Alvin T Yeh

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses
    Qiaofeng Wu
    Department of Biomedical Engineering, Texas A and M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, TX 77843, USA
    Biomed Opt Express 2:1135-46. 2011
  2. ncbi request reprint Molecular interactions of exogenous chemical agents with collagen--implications for tissue optical clearing
    Alvin T Yeh
    Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    J Biomed Opt 11:014003. 2006
  3. ncbi request reprint Advances in nonlinear optical microscopy for visualizing dynamic tissue properties in culture
    Alvin T Yeh
    Department of Biomedical Engineering, Texas A and M University, College Staion, TX 77843, USA
    Tissue Eng Part B Rev 14:119-31. 2008
  4. doi request reprint Two-photon excited fluorescence enhancement with broadband versus tunable femtosecond laser pulse excitation
    Chao Wang
    Texas A and M University, Department of Biomedical Engineering, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 17:025003. 2012
  5. pmc Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling
    Laura E Niklason
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:3335-9. 2010
  6. ncbi request reprint Correlation between collagen solubility and skin optical clearing using sugars
    Jason Hirshburg
    Department of Biomedical Engineering, Texas A and M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    Lasers Surg Med 39:140-4. 2007
  7. doi request reprint Molecular basis for optical clearing of collagenous tissues
    Jason M Hirshburg
    Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    J Biomed Opt 15:055002. 2010
  8. pmc Dynamic multicomponent engineered tissue reorganization and matrix deposition measured with an integrated nonlinear optical microscopy-optical coherence microscopy system
    Yuqiang Bai
    Texas A and M University, Department of Biomedical Engineering, 5045 Emerging Technologies Building, College Station, Texas 77843
    J Biomed Opt 19:36014. 2014
  9. doi request reprint Rabbit cornea microstructure response to changes in intraocular pressure visualized by using nonlinear optical microscopy
    Qiaofeng Wu
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Cornea 27:202-8. 2008
  10. doi request reprint Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices
    Po Feng Lee
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Exp Cell Res 315:396-410. 2009

Research Grants

Collaborators

Detail Information

Publications26

  1. pmc Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses
    Qiaofeng Wu
    Department of Biomedical Engineering, Texas A and M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, TX 77843, USA
    Biomed Opt Express 2:1135-46. 2011
    ..Cross-sectional images of collagen lamellae, visible in NLOM, showed inhomogeneous collagen structure along the anterior-posterior direction that correlated well with the noted heterogeneous corneal mechanical responses...
  2. ncbi request reprint Molecular interactions of exogenous chemical agents with collagen--implications for tissue optical clearing
    Alvin T Yeh
    Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    J Biomed Opt 11:014003. 2006
    ..A mechanism of tissue optical clearing is proposed based on agent destabilization of high-order collagen structures...
  3. ncbi request reprint Advances in nonlinear optical microscopy for visualizing dynamic tissue properties in culture
    Alvin T Yeh
    Department of Biomedical Engineering, Texas A and M University, College Staion, TX 77843, USA
    Tissue Eng Part B Rev 14:119-31. 2008
    ....
  4. doi request reprint Two-photon excited fluorescence enhancement with broadband versus tunable femtosecond laser pulse excitation
    Chao Wang
    Texas A and M University, Department of Biomedical Engineering, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 17:025003. 2012
    ..These pulse properties were also exploited for demonstrating its potential applications in multicolor imaging with TPM...
  5. pmc Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modeling
    Laura E Niklason
    Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 107:3335-9. 2010
    ....
  6. ncbi request reprint Correlation between collagen solubility and skin optical clearing using sugars
    Jason Hirshburg
    Department of Biomedical Engineering, Texas A and M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    Lasers Surg Med 39:140-4. 2007
    ..This study examines the correlation between collagen solubility and the optical clearing potential (OCP) of sugars and sugar-alcohols using in vitro rodent skin...
  7. doi request reprint Molecular basis for optical clearing of collagenous tissues
    Jason M Hirshburg
    Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    J Biomed Opt 15:055002. 2010
    ..Our results suggest that a necessary property of optical clearing agents is hyperosmolarity to tissue, but that the most effective agents with the highest rates of optical clearing are a subset with the highest collagen solubilities...
  8. pmc Dynamic multicomponent engineered tissue reorganization and matrix deposition measured with an integrated nonlinear optical microscopy-optical coherence microscopy system
    Yuqiang Bai
    Texas A and M University, Department of Biomedical Engineering, 5045 Emerging Technologies Building, College Station, Texas 77843
    J Biomed Opt 19:36014. 2014
    ....
  9. doi request reprint Rabbit cornea microstructure response to changes in intraocular pressure visualized by using nonlinear optical microscopy
    Qiaofeng Wu
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Cornea 27:202-8. 2008
    ..To characterize the microstructural response of the rabbit cornea to changes in intraocular pressure (IOP) by using nonlinear optical microscopy (NLOM)...
  10. doi request reprint Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matrices
    Po Feng Lee
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Exp Cell Res 315:396-410. 2009
    ..This study followed sprouting ECs within a 3D matrix and revealed that the advancing structures recognize and significantly alter their extracellular environment at the periphery of lumens as they progress...
  11. pmc Characterization of engineered tissue development under biaxial stretch using nonlinear optical microscopy
    Jin Jia Hu
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Tissue Eng Part A 15:1553-64. 2009
    ..The integration of intravital NLOM with novel bioreactors enables visualization of dynamic tissue properties in culture...
  12. pmc Perivascular tethering modulates the geometry and biomechanics of cerebral arterioles
    Samantha M Steelman
    Department of Systems Biology and Translational Medicine, Texas A and M Health Science Center, College Station, TX, USA
    J Biomech 43:2717-21. 2010
    ..This characterization of effects of perivascular tethering on pial arterioles should prove useful in future studies of roles of perturbed cerebral blood flow on the propensity of the cerebral microcirculation to remodel...
  13. ncbi request reprint Delivery of sub-10-fs pulses for nonlinear optical microscopy by polarization-maintaining single mode optical fiber
    Adam M Larson
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Opt Express 16:14723-30. 2008
    ....
  14. ncbi request reprint Sequential multimodal microscopic imaging and biaxial mechanical testing of living multicomponent tissue constructs
    Yuqiang Bai
    Department of Biomedical Engineering, Texas A and M University, College Station, TX, 77843, USA
    Ann Biomed Eng 42:1791-805. 2014
    ....
  15. pmc Passive pressure-diameter relationship and structural composition of rat mesenteric lymphangions
    Elaheh Rahbar
    Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Lymphat Res Biol 10:152-63. 2012
    ..Here we aim to characterize the passive mechanical properties of a lymphangion in both mid-lymphangion and valve segments to assess regional differences along a lymphangion, as well as evaluating its structural composition...
  16. ncbi request reprint Ex vivo characterization of sub-10-fs pulses
    Adam M Larson
    Departmetn of Biomedical Engineering, Texas A and M University, Texas 77843, USA
    Opt Lett 31:1681-3. 2006
    ..Compensated autocorrelation traces are presented for biologically relevant objective lenses...
  17. pmc Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndrome
    Jacopo Ferruzzi
    Department of Biomedical Engineering, Texas A and M University, College Station, TX, USA
    Cardiovasc Res 92:287-95. 2011
    ....
  18. doi request reprint Beyond the 1/Tp limit: two-photon-excited fluorescence using pulses as short as sub-10-fs
    Shuo Pang
    Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
    J Biomed Opt 14:054041. 2009
    ..Experimental measurements are consistent with the predicted behavior. The impact of using ultrashort laser pulses on the performance characteristics of nonlinear optical microscopy is discussed...
  19. doi request reprint Time-lapse ultrashort pulse microscopy of infection in three-dimensional versus two-dimensional culture environments reveals enhanced extra-chromosomal virus replication compartment formation
    Holly C Gibbs
    Department of Biomedical Engineering, Texas A and M University, College Station, Texas, USA
    J Biomed Opt 18:031111. 2013
    ..These advances will require broader adoption of modalities, such as UPM, to image deep within scattering tissues...
  20. ncbi request reprint Influence of glycerol on the mechanical reversibility and thermal damage susceptibility of collagenous tissues
    Paul B Wells
    Texas A and M University, College Station, TX 7784, USA
    IEEE Trans Biomed Eng 53:747-53. 2006
    ..Moreover, glycerol protects cleared tissue by increasing its thermal stability and minimizing thermal alterations of mechanical properties...
  21. ncbi request reprint Nonlinear optical microscopy of articular cartilage
    Alvin T Yeh
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Osteoarthritis Cartilage 13:345-52. 2005
    ..To assess the ability of nonlinear optical microscopy (NLOM) to image ex vivo healthy and degenerative bovine articular cartilage...
  22. ncbi request reprint Collagen solubility correlates with skin optical clearing
    Jason Hirshburg
    J Biomed Opt 11:040501. 2006
    ..Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations...
  23. ncbi request reprint Photodynamic therapy on keloid fibroblasts in tissue-engineered keratinocyte-fibroblast co-culture
    Lynn L Chiu
    Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
    Lasers Surg Med 37:231-44. 2005
    ..PDT is already used to treat several benign and malignant diseases in organs such as the skin, retina, and esophagus...
  24. ncbi request reprint Reversible dissociation of collagen in tissues
    Alvin T Yeh
    Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, California, USA
    J Invest Dermatol 121:1332-5. 2003
    ..These results reveal the assembly process of high-order collagen structures and propose a molecular mechanism for the increase in tissue transparency observed after glycerol application...
  25. ncbi request reprint Modeling aberrant wound healing using tissue-engineered skin constructs and multiphoton microscopy
    Behrooz A Torkian
    Department of Otolaryngology Head and Neck Surgery, University of California, Irvine Medical Center, Irvine, CA 92612, USA
    Arch Facial Plast Surg 6:180-7. 2004
    ..Endogenous second-harmonic-generation (SHG) signals in collagen can be collected to form an MPM image...
  26. ncbi request reprint Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue model
    Alvin T Yeh
    University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
    J Biomed Opt 9:248-53. 2004
    ..This study illustrates the complementary features of linear and nonlinear light-tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues...

Research Grants1

  1. Characterizing Tissue Development Under Biaxial Loading
    Alvin Yeh; Fiscal Year: 2006
    ..This novel experimental platform will form the basis for novel and innovative studies in mechanobiology. ..