Jianming Xu

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression
    Lan Liao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 28:2460-9. 2008
  2. ncbi Review of the in vivo functions of the p160 steroid receptor coactivator family
    Jianming Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 17:1681-92. 2003
  3. pmc Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
    Jianming Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Rev Cancer 9:615-30. 2009
  4. ncbi Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function
    Jianming Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Rev Endocr Metab Disord 3:185-92. 2002
  5. pmc The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
    J Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:6379-84. 2000
  6. pmc Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 25:8150-65. 2005
  7. ncbi Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:45-55. 2006
  8. ncbi Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1
    Lan Liao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 83:3-14. 2002
  9. pmc Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice
    Qingtian Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:8073-86. 2007
  10. pmc Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology
    Brian York
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:11122-7. 2010

Research Grants

  1. CORE--ANIMAL
    Jianming Xu; Fiscal Year: 2007
  2. Role of AIB3 in Mammary Gland and Breast Cancer
    Jianming Xu; Fiscal Year: 2009
  3. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2009
  4. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2010
  5. The Role of SRC-1 in Breast Cancer
    Jianming Xu; Fiscal Year: 2010
  6. ROLES FOR SRC-3 IN DEVELOPMENT AND DISEASE
    Jianming Xu; Fiscal Year: 2004
  7. The Role of SRC-1 in Breast Cancer
    Jianming Xu; Fiscal Year: 2009

Collaborators

Detail Information

Publications83

  1. pmc Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression
    Lan Liao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 28:2460-9. 2008
    ..In agreement with the role of SRC-3 in VDR function, the expression of several VDR target genes was also reduced in SRC-3(-/-) mice. Therefore, SRC-3 maintains IGF-I in the circulation through enhancing VDR-regulated IGFBP-3 expression...
  2. ncbi Review of the in vivo functions of the p160 steroid receptor coactivator family
    Jianming Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 17:1681-92. 2003
    ..Furthermore, this article also reviews our current understanding of the role of SRC-3 in breast cancer and discusses possible mechanisms for functional specificity and redundancy among SRC family members...
  3. pmc Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family
    Jianming Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Rev Cancer 9:615-30. 2009
    ..These studies have identified new challenges for cancer research and therapy...
  4. ncbi Molecular mechanisms and cellular biology of the steroid receptor coactivator (SRC) family in steroid receptor function
    Jianming Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Rev Endocr Metab Disord 3:185-92. 2002
  5. pmc The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development
    J Xu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:6379-84. 2000
    ..These results suggest that the physiological role of SRC-3 is different from that of SRC-1 and prove the diversity among coactivator family members...
  6. pmc Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 25:8150-65. 2005
    ....
  7. ncbi Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor
    Sang Jun Han
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:45-55. 2006
    ..SRC-3 is the primary coactivator for PR in breast and SRC-1 is the primary coactivator for PR in uterus...
  8. ncbi Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1
    Lan Liao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 83:3-14. 2002
    ....
  9. pmc Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice
    Qingtian Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 27:8073-86. 2007
    ....
  10. pmc Reprogramming the posttranslational code of SRC-3 confers a switch in mammalian systems biology
    Brian York
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 107:11122-7. 2010
    ..Consequently, these mice displayed increased liver tumorigenesis, which likely results from elevated IGF1 signaling...
  11. ncbi AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:1875-85. 2004
    ..These results suggest that a more effective strategy to control breast cancer is to target AIB1-mediated and ovarian hormone-initiated pathways...
  12. pmc Roles of steroid receptor coactivator (SRC)-1 and transcriptional intermediary factor (TIF) 2 in androgen receptor activity in mice
    Xiangcang Ye
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 102:9487-92. 2005
    ..Our results provide unique in vivo insights to the multidimensional cell-type-specific interactions between AR and coregulators...
  13. ncbi Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency
    Lan Liao
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 147:3877-88. 2006
    ..Higher circulating levels of IGF-I can stimulate somatic growth and lean mass and improve glucose tolerance...
  14. pmc The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression
    Li Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 28:5937-50. 2008
    ..These findings suggest a new alternative strategy for controlling the deleterious roles of these MMPs in breast cancer by inhibiting their upstream coregulator AIB1...
  15. pmc Genetic screening reveals an essential role of p27kip1 in restriction of breast cancer progression
    Yuhui Yuan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 67:8032-42. 2007
    ..These findings suggest that p27 plays an essential role in restriction of breast cancer progression...
  16. pmc Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction
    Manuel Mark
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4453-8. 2004
    ....
  17. ncbi Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7993-8002. 2005
    ..Our results suggest that AIB1 may serve as a potential target for prevention of carcinogen-induced breast cancer initiation and for treatment of breast cancer progression...
  18. pmc Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy
    Brian York
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 15:752-63. 2012
    ..Moreover, these findings allow us to consider platform coactivators such as the SRCs as potential contributors to syndromes such as CACT deficiency, previously considered as monogenic...
  19. pmc Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness
    Jun Hong
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 71:3980-90. 2011
    ..These findings suggest that activation of MAPKs by tyrosine kinase receptors and Ras signaling pathways may substantially promote breast tumor cell EMT and metastasis via phoshorylation and stabilization of Twist1...
  20. pmc Loss-of-function deletion of the steroid receptor coactivator-1 gene in mice reduces estrogen effect on the vascular injury response
    Yuhui Yuan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 27:1521-7. 2007
    ..In this study, we have tested the hypothesis that SRC-1 is required for the inhibition of neointima formation by estrogen in a vascular wall...
  21. pmc The role of SRC-1 in murine prostate cancinogenesis is nonessential due to a possible compensation of SRC-3/AIB1 overexpression
    Jean Ching Yi Tien
    1 Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA
    Int J Biol Sci 5:256-64. 2009
    ..Therefore, the loss of SRC-1 function may be compensated by SRC-3 overexpression during prostate tumorigenesis in SRC-1(-/-) mice...
  22. pmc Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family
    Brian York
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 27:366-80. 2013
    ..Furthermore, this work also demonstrates the use of metabolomics as a means for identifying novel metabolic regulatory functions of transcriptional coregulators...
  23. pmc Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation
    Shu Wang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 106:151-6. 2009
    ..Therefore, functional interventions for coactivators like SRC-1 may provide unique approaches to control breast cancer progression and metastasis...
  24. pmc The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis
    Junjiang Fu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Res 21:275-89. 2011
    ..These findings not only provide novel mechanistic and functional links between TWIST and the Mi2/NuRD complex but also establish new essential roles for the components of Mi2/NuRD complex in cancer metastasis...
  25. pmc Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice
    Arthur C K Chung
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 67:5965-75. 2007
    ..Inhibition of AIB1 expression or function in the prostate epithelium may be a potential strategy to suppress prostate cancer initiation and progression...
  26. ncbi Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary t
    Hao Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 64:7169-77. 2004
    ..These results suggest that AIB3 may be a tumor suppressor that is required for the inhibition of cell proliferation by PPARgamma and RXR...
  27. pmc Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner
    Jian Zhou
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 287:17248-56. 2012
    ..1 is reduced drastically in the prostatic fluid and urine of mice with PCa. These results indicate that Nkx3.1 can function as a PTF to suppress PCa and the urinary Nkx3.1 may be a potential biomarker for PCa diagnosis...
  28. pmc Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout
    Zhaoliang Liu
    Department of Molecular, Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Int J Biol Sci 4:202-7. 2008
    ..These results demonstrate that the floxed SRC-3 mouse lines have been successfully established. These mice will be useful for investigating the cell type- and developmental stage-specific functions of SRC-3...
  29. pmc The coactivator SRC-1 is an essential coordinator of hepatic glucose production
    Jean Francois Louet
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Metab 12:606-18. 2010
    ..We propose that SRC-1 acts as a critical mediator of glucose homeostasis in the liver by adjusting the transcriptional activity of key genes involved in the hepatic glucose production machinery...
  30. pmc Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK
    Jun Xu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA
    J Biol Chem 284:14377-85. 2009
    ..These findings support the model that CISK phosphorylates FLII and activates nuclear receptor transcription and suggest a new cell survival signaling pathway mediated by PI 3-kinase and CISK...
  31. pmc The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis
    Li Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 69:3819-27. 2009
    ..Therefore, SRC-1 promotes breast cancer invasiveness and metastasis by coactivating PEA3-mediated Twist expression. Intervention of SRC-1 function may provide new strategies to inhibit breast cancer metastasis...
  32. pmc The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer
    Jean C Y Tien
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 73:3997-4008. 2013
    ..Together, our results show that SRC-3 drives CRPC formation and offer preclinical proof of concept for a transcriptional coactivator as a therapeutic target to abrogate CRPC progression...
  33. ncbi Spatial distribution of the messenger ribonucleic acid and protein of the nuclear receptor coactivator, amplified in breast cancer-3, in mice
    Hao Zhang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:1435-43. 2003
    ..These results demonstrate that AIB3 mRNA and protein are preferentially expressed in specific cell types, suggesting that AIB3 may support the function of nuclear receptors in a cell type-specific manner...
  34. pmc An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response
    Chundong Yu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 25:765-78. 2007
    ..Collectively, our studies reveal an essential function of SRC-3 as a coordinator of inflammatory mRNA translation and as a physiologic protective factor against the lethal endotoxic shock triggered by an acute inflammatory response...
  35. pmc Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice
    Liangru Zhu
    Children s Nutrition Research Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77479, USA
    Endocrinology 154:150-8. 2013
    ..Collectively our results indicate that SRC1 is functionally required to mediate the antiobesity effects of estrogen-ERα signals...
  36. pmc Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation
    Jun Kawagoe
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 23:858-65. 2012
    ..Therefore, NCOA6 controls E(2) sensitivity and uterine receptivity by regulating multiple E(2)-signaling components...
  37. pmc Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis
    Zhaoliang Liu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Texas A and M University Health Science Center, Texas 77030, USA
    J Biol Chem 285:2758-70. 2010
    ..These results indicate that the Jmjd1a-controlled epigenetic histone modifications are crucial for Crem-regulated gene expression and spermatogenesis...
  38. pmc Altered mammary gland development in the p53+/m mouse, a model of accelerated aging
    Catherine E Gatza
    Interdepartmental Graduate Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Biol 313:130-41. 2008
    ..These data indicate that appropriate levels of p53 activity are important in regulating mammary gland ductal morphogenesis, in part through regulation of the IGF-1 pathway...
  39. pmc Steroid receptor coactivator-1 upregulates integrin α₅ expression to promote breast cancer cell adhesion and migration
    Li Qin
    Department of Molecular and Cellular Biology and Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 71:1742-51. 2011
    ..Therefore, targeting ITGA5 in SRC-1-positive breast cancers may result in inhibition of SRC-1-promoted breast cancer metastasis...
  40. pmc Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland
    Paola Mussi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:16716-21. 2006
    ..Consequently, a reduction or loss of REA function may cause overactivation of ER and increase breast cancer risk in humans...
  41. ncbi Stimulation of steroid receptor coactivator-3 (SRC-3) gene overexpression by a positive regulatory loop of E2F1 and SRC-3
    Paola Mussi
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:3105-19. 2006
    ....
  42. pmc The cooperative function of nuclear receptor coactivator 1 (NCOA1) and NCOA3 in placental development and embryo survival
    Xian Chen
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1917-34. 2010
    ..These findings demonstrate that NCOA1 and NCOA3 cooperatively regulate placental morphogenesis and embryo survival...
  43. ncbi SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells
    Eijun Nishihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:213-22. 2003
    ..Disruption of SRC-1 specifically delays the PC development and maturation in early stages and results in moderate motor dysfunction in adulthood...
  44. pmc Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease
    Atul R Chopra
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 322:1395-9. 2008
    ..In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production...
  45. ncbi Interactions between activating signal cointegrator-2 and the tumor suppressor retinoblastoma in androgen receptor transactivation
    Young Hwa Goo
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:7131-5. 2004
    ..Su, C., and Chang C. (1998) Biochem. Biophys. Res. Commun. 248, 361-367), suggest that the AR-ASC-2 interactions in vivo may involve Rb. Thus, ASC-2 appears to contain at least three distinct nuclear receptor interaction domains...
  46. pmc A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis
    Robert K Dearth
    Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    BMC Cancer 11:377. 2011
    ..The purpose of this study was to assess the ability of circulating IGF-I to independently initiate mammary tumorigenesis and/or accelerate the progression of ErbB2 mediated mammary tumor growth...
  47. ncbi Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality
    Shao Qing Kuang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:45356-60. 2002
    ..These results also indicate that the biological function of AIB3 is not redundant with other classes of nuclear receptor coactivators such as PBP and members of the steroid receptor coactivator family...
  48. pmc Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase
    Ray Chang Wu
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 22:3549-61. 2002
    ..Taken together, our results not only reveal the IKK-mediated phosphorylation of SRC-3 to be a regulated event that plays an important role but also substantiate the role of SRC-3 in multiple signaling pathways...
  49. ncbi Nuclear receptor coregulators are new players in nervous system development and function
    Eijun Nishihara
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA
    Mol Neurobiol 30:307-25. 2004
    ....
  50. pmc SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart
    Erin L Reineke
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e53395. 2012
    ....
  51. ncbi Steroid receptor coactivator-3 is required for inhibition of neointima formation by estrogen
    Yuhui Yuan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 105:2653-9. 2002
    ..This study has characterized the expression of SRC-3 in cardiovascular tissue and the role of SRC-3 in estrogen-dependent vasoprotection from vascular injury...
  52. pmc Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms
    Qingtian Li
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Int J Biol Sci 7:505-16. 2011
    ..These results suggest that the diverse physiological function of NCOA6 may be mediated by multiple isoforms expressed in different tissues and localized in different subcellular compartments...
  53. ncbi Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes
    B E Tubb
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Genomics 65:146-56. 2000
    ..The likely function of retinal fascin, in light of known fascin roles in other cell types, is to assemble actin microfilaments in support of photoreceptor disk morphogenesis...
  54. ncbi Reduced expression of hMLH1 and hGTBP/hMSH6: a risk factor for head and neck cancer
    Q Wei
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 7:309-14. 1998
    ..The results suggest that low hMLH1 and hGTBP/hMSH6 expression is associated with an increased risk of head and neck cancer. Additional studies with a larger number of subjects are warranted to confirm these findings...
  55. pmc Mitochondrial localization of telomeric protein TIN2 links telomere regulation to metabolic control
    Liuh Yow Chen
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell 47:839-50. 2012
    ..These results suggest a link between telomeric proteins and metabolic control, providing an additional mechanism by which telomeric proteins regulate cancer and aging...
  56. pmc Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
    Qian Qin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 22:90-106. 2012
    ..Further understanding of the mechanisms by which Twist1 promotes metastasis and identification of Twist1 functional modulators may hold promise for developing new strategies to inhibit EMT and cancer metastasis...
  57. doi Preparation, culture, and immortalization of mouse embryonic fibroblasts
    Jianming Xu
    Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Mol Biol . 2005
    ....
  58. pmc Steroid receptor coactivator-3 as a potential molecular target for cancer therapy
    Jean Ching Yi Tien
    Baylor College of Medicine, Department of Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Expert Opin Ther Targets 16:1085-96. 2012
    ..Ultimately, blockade of SRC-3 oncogenic function may inhibit multiple cancer-related signaling pathways...
  59. ncbi Partial hormone resistance in mice with disruption of the steroid receptor coactivator-1 (SRC-1) gene
    J Xu
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 279:1922-5. 1998
    ..The results indicate that SRC-1 mediates steroid hormone responses in vivo and that loss of its coactivator function results in partial resistance to hormone...
  60. ncbi Structure and chromosomal locations of mouse steroid receptor coactivator gene family
    G Ning
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    In Vitro Cell Dev Biol Anim 35:481-6. 1999
    ..This information is important for developing valuable animal models harboring multiple disruptions of the SRC gene family to study their biological functions...
  61. pmc Global characterization of the SRC-1 transcriptome identifies ADAM22 as an ER-independent mediator of endocrine-resistant breast cancer
    Damian McCartan
    Endocrine Oncology Research, Department of Surgery, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cancer Res 72:220-9. 2012
    ....
  62. pmc Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity
    Y Piao
    Department of Neuro Oncology, Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Gene Ther 16:256-65. 2009
    ..DeltaEGFR cells. Therefore, our results constitute the first proof of the direct targeting of a cancer-specific receptor using an oncolytic adenovirus...
  63. pmc Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters
    V Martin
    Department of Neuro Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Oncogene 28:2358-63. 2009
    ....
  64. ncbi Identification and characterization of a novel gene (C4orf5) located on human chromosome 4q with specific expression in cardiac and skeletal muscle
    F Ahmad
    Section of Cardiology, The DeBakey Heart Center, Houston, Texas 77030, USA
    Genomics 70:347-53. 2000
    ..3-kb transcript. The gene was mapped to human chromosome 4q26-q27. Computer-based analysis indicated that this gene is novel with no known function...
  65. pmc Regulation of cytokine-independent survival kinase (CISK) by the Phox homology domain and phosphoinositides
    J Xu
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 154:699-705. 2001
    ..Therefore, CISK and Akt have evolved to utilize different lipid binding domains to accomplish a similar mechanism of activation in response to PI-3 kinase signaling...
  66. ncbi Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo
    Yoko Takeuchi
    Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    Endocrinology 143:1346-52. 2002
    ..SRC-1 appears to be involved not only in transcriptional activation by liganded TRs, but also in the suppression by liganded or unliganded TRs. Some of the effects of SRC-1 may be TR isoform specific...
  67. ncbi Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action
    Peter M Sadow
    Departments of Medicine and Pathology, University of Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 284:E36-46. 2003
    ....
  68. ncbi Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function
    Jonathon N Winnay
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0678, USA
    Endocrinology 147:1322-32. 2006
    ..Collectively, these data are consistent with an indispensable role for SRC-1 in mediating actions of glucocorticoids in pituitary and liver...
  69. pmc Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone
    Hao Ying
    Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892 4264, USA
    Mol Cell Biol 25:7687-95. 2005
    ..Thus, SRC-3 modulates RTH by at least two mechanisms, one via its role as a receptor coregulator and the other via its growth regulatory role through the IGF-1/PI3K/AKT/mTOR signaling...
  70. pmc Redundant enhancement of mouse constitutive androstane receptor transactivation by p160 coactivator family members
    Jun Xia
    Department of Cell and Development Biology, University of Illinois at Urbana Champaign, Urbana, IL 60801, USA
    Arch Biochem Biophys 468:49-57. 2007
    ..SRC-3 alone of the p160 coactivators enhanced CAR transactivation in hepatic cells without PB treatment...
  71. ncbi Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD
    Hung Yi Wu
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 280:3129-37. 2005
    ..This suggests that competition by GRIP1 for SRC1A, p/CIP, and p300 binding sites on a transcription factor may regulate the activity of the factor...
  72. pmc The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice
    Mark P Fereshteh
    Departments of Oncology and Pharmacology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia, USA
    Cancer Res 68:3697-706. 2008
    ..We predict that reducing AIB1/SRC-3 levels or activity in the mammary epithelium could potentiate therapies aimed at inhibiting HER2/neu signaling in breast cancer...
  73. ncbi Effects of loss of steroid receptor coactivator-1 on the skeletal response to estrogen in mice
    Ulrike I L Modder
    Mayo Clinic, 200 First Street SW, 5 194 Joseph, Rochester, MN 55905, USA
    Endocrinology 145:913-21. 2004
    ..These findings establish that, in mice, loss of SRC-1 leads to skeletal resistance to E predominantly in cancellous bone...
  74. pmc Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells
    Annabell S Oh
    Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington, DC 20057, USA
    Mol Cell Biol 28:6580-93. 2008
    ..Thus, the phosphorylation state of Y1357 can function as a molecular on/off switch and facilitates the cross talk between hormone, growth factor, and intracellular kinase signaling pathways in cancer...
  75. ncbi Steroid receptor coactivator-1 is not required for androgen-mediated sexual differentiation of spinal motoneurons
    Douglas A Monks
    Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Neuroendocrinology 78:45-51. 2003
    ..These results demonstrate that SRC-1 is not essential for the development and maintenance of a sexually dimorphic neuromuscular system...
  76. ncbi Regulation of expression of thyroid hormone receptor isoforms and coactivators in liver and heart by thyroid hormone
    Peter M Sadow
    Department of Medicine, Thyroid Study Unit, MC 3090, The University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Mol Cell Endocrinol 203:65-75. 2003
    ..We have demonstrated that TR isoforms and NCoAs are autoregulated transcription factors with tissue specificity...
  77. pmc FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform
    Zuocheng Yang
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Endocrinol 20:2682-94. 2006
    ..These data may now provide the basis for selective targeting of steroid-regulated physiology through tetratricopeptide repeat proteins...
  78. ncbi Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency
    Roy E Weiss
    Department of Medicine, University of Chicago, Chicago, Illinois 60037, USA
    Endocrinology 143:1554-7. 2002
    ..This work demonstrates gene dosage effect in nuclear coactivators manifesting as haploinsufficiency and functional redundancy of SRC-1 and TIF-2...
  79. pmc Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo
    Seong Eun Park
    University of Illinois, Department of Molecular and Integrative Physiology, 524 Burrill Hall, 407 South Goodwin Ave, Urbana, IL 61801 3704, USA
    Mol Cell Biol 25:1989-99. 2005
    ..These studies demonstrate that REA is a significant modulator of estrogen responsiveness in vivo: it normally restrains estrogen actions, moderating ER stimulation and enhancing ER repression of E2-regulated genes...
  80. ncbi Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary
    Peter M Sadow
    Department of Medicine, University of Chicago, Illinois, USA
    Mol Endocrinol 17:882-94. 2003
    ..We conclude that SRC-1 action in the pituitary mediates TH action via specific TR subtypes...
  81. ncbi Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone
    Yuji Kamiya
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4264, USA
    Endocrinology 144:4144-53. 2003
    ..Thus, the present studies show that a coactivator such as SRC-1 could modulate the in vivo action of TR beta mutants in a tissue-dependent manner...
  82. pmc In vivo activation of PPAR target genes by RXR homodimers
    Annemieke IJpenberg
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    EMBO J 23:2083-91. 2004
    ..These observations have important pharmacological implications for the development of new rexinoid-based treatments...
  83. pmc Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2
    Seon Yong Yeom
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Songpa Gu, Seoul 138 736, South Korea
    Mol Cell Biol 26:4553-63. 2006
    ..These results suggest that ASC-2 regulates insulin secretion and beta-cell survival and that the regulatory role of ASC-2 in insulin secretion appears to involve, at least in part, its interaction with NRs via its two NR boxes...

Research Grants20

  1. CORE--ANIMAL
    Jianming Xu; Fiscal Year: 2007
    ..The Animal Core will minimize the cost of utilizing animal models in this PPG by consolidating the equipment, expertise and animal resources, ensuring an efficient use of animal resources at minimal cost...
  2. Role of AIB3 in Mammary Gland and Breast Cancer
    Jianming Xu; Fiscal Year: 2009
    ..It is very hopeful to identify AIB3 as an oncogene in the breast and a molecular target for breast cancer treatment. ..
  3. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2009
    ..These studies will help to identify SRC3-positive cancer stem cells, potential diagnostic markers and drug targets for human prostate cancer treatment. ..
  4. Roles of SRC-3 in Development and Disease
    Jianming Xu; Fiscal Year: 2010
    ..These studies will help to identify SRC3-positive cancer stem cells, potential diagnostic markers and drug targets for human prostate cancer treatment. ..
  5. The Role of SRC-1 in Breast Cancer
    Jianming Xu; Fiscal Year: 2010
    ....
  6. ROLES FOR SRC-3 IN DEVELOPMENT AND DISEASE
    Jianming Xu; Fiscal Year: 2004
    ..It is hoped that these studies will reveal new molecular targets for the diagnosis and treatment of breast cancer. ..
  7. The Role of SRC-1 in Breast Cancer
    Jianming Xu; Fiscal Year: 2009
    ....