M Zhang

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate
    Long jiang Shao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:5143-51. 2008
  2. pmc Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
    Weiguo Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 5:50. 2005
  3. ncbi request reprint Maspin plays an important role in mammary gland development
    M Zhang
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Biol 215:278-87. 1999
  4. ncbi request reprint Maspin is an angiogenesis inhibitor
    M Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Med 6:196-9. 2000
  5. ncbi request reprint Multiple functions of maspin in tumor progression and mouse development
    Ming Zhang
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, TX 77030, USA
    Front Biosci 9:2218-26. 2004
  6. ncbi request reprint Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model
    H Y Shi
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Cancer Res 61:6945-51. 2001
  7. ncbi request reprint Modeling human breast cancer metastasis in mice: maspin as a paradigm
    H Y Shi
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Histol Histopathol 18:201-6. 2003
  8. ncbi request reprint Cardiolipin in energy transducing membranes
    E Mileykovskaya
    Department of Biochemistry and Molecular Biology, University of Texas Houston, Medical School, Houston, TX 77030, USA
    Biochemistry (Mosc) 70:154-8. 2005
  9. ncbi request reprint Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ
    J A Putkey
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77225, USA
    Biochemistry 36:970-8. 1997
  10. ncbi request reprint Lack of mitochondrial anionic phospholipids causes an inhibition of translation of protein components of the electron transport chain. A yeast genetic model system for the study of anionic phospholipid function in mitochondria
    D B Ostrander
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77225, USA
    J Biol Chem 276:25262-72. 2001

Collaborators

Detail Information

Publications68

  1. pmc Haploinsufficiency of the maspin tumor suppressor gene leads to hyperplastic lesions in prostate
    Long jiang Shao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 68:5143-51. 2008
    ..This is the first report that a partial loss of maspin caused an early developmental defect of the prostate and prostate hyperplastic lesions in mouse...
  2. pmc Maspin overexpression modulates tumor cell apoptosis through the regulation of Bcl-2 family proteins
    Weiguo Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 5:50. 2005
    ..However, the molecular mechanism underlying this inhibition has not been fully elucidated. In this report, we analyze the effect of maspin on tumor cell apoptosis under several stress conditions...
  3. ncbi request reprint Maspin plays an important role in mammary gland development
    M Zhang
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Dev Biol 215:278-87. 1999
    ..These findings demonstrate that maspin plays an important role in mammary development and that its effect is stage dependent...
  4. ncbi request reprint Maspin is an angiogenesis inhibitor
    M Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Med 6:196-9. 2000
    ....
  5. ncbi request reprint Multiple functions of maspin in tumor progression and mouse development
    Ming Zhang
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, TX 77030, USA
    Front Biosci 9:2218-26. 2004
    ..These data demonstrate that maspin not only plays a role in tumor progression and metastasis but also is a key regulatory molecule for normal mammary gland and embryonic development...
  6. ncbi request reprint Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model
    H Y Shi
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Cancer Res 61:6945-51. 2001
    ..Thus, maspin can block primary tumor growth as well as invasion and metastasis. These data support the concept that maspin has a strong protective role against tumor progression...
  7. ncbi request reprint Modeling human breast cancer metastasis in mice: maspin as a paradigm
    H Y Shi
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, Texas 77030, USA
    Histol Histopathol 18:201-6. 2003
    ..Elucidating the molecular mechanism of maspin action will shed light on our understanding of breast cancer invasion and metastasis...
  8. ncbi request reprint Cardiolipin in energy transducing membranes
    E Mileykovskaya
    Department of Biochemistry and Molecular Biology, University of Texas Houston, Medical School, Houston, TX 77030, USA
    Biochemistry (Mosc) 70:154-8. 2005
    ..The role of cardiolipin in higher order organization of components of the mitochondrial respiratory chain revealed by a combined molecular genetic and biochemical approach is described...
  9. ncbi request reprint Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ
    J A Putkey
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77225, USA
    Biochemistry 36:970-8. 1997
    ....
  10. ncbi request reprint Lack of mitochondrial anionic phospholipids causes an inhibition of translation of protein components of the electron transport chain. A yeast genetic model system for the study of anionic phospholipid function in mitochondria
    D B Ostrander
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77225, USA
    J Biol Chem 276:25262-72. 2001
    ..Thus, the molecular basis for the lack of mitochondrial function in pgs1Delta cells is the failure to translate gene products essential to the electron transport chain...
  11. ncbi request reprint Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase
    Heidi Y Shi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Cell Motil Cytoskeleton 64:338-46. 2007
    ..In addition, the AP-1 transcription activity downstream of JNK kinase pathway was also reduced. Together, we have identified Rac1 and Cdc42 as the downstream targets that mediate the inhibition of mammary tumor cell migration by maspin...
  12. ncbi request reprint Cluster models of dose-volume effects
    Howard D Thames
    Department of Biostatistics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:1491-504. 2004
    ..Describe cluster models, normal-tissue complication probability models in which both the number and the spatial location of radiation-sterilized functional subunits play a role in defining complication probability...
  13. pmc Maspin mediates increased tumor cell apoptosis upon induction of the mitochondrial permeability transition
    Khatri Latha
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 25:1737-48. 2005
    ..Our data indicate that maspin inhibits tumor progression through the mitochondrial apoptosis pathway. These findings will be useful for maspin-based therapeutic interventions against breast cancer...
  14. pmc Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin
    Hirohito Yamaguchi
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Carcinog 47:739-43. 2008
    ..Together, these data provide novel insights into the tumor-suppressive function of IFIXalpha...
  15. ncbi request reprint Signaling through 3',5'-cyclic adenosine monophosphate and phosphoinositide-3 kinase induces sodium/iodide symporter expression in breast cancer
    Katherine A B Knostman
    Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio 43210, USA
    J Clin Endocrinol Metab 89:5196-203. 2004
    ..This study is the first to demonstrate that NIS expression is induced by cAMP and/or PI3K in breast cancer both in vivo and in vitro...
  16. pmc BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells
    Shuang Yang
    Medical College of Nankai University, Tianjin, China
    BMC Cancer 7:211. 2007
    ..Bone morphogenetic protein-6 (BMP-6) is critically involved in many developmental processes. Recent studies indicate that BMP-6 is closely related to tumor differentiation and metastasis...
  17. ncbi request reprint Targeted expression of maspin in tumor vasculatures induces endothelial cell apoptosis
    Zhigang Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 24:2008-19. 2005
    ..These findings demonstrate that neovascular endothelial cells are highly sensitive to maspin level inside the cells. This property can be used for targeted therapy against tumor angiogenesis and metastasis...
  18. ncbi request reprint Maspin is physically associated with [beta]1 integrin regulating cell adhesion in mammary epithelial cells
    Nathalie Cella
    Baylor College of Medicine, Department of Molecular and Cellular Biology, ALKEK Bldg, Rm N630, One Baylor Plaza, Houston, Texas 77030, USA
    FASEB J 20:1510-2. 2006
    ..Collectively, these results suggest that maspin is part of the supramolecular structure of the adhesion plaque and it modulates cell adhesion via a beta1 integrin-dependent mechanism...
  19. ncbi request reprint Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin
    Jun Li Luo
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nature 446:690-4. 2007
    ..We propose that tumour-infiltrating RANKL-expressing cells lead to nuclear IKKalpha activation and inhibition of Maspin transcription, thereby promoting the metastatic phenotype...
  20. pmc Expression of endothelial nitric oxide synthase and vascular endothelial growth factor in association with neovascularization in human primary astrocytoma
    Jian Wei Pan
    Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Zhejiang Univ Sci B 6:693-8. 2005
    ..To investigate the relationship between the expression of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor (VEGF) and angiogenesis in primary astrocytoma...
  21. ncbi request reprint Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: a case-control study
    Susan L Tucker
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 64:1255-64. 2006
    ..The purpose of this study was to test the validity of a two-dimensional cluster model of late rectal toxicity based on maximum cluster size of damage to rectal surface...
  22. ncbi request reprint Downregulation of survivin expression and elevation of caspase-3 activity involved in pitavastatin-induced HepG 2 cell apoptosis
    Juyong Wang
    Tumor Research Institute, Shanghai Academy of Traditional Chinese Medicine, Shanghai 200032, PR China
    Oncol Rep 18:383-7. 2007
    ..These results suggest that pitavastatin at 10 microM induces apoptosis of HepG 2 cells, which is associated with the decreased expression of survivin mRNA and increased caspase-3 activity of HepG 2 cells...
  23. ncbi request reprint Hypoxia effects: implications for maspin regulation of the uPA/uPAR complex
    Jeremy S Schaefer
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Biol Ther 4:1033-5. 2005
    ....
  24. ncbi request reprint Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development
    Heidi Y Shi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 18:2196-207. 2004
    ..In PRKO mice, a compensatory mechanism occurs that rescues the ductal defect at a late stage of mammary development...
  25. ncbi request reprint Tamoxifen induces the expression of maspin through estrogen receptor-alpha
    Zesheng Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, ALKEK Bldg, N630 Houston, TX 77030, USA
    Cancer Lett 209:55-65. 2004
    ..This finding indicates that one of the pathways for cancer prevention and tumor inhibition by TAM is mediated through the activation of tumor suppressor gene maspin in breast cancer...
  26. ncbi request reprint Maspin functions as tumor suppressor by increasing cell adhesion to extracellular matrix in prostate tumor cells
    Shaji Abraham
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Urol 169:1157-61. 2003
    ..We used prostate tumor cells derived from the TRAMP (transgenic adenocarcinoma of mouse prostate) prostate tumor model to study the tumor suppressive function of maspin in prostate cancer...
  27. ncbi request reprint Toward re-expressing tumor suppresor gene maspin in breast cancer
    Ming Zhang
    Clin Breast Cancer 3:353-4. 2002
  28. ncbi request reprint Maspin expression in invasive breast cancer: association with other prognostic factors
    Syed K Mohsin
    Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Pathol 199:432-5. 2003
    ..Additional studies are needed to evaluate further this expression profile of maspin in breast cancer...
  29. ncbi request reprint Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer
    Nicolai Maass
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kiel, Michaelisstrasse 16, 24105 Kiel, Germany
    Biochem Biophys Res Commun 297:125-8. 2002
    ..The re-expression of maspin by pharmacological intervention potentially offers a promising new target as a therapeutic option in breast cancer...
  30. ncbi request reprint Inhibition of breast tumor progression by systemic delivery of the maspin gene in a syngeneic tumor model
    Heidi Y Shi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Ther 5:755-61. 2002
    ..Such inhibition is mediated by SERPINB5 transgene through increased apoptosis in SERPINB5-treated tumors. Thus, SERPINB5 can be used in gene therapy against breast tumor growth and metastasis...
  31. ncbi request reprint Clinicopathological significance and molecular regulation of maspin expression in ductal adenocarcinoma of the pancreas
    Nobuyuki Ohike
    Department of Pathology, University of Kiel, Kiel, Germany
    Cancer Lett 199:193-200. 2003
    ....
  32. ncbi request reprint Tissue microarray analysis of maspin expression and its reverse correlation with mutant p53 in various tumors
    Weiguo Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Int J Oncol 20:1145-50. 2002
    ..Our data indicate that maspin expression inversely correlates with mutant p53 level in majority of cancer, suggesting maspin is likely a p53 target gene in vivo...
  33. ncbi request reprint Role of maspin in tumor metastasis and angiogenesis
    Jeremy S Schaefer
    Baylor College of Medicine, Department of Molecular and Cellular Biology, Houston, TX 77030, USA
    Curr Mol Med 3:653-8. 2003
    ..Efforts underway to understand the molecular mechanisms involved in the diverse functions influenced by maspin have yielded promising results and shed light on the cancer pathways...
  34. ncbi request reprint Expression and regulation of tumor suppressor gene maspin in human bladder cancer
    Shuji Sugimoto
    Department of Urology, University of Kiel, Arnold Heller Strasse 7, Kiel 24105, Germany
    Cancer Lett 203:209-15. 2004
    ..Our results indicate that maspin may contribute to bladder cancer development and that DNA methylation and histone deacetylation may be important for regulating maspin gene activation in bladder cancer cells...
  35. ncbi request reprint Maspin plays an essential role in early embryonic development
    Fei Gao
    Baylor College of Medicine, Department of Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Development 131:1479-89. 2004
    ..We conclude that deletion of maspin affects VE function by reducing cell proliferation and adhesion, thereby controlling early embryonic development...
  36. ncbi request reprint Valproic acid induces p21 and topoisomerase-II (alpha/beta) expression and synergistically enhances etoposide cytotoxicity in human glioblastoma cell lines
    Chandra M Das
    Department of Pediatrics, Unit 853, University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Neurooncol 85:159-70. 2007
    ..In this study, we have examined the ability of the histone deacetylase inhibitor, valproic acid (VPA) to modulate gene expression and sensitize glioblastoma cell lines to the cytotoxic effects of etoposide in vitro...
  37. ncbi request reprint Epigenetic regulation of bone morphogenetic protein-6 gene expression in breast cancer cells
    Ming Zhang
    Laboratory of Molecular Medicines, Medical College, Nankai University, Tianjin 300071, China
    J Steroid Biochem Mol Biol 105:91-7. 2007
    ....
  38. pmc The complementary neighborhood patterns and methylation-to-mutation likelihood structures of 15,110 single-nucleotide polymorphisms in the bovine genome
    Zhihua Jiang
    Department of Animal Sciences, Washington State University, Pullman, Washington 99164 6351, USA
    Genetics 180:639-47. 2008
    ..In addition, conversion can occur at both CpG sites and non-CpG sites. Our study provides new insights into understanding molecular mechanisms of mutations and genome evolution...
  39. ncbi request reprint Proteomics demonstration that normal breast epithelial cells can induce apoptosis of breast cancer cells through insulin-like growth factor-binding protein-3 and maspin
    Robert Alain Toillon
    INSERM ERI 8 JE 2488 Signalisation des facteurs de croissance dans le cancer du sein Protéomique fonctionnelle, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
    Mol Cell Proteomics 6:1239-47. 2007
    ..These findings provide a molecular hypothesis for the long observed inhibitory effect of normal surrounding cells on breast cancer development...
  40. doi request reprint Commutability of NIST SRM 1955 Homocysteine and Folate in Frozen Human Serum with selected total homocysteine immunoassays and enzymatic assays
    Bryant C Nelson
    National Institute of Standards and Technology, Biochemical Science Division, Gaithersburg, MD 20899 0001, USA
    Clin Chim Acta 395:99-105. 2008
    ..NIST has performed an international, interlaboratory assessment of SRM 1955 commutability; results are reported for tHcy only...
  41. doi request reprint Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung
    Ming Zhang
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 5582, USA
    Clin Cancer Res 14:1868-76. 2008
    ..Radiation-induced lung toxicity limits the delivery of high-dose radiation to thoracic tumors. Here, we investigated the potential of inhibiting the tumor necrosis factor-alpha (TNF-alpha) pathway as a novel radioprotection strategy...
  42. ncbi request reprint Extended operation for thoracic malignancies invading superior vena cava and/or innominate vein
    Chun Bo Zhai
    Department of Cardiothoracic Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Chin Med J (Engl) 120:1277-80. 2007
  43. pmc Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory
    Ming Zhang
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Neurosci 28:4736-44. 2008
    ....
  44. ncbi request reprint Atorvastatin downregulates BMP-2 expression induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells
    Ming Zhang
    Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha Hunan, China
    Circ J 72:807-12. 2008
    ..The present study investigates the effects of ox-LDL on BMP-2 expression. Furthermore, the influence of atorvastatin on ox-LDL-induced BMP-2 expression is also examined...
  45. ncbi request reprint Rho signaling inhibitor, Y-27632, inhibits invasiveness of metastastic hepatocellular carcinoma in a mouse model
    Feng Xue
    Organ Transplantation Center, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    Chin Med J (Engl) 120:2304-7. 2007
  46. doi request reprint V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies
    Ming Zhang
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, Nebraska 68178, USA
    J Biol Chem 283:6717-27. 2008
    ..In contrast, Hox11 and SCL are nicked but not cleaved efficiently in vitro, and cleavage at other adventitious sites in plasmid substrates may also limit the ability to detect recombination activity at these cRSSs in cell culture...
  47. pmc Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia
    Huilin Shi
    Department of Biochemistry and Cancer Biology, University of Toledo Health Science Campus, Toledo, Ohio 43614, USA
    J Comp Neurol 508:867-78. 2008
    ..Together, these results establish nestin as a common marker for sympathetic neuronal and glial progenitor cells and delineate the cellular basis for the generation and maturation of sympathetic satellite cells...
  48. pmc Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells
    Dan Shen
    Department 1 of Internal Medicine and Geriatrics, Zhongnan Hospital, Wuhan University, Wuhan, PR China
    Postgrad Med J 83:414-9. 2007
    ..This study was designed to examine the effects of PPAR-gamma agonists on the proliferation and invasion of two colon cancer cells to identify the role of PPAR-gamma in colon cancer growth and metastasis...
  49. ncbi request reprint BTNL2, a butyrophilin/B7-like molecule, is a negative costimulatory molecule modulated in intestinal inflammation
    Heather A Arnett
    Inflammation, Amgen, Seattle, WA 98119, USA
    J Immunol 178:1523-33. 2007
    ..These data suggest a role for BTNL2 as a negative costimulatory molecule with implications for inflammatory disease...
  50. ncbi request reprint Reduction of intracellular pH inhibits the expression of VEGF in K562 cells after targeted inhibition of the Na+/H+ exchanger
    Bingyan He
    Pediatrics Department of Zhongnan Hospital, Wuhan University, East Lake Road, Wuhan, Hubei Province 430071, PR China
    Leuk Res 31:507-14. 2007
    ..These data strongly suggested that the expression of VEGF mRNA and protein in K562 cells was inhibited accompanying its reduction in pHi value after targeted inhibition of NHE1...
  51. ncbi request reprint Functional activity of natural antibody is altered in Cr2-deficient mice
    Russell R Reid
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:5433-40. 2002
    ..These results suggest that complement receptors CD21/CD35 are important in maintenance of the B-1 cell repertoire to some, but not all, specificities...
  52. ncbi request reprint Potent activity of soluble B7RP-1-Fc in therapy of murine tumors in syngeneic hosts
    Gulshan Ara
    Department of Pharmacology, Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320, USA
    Int J Cancer 103:501-7. 2003
    ..As expected, T cells appeared to be targeted by B7RP-1-Fc treatment. Thus, the administration of soluble B7RP-1-Fc may have therapeutic value in generating or enhancing anti-tumor activity in a clinical setting...
  53. ncbi request reprint Census of genes expressed in porcine embryos and reproductive tissues by mining an expressed sequence tag database based on human genes
    Zhihua Jiang
    Department of Animal Sciences, Washington State University, Pullman 99164, USA
    Biol Reprod 69:1177-82. 2003
    ..The census provides a panel of transcripts in a broad sense that can be used as targets to study the mechanisms involved in embryo development and reproduction in pigs and other mammals, including humans...
  54. ncbi request reprint Ionizing radiation increases adenovirus uptake and improves transgene expression in intrahepatic colon cancer xenografts
    Ming Zhang
    Department of Radiation Oncology, Ann Arbor, Michigan 48109 0582, USA
    Mol Ther 8:21-8. 2003
    ..4-fold after a 25-Gy treatment. These data suggest that a combination of regional radiation treatment with adenovirus gene therapy is a rational strategy for improving adenoviral targeting and transgene expression in tumors...
  55. ncbi request reprint Changes in the proportion and number of Pax(7+ve) and MF20(+ve) myoblasts during chick myogenesis in the head and limb
    Antonio S J Lee
    Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand
    Int J Dev Biol 48:31-8. 2004
    ..Moreover, we have found that the proportion of terminally differentiated myoblasts is maintained at a low level (less than 3%) during primary and secondary myogenesis...
  56. ncbi request reprint Quantitative comparison of plantar foot shapes under different weight-bearing conditions
    Bonnie Yuk San Tsung
    Jockey Club Rehabilitation Engineering Centre, The Hong Kong Polytechnic University, Hong Kong, China
    J Rehabil Res Dev 40:517-26. 2003
    ..7% +/- 4.9%, and decreases in the arch height of 20.0% +/- 9.2% and arch angle of 41.2% +/- 16.2%. The findings may be useful for considering the change of foot shape in the selection of shoe size and shoe or insole design...
  57. ncbi request reprint Role of stem cell homing in myocardial regeneration
    Marc S Penn
    Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Cardiol 95:S23-5. 2004
    ....
  58. ncbi request reprint Effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocytes
    Ai Guo Wang
    Department of Environmental Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China
    Biomed Environ Sci 17:217-22. 2004
    ..To investigate the effects of fluoride on lipid peroxidation, DNA damage and apoptosis in human embryo hepatocyte L-02 cells...
  59. ncbi request reprint Improving conformational searches by geometric screening
    Ming Zhang
    Department of Biostatistics and Applied Mathematics, The University of Texas M D Anderson Cancer Center Houston, TX 77030, USA
    Bioinformatics 21:624-30. 2005
    ..We propose adding a geometric screening phase before an energy minimization procedure so that only conformations that geometrically fit in the binding site will be prompted for energy calculation...
  60. ncbi request reprint 5-fluorouracil and hydroxyurea enhance adenovirus-mediated transgene expression in colon and hepatocellular carcinoma cells
    Xiao W Huang
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0582, USA
    J Cancer Res Clin Oncol 131:184-90. 2005
    ..To investigate the efficient transduction of tumor cells which remains a major limitation of cancer gene therapy...
  61. ncbi request reprint Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM
    William G Austen
    Department of Surgery, Harvard Medical School, The Brigham and Women s Hospital, Boston, MA 02115, USA
    Surgery 136:401-6. 2004
    ..Cr2-/- and wild type (WT) mice were studied to isolate the antibody or antibodies responsible for initiation of I/R...
  62. ncbi request reprint Ionizing radiation-induced adenovirus infection is mediated by Dynamin 2
    Jun Qian
    Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 65:5493-7. 2005
    ....
  63. ncbi request reprint Activation of bone morphogenetic protein-6 gene transcription in MCF-7 cells by estrogen
    Ming Zhang
    Laboratory of Molecular Medicines, Medical College, Nankai University, Tianjin 300071, China
    Chin Med J (Engl) 118:1629-36. 2005
    ..This experiment is designed to detect the molecular mechanism of estrogen activating BMP-6 gene transcription in human estrogen receptor positive (ER+) breast cancer cell line MCF-7...
  64. pmc Identification of the target self-antigens in reperfusion injury
    Ming Zhang
    CBR Institute for Biomedical Research, Inc, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 203:141-52. 2006
    ..These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction...
  65. ncbi request reprint Attenuation of skeletal muscle reperfusion injury with intravenous 12 amino acid peptides that bind to pathogenic IgM
    Rodney K Chan
    From the Department of Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston
    Surgery 139:236-43. 2006
    ..In these experiments, we examine the properties of short peptide sequences, and their homologues, that bind to the antigen-combining site of this pathogenic IgM clone...
  66. ncbi request reprint [Alteration of expression of survivin in HL-60 cells treated with chemotherapeutic drugs]
    Yao Hui Wu
    Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 14:347-50. 2006
    ..This phenomenon may be associated with the resistance in chemotherapy for leukemia. On the other hand, As2O3 shows a different mechanism that may play a significant role to reverse resistance...
  67. ncbi request reprint Targeting maspin in endothelial cells to induce cell apoptosis
    Jeremy S Schaefer
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Expert Opin Ther Targets 10:401-8. 2006
    ..A separate study showed the ability of maspin to induce apoptosis in tumour-specific endothelial cells. Taken together, these studies demonstrate the potential use of maspin as a viable anticancer therapeutic agent...
  68. ncbi request reprint High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer
    Mukesh K Nyati
    Department of Radiation Oncology, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0010, USA
    Cancer Res 62:2337-42. 2002
    ..These findings suggest that the CEA promoter-enhancer strategy confers specificity while preserving activity and is worth exploring in additional animal and, potentially, clinical trials...