Momiao Xiong

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Extended kalman filter for estimation of parameters in nonlinear state-space models of biochemical networks
    Xiaodian Sun
    Laboratory of Theoretical Systems Biology and Center for Evolutionary Biology, School of Life Science and Institute for Biomedical Sciences, Fudan University, Shanghai, China
    PLoS ONE 3:e3758. 2008
  2. pmc A novel statistic for genome-wide interaction analysis
    Xuesen Wu
    Department of Epidemiology and Statistics, Bengbu Medical College at Bengbu, Anhui, China
    PLoS Genet 6:e1001131. 2010
  3. pmc Weighted pedigree-based statistics for testing the association of rare variants
    Yin Yao Shugart
    Unit of Statistical Genomics, Division of Intramural Division Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
    BMC Genomics 13:667. 2012
  4. pmc Quantitative trait locus analysis for next-generation sequencing with the functional linear models
    Li Luo
    Division of Epidemiology, Biostatistics and Preventive Medicine, University of New Mexico, Albuquerque, NM, USA
    J Med Genet 49:513-24. 2012
  5. doi request reprint Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population
    Rong Lin
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, and Ruijin Hospital, Shanghai, China
    Pharmacogenet Genomics 19:310-8. 2009
  6. doi request reprint Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations
    Rong Lin
    Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Hum Mutat 30:609-15. 2009
  7. pmc Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma
    Hua Dong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China
    BMC Syst Biol 4:163. 2010
  8. pmc Implication of next-generation sequencing on association studies
    Hoicheong Siu
    MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China
    BMC Genomics 12:322. 2011
  9. pmc Manifold learning for human population structure studies
    Hoicheong Siu
    MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 7:e29901. 2012
  10. pmc Investigation gene and microRNA expression in glioblastoma
    Hua Dong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
    BMC Genomics 11:S16. 2010

Collaborators

Detail Information

Publications29

  1. pmc Extended kalman filter for estimation of parameters in nonlinear state-space models of biochemical networks
    Xiaodian Sun
    Laboratory of Theoretical Systems Biology and Center for Evolutionary Biology, School of Life Science and Institute for Biomedical Sciences, Fudan University, Shanghai, China
    PLoS ONE 3:e3758. 2008
    ..The preliminary results show that EKF can accurately estimate the parameters and predict states in nonlinear state-space equations for modeling dynamic biochemical networks...
  2. pmc A novel statistic for genome-wide interaction analysis
    Xuesen Wu
    Department of Epidemiology and Statistics, Bengbu Medical College at Bengbu, Anhui, China
    PLoS Genet 6:e1001131. 2010
    ..Real data analysis showed that the results of genome-wide interaction analysis can be replicated in two independent studies...
  3. pmc Weighted pedigree-based statistics for testing the association of rare variants
    Yin Yao Shugart
    Unit of Statistical Genomics, Division of Intramural Division Program, National Institute of Mental Health, National Institute of Health, Bethesda, MD, USA
    BMC Genomics 13:667. 2012
    ..Note that while the proposed statistic can be applied with and without statistical weighting, our simulations show that its power increases when weighting (WSS and VT) are applied...
  4. pmc Quantitative trait locus analysis for next-generation sequencing with the functional linear models
    Li Luo
    Division of Epidemiology, Biostatistics and Preventive Medicine, University of New Mexico, Albuquerque, NM, USA
    J Med Genet 49:513-24. 2012
    ..Analysis from low dimensional data to high dimensional genomic data demands changes in statistical methods from multivariate data analysis to functional data analysis...
  5. doi request reprint Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population
    Rong Lin
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, and Ruijin Hospital, Shanghai, China
    Pharmacogenet Genomics 19:310-8. 2009
    ....
  6. doi request reprint Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations
    Rong Lin
    Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Hum Mutat 30:609-15. 2009
    ..Finally, we observed that significant differences of TBIL levels existed among the three populations; however, this could not be completely explained by the differences at the (TA)n repeat polymorphism and SNP rs4148323:G>A...
  7. pmc Integrated analysis of mutations, miRNA and mRNA expression in glioblastoma
    Hua Dong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, China
    BMC Syst Biol 4:163. 2010
    ....
  8. pmc Implication of next-generation sequencing on association studies
    Hoicheong Siu
    MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China
    BMC Genomics 12:322. 2011
    ..In this report, we explore different strategies and study designs for the near future GWAS in the post-era, based on both low coverage pilot data and exon pilot data in 1000 Genomes Project...
  9. pmc Manifold learning for human population structure studies
    Hoicheong Siu
    MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 7:e29901. 2012
    ..The preliminary results demonstrated that next generation sequencing offers a rich resources and LLE provide a powerful tool for population structure analysis...
  10. pmc Investigation gene and microRNA expression in glioblastoma
    Hua Dong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
    BMC Genomics 11:S16. 2010
    ..Glioblastoma is the most common primary brain tumor in adults. Though a lot of research has been focused on this disease, the causes and pathogenesis of glioblastoma have not been indentified clearly...
  11. pmc Gene and pathway-based second-wave analysis of genome-wide association studies
    Gang Peng
    School of Life Science, Fudan University, Shanghai, China
    Eur J Hum Genet 18:111-7. 2010
    ..The results also showed that the new paradigm for GWAS was able to identify biologically meaningful pathways associated with the diseases, which were confirmed by a gene-set-rich analysis using gene expression data...
  12. pmc Mutual information for testing gene-environment interaction
    Xuesen Wu
    School of Life Science, Theoretic Systems Biology Laboratory and Center for Evolutionary Biology, Fudan University, Shanghai, China
    PLoS ONE 4:e4578. 2009
    ..Our results showed that P-values for the mutual information-based statistics were much smaller than that obtained by other approaches including logistic regression models...
  13. doi request reprint Present Y chromosomes reveal the ancestry of Emperor CAO Cao of 1800 years ago
    Chuanchao Wang
    MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Department of History, Fudan University, Shanghai, China
    J Hum Genet 57:216-8. 2012
    ..Therefore, Emperor CAO Cao's claim was not supported by genetic evidence. This study offers a successful showcase of the utility of genetics in studying the ancient history...
  14. doi request reprint Gene co-expression network and functional module analysis of ovarian cancer
    Shengjun Hong
    MOE Key Laboratory of Contemporary Anthropology and State Key, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Int J Comput Biol Drug Des 4:147-64. 2011
    ..In addition, we detected two ovarian cancer susceptibility genes: CCEN2 and BRIC5...
  15. ncbi request reprint Composite measure of linkage disequilibrium for testing interaction between unlinked loci
    Xuesen Wu
    School of Life Science, Fudan University, Shanghai, China
    Eur J Hum Genet 16:644-51. 2008
    ..The preliminary results demonstrate that the composite LD-based statistic is a strong alternative to the logistic regressions and the intragametic LD-based statistic for the detection of interaction between two unlinked loci...
  16. pmc Accelerating haplotype-based genome-wide association study using perfect phylogeny and phase-known reference data
    Yungang He
    Department of Computational Genomics, CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS ONE 6:e22097. 2011
    ..With only a medium-size reference panel, phasing error in our method is comparable to the genotyping error afforded by commercial genotyping solutions...
  17. pmc Generalized T2 test for genome association studies
    Momiao Xiong
    Human Genetics Center, University of Texas Houston, 77225, USA
    Am J Hum Genet 70:1257-68. 2002
    ..Finally, examples are given to evaluate the performance of the proposed T2 statistic for association studies using simulated and real data...
  18. ncbi request reprint Haplotype block linkage disequilibrium mapping
    Momiao Xiong
    Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
    Front Biosci 8:a85-93. 2003
    ..Our preliminary results of theoretic analysis further demonstrate that the haplotype block LD analysis is a breakthrough in LD mapping and is a promising tool for genome-wide association studies...
  19. ncbi request reprint cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Med Sci Monit 10:BR191-7. 2004
    ..This study was to use gene microarray analysis of muscle biopsies from PM and DM patients to obtain a comprehensive view of molecules participating in disease pathogenesis...
  20. ncbi request reprint Network-based regulatory pathways analysis
    Momiao Xiong
    Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Bioinformatics 20:2056-66. 2004
    ..It is important to extend the concept of network-based metabolic pathways to genetic networks and develop mathematical procedures for network-based regulatory pathway analysis...
  21. pmc Identification of genetic networks
    Momiao Xiong
    Human Genetics Center, University of Texas, Houston Health Science Center, TX 77030, USA
    Genetics 166:1037-52. 2004
    ..To illustrate the concepts and methods for reconstruction of genetic networks and identification of association of genetic networks with function, we applied the proposed models and algorithms to three data sets...
  22. pmc Canonical correlation analysis for RNA-seq co-expression networks
    Shengjun Hong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
    Nucleic Acids Res 41:e95. 2013
    ..Our new methods substantially outperform the current statistical methods for co-expression network construction with microarray expression data or RNA-seq data based on overall gene expression levels...
  23. pmc A novel genome-information content-based statistic for genome-wide association analysis designed for next-generation sequencing data
    Li Luo
    Human Genetics Center, School of Public Health, University of Texas, Houston, TX, USA
    J Comput Biol 19:731-44. 2012
    ..We report that the genome-information content-based statistic has significantly improved type 1 error rates and higher power than the other six statistics in both simulated and empirical datasets...
  24. pmc Significant SNPs have limited prediction ability for thyroid cancer
    Shicheng Guo
    State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China Human Genetics Center, University of Texas School of Public Health, Houston, Texas, 77030
    Cancer Med 3:731-5. 2014
    ..Small familial relative risks (1.02-1.05) and limited power to predict thyroid cancer (AUCs: 0.54-0.60) indicate limited clinical potential. Four significant SNPs have limited prediction ability for thyroid cancer...
  25. ncbi request reprint Dissecting linkage disequilibrium in African-American genomes: roles of markers and individuals
    Shuhua Xu
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Mol Biol Evol 24:2049-58. 2007
    ....
  26. pmc Family-based association studies for next-generation sequencing
    Yun Zhu
    Human Genetics Center and Division of Biostatistics, The University of Texas School of Public Health, Houston, 77030, USA
    Am J Hum Genet 90:1028-45. 2012
    ..The proposed statistics are applied to two data sets with pedigree structures. The results show that the smoothed FPCA has a much smaller p value than other statistics...
  27. pmc Genome-wide gene and pathway analysis
    Li Luo
    Human Genetics Center, School of Public Health, The University of Texas, Houston, TX 77225, USA
    Eur J Hum Genet 18:1045-53. 2010
    ..Third, replication of association findings at the gene or pathway level is much easier than replication at the individual SNP level...
  28. pmc Association studies for next-generation sequencing
    Li Luo
    Human Genetics Center, University of Texas School of Public Health, Houston, TX 77030, USA
    Genome Res 21:1099-108. 2011
    ..We report that FPCA-based statistics have a higher power to detect association of rare variants and a stronger ability to filter sequence errors than the other seven methods...

Research Grants2

  1. Network Approach to GWA Studies of Rheumatoid Arthritis (RA), Ankylosing Spondyli
    Momiao Xiong; Fiscal Year: 2009
    ..We believe that the proposed study is timely and we expect that the methodological developments and insights we gain will influence genetic studies of RA, AS, psoriasis and other complex diseases and continue beyond this project. ..
  2. Network Approach to GWA Studies of Rheumatoid Arthritis (RA), Ankylosing Spondyli
    Momiao Xiong; Fiscal Year: 2010
    ..We believe that the proposed study is timely and we expect that the methodological developments and insights we gain will influence genetic studies of RA, AS, psoriasis and other complex diseases and continue beyond this project. ..