Research Topics
Genomes and GenesSpecies | Alvin T YehSummaryAffiliation: Texas A and M University Country: USA Publications
Research Grants
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Publications
Advances in nonlinear optical microscopy for visualizing dynamic tissue properties in cultureAlvin T Yeh
Department of Biomedical Engineering, Texas A and M University, College Staion, TX 77843, USA
Tissue Eng Part B Rev 14:119-31. 2008....
Molecular interactions of exogenous chemical agents with collagen--implications for tissue optical clearingAlvin T Yeh
Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
J Biomed Opt 11:014003. 2006..A mechanism of tissue optical clearing is proposed based on agent destabilization of high-order collagen structures...- Two-photon excited fluorescence enhancement with broadband versus tunable femtosecond laser pulse excitationChao Wang
Texas A and M University, Department of Biomedical Engineering, 3120 TAMU, College Station, Texas 77843 3120, USA
J Biomed Opt 17:025003. 2012..These pulse properties were also exploited for demonstrating its potential applications in multicolor imaging with TPM... - Molecular basis for optical clearing of collagenous tissuesJason M Hirshburg
Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
J Biomed Opt 15:055002. 2010..Our results suggest that a necessary property of optical clearing agents is hyperosmolarity to tissue, but that the most effective agents with the highest rates of optical clearing are a subset with the highest collagen solubilities... 
Enabling tools for engineering collagenous tissues integrating bioreactors, intravital imaging, and biomechanical modelingLaura E Niklason
Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 107:3335-9. 2010....- Correlation between collagen solubility and skin optical clearing using sugarsJason Hirshburg
Department of Biomedical Engineering, Texas A and M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
Lasers Surg Med 39:140-4. 2007..This study examines the correlation between collagen solubility and the optical clearing potential (OCP) of sugars and sugar-alcohols using in vitro rodent skin... - Delivery of sub-10-fs pulses for nonlinear optical microscopy by polarization-maintaining single mode optical fiberAdam M Larson
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Opt Express 16:14723-30. 2008.... - Characterization of engineered tissue development under biaxial stretch using nonlinear optical microscopyJin Jia Hu
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Tissue Eng Part A 15:1553-64. 2009..The integration of intravital NLOM with novel bioreactors enables visualization of dynamic tissue properties in culture... - Nonlinear optical microscopy reveals invading endothelial cells anisotropically alter three-dimensional collagen matricesPo Feng Lee
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Exp Cell Res 315:396-410. 2009..This study followed sprouting ECs within a 3D matrix and revealed that the advancing structures recognize and significantly alter their extracellular environment at the periphery of lumens as they progress... - Perivascular tethering modulates the geometry and biomechanics of cerebral arteriolesSamantha M Steelman
Department of Systems Biology and Translational Medicine, Texas A and M Health Science Center, College Station, TX, USA
J Biomech 43:2717-21. 2010..This characterization of effects of perivascular tethering on pial arterioles should prove useful in future studies of roles of perturbed cerebral blood flow on the propensity of the cerebral microcirculation to remodel... - Rabbit cornea microstructure response to changes in intraocular pressure visualized by using nonlinear optical microscopyQiaofeng Wu
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Cornea 27:202-8. 2008..To characterize the microstructural response of the rabbit cornea to changes in intraocular pressure (IOP) by using nonlinear optical microscopy (NLOM)... - Ex vivo characterization of sub-10-fs pulsesAdam M Larson
Departmetn of Biomedical Engineering, Texas A and M University, Texas 77843, USA
Opt Lett 31:1681-3. 2006..Compensated autocorrelation traces are presented for biologically relevant objective lenses... - Mechanical assessment of elastin integrity in fibrillin-1-deficient carotid arteries: implications for Marfan syndromeJacopo Ferruzzi
Department of Biomedical Engineering, Texas A and M University, College Station, TX, USA
Cardiovasc Res 92:287-95. 2011.... - Beyond the 1/Tp limit: two-photon-excited fluorescence using pulses as short as sub-10-fsShuo Pang
Texas A and M University, Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, College Station, Texas 77843, USA
J Biomed Opt 14:054041. 2009..Experimental measurements are consistent with the predicted behavior. The impact of using ultrashort laser pulses on the performance characteristics of nonlinear optical microscopy is discussed... - Passive pressure-diameter relationship and structural composition of rat mesenteric lymphangionsElaheh Rahbar
Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
Lymphat Res Biol 10:152-63. 2012..Here we aim to characterize the passive mechanical properties of a lymphangion in both mid-lymphangion and valve segments to assess regional differences along a lymphangion, as well as evaluating its structural composition... - Influence of glycerol on the mechanical reversibility and thermal damage susceptibility of collagenous tissuesPaul B Wells
Texas A and M University, College Station, TX 7784, USA
IEEE Trans Biomed Eng 53:747-53. 2006..Moreover, glycerol protects cleared tissue by increasing its thermal stability and minimizing thermal alterations of mechanical properties... - Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulsesQiaofeng Wu
Department of Biomedical Engineering, Texas A and M University, 337 Zachry Engineering Center, 3120 TAMU, College Station, TX 77843, USA
Biomed Opt Express 2:1135-46. 2011..Cross-sectional images of collagen lamellae, visible in NLOM, showed inhomogeneous collagen structure along the anterior-posterior direction that correlated well with the noted heterogeneous corneal mechanical responses... - Nonlinear optical microscopy of articular cartilageAlvin T Yeh
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Osteoarthritis Cartilage 13:345-52. 2005..NLOM was sensitive to macromolecular composition and pathologic changes in articular cartilage matrix. Advances in instrumentation may lead to the application of NLOM to study articular cartilage in vivo... - Collagen solubility correlates with skin optical clearingJason Hirshburg
J Biomed Opt 11:040501. 2006..Herein we show that a chemical agent's tissue optical clearing potential is directly related to its collagen solubility, providing a rational design basis for effective, percutaneous formulations... - Photodynamic therapy on keloid fibroblasts in tissue-engineered keratinocyte-fibroblast co-cultureLynn L Chiu
Beckman Laser Institute, University of California Irvine, Irvine, California 92612, USA
Lasers Surg Med 37:231-44. 2005..Contraction and collagen density were greatest in keloid and neonatal Rafts. CONCLUSIONS: A PDT dosimetry range was established, which reduces tissue contraction and collagen density while minimizing injury to fibroblasts... - Reversible dissociation of collagen in tissuesAlvin T Yeh
Laser Microbeam and Medical Program, Beckman Laser Institute, University of California, Irvine, California, USA
J Invest Dermatol 121:1332-5. 2003..These results reveal the assembly process of high-order collagen structures and propose a molecular mechanism for the increase in tissue transparency observed after glycerol application... - Modeling aberrant wound healing using tissue-engineered skin constructs and multiphoton microscopyBehrooz A Torkian
Department of Otolaryngology- Head and Neck Surgery, University of California, Irvine Medical Center, Irvine, CA 92612, USA
Arch Facial Plast Surg 6:180-7. 2004..Furthermore, it demonstrates the biologic activity of RAFT artificial tissue constructs... - Imaging wound healing using optical coherence tomography and multiphoton microscopy in an in vitro skin-equivalent tissue modelAlvin T Yeh
University of California, Beckman Laser Institute, Laser Microbeam and Medical Program, 1002 Health Sciences Road East, Irvine, California 92612, USA
J Biomed Opt 9:248-53. 2004..This study illustrates the complementary features of linear and nonlinear light-tissue interaction in intrinsic signal optical imaging and their use for noninvasive, serial monitoring of wound healing processes in biological tissues...
Research Grants
- Characterizing Tissue Development Under Biaxial LoadingAlvin Yeh; Fiscal Year: 2006..This novel experimental platform will form the basis for novel and innovative studies in mechanobiology. ..