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Genomes and Genes | The Rockefeller UniversitySummaryOrganization: The Rockefeller University Country: USA Top Publications
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Publications
A coordinated global control over cellular transcriptionJacob Zhurinsky
Laboratory of Yeast Genetics and Cell Biology, The Rockefeller University, 1230 York Avenue P O Box 5, New York, NY 10065, USA
Curr Biol 20:2010-5. 2010..We propose that there is a coordinated, global control that determines the rate of transcription of most genes and that this control plays a role in regulating growth rate of the cell...- The 2006 Pittendrigh/Aschoff lecture: new roles for old proteins in the Drosophila circadian clockPablo Meyer
Laboratory of Genetics, The Rockefeller University, New York, NY10021, USA
J Biol Rhythms 22:283-90. 2007..The authors will then introduce a novel timing mechanism uncovered by a single cell-based assay, with the new ideas and prospects for future research that it has raised... - Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard gel: a new formulation for "dual protection" contraceptionRegine Sitruk-Ware
Population Council, Center for Biomedical Research, New York, NY 10021, USA
Contraception 75:454-60. 2007.... - Age- and stress-induced changes in corticotropin-releasing hormone mRNA expression in the paraventricular nucleus of the hypothalamusRussell D Romeo
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
Neuroendocrinology 85:199-206. 2007..Interestingly, in response to repeated restraint, neither age nor stress significantly influence CRH expression. Together, these data indicate that both age and experience with stress interact to modulate CRH expression in the PVN... - Rab4A GTPase catenin interactions are involved in cell junction dynamics in the testisDolores D Mruk
Population Council, Center for Biomedical Research, 1230 York Ave, New York, NY 10021, USA
J Androl 28:742-54. 2007..Taken collectively, these results suggest that Rab4A participates in adherens junction dynamics... - A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorptionEphraim Sehayek
Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
J Lipid Res 47:2291-6. 2006.... - Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalizationAnna Gazumyan
Laboratory of Molecular Immunology and 2Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
J Exp Med 203:1785-94. 2006..In addition, B cells with the ITAM mutant receptor showed an enhanced response to a T-independent antigen. Thus, Igbeta ITAM tyrosines help set BCR signaling threshold by regulating receptor internalization... - Extensive low-affinity transcriptional interactions in the yeast genomeAmos Tanay
Center for Studies in Physics and Biology, Rockefeller University, New York, New York 10021, USA
Genome Res 16:962-72. 2006..Low-affinity transcription factor-DNA interaction may therefore be important both evolutionarily and functionally... - The ABC protein turned chloride channel whose failure causes cystic fibrosisDavid C Gadsby
Laboratory of Cardiac Membrane Physiology, The Rockefeller University, New York, NY 10021, USA
Nature 440:477-83. 2006..New structural and biochemical information from prokaryotic ABC proteins and functional information from CFTR channels has led to a unifying mechanism explaining those ATP-driven conformational changes... - Overexpression of genes of the cell wall stimulon in clinical isolates of Staphylococcus aureus exhibiting vancomycin-intermediate- S. aureus-type resistance to vancomycinFionnuala McAleese
The Rockefeller University, 1230 York Ave, New York, NY 10021
J Bacteriol 188:1120-33. 2006..Utaida et al., Microbiology 149:2719-2732, 2003)... - 2005 Irving Sigal Young Investigator AwardTom W Muir
Laboratory of Synthetic Protein Chemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Protein Sci 14:3140-4. 2005 - T cell traffic signalsHeather L Van Epps
J Exp Med 202:460. 2005.... - Nonlinear protein degradation and the function of genetic circuitsNicolas E Buchler
Center for Studies in Physics and Biology, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:9559-64. 2005..Our results suggest that cooperative stability needs to be considered explicitly and characterized quantitatively in any systematic experimental or theoretical study of gene circuits... - The career of Maclyn McCartyEmil C Gotschlich
Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, NY 10021, USA
J Exp Med 201:1699-707. 2005..But McCarty's scientific career was long and fruitful, and his contributions to science were vast. This retrospective offers a look at some of Mac's other notable scientific achievements... - Viral evasion of autophagyCHRISTIAN MUNZ
Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Cell Host Microbe 1:9-11. 2007..In this issue of Cell Host & Microbe, Orvedahl et al. demonstrate for the first time that inhibition of autophagy by a viral gene product is essential for neurovirulence of herpesviruses... - Hormonal induction of lordosis and ear wiggling in rat pups: gender and age differencesL M Kow
Laboratory of Neurobiology and Behavior, The Rockefeller University, 1230 York Avenue, Box 336, New York, NY 10021 6399, USA
Endocrine 32:287-96. 2007..These results show that ERs and their signaling systems in the VMN of rat pups are functional at least after D11 but only in females, and that the gender differences appeared to be due to differences in the molecular biology of ERalpha... - Mechanisms underlying an ability to behave ethicallyDonald W Pfaff
Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
Am J Bioeth 8:10-9. 2008..That balance results not only from genetic influences on temperament but also from environmental effects particularly during critical neonatal and pubertal periods... - Mass spectrometric protein identification using the global proteome machineDavid Fenyo
The Rockefeller University, New York, NY, USA
Methods Mol Biol 673:189-202. 2010..We cover identification by searching protein sequence collections and spectral libraries as well as validation of the results using expectation values, rho-diagrams, and spectrum databases... - Temporal patterning of pulses during deep brain stimulation affects central nervous system arousalAmy Wells Quinkert
Laboratory of Neurobiology and Behavior, Rockefeller University, 1230 York Ave, New York, NY 10065, United States
Behav Brain Res 214:377-85. 2010..Our data comprise the first demonstration that the temporal pattern of DBS can be used to elevate its effectiveness, and also point the way toward the use of nonlinear dynamics in the exploration of means to optimize DBS... - Structural analysis of biodiversityLawrence Sirovich
Laboratory of Applied Mathematics, Mount Sinai School of Medicine, New York, New York, United States of America
PLoS ONE 5:e9266. 2010..These results support application of indicator vectors for comparative analysis of large nucleotide data sets and raise prospect of gaining insight into broad-scale patterns in the genetic structure of biodiversity... - The MitoPark Mouse - an animal model of Parkinson's disease with impaired respiratory chain function in dopamine neuronsMats I Ekstrand
Howard Hughes Medical Institute and Rockefeller University, New York, NY 10065, USA
Parkinsonism Relat Disord 15:S185-8. 2009..In this review we compare the MitoPark mouse to other genetic or toxin-based rodent models of Parkinson's disease... - A tetrahedral entropy for waterPradeep Kumar
Center for Studies in Physics and Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 106:22130-4. 2009..Finally, we show that tau(Q) can be extracted from S (Q) by using an analog of the Adam-Gibbs relation... - Relationship of arousal to circadian anticipatory behavior: ventromedial hypothalamus: one node in a hunger-arousal networkAna C Ribeiro
Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10065, USA
Eur J Neurosci 30:1730-8. 2009.... - The levonorgestrel intrauterine system: long-term contraception and therapeutic effectsRegine Sitruk-Ware
Population Council, 1230 York Avenue, New York 10021, USA
Womens Health (Lond Engl) 1:171-82. 2005..It is one of the most effective methods of contraception and is approved in more than 100 countries for 5 years of use... - galign: a tool for rapid genome polymorphism discoveryShai Shaham
Laboratory of Developmental Genetics, The Rockefeller University, New York, New York, United States of America
PLoS ONE 4:e7188. 2009..Highly parallel sequencing technologies have become important tools in the analysis of sequence polymorphisms on a genomic scale. However, the development of customized software to analyze data produced by these methods has lagged behind... - An intracellular trafficking pathway in the seminiferous epithelium regulating spermatogenesis: a biochemical and molecular perspectiveC Yan Cheng
Center for Biomedical Research, Population Council, 1230 York Avenue, New York, New York 10065, USA
Crit Rev Biochem Mol Biol 44:245-63. 2009..Herein, we provide a critical review based on the latest findings in the field regarding the regulation of these cellular events. These recent findings also open up a new window for investigators studying blood-tissue barriers... - Heat shock protein 90: translation from cancer to Alzheimer's disease treatment?Wenjie Luo
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University and Fisher Foundation for Alzheimer s Disease, New York, NY 10021, USA
BMC Neurosci 9:S7. 2008..It will present experimentally demonstrated, but also hypothetical, roles that suggest Hsp90 can act as a regulator of pathogenic changes that lead to the neurodegenerative phenotype in Alzheimer's disease... - Ordered patterns of cell shape and orientational correlation during spontaneous cell migrationYusuke T Maeda
Department of Physics, Graduate School of Science, The University of Tokyo, Tokyo, Japan
PLoS ONE 3:e3734. 2008..Yet little is known about how cells change their own shape and how cells coordinate the deformation and movement. Here, we investigated the mechanism of spontaneous cell migration by using computational analyses... - Long-term safety and efficacy of low-density lipoprotein apheresis in childhood for homozygous familial hypercholesterolemiaLisa C Hudgins
The Rogosin Institute, New York, New York, USA
Am J Cardiol 102:1199-204. 2008..It effectively lowers LDL cholesterol, but target LDL levels are not achieved, and some patients will show progression of cardiovascular disease... - Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addictsDavid A Nielsen
Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
Neuropsychopharmacology 34:867-73. 2009..080). Both the -18 and the +84 CpG sites are located in potential Sp1 transcription factor-binding sites. Methylation of these CpG sites may lead to reduced OPRM1 expression in the lymphocytes of these former heroin addicts... - Species differences in brain distribution of CART mRNA and CART peptide between prairie and meadow volesRichard G Hunter
Yerkes National Primate Center, Emory University, Atlanta, GA 30322, USA
Brain Res 1048:12-23. 2005..Our findings also point to novel avenues of investigation regarding the brain mechanisms for the evolution of diverse social organization... - Replaceable neurons and neurodegenerative disease share depressed UCHL1 levelsAnthony J Lombardino
Laboratory of Animal Behavior, The Rockefeller University, Box 137, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:8036-41. 2005..UCHL1 dysfunction has been associated with neurodegeneration in Parkinson's, Alzheimer's, and Huntington's disease patients. In all these instances, reduced UCHL1 function may jeopardize the survival of CNS neurons... - Modulation of rat Leydig cell steroidogenic function by di(2-ethylhexyl)phthalateB T Akingbemi
Center for Biomedical Research, Population Council, New York, New York 10021, USA
Biol Reprod 65:1252-9. 2001..In conclusion, data from this study show that DEHP effects on Leydig cell steroidogenesis are influenced by the stage of development at exposure and may occur through modulation of T-biosynthetic enzyme activity and serum LH levels... - Searching for a spindle matrixW A Wells
J Cell Biol 154:1102-4. 2001..New evidence supports the idea of a nonmicrotubule spindle matrix, but the debate about the reality of this structure continues... - The Ising model in physics and statistical geneticsJ Majewski
Laboratory of Statistical Genetics, The Rockefeller University, New York, NY, 10021, USA
Am J Hum Genet 69:853-62. 2001..A reanalysis of data on type 1 diabetes detects several susceptibility loci not previously found by other methods of analysis... - Penicillin-resistant Streptococcus pneumoniae in metropolitan New York hospitals: case control study and molecular typing of resistant isolatesR B Roberts
The Rockefeller University, New York, NY 10021, USA
Microb Drug Resist 7:137-52. 2001.... - Insights from mouse models into the molecular basis of neurodegenerationN Heintz
Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021, USA
Annu Rev Physiol 62:779-802. 2000..Finally, we discuss common mechanisms of cell death and lessons learned from these mouse models that might have broader relevance to other neurologic disorders... - Apolipoprotein E4: an allele associated with many diseasesJ D Smith
Laboratory of Biomedical Genetics and Metabolism, The Rockefeller University, New York, NY 10021, USA
Ann Med 32:118-27. 2000..The apoE polymorphism also affects response to head trauma, cognitive decline upon ageing and several other disorders. Thus, common genetic variation in the apoE gene may be associated with successful ageing... - Apparent efficacy of kappa-opioid receptor ligands on serum prolactin levels in rhesus monkeysE R Butelman
Laboratory of the Biology of Addictive Diseases, Rockefeller University, 1230 York Avenue Box 171, New York, NY 10021, USA
Eur J Pharmacol 383:305-9. 1999..Prolactin may therefore be a quantitative marker of the apparent efficacy of kappa-opioid receptor ligands in primates... - Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeysE R Butelman
Rockefeller University, New York, NY 10021, USA
Psychopharmacology (Berl) 147:73-80. 1999..The dynorphins are endogenous opioid peptides with relative binding selectivity for kappa-receptors. It is unclear whether the dynorphins share the pharmacological profile observed with synthetic kappa-agonists in primates... - Enhancing versus suppressive effects of stress hormones on skin immune functionF S Dhabhar
The Rockefeller University, 1230 York Avenue, Box 165, New York, NY 10021, USA
Proc Natl Acad Sci U S A 96:1059-64. 1999..g., wounding or infection) for which stress perception by the brain may serve as an early warning signal... - Neuroendocrine-related effects of long-term, 'binge' cocaine administration: diminished individual differences in stress-induced corticosterone responseZ Sarnyai
Laboratory of Neuroendocrinology, The Rockefeller University, New York, N Y, 10021, USA
Neuroendocrinology 68:334-44. 1998..These results indicate that chronic binge cocaine administration leads to sustained activation of the HPA axis and alters processes underlying individual vulnerability to stress... - Structural and biochemical analysis of the sheath of Phormidium uncinatumE Hoiczyk
Max Planck Institut fur Biochemie, D 82152 Martinsried, Germany
J Bacteriol 180:3923-32. 1998..Both the chemical composition and the rigid highly ordered structure clearly distinguish the sheaths from the slime secreted by the filaments during gliding motility... - Novelty-induced locomoter activity in Long-Evans rats pre- and post-chronic 'binge'-pattern cocaine treatmentL R Lucas
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
Neurosci Lett 237:25-8. 1997..These findings suggest that behavioral sensitization, as a result of CBP cocaine treatment, changes novelty-stress induced behavior which may reflect altered individual vulnerability to drugs of abuse... - Adaptation of metabolic enzyme activities of Trypanosoma brucei promastigotes to growth rate and carbon regimenB H ter Kuile
The Rockefeller University, New York, New York 10021, USA
J Bacteriol 179:4699-705. 1997..brucei adapted the activities of each of the metabolic enzymes studied separately. The results of this complex manner of adaptation were more or less constant ratios of the end products and a very efficient energy metabolism... - The dynamics of primate retinal ganglion cellsE Kaplan
Departments of Ophthalmology Biophysics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10016, USA
Prog Brain Res 134:17-34. 2001..The different dynamical properties of the two populations suggest that M cells participate in motion analysis, while P cells are used for the analysis of form, texture, and perhaps color... - The Personality Assessment Inventory Drug Problems Scale: a validity analysisScott H Kellogg
Laboratory of the Biology of the Addictive Diseases, Rockefeller University, New York, NY 10021 6399, USA
J Pers Assess 79:73-84. 2002..Overall, higher scores did reflect both more serious involvements with drug use and more serious problems as a consequence of their involvement... - Loose ends: axenic culture, parasitophorous vacuoles, bird malariaW Trager
Rockefeller University, 1230 York Avenue Box 17, New York, NY 10021 6399, USA
Parassitologia 44:117-21. 2002..Finally, attention is given to speculations on the origin of P. falciparum... - Neuropsychological characteristics of children with the 22q11 Deletion Syndrome: a descriptive analysisChristina Sobin
Laboratory of Human Neurogenetics, The Rockefeller University, New York, New York 10021, USA
Child Neuropsychol 11:39-53. 2005..Implications of these findings are considered with regard to past results... - Hepatitis C virus infection. How does the host respond?A Grakoui
Center for the Study of Hepatitis C, Laboratory for Virology and Infectious Disease, The Rockefeller University, New York, NY 10021 6399, USA
Minerva Gastroenterol Dietol 50:21-8. 2004..Recent studies have provided us with a better understanding of the virus-host interactions and may help us unravel the immunologic components necessary for successful HCV clearance... - Photoreceptor differentiation in Drosophila: from immature neurons to functional photoreceptorsBertrand Mollereau
Strang Laboratory of Cancer Research, The Rockefeller University, New York, New York 10021, USA
Dev Dyn 232:585-92. 2005..In the second part, we review the roles of several transcription factors, which are required for the terminal photoreceptor differentiation and rhodopsin expression... - Protection and damage from acute and chronic stress: allostasis and allostatic overload and relevance to the pathophysiology of psychiatric disordersBruce S McEwen
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
Ann N Y Acad Sci 1032:1-7. 2004..Yet, these are not necessarily "damaged" and may be treatable with the right medications... - Molecular mechanisms of neuroplasticity and pharmacological implications: the example of tianeptineBruce S McEwen
Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology Rockefeller University, New York, NY 10021, USA
Eur Neuropsychopharmacol 14:S497-502. 2004..Chronic treatment with the antidepressant tianeptine may prevent these effects in hippocampus and amygdala... - Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell targetCHRISTIAN MUNZ
Laboratory of Viral Immunobiology, The Rockefeller University, 1230 York Ave, New York, NY 10021, USA
J Exp Med 199:1301-4. 2004..However, recent studies show that EBNA1 can be presented to both CD4+ and CD8+ T cells, making it a potential new target for immunotherapy of EBV-related cancers... - Primary structure of guinea pig preprodynorphin and preproenkephalin mRNAs: multiple transcription initiation sites for preprodynorphinK Steven LaForge
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
Brain Res Bull 63:119-26. 2004..These studies confirmed that the primary transcription start site is 28 nucleotides downstream from the TATAA site, and that intron A sequences are not present in significant amounts in these tissues... - Combining several ordinal measures in clinical studiesKnut M Wittkowski
General Clinical Research Center, The Rockefeller University, New York, NY 10021, USA
Stat Med 23:1579-92. 2004..The scoring method is demonstrated to be applicable to scoring clinical response profiles in the treatment of psoriasis and then to identifying genomic pathways that best correlate with these profiles... - Human population: the next half centuryJoel E Cohen
Rockefeller University and Columbia University, 1230 New York Avenue, Box 20, New York, NY 10021, USA
Science 302:1172-5. 2003..Economies, nonhuman environments, and cultures (including values, religions, and politics) strongly influence demographic changes. Hence, human choices, individual and collective, will have demographic effects, intentional or otherwise... - Measurement of enthalpy and volume changes in photoinitiated reactions on the ms timescale with a novel pressure cellDavid Mauzerall
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Photochem Photobiol Sci 2:788-90. 2003..Because of the similar cell structure and data analysis it is now possible to determine enthalpy and volume changes in photo-initiated reactions over the timescale of nanoseconds to seconds with the same solution... - Making sense with TRP channels: store-operated calcium entry and the ion channel Trpm5 in taste receptor cellsCristian A Perez
Department of Physiology and Biophysics, Howard Hughes Medical Institute, Mount Sinai School of Medicine, New York University, New York, NY 10029, USA
Cell Calcium 33:541-9. 2003..The role of store-operated channels and Trpm5 in capacitative calcium entry in taste receptor cells in response to bitter compounds is discussed... - A war on obesity, not the obeseJeffrey M Friedman
Howard Hughes Medical Institute, The Rockefeller University, 1230 New York Avenue, New York, NY 10021 USA
Science 299:856-8. 2003..In their efforts to lose weight, obese individuals may be fighting a powerful set of evolutionary forces honed in an environment drastically different from that of today... - LDL Apheresis: an effective and safe treatment for refractory hypercholesterolemiaLisa Cooper Hudgins
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Cardiovasc Drug Rev 20:271-80. 2002..Whole blood compatible columns in development offer the possibility of simpler and less expensive treatments... - Reafferent thalamo- "cortical" loops in the song system of oscine songbirdsG E Vates
Laboratory of Animal Behavior, Rockefeller University, New York, New York 10021, USA
J Comp Neurol 380:275-90. 1997....
Research Grants
- Evaluation of a progesterone vaginal ring as a new contraceptive option in IndiaREGINE SITRUK contact WARE; Fiscal Year: 2010....
- Cooporative Contraceptive Research CenterRegine Sitruk Ware; Fiscal Year: 2007..The overall goal is to explore the prospect of the Adjudin-FSH mutant conjugate's candidacy as a male contraceptive, by targeting germ cell adhesion. Alternative delivery routes will be studied. ..
- GENE EXPRESSION IN NERVOUS TISSUEBruce S McEwen; Fiscal Year: 2010..abstract_text> ..
- GENE EXPRESSION IN NERVOUS TISSUEBruce McEwen; Fiscal Year: 2000..Finally, the sexual differentiation of synapse formation and the role of androgen as well as estrogens in males will be investigated. ..
- GENE EXPRESSION IN NERVOUS TISSUEBruce McEwen; Fiscal Year: 2004..We plan to use the power of mouse genetics by employing mice lacking ERa and ERb to provide more definitive information regarding the role of the two known intracellular ER types in these E effects. ..
- STRESS, ADRENAL STEROIDS AND THE BRAINBruce McEwen; Fiscal Year: 2009..abstract_text> ..
- STRESS, ADRENAL STEROIDS AND THE BRAINBruce McEwen; Fiscal Year: 2007..abstract_text> ..
- GENE EXPRESSION IN NERVOUS TISSUEBruce McEwen; Fiscal Year: 2007....
- GENE EXPRESSION IN NERVOUS TISSUEBruce McEwen; Fiscal Year: 1980..These effects may take the form of permanent differences in brain circuitry, levels of steroid receptors, of inducibility of gene products by steroids and other agents. ..
- STRESS, ADRENAL STEROIDS AND THE BRAINBruce McEwen; Fiscal Year: 1990..hostages, prisoners of war)...
- STRESS, ADRENAL STEROIDS AND THE BRAINBruce McEwen; Fiscal Year: 1993..Better understanding of the beneficial as well as destructive aspects of GC actions on neuronal survival may aid in developing treatment strategies to slow the rate of progress of neural degenerative diseases...
- GENE EXPRESSION IN NERVOUS TISSUEBruce McEwen; Fiscal Year: 1993....
- Sex Differences in Hippocampal Synaptic Protein & mRNARussell Romeo; Fiscal Year: 2005..Finally, additional experiments will provide novel information on how exposure to steroid hormones during prenatal development sexually differentiates the ability of estrogen to affect hippocampal synapses. ..
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2009..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2010..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..
- An in vivo model to study blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2007..Second and perhaps most importantly, the disrupted BTB can be "resealed", making this model uniquely suitable to study the biology and regulation of BTB re-assembly during spermatogenesis. ..
- Junction Dynamics and Male Fertility RegulationC Yan Cheng; Fiscal Year: 2007..In summary, these studies not only will define the regulation of AJ dynamics, they will identify new leads and innovative approaches for male contraceptive development. ..
- The biology of blood-testis barrier dynamicsC Yan Cheng; Fiscal Year: 2010..It also offers new insight into: (i) developing novel approaches for male contraception, and (ii) the causes of unexplained male infertility. ..