Hong Zhang

Summary

Affiliation: Texas Scottish Rite Hospital for Children
Country: USA

Publications

  1. ncbi request reprint Histomorphometric assessment of thoracoscopically assisted anterior release in a porcine model: safety and completeness of disc discectomy with surgeon learning curve
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 32:188-92. 2007
  2. ncbi request reprint Novel dual-rod screw for thoracoscopic anterior instrumentation: biomechanical evaluation compared with single-rod and double-screw/double-rod anterior constructs
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 34:E183-8. 2009
  3. doi request reprint Morphometric analysis of neurocentral synchondrosis using magnetic resonance imaging in the normal skeletally immature spine
    Hong Zhang
    Center for Excellence in Spine Research, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 35:76-82. 2010
  4. ncbi request reprint Anterior vertebral body screw position placed thoracoscopically: a function of anatomy and surgeon experience in a porcine model
    Hong Zhang
    Texas Scottish Rite Hospital, Dallas 75219, USA
    Spine (Phila Pa 1976) 29:815-22. 2004
  5. pmc Neurocentral synchondrosis screws to create and correct experimental deformity: a pilot study
    Hong Zhang
    The Center for Excellence in Spine Research, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    Clin Orthop Relat Res 469:1383-90. 2011
  6. ncbi request reprint New rod-plate anterior instrumentation for thoracolumbar/lumbar scoliosis: biomechanical evaluation compared with dual-rod and single-rod with structural interbody support
    Hong Zhang
    Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 31:E934-40. 2006
  7. doi request reprint Unilateral pedicle screw epiphysiodesis of the neurocentral synchondrosis. Production of idiopathic-like scoliosis in an immature animal model
    Hong Zhang
    Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    J Bone Joint Surg Am 90:2460-9. 2008
  8. ncbi request reprint Recombinant human bone morphogenic protein-2-enhanced anterior spine fusion without bone encroachment into the spinal canal: a histomorphometric study in a thoracoscopically instrumented porcine model
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA
    Spine (Phila Pa 1976) 30:512-8. 2005
  9. ncbi request reprint Recombinant human bone morphogenetic protein-2 enhances anterior spinal fusion in a thoracoscopically instrumented animal model
    Daniel J Sucato
    Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    J Bone Joint Surg Am 86:752-62. 2004
  10. pmc Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism
    Nian Huang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Structure 16:196-209. 2008

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Histomorphometric assessment of thoracoscopically assisted anterior release in a porcine model: safety and completeness of disc discectomy with surgeon learning curve
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 32:188-92. 2007
    ..A retrospective study using histomorphometric analysis to quantify the percentage of discectomy following thoracoscopic anterior release and fusion in a porcine model...
  2. ncbi request reprint Novel dual-rod screw for thoracoscopic anterior instrumentation: biomechanical evaluation compared with single-rod and double-screw/double-rod anterior constructs
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 34:E183-8. 2009
    ..Biomechanical testing was performed on pig thoracic spines instrumented with 7-segment anterior scoliosis constructs...
  3. doi request reprint Morphometric analysis of neurocentral synchondrosis using magnetic resonance imaging in the normal skeletally immature spine
    Hong Zhang
    Center for Excellence in Spine Research, Texas Scottish Rite Hospital for Children, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 35:76-82. 2010
    ..Morphometric analysis of the neurocentral synchondrosis (NCS) using magnetic resonance imaging in the normal infantile and juvenile patients...
  4. ncbi request reprint Anterior vertebral body screw position placed thoracoscopically: a function of anatomy and surgeon experience in a porcine model
    Hong Zhang
    Texas Scottish Rite Hospital, Dallas 75219, USA
    Spine (Phila Pa 1976) 29:815-22. 2004
    ....
  5. pmc Neurocentral synchondrosis screws to create and correct experimental deformity: a pilot study
    Hong Zhang
    The Center for Excellence in Spine Research, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    Clin Orthop Relat Res 469:1383-90. 2011
    ..Unilateral pedicle screw epiphysiodesis of the neurocentral synchondrosis (NCS) can produce asymmetric growth of the synchondrosis to create scoliosis in an immature animal model...
  6. ncbi request reprint New rod-plate anterior instrumentation for thoracolumbar/lumbar scoliosis: biomechanical evaluation compared with dual-rod and single-rod with structural interbody support
    Hong Zhang
    Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    Spine (Phila Pa 1976) 31:E934-40. 2006
    ..OBJECTIVES.: To analyze the initial and post-fatigue biomechanical performance of the new implant, and compare it to an anterior dual-rod construct and a single-rod construct with interbody cages...
  7. doi request reprint Unilateral pedicle screw epiphysiodesis of the neurocentral synchondrosis. Production of idiopathic-like scoliosis in an immature animal model
    Hong Zhang
    Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    J Bone Joint Surg Am 90:2460-9. 2008
    ..The goal of this study was to determine whether asymmetric epiphysiodesis of this synchondrosis creates a scoliotic deformity in a growing-animal model and to correlate curve magnitude with the degree of closure of the synchondrosis...
  8. ncbi request reprint Recombinant human bone morphogenic protein-2-enhanced anterior spine fusion without bone encroachment into the spinal canal: a histomorphometric study in a thoracoscopically instrumented porcine model
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas, Texas 75219, USA
    Spine (Phila Pa 1976) 30:512-8. 2005
    ....
  9. ncbi request reprint Recombinant human bone morphogenetic protein-2 enhances anterior spinal fusion in a thoracoscopically instrumented animal model
    Daniel J Sucato
    Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219, USA
    J Bone Joint Surg Am 86:752-62. 2004
    ..The purpose of this study was to compare autologous iliac crest and rib graft with recombinant human bone morphogenetic protein-2 (rhBMP-2) in thoracoscopically assisted anterior spinal arthrodesis and instrumentation in an animal model...
  10. pmc Bifunctional NMN adenylyltransferase/ADP-ribose pyrophosphatase: structure and function in bacterial NAD metabolism
    Nian Huang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Structure 16:196-209. 2008
    ..The latter observation provided new insights into the ligand binding mode of ADPR-gated Ca2+ channel TRPM2...
  11. pmc A comprehensive update of the sequence and structure classification of kinases
    Sara Cheek
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    BMC Struct Biol 5:6. 2005
    ..This survey presents a complete global picture of this large functional class of proteins and confirms the soundness of our initial kinase classification scheme...
  12. ncbi request reprint Experimental tibial plateau fractures augmented with calcium phosphate cement or autologous bone graft
    Robert D Welch
    Seay Research Center, Texas Scottish Rite Hospital for Children, Dallas 75219, USA
    J Bone Joint Surg Am 85:222-31. 2003
    ..The objective of this study was to compare the effect of a calcium phosphate cement with that of impacted cancellous autograft for maintaining an anatomical reduction in an experimental model of a tibial plateau fracture...
  13. ncbi request reprint Thoracoscopic discectomy and fusion in an animal model: safe and effective when segmental blood vessels are spared
    Daniel J Sucato
    Texas Scottish Rite Hospital, Dallas, Texas, USA
    Spine (Phila Pa 1976) 27:880-6. 2002
    ....
  14. doi request reprint Structural basis for substrate binding and the catalytic mechanism of type III pantothenate kinase
    Kun Yang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biochemistry 47:1369-80. 2008
    ....
  15. pmc Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement
    Nian Huang
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    J Med Chem 53:5229-39. 2010
    ....
  16. ncbi request reprint Crystal structure of alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase: insight into the active site and catalytic mechanism of a novel decarboxylation reaction
    Dariusz Martynowski
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8816, USA
    Biochemistry 45:10412-21. 2006
    ..These data enable us to propose possible catalytic mechanisms for ACMSD which appear to be unprecedented among all currently characterized decarboxylases...
  17. pmc Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
    Nian Huang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Structure 17:939-51. 2009
    ..By comparing the crystal structures of NrtR in complex with DNA and with ADP-ribose, we identified a "Nudix switch" element that likely plays a critical role in the allosteric regulation of DNA binding and repressor function of NrtR...
  18. ncbi request reprint The thrH gene product of Pseudomonas aeruginosa is a dual activity enzyme with a novel phosphoserine:homoserine phosphotransferase activity
    S Kumar Singh
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Biol Chem 279:13166-73. 2004
    ....
  19. ncbi request reprint Structural analysis of Pseudomonas 1-aminocyclopropane-1-carboxylate deaminase complexes: insight into the mechanism of a unique pyridoxal-5'-phosphate dependent cyclopropane ring-opening reaction
    Subramanian Karthikeyan
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9038, USA
    Biochemistry 43:13328-39. 2004
    ..The results of mutagenesis studies corroborated the assigned critical role for Tyr294 in the catalysis...
  20. pmc Structure and mechanism of a eukaryotic FMN adenylyltransferase
    Carlos Huerta
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Mol Biol 389:388-400. 2009
    ..Structure-based investigation of the kinetic properties of FMNAT should offer insights into the regulatory mechanisms of FAD homeostasis by FMNAT in eukaryotic organisms...
  21. ncbi request reprint Ligand binding-induced conformational changes in riboflavin kinase: structural basis for the ordered mechanism
    Subramanian Karthikeyan
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biochemistry 42:12532-8. 2003
    ..The structural data obtained so far on human and yeast RFK complexes provide a rationale for the ordered kinetic mechanism of RFK...
  22. ncbi request reprint Subchondral defects in caprine femora augmented with in situ setting hydroxyapatite cement, polymethylmethacrylate, or autogenous bone graft: biomechanical and histomorphological analysis after two-years
    Robert D Welch
    Seay Center for Musculoskeletal Research, Texas Scottish Rite Hospital for Children, Dallas 75219, USA
    J Orthop Res 20:464-72. 2002
    ....
  23. ncbi request reprint Regional differences in anatomical landmarks for placing anterior instrumentation of the thoracic spine in both normal patients and patients with adolescent idiopathic scoliosis
    Hong Zhang
    Texas Scottish Rite Hospital for Children, Dallas 75219, USA
    Spine (Phila Pa 1976) 31:183-9. 2006
    ..A retrospective analysis of patients who had magnetic resonance imaging (MRI) of the thoracic spine, comparing those with a normal straight spine and those with a right thoracic adolescent idiopathic scoliosis (AIS)...
  24. ncbi request reprint Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch
    Subramanian Karthikeyan
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Structure 11:265-73. 2003
    ..The invariant residues Asn36 and Glu86 are implicated in the catalysis...
  25. pmc Crystal structure of a type III pantothenate kinase: insight into the mechanism of an essential coenzyme A biosynthetic enzyme universally distributed in bacteria
    Kun Yang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8816, USA
    J Bacteriol 188:5532-40. 2006
    ..coli PanK -- which is a member of the "P-loop kinase"superfamily -- this finding represents yet another example of convergent evolution of the same biological function from a different protein ancestor...
  26. pmc Structure of C3PO and mechanism of human RISC activation
    Xuecheng Ye
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Nat Struct Mol Biol 18:650-7. 2011
    ..The current work supports a Dicer-independent mechanism for human RISC activation, in which Ago2 directly binds duplex siRNA and nicks the passenger strand, and then C3PO activates RISC by degrading the Ago2-nicked passenger strand...
  27. ncbi request reprint Chemically functionalized carbon films for single molecule imaging
    Marc C Llaguno
    Department of Cell Biology, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390, USA
    J Struct Biol 185:405-17. 2014
    ....
  28. pmc Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting
    Shwu Yuan Wu
    Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 49:843-57. 2013
    ..The unmasking of bromodomains and activator recruitment, concurrently triggered by the CK2 phospho switch, provide an intriguing mechanism for gene-specific targeting by a universal epigenetic reader...
  29. pmc Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein
    Qiang Ge
    Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41914-21. 2012
    ....
  30. pmc Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex
    Nian Huang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 337:189-94. 2012
    ..The structure of the CLOCK:BMAL1 complex is a starting point for understanding at an atomic level the mechanism driving the mammalian circadian clock...
  31. ncbi request reprint The effect of hemorrhagic shock in a caprine tibial fracture model
    Adam J Starr
    Department of Orthopaedic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Orthop Trauma 16:250-6. 2002
    ..The purpose of this study was to assess effects of hemorrhagic shock on fracture healing in a large animal closed fracture model...
  32. ncbi request reprint Raptor protein contains a caspase-like domain
    Krzysztof Ginalski
    Biochemistry Department, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    Trends Biochem Sci 29:522-4. 2004
    ..This finding suggests several unexpected aspects of raptor function in the target of rapamycin (TOR) signaling pathway...
  33. pmc Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2
    Paul R Mayer
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 285:40387-96. 2010
    ..These studies show that Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway...
  34. ncbi request reprint Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis
    Xuejun Zhang
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 278:13503-11. 2003
    ..The characterization of the cytosolic human PNAT-3 provided compelling evidence that the final steps of NAD biosynthesis pathways may exist in mammalian cytoplasm and mitochondria, potentially contributing to their NAD/NADP pool...
  35. doi request reprint Progress of experimental study on treatment of psoriasis by Chinese medicinal monomer and single or compound recipe in Chinese materia medica
    Hong Zhang
    Department of Dermatology, Changhai Hospital, The Second Military Medical University, Shanghai, 200433, China
    Chin J Integr Med 13:312-6. 2007
    ..However, the exploration into traditional Chinese medicines' biomechanics in psoriasis and the therapeutic mechanism of CMs by integrative medicine still requires further studies...
  36. ncbi request reprint Identification and characterization of label-retaining cells in mouse pancreas
    Chunbo Teng
    Laboratory of Chemical Genomics, Shenzhen Graduate School, Peking University, Shenzhen, China
    Differentiation 75:702-12. 2007
    ....
  37. ncbi request reprint [Influence of N-acetylcysteine on the cytokines and matrix metalloproteinases in chronic obstructive pulmonary disease rat models]
    Ling Xu
    Department of Respiratory Disease, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China
    Zhonghua Nei Ke Za Zhi 43:595-9. 2004
    ....
  38. pmc Identification and characterization of an archaeon-specific riboflavin kinase
    Zahra Mashhadi
    Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    J Bacteriol 190:2615-8. 2008
    ..Some divalent metals were found to be potent inhibitors of the reaction. The enzyme represents a unique CTP-dependent family of kinases...
  39. ncbi request reprint Optimal expression condition of recombinant RAP
    Jie Zhang
    Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    J Huazhong Univ Sci Technolog Med Sci 27:5-8. 2007
    ..It was concluded that the expression condition of recombinant RAP was optimized and functional RAP was obtained, which offered a good foundation for the further production of RAP as research tool...
  40. pmc Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice
    Joel N H Stern
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 105:5172-6. 2008
    ..e., PLP139-151(EAE), MBP85-99 (EAE), and bovine peripheral nerve myelin (experimental autoimmune neuritis), indicating they function by bystander suppression...
  41. doi request reprint Efficient recovery of a functional extracellular domain of bovine IgG2 Fc receptor (boFcgamma2R) from inclusion bodies by a rapid dilution refolding system
    Gaiping Zhang
    Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China
    J Immunol Methods 334:21-8. 2008
    ..68 microM. The overall yield of the active rsbo2R was up to 20 mg/l of culture. Crystals of the rsbo2R were grown at 293 K by the hanging-drop vapour diffusion method showed weak diffraction...
  42. pmc Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
    Heng Du
    Department of Surgery, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, New York, New York 10032, USA
    Nat Med 14:1097-105. 2008
    ..Blockade of CypD may be a therapeutic strategy in Alzheimer's disease...
  43. pmc Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease
    Fabrizio Trinchese
    Department of Pathology and Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, New York, USA
    J Clin Invest 118:2796-807. 2008
    ..Thus, calpain inhibition may prove useful in the alleviation of memory loss in AD...
  44. ncbi request reprint Association of first ocular melanoma with subsequent cutaneous melanoma: results from the Swedish Family-Cancer Database
    Kari Hemminki
    Int J Cancer 104:257-8. 2003
  45. pmc Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
    Sergey V Voronov
    Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:9415-20. 2008
    ....
  46. doi request reprint Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors
    Martin A Storr
    Division of Gastroenterology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Mol Med (Berl) 86:925-36. 2008
    ..In conclusion, drugs targeting EC degradation offer therapeutic potential in the treatment of inflammatory bowel diseases. Furthermore, reduction of FAAH mRNA expression is involved in the pathophysiological response to colitis...
  47. doi request reprint Antibody microarray analyses of signal transduction protein expression and phosphorylation during porcine oocyte maturation
    Steven Pelech
    Kinexus Bioinformatics Corporation, Suite 1, 8755 Ash Street, Vancouver, BC, Canada V6P 6T3
    J Proteome Res 7:2860-71. 2008
    ....
  48. pmc Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation
    Alim Muhammad
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 105:7327-32. 2008
    ..By recapitulating features of the disease, these animal models suggest that retromer deficiency observed in late-onset Alzheimer's disease can contribute to disease pathogenesis...
  49. doi request reprint Tumor response kinetics after schedule-dependent paclitaxel chemoradiation treatment for inoperable non-small cell lung cancer: a model for low-dose chemotherapy radiosensitization
    Hong Zhang
    Departments of Radiation Oncology, James P Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York, USA
    J Thorac Oncol 3:563-8. 2008
    ..Given our unique results, we analyzed the tumor response kinetics and conducted a statistical modeling of tumor response to characterize this regimen...
  50. pmc Use of gene expression profiles in cells of peripheral blood to identify new molecular markers of acute pancreatitis
    Martin Bluth
    Department of Surgery, SUNY Downstate Medical Center, Box 40, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Arch Surg 143:227-33; discussion 233-4. 2008
    ....
  51. ncbi request reprint Hepatocyte growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells
    Sheng Hua Chu
    Department of Neurosurgery, No 3 People s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China
    J Neurooncol 85:33-8. 2007
    ..These results suggest that both TGF-betas and gangliosides may act as indirect angiogenic factors by stimulating HGF secretion...
  52. ncbi request reprint [Effect of the ethyl acetate extract of zhi ju zi on serum makers and the expression of TGF-beta1 in rats with hepatic fibrosis]
    Fei Wang
    Renmin Hospital, Wuhan University, Wuhan 430060, China
    Zhong Yao Cai 29:577-80. 2006
    ..To study the effect of the Ethyl Acetate Extract of Zhi Ju Zi on hepatic fibrosis...
  53. ncbi request reprint Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
    Bing Gong
    Department of Pathology and Taub Institute, Columbia University, New York, NY 10032, USA
    Cell 126:775-88. 2006
    ..The beneficial effect of the Uch-L1 fusion protein is associated with restoration of normal levels of the PKA-regulatory subunit IIalpha, PKA activity, and CREB phosphorylation...
  54. ncbi request reprint Clinical significance of TGF- beta1 and beta-glucuronidase synchronous detection in human pancreatic cancer
    Hui Yue
    Department of Digestive Diseases, People s Hospital, Wuhan University, Wuhan 430071, China
    Hepatobiliary Pancreat Dis Int 1:309-11. 2002
    ..To investigate the relation of transfer growth factor (TGF-beta1) and beta-glucuronidase (beta-GCD) on the occurrence and progress of pancreatic cancer...
  55. ncbi request reprint Lethality in mice infected with recombinant vaccinia virus expressing hepatitis C virus core protein
    Hong Zhang
    Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA
    Hepatobiliary Pancreat Dis Int 2:374-82. 2003
    ..To establish a mouse model of HCV core expression and investigate the toxicity of HCV core protein or the possible pathogenic effects...
  56. ncbi request reprint Establishment of BMD reference plots and determination of peak BMD at multiple skeletal regions in mainland Chinese women and the diagnosis of osteoporosis
    Xian Ping Wu
    Institute of Metabolism and Endocrinology, Second Xiang Ya Hospital, Central South University, 86 Renmin Zhong Road, 410011 Changsha, Hunan, China
    Osteoporos Int 15:71-9. 2004
    ..Therefore, we suggest that a standardized method be established to calculate site-specific PBMDs based on the peak values of best-fit reference curves in appropriate age groups...
  57. ncbi request reprint The expression and functional characterization of ABCG2 in brain endothelial cells and vessels
    Wandong Zhang
    Institute for Biological Sciences, NRC, 1200 Montreal Road Campus, Bldg M 54, Ottawa, Ontario, Canada K1A 0R6
    FASEB J 17:2085-7. 2003
    ..ABCG2 was up-regulated in both glioblastoma vessels and parenchymal tissue. These studies suggest a role for brain endothelial ABCG2 transporter in modulating drug delivery to the brain and in conferring drug resistance to glioblastomas...
  58. ncbi request reprint Antisense oligonucleotide inhibition of Bcl-xL and Bid expression in liver regulates responses in a mouse model of Fas-induced fulminant hepatitis
    Hong Zhang
    Gene Trove Division, Isis Pharmaceuticals, Inc, Carlsbad, California, USA
    J Pharmacol Exp Ther 307:24-33. 2003
    ..In addition, this is the first reported example demonstrating the ability of antisense inhibitors to reduce expression of multiple proteins in animals by simultaneous dosing...
  59. ncbi request reprint Screening for functional genes related to a novel gene, AngRem104, in human mesangial cells by cDNA microarray
    Xiu Bin Liang
    Renal Division of Peking University First Hospital, Institute of Nephrology, Peking University, Beijing 100034, PR China
    Biotechnol Lett 25:139-42. 2003
    ..Thirty-one genes were up-regulated while 2 genes were down-regulated. Of all the up-regulated genes, fibronectin, one of the major extracellular matrixes, was up-regulated with over-expression of AngRem104...
  60. ncbi request reprint Effects of fucoidan on chronic renal failure in rats
    Quanbin Zhang
    Institute of Oceanology, Chinese Academy of Sciences, Qingdao, P R China
    Planta Med 69:537-41. 2003
    ..Histopathological changes of renal tubules and interstitium were markedly alleviated by fucoidan and the mesangial areas were also greatly reduced. The activities of fucoidan were dose-dependent...
  61. ncbi request reprint Establishment and evaluation of bone mineral density reference databases appropriate for diagnosis and evaluation of osteoporosis in Chinese women
    Er Yuan Liao
    Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, Changsha, 86 Renmin Zhong Rd, Hunan 410011, P R China
    J Bone Miner Metab 21:184-92. 2003
    ....
  62. ncbi request reprint Site-directed mutagenesis and functional analysis of an active site tryptophan of insect chitinase
    Hong Zhang
    Department of Biochemistry, Kansas State University, Manhattan, Kansas 66506, USA
    Insect Biochem Mol Biol 32:1477-88. 2002
    ..The variations in kcat's among the mutated enzymes and the IC50 for the transition state inhibitor analog, allosamidin, indicate that W145 also influences formation of the transition state during catalysis...
  63. ncbi request reprint [The change in apoptosis and proliferation of pulmonary tissue cells in rats with smoke inhalation injury]
    Wenjun Li
    Institute of Burn Research, Southwestern Hospital, The Third Military Medical University, Chongqing 400038, P R China
    Zhonghua Shao Shang Za Zhi 18:139-41. 2002
    ..To observe the rule of the change of apoptosis and proliferation of pulmonary tissue cells in rats with inhalation injury, so as to explore the significance of apoptosis in the repairing process of pulmonary tissue injury...
  64. ncbi request reprint Cellular response to hypoxia involves signaling via Smad proteins
    Hong Zhang
    Department of Anatomy and Cell Biology, The Division of Hematology Oncology, Center for Cardiovascular and Molecular Medicine, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Blood 101:2253-60. 2003
    ..Autocrine regulation of TGF-beta2 production in hypoxia may involve cross-talk between Smad3 and HIF-1alpha signaling pathways, and could be an important mechanism by which endothelial cells respond to hypoxic stress...
  65. ncbi request reprint [Clinical analysis of 271 cases of orbital inflammatory pseudotumors]
    Hong Zhang
    Department of Ophthalmology, The Second Teaching Hospital, Tianjin Medical University, Tianjin 300211, China
    Zhonghua Yan Ke Za Zhi 38:484-7. 2002
    ..To analyze and summarize the clinical signs, the diagnostic and differential diagnostic value of imaging examination in orbital inflammatory pseudo-tumors and the comparison of the therapeutic effect of various treatments...
  66. pmc Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
    Hong Zhang
    Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Mol Cell Biol 22:6498-508. 2002
    ..Our results indicate that both SUMO modification and demodification of proteins may occur at the NPC and suggest a connection between the SUMO modification pathway and nucleocytoplasmic transport...
  67. ncbi request reprint Purification and characterization of acylation stimulating protein from porcine serum
    Hong Zhang
    Department of Animal Science, Biotechnology Center, University of Nebraska, Lincoln, NE 68583 0908, USA
    Protein Expr Purif 25:348-52. 2002
    ..Based on this evidence that ASP exists in porcine blood, and that it has acylation stimulating activity, we propose that ASP may play a role in regulation of energy storage in adipose tissue in the pig...
  68. ncbi request reprint Characterization of recombinant microsporidian methionine aminopeptidase type 2
    Louis M Weiss
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Eukaryot Microbiol 50:597-9. 2003
  69. ncbi request reprint [The experimental study of histomorphology and biomechanical of cortical strut allograft in proximal femoral]
    Ying Li
    Department of Orthopeadics and Traumatology, Jishuitan Hospital, Medical School, Peking University, Beijing 100035, China
    Zhonghua Wai Ke Za Zhi 42:107-9. 2004
    ..To explore the deep-frozen allograft strut in the rabbits for the sake of finding some evidence to support the clinical practice of cortical strut allograft...
  70. ncbi request reprint Improvement of expression level and bioactivity of soluble tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) by a novel zinc ion feeding strategy
    Ai You Sun
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, PR China
    Biotechnol Lett 28:1215-9. 2006
    ..Furthermore, the purified TRAIL showed stronger cytotoxicity activity against human pancreatic 1990 tumor cells as the molar ratio of Zn(2+) to TRAIL monomer was 2 in purified TRAIL solution...
  71. pmc A biochemical rationale for the anticancer effects of Hsp90 inhibitors: slow, tight binding inhibition by geldanamycin and its analogues
    Lata T Gooljarsingh
    Department of Enzymology and Mechanistic Pharmacology, GlaxoSmithKline, Collegeville, PA 19426, USA
    Proc Natl Acad Sci U S A 103:7625-30. 2006
    ..In the broader context, these studies highlight the essentiality of detailed biochemical characterization of drug-target interactions for the effective translation of in vitro pharmacology to cellular and in vivo efficacy...
  72. ncbi request reprint Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics
    Hong Zhang
    Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario M5S 3H6, Canada
    Biomacromolecules 7:1568-72. 2006
    ..This rational drug delivery design may be useful in enhancing cancer therapy and reducing side effects...
  73. ncbi request reprint Enhancement of splenic glucose metabolism during acute malarial infection: correlation of findings of FDG-PET imaging with pathological changes in a primate model of severe human malaria
    Satoru Kawai
    Department of Tropical Medicine and Parasitology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Am J Trop Med Hyg 74:353-60. 2006
    ..We suggest that increase in splenic glucose uptake may thus be closely related to activation of splenic clearance system against blood-stage malarial parasites...
  74. ncbi request reprint Sophorolipids block lethal effects of septic shock in rats in a cecal ligation and puncture model of experimental sepsis
    Martin H Bluth
    SUNY Downstate Medical Center, Department of Surgery, Brooklyn, NY 11203, USA
    Crit Care Med 34:188-95. 2006
    ..The potential of the therapeutic effect of sophorolipids was investigated in vivo in a rat model of sepsis and in vitro by analysis of nitric oxide and cytokine production...
  75. ncbi request reprint Fabrication of three-dimensional porous scaffolds of complicated shape for tissue engineering. I. Compression molding based on flexible-rigid combined mold
    Linbo Wu
    Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai, China
    Tissue Eng 11:1105-14. 2005
    ..Good viability of cells seeded in the porous scaffolds was confirmed. This novel fabrication method is promising in tissue engineering because of its ability to produce precise and complexly (anatomically) shaped porous scaffolds...
  76. ncbi request reprint Synaptic fatigue is more pronounced in the APP/PS1 transgenic mouse model of Alzheimer's disease
    Hong Zhang
    Department of Pathology and the Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Curr Alzheimer Res 2:137-40. 2005
    ..26 -/+ 2% in WT. Thus, it is likely that presynaptic mechanisms underlying SF but not PPF and PTP, may account for synaptic dysfunction in APP/PS1 mice...
  77. ncbi request reprint Cerebral metabolic reduction in severe malaria: fluorodeoxyglucose-positron emission tomography imaging in a primate model of severe human malaria with cerebral involvement
    Munehiro Sugiyama
    Department of Parasitology, Gunma University Graduate School of Medicine, Maebashi 371 8511, Japan
    Am J Trop Med Hyg 71:542-5. 2004
    ..This suggests that reduction of cerebral metabolism occurs before parenchymal changes appear in the brain. This may be one reason why more than half of the patients with cerebral malaria have no neurologic sequelae after recovery...
  78. ncbi request reprint Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy
    Jimmy Lindberg
    Department of Cell and Molecular Biology, BMC, Uppsala University, Sweden
    Eur J Biochem 271:4594-602. 2004
    ..These data will be used in the development of potent inhibitors with different pharmacokinetic profiles towards resistant protease mutants...
  79. ncbi request reprint Monodisperse chitosan nanoparticles for mucosal drug delivery
    Hong Zhang
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario M5S 3H6, Canada
    Biomacromolecules 5:2461-8. 2004
    ..The model protein, bovine serum albumin, was encapsulated into the NPs, and the in vitro release profiles were examined in physiologically relevant media at 37 degrees C...
  80. ncbi request reprint [Effect of dexamethasone on adhesion and phagocytosis of bovine trebacular meshwork cells]
    Zhongguo Li
    Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Yan Ke Xue Bao 20:127-30. 2004
    ..To study the effect of dexamethasone on adhesion and phagocyosis of bovine trebacular cells (BTC)...
  81. ncbi request reprint Relationship of body surface area with bone density and its risk of osteoporosis at various skeletal regions in women of mainland China
    Xian Ping Wu
    Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, 86 Renmin Zhong Road, 410011, Changsha, Hunan, People s Republic of China
    Osteoporos Int 15:751-9. 2004
    ..However, when vBMD is used, these differences diminish or even disappear...
  82. ncbi request reprint Vascular tone estimation in patients implanted with the AbioCor implantable replacement heart
    Robert T V Kung
    ABIOMED Inc, 22 Cherry Hill Drive, Danvers, MA 01923, U S A
    Artif Organs 28:543-8. 2004
    ..The AbioCor implantable replacement heart's hydraulic drive system is capable of providing valuable physiological information, including estimates of physiological pressures, cardiac outputs, and vascular tones...
  83. ncbi request reprint Effects of skeletal size of the lumbar spine on areal bone density, volumetric bone density, and the diagnosis of osteoporosis in postmenopausal women in China
    Er Yuan Liao
    Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, Changsha, 86 Renmin Zhong Road, Hunan 410011, PR China
    J Bone Miner Metab 22:270-7. 2004
    ..When we use vBMD to diagnose osteoporosis, the effect of body size on BMD will diminish...
  84. ncbi request reprint [Protective effect of Ginkgo biloba extract on acute lung injury induced by lipopolysaccharide in D-galactose aging rats]
    Renyu Sun
    Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China
    Zhonghua Jie He He Hu Xi Za Zhi 25:352-5. 2002
    ..To investigate the effect of Ginkgo biloba extract (GBE) on acute lung injury(ALI) induced by lipopolysaccharide (LPS) in aging rats...