularly during critical neonatal and pubertal periods...
  18. pmc Mass spectrometric protein identification using the global proteome machine
    David Fenyo
    The Rockefeller University, New York, NY, USA
    Methods Mol Biol 673:189-202. 2010
    ..We cover identification by searching protein sequence collections and spectral libraries as well as validation of the results using expectation values, rho-diagrams, and spectrum databases...
  19. doi Temporal patterning of pulses during deep brain stimulation affects central nervous system arousal
    Amy Wells Quinkert
    Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, New York, NY 10065, United States
    Behav Brain Res 214:377-85. 2010
    ..Our data comprise the first demonstration that the temporal pattern of DBS can be used to elevate its effectiveness, and also point the way toward the use of nonlinear dynamics in the exploration of means to optimize DBS...
  20. pmc Structural analysis of biodiversity
    Lawrence Sirovich
    Laboratory of Applied Mathematics, Mount Sinai School of Medicine, New York, New York, United States of America
    PLoS ONE 5:e9266. 2010
    ..These results support application of indicator vectors for comparative analysis of large nucleotide data sets and raise prospect of gaining insight into broad-scale patterns in the genetic structure of biodiversity...
  21. doi The MitoPark Mouse - an animal model of Parkinson's disease with impaired respiratory chain function in dopamine neurons
    Mats I Ekstrand
    Howard Hughes Medical Institute and Rockefeller University, New York, NY 10065, USA
    Parkinsonism Relat Disord 15:S185-8. 2009
    ..In this review we compare the MitoPark mouse to other genetic or toxin-based rodent models of Parkinson's disease...
  22. pmc A tetrahedral entropy for water
    Pradeep Kumar
    Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 106:22130-4. 2009
    ..Finally, we show that tau(Q) can be extracted from S (Q) by using an analog of the Adam-Gibbs relation...
  23. pmc Relationship of arousal to circadian anticipatory behavior: ventromedial hypothalamus: one node in a hunger-arousal network
    Ana C Ribeiro
    Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065, USA
    Eur J Neurosci 30:1730-8. 2009
    ....
  24. ncbi The levonorgestrel intrauterine system: long-term contraception and therapeutic effects
    Regine Sitruk-Ware
    Population Council, 1230 York Avenue, New York 10021, USA
    Womens Health (Lond Engl) 1:171-82. 2005
    ..It is one of the most effective methods of contraception and is approved in more than 100 countries for 5 years of use...
  25. pmc galign: a tool for rapid genome polymorphism discovery
    Shai Shaham
    Laboratory of Developmental Genetics, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 4:e7188. 2009
    ..Highly parallel sequencing technologies have become important tools in the analysis of sequence polymorphisms on a genomic scale. However, the development of customized software to analyze data produced by these methods has lagged behind...
  26. pmc An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspective
    C Yan Cheng
    Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10065, USA
    Crit Rev Biochem Mol Biol 44:245-63. 2009
    ..Herein, we provide a critical review based on the latest findings in the field regarding the regulation of these cellular events. These recent findings also open up a new window for investigators studying blood-tissue barriers...
  27. pmc Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?
    Wenjie Luo
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
    BMC Neurosci 9:S7. 2008
    ..It will present experimentally demonstrated, but also hypothetical, roles that suggest Hsp90 can act as a regulator of pathogenic changes that lead to the neurodegenerative phenotype in Alzheimer's disease...
  28. pmc Ordered patterns of cell shape and orientational correlation during spontaneous cell migration
    Yusuke T Maeda
    Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    PLoS ONE 3:e3734. 2008
    ..Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using computational analyses...
  29. doi Long-term safety and efficacy of low-density lipoprotein apheresis in childhood for homozygous familial hypercholesterolemia
    Lisa C Hudgins
    The Rogosin Institute, New York, New York, USA
    Am J Cardiol 102:1199-204. 2008
    ..It effectively lowers LDL cholesterol, but target LDL levels are not achieved, and some patients will show progression of cardiovascular disease...
  30. pmc Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts
    David A Nielsen
    Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Neuropsychopharmacology 34:867-73. 2009
    ..080). Both the -18 and the +84 CpG sites are located in potential Sp1 transcription factor-binding sites. Methylation of these CpG sites may lead to reduced OPRM1 expression in the lymphocytes of these former heroin addicts...
  31. ncbi Species differences in brain distribution of CART mRNA and CART peptide between prairie and meadow voles
    Richard G Hunter
    Yerkes National Primate Center, Emory University, Atlanta, GA 30322, USA
    Brain Res 1048:12-23. 2005
    ..Our findings also point to novel avenues of investigation regarding the brain mechanisms for the evolution of diverse social organization...
  32. pmc Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels
    Anthony J Lombardino
    Laboratory of Animal Behavior, The Rockefeller University, Box 137, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:8036-41. 2005
    ..UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. In all these instances, reduced UCHL1 function may jeopardize the survival of CNS neurons...
  33. ncbi Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalate
    B T Akingbemi
    Center for Biomedical Research, Population Council, New York, New York 10021, USA
    Biol Reprod 65:1252-9. 2001
    ..In conclusion, data from this study show that DEHP effects on Leydig cell steroidogenesis are influenced by the stage of development at exposure and may occur through modulation of T-biosynthetic enzyme activity and serum LH levels...
  34. pmc Searching for a spindle matrix
    W A Wells
    J Cell Biol 154:1102-4. 2001
    ..New evidence supports the idea of a nonmicrotubule spindle matrix, but the debate about the reality of this structure continues...
  35. pmc The Ising model in physics and statistical genetics
    J Majewski
    Laboratory of Statistical Genetics, The Rockefeller University, New York, NY, 10021, USA
    Am J Hum Genet 69:853-62. 2001
    ..A reanalysis of data on type 1 diabetes detects several susceptibility loci not previously found by other methods of analysis...
  36. ncbi Penicillin-resistant Streptococcus pneumoniae in metropolitan New York hospitals: case control study and molecular typing of resistant isolates
    R B Roberts
    The Rockefeller University, New York, NY 10021, USA
    Microb Drug Resist 7:137-52. 2001
    ....
  37. ncbi Insights from mouse models into the molecular basis of neurodegeneration
    N Heintz
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
    Annu Rev Physiol 62:779-802. 2000
    ..Finally, we discuss common mechanisms of cell death and lessons learned from these mouse models that might have broader relevance to other neurologic disorders...
  38. ncbi Apolipoprotein E4: an allele associated with many diseases
    J D Smith
    Laboratory of Biomedical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
    Ann Med 32:118-27. 2000
    ..The apoE polymorphism also affects response to head trauma, cognitive decline upon ageing and several other disorders. Thus, common genetic variation in the apoE gene may be associated with successful ageing...
  39. ncbi Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeys
    E R Butelman
    Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue Box 171, New York, NY 10021, USA
    Eur J Pharmacol 383:305-9. 1999
    ..Prolactin may therefore be a quantitative marker of the apparent efficacy of kappa-opioid receptor ligands in primates...
  40. ncbi Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys
    E R Butelman
    Rockefeller University, New York, NY 10021, USA
    Psychopharmacology (Berl) 147:73-80. 1999
    ..The dynorphins are endogenous opioid peptides with relative binding selectivity for kappa-receptors. It is unclear whether the dynorphins share the pharmacological profile observed with synthetic kappa-agonists in primates...
  41. pmc Enhancing versus suppressive effects of stress hormones on skin immune function
    F S Dhabhar
    The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:1059-64. 1999
    ..g., wounding or infection) for which stress perception by the brain may serve as an early warning signal...
  42. ncbi Neuroendocrine-related effects of long-term, 'binge' cocaine administration: diminished individual differences in stress-induced corticosterone response
    Z Sarnyai
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y, 10021, USA
    Neuroendocrinology 68:334-44. 1998
    ..These results indicate that chronic binge cocaine administration leads to sustained activation of the HPA axis and alters processes underlying individual vulnerability to stress...
  43. pmc Structural and biochemical analysis of the sheath of Phormidium uncinatum
    E Hoiczyk
    Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
    J Bacteriol 180:3923-32. 1998
    ..Both the chemical composition and the rigid highly ordered structure clearly distinguish the sheaths from the slime secreted by the filaments during gliding motility...
  44. ncbi Novelty-induced locomoter activity in Long-Evans rats pre- and post-chronic 'binge'-pattern cocaine treatment
    L R Lucas
    Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    Neurosci Lett 237:25-8. 1997
    ..These findings suggest that behavioral sensitization, as a result of CBP cocaine treatment, changes novelty-stress induced behavior which may reflect altered individual vulnerability to drugs of abuse...
  45. pmc Adaptation of metabolic enzyme activities of Trypanosoma brucei promastigotes to growth rate and carbon regimen
    B H ter Kuile
    The Rockefeller University, New York, New York 10021, USA
    J Bacteriol 179:4699-705. 1997
    ..brucei adapted the activities of each of the metabolic enzymes studied separately. The results of this complex manner of adaptation were more or less constant ratios of the end products and a very efficient energy metabolism...
  46. ncbi The dynamics of primate retinal ganglion cells
    E Kaplan
    Departments of Ophthalmology Biophysics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10016, USA
    Prog Brain Res 134:17-34. 2001
    ..The different dynamical properties of the two populations suggest that M cells participate in motion analysis, while P cells are used for the analysis of form, texture, and perhaps color...
  47. ncbi The Personality Assessment Inventory Drug Problems Scale: a validity analysis
    Scott H Kellogg
    Laboratory of the Biology of the Addictive Diseases, Rockefeller University, New York, NY 10021 6399, USA
    J Pers Assess 79:73-84. 2002
    ..Overall, higher scores did reflect both more serious involvements with drug use and more serious problems as a consequence of their involvement...
  48. ncbi Loose ends: axenic culture, parasitophorous vacuoles, bird malaria
    W Trager
    Rockefeller University, 1230 York Avenue Box 17, New York, NY 10021 6399, USA
    Parassitologia 44:117-21. 2002
    ..Finally, attention is given to speculations on the origin of P. falciparum...
  49. pmc Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysis
    Christina Sobin
    Laboratory of Human Neurogenetics, The Rockefeller University, New York, New York 10021, USA
    Child Neuropsychol 11:39-53. 2005
    ..Implications of these findings are considered with regard to past results...
  50. ncbi Hepatitis C virus infection. How does the host respond?
    A Grakoui
    Center for the Study of Hepatitis C, Laboratory for Virology and Infectious Disease, The Rockefeller University, New York, NY 10021 6399, USA
    Minerva Gastroenterol Dietol 50:21-8. 2004
    ..Recent studies have provided us with a better understanding of the virus-host interactions and may help us unravel the immunologic components necessary for successful HCV clearance...
  51. ncbi Photoreceptor differentiation in Drosophila: from immature neurons to functional photoreceptors
    Bertrand Mollereau
    Strang Laboratory of Cancer Research, The Rockefeller University, New York, New York 10021, USA
    Dev Dyn 232:585-92. 2005
    ..In the second part, we review the roles of several transcription factors, which are required for the terminal photoreceptor differentiation and rhodopsin expression...
  52. ncbi Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disorders
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Ann N Y Acad Sci 1032:1-7. 2004
    ..Yet, these are not necessarily "damaged" and may be treatable with the right medications...
  53. ncbi Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptine
    Bruce S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
    Eur Neuropsychopharmacol 14:S497-502. 2004
    ..Chronic treatment with the antidepressant tianeptine may prevent these effects in hippocampus and amygdala...
  54. pmc Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target
    CHRISTIAN MUNZ
    Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    J Exp Med 199:1301-4. 2004
    ..However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV-related cancers...
  55. ncbi Primary structure of guinea pig preprodynorphin and preproenkephalin mRNAs: multiple transcription initiation sites for preprodynorphin
    K Steven LaForge
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 63:119-26. 2004
    ..These studies confirmed that the primary transcription start site is 28 nucleotides downstream from the TATAA site, and that intron A sequences are not present in significant amounts in these tissues...
  56. ncbi Combining several ordinal measures in clinical studies
    Knut M Wittkowski
    General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA
    Stat Med 23:1579-92. 2004
    ..The scoring method is demonstrated to be applicable to scoring clinical response profiles in the treatment of psoriasis and then to identifying genomic pathways that best correlate with these profiles...
  57. ncbi Human population: the next half century
    Joel E Cohen
    Rockefeller University and Columbia University, 1230 New York Avenue, Box 20, New York, NY 10021, USA
    Science 302:1172-5. 2003
    ..Economies, nonhuman environments, and cultures (including values, religions, and politics) strongly influence demographic changes. Hence, human choices, individual and collective, will have demographic effects, intentional or otherwise...
  58. ncbi Measurement of enthalpy and volume changes in photoinitiated reactions on the ms timescale with a novel pressure cell
    David Mauzerall
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Photochem Photobiol Sci 2:788-90. 2003
    ..Because of the similar cell structure and data analysis it is now possible to determine enthalpy and volume changes in photo-initiated reactions over the timescale of nanoseconds to seconds with the same solution...
  59. ncbi Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cells
    Cristian A Perez
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
    Cell Calcium 33:541-9. 2003
    ..The role of store-operated channels and Trpm5 in capacitative calcium entry in taste receptor cells in response to bitter compounds is discussed...
  60. ncbi A war on obesity, not the obese
    Jeffrey M Friedman
    Howard Hughes Medical Institute, The Rockefeller University, 1230 New York Avenue, New York, NY 10021 USA
    Science 299:856-8. 2003
    ..In their efforts to lose weight, obese individuals may be fighting a powerful set of evolutionary forces honed in an environment drastically different from that of today...
  61. ncbi LDL Apheresis: an effective and safe treatment for refractory hypercholesterolemia
    Lisa Cooper Hudgins
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cardiovasc Drug Rev 20:271-80. 2002
    ..Whole blood compatible columns in development offer the possibility of simpler and less expensive treatments...
  62. ncbi Reafferent thalamo- "cortical" loops in the song system of oscine songbirds
    G E Vates
    Laboratory of Animal Behavior, Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 380:275-90. 1997
    ....

Research Grants62

  1. Evaluation of a progesterone vaginal ring as a new contraceptive option in India
    REGINE SITRUK contact WARE; Fiscal Year: 2010
    ....
  2. Cooporative Contraceptive Research Center
    Regine Sitruk Ware; Fiscal Year: 2007
    ..The overall goal is to explore the prospect of the Adjudin-FSH mutant conjugate's candidacy as a male contraceptive, by targeting germ cell adhesion. Alternative delivery routes will be studied. ..
  3. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce S McEwen; Fiscal Year: 2010
    ..abstract_text> ..
  4. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2000
    ..Finally, the sexual differentiation of synapse formation and the role of androgen as well as estrogens in males will be investigated. ..
  5. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2004
    ..We plan to use the power of mouse genetics by employing mice lacking ERa and ERb to provide more definitive information regarding the role of the two known intracellular ER types in these E effects. ..
  6. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2009
    ..abstract_text> ..
  7. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 2007
    ..abstract_text> ..
  8. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 2007
    ....
  9. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1980
    ..These effects may take the form of permanent differences in brain circuitry, levels of steroid receptors, of inducibility of gene products by steroids and other agents. ..
  10. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1990
    ..hostages, prisoners of war)...
  11. STRESS, ADRENAL STEROIDS AND THE BRAIN
    Bruce McEwen; Fiscal Year: 1993
    ..Better understanding of the beneficial as well as destructive aspects of GC actions on neuronal survival may aid in developing treatment strategies to slow the rate of progress of neural degenerative diseases...
  12. GENE EXPRESSION IN NERVOUS TISSUE
    Bruce McEwen; Fiscal Year: 1993
    ....
  13. Sex Differences in Hippocampal Synaptic Protein & mRNA
    Russell Romeo; Fiscal Year: 2005
    ..Finally, additional experiments will provide novel information on how exposure to steroid hormones during prenatal development sexually differentiates the ability of estrogen to affect hippocampal synapses. ..
  14. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2009
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
  15. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2010
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
  16. An in vivo model to study blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2007
    ..Second and perhaps most importantly, the disrupted BTB can be "resealed", making this model uniquely suitable to study the biology and regulation of BTB re-assembly during spermatogenesis. ..
  17. Junction Dynamics and Male Fertility Regulation
    C Yan Cheng; Fiscal Year: 2007
    ..In summary, these studies not only will define the regulation of AJ dynamics, they will identify new leads and innovative approaches for male contraceptive development. ..
  18. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2010
    ..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..