M Younes

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint What is the role of cytokeratins in Barrett/cardia differentiation?
    Mamoun Younes
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:181-2. 2005
  2. ncbi request reprint Incidence and survival trends of esophageal carcinoma in the United States: racial and gender differences by histological type
    M Younes
    Dept of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Scand J Gastroenterol 37:1359-65. 2002
  3. ncbi request reprint Receptor activator of nuclear factor kappaB (RANK) is expressed as a late event during malignant progression in Barrett's metaplasia
    R Yorke
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Eur J Cancer 39:2099-102. 2003
  4. ncbi request reprint Estrogen receptor beta is expressed in human colorectal adenocarcinoma
    D Witte
    Department of Pathology, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Hum Pathol 32:940-4. 2001
  5. ncbi request reprint Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival
    M Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Anticancer Res 21:575-8. 2001
  6. ncbi request reprint Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines
    P Fiumara
    Department of Lymphoma and Myeloma, Head and Neck Surgery, and Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 98:2784-90. 2001
  7. ncbi request reprint Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas
    M Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Anticancer Res 20:3775-9. 2000
  8. ncbi request reprint Detection of oxidative DNA damage in oesophageal biopsies of patients with reflux symptoms and normal pH monitoring
    L Liu
    Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Aliment Pharmacol Ther 18:693-8. 2003
  9. ncbi request reprint Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation
    Nicole Carlson
    Department of Pathology and Medicine, Baylor College of Medicine, Methodist Hospital, Houston, Texas 77030, USA
    Am J Gastroenterol 97:1340-5. 2002
  10. ncbi request reprint Expression of estrogen receptor-beta isoforms in Barrett's metaplasia, dysplasia and esophageal adenocarcinoma
    Liang Liu
    Department of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, TX 77030, USA
    Anticancer Res 24:2919-24. 2004

Collaborators

Detail Information

Publications25

  1. ncbi request reprint What is the role of cytokeratins in Barrett/cardia differentiation?
    Mamoun Younes
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Arch Pathol Lab Med 129:181-2. 2005
    ..However, because it may be associated with premalignant lesions elsewhere in the gastric mucosa, we propose that intestinal metaplasia of the gastric cardia may have the same clinical implication as Barrett metaplasia...
  2. ncbi request reprint Incidence and survival trends of esophageal carcinoma in the United States: racial and gender differences by histological type
    M Younes
    Dept of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, Texas 77030, USA
    Scand J Gastroenterol 37:1359-65. 2002
    ....
  3. ncbi request reprint Receptor activator of nuclear factor kappaB (RANK) is expressed as a late event during malignant progression in Barrett's metaplasia
    R Yorke
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Eur J Cancer 39:2099-102. 2003
    ..These results indicate that RANK is expressed as a late event during malignant progression in BM. Studies are needed to determine whether interfering with RANK signalling affects the survival of EA cells...
  4. ncbi request reprint Estrogen receptor beta is expressed in human colorectal adenocarcinoma
    D Witte
    Department of Pathology, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Hum Pathol 32:940-4. 2001
    ..Whether different ER-beta isoforms are differentially expressed in CRCs, and whether human CRCs respond to treatment with antiestrogens, is the subject of studies currently in progress...
  5. ncbi request reprint Glut 1 expression in transitional cell carcinoma of the urinary bladder is associated with poor patient survival
    M Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Anticancer Res 21:575-8. 2001
    ..0109), but showed no significant difference in the incidence of nodal metastasis (p = 0.4258). Our results suggest that Glut1 expression in TCCB is a marker of aggressive biologic potential in patients undergoing cystectomy...
  6. ncbi request reprint Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines
    P Fiumara
    Department of Lymphoma and Myeloma, Head and Neck Surgery, and Bioimmunotherapy, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 98:2784-90. 2001
    ..The coexpression of RANK and RANKL in H/RS cells suggests that they may regulate cytokine and chemokine secretion in H/RS cells by an autocrine mechanism...
  7. ncbi request reprint Expression of the neutral amino acids transporter ASCT1 in esophageal carcinomas
    M Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Anticancer Res 20:3775-9. 2000
    ..Additional studies with larger number of patients are needed to determine the biological significance of ASCT1 expression in esophageal carcinomas...
  8. ncbi request reprint Detection of oxidative DNA damage in oesophageal biopsies of patients with reflux symptoms and normal pH monitoring
    L Liu
    Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Aliment Pharmacol Ther 18:693-8. 2003
    ..Gastro-oesophageal reflux has been shown to induce oxidative DNA damage...
  9. ncbi request reprint Acid suppression therapy may not alter malignant progression in Barrett's metaplasia showing p53 protein accumulation
    Nicole Carlson
    Department of Pathology and Medicine, Baylor College of Medicine, Methodist Hospital, Houston, Texas 77030, USA
    Am J Gastroenterol 97:1340-5. 2002
    ..The aim of this study was to test the hypothesis that AST may not alter malignant progression in BM if key genes involved in DNA repair and cell cycle control, particularly p53, are defective...
  10. ncbi request reprint Expression of estrogen receptor-beta isoforms in Barrett's metaplasia, dysplasia and esophageal adenocarcinoma
    Liang Liu
    Department of Pathology, Baylor College of Medicine, The Methodist Hospital, Houston, TX 77030, USA
    Anticancer Res 24:2919-24. 2004
    ..T1 and T2, p=0.051). We conclude that ER-B1, ER-B2, ER-B3 and ER-B5 are overexpressed in EA compared to its precursor lesion BMND, suggesting a significant biological role for steroid hormones in EA...
  11. ncbi request reprint Expression of the high mobility group proteins HMGI(Y) correlates with malignant progression in Barrett's metaplasia
    Xueyun Chen
    Department of Pathology, Section of Gastroenterology, Baylor College of Medicine and The Methodist Hospital, Houston, Texas, USA
    Cancer Epidemiol Biomarkers Prev 13:30-3. 2004
    ..Additional studies are needed to determine whether BM biopsies that are ND or LGD/IND and positive for HMGI(Y) are more likely to progress to adenocarcinoma...
  12. ncbi request reprint Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia
    Mamoun Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arch Pathol Lab Med 131:571-5. 2007
    ..However, we have seen cases diagnosed as Barrett metaplasia based solely on cells that pose morphologic similarity to ITGCs on hematoxylin-eosin staining or stain positive with Alcian blue...
  13. ncbi request reprint Non-dysplastic and dysplastic Barrett's mucosa and adenocarcinoma lack a subepithelial myofibroblastic cell layer
    Yve Huttenbach
    Department of Pathology, Baylor College of Medicine, Methodist Hospital, Houston, TX 77030, USA
    Anticancer Res 23:2261-5. 2003
    ..We hypothesize that lack of the SMF cell layer in BM may contribute to the quick progression to esophageal adenocarcinoma, which, unlike that in the colon, occurs before an exophytic lesion becomes evident...
  14. doi request reprint Gastrointestinal pathology: selected reviews from the 47th Annual Spring Symposium of the Houston Society of Clinical Pathologists, April 2007
    Mamoun Younes
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Arch Pathol Lab Med 132:1576. 2008
  15. ncbi request reprint Estrogen receptor-beta is expressed in Barrett's metaplasia and associated adenocarcinoma of the esophagus
    Hulya Akgun
    Department of Pathology, Baylor College of Medicine and The Methodist Hospital Houston, TX 77030, USA
    Anticancer Res 22:1459-61. 2002
    ..These findings raise the possibility that esophageal adenocarcinomas may benefit from treatment and/or chemoprevention with antiestrogens, such as tamoxifen...
  16. ncbi request reprint Is the incidence of esophageal adenocarcinomas in patients with Barrett's esophagus really overestimated?
    Mamoun Younes
    Gastroenterology 129:2125-6; author reply 2126. 2005
  17. ncbi request reprint Differential trends in the intestinal and diffuse types of gastric carcinoma in the United States, 1973-2000: increase in the signet ring cell type
    Donald Earl Henson
    Department of Pathology and the Office of Cancer Prevention and Control, The George Washington University Cancer Institute, Washington, DC 20037, USA
    Arch Pathol Lab Med 128:765-70. 2004
    ..This decline has primarily included the intestinal type (Lauren classification). However, there is an impression among pathologists that the diffuse type, especially the signet ring cell subtype, has become more prevalent...
  18. ncbi request reprint Glut3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival
    Susan Baer
    Department of Pathology, Baylor College of Medicine and Methodist Hospital, Houston, Texas 77030, USA
    Laryngoscope 112:393-6. 2002
    ..The aim of the study was to determine the clinical significance of the expression of Glut1 and Glut3 proteins in biopsy specimens of squamous cell carcinoma (SCC) of the larynx...
  19. ncbi request reprint Functional expression of TRAIL receptors TRAIL-R1 and TRAIL-R2 in esophageal adenocarcinoma
    Mamoun Younes
    Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Eur J Cancer 42:542-7. 2006
    ..Targeting of these receptors by agonist monoclonal antibodies may be of therapeutic value in patients with EA...
  20. ncbi request reprint Expression of the vascular endothelial growth factor receptor-3 (VEGFR-3) and its ligand VEGF-C in human colorectal adenocarcinoma
    Deborah Witte
    Department of Pathology, Baylor College of Medicine and The Methodist Hospital, Houston, TX 77030, USA
    Anticancer Res 22:1463-6. 2002
    ..05), but not with lymph node metastasis or depth of tumor invasion. Our results suggest that VEGFs promote cancer growth not only by stimulating angiogenesis, but also by acting on receptors present on the cancer cells themselves...
  21. ncbi request reprint Immunohistochemical detection of telomerase reverse transcriptase in colorectal adenocarcinoma and benign colonic mucosa
    Randy Wei
    Department of Pathology, Baylor College of Medicine and Methodist Hospital, Houston, TX 77030, USA
    Hum Pathol 33:693-6. 2002
    ..Additional studies with larger patient samples and multivariate analysis are needed to determine whether TRT expression is an independent prognostic factor in CRC...
  22. ncbi request reprint Can proton pump inhibitors be blamed for the rising incidence of esophageal cancer?
    Mamoun Younes
    Gastroenterology 125:1912; author reply 1912-3. 2003
  23. ncbi request reprint c-kit proto-oncogene product is rarely detected in colorectal adenocarcinoma
    Rebecca Yorke
    J Clin Oncol 21:3885-6; discussion 3886-7. 2003
  24. ncbi request reprint Overexpression of the neutral amino acid transporter ASCT2 in human colorectal adenocarcinoma
    Deborah Witte
    Department of Pathology, Baylor College of Medicine, Methodist Hospital, Houston, TX, USA
    Anticancer Res 22:2555-7. 2002
    ..Larger studies with multivariate analysis are needed to determine whether ASCT2 expression is an independent prognostic marker in CRC...
  25. ncbi request reprint P53 protein and malignant progression in Barrett's metaplasia (Barrett's esophagus)
    Mamoun Younes
    Am J Gastroenterol 98:1200-1; author reply 1201. 2003