M Xiong

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Generalized T2 test for genome association studies
    Momiao Xiong
    Human Genetics Center, University of Texas Houston, 77225, USA
    Am J Hum Genet 70:1257-68. 2002
  2. ncbi request reprint Haplotype block linkage disequilibrium mapping
    Momiao Xiong
    Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
    Front Biosci 8:a85-93. 2003
  3. ncbi request reprint Linkage disequilibrium mapping of quantitative trait loci under truncation selection
    M Xiong
    Human Genetics Center, University of Texas Houston, Houston, Tex 77225, USA
    Hum Hered 53:158-72. 2002
  4. ncbi request reprint Network-based regulatory pathways analysis
    Momiao Xiong
    Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Bioinformatics 20:2056-66. 2004
  5. pmc Identification of genetic networks
    Momiao Xiong
    Human Genetics Center, University of Texas, Houston Health Science Center, TX 77030, USA
    Genetics 166:1037-52. 2004
  6. pmc The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures
    J M Akey
    Human Genetics Center, School of Public Health, University of Texas Houston, Houston, TX, 77030, USA
    Am J Hum Genet 68:1447-56. 2001
  7. ncbi request reprint Population based linkage disequilibrium mapping of QTL: an application to simulated data in an isolated population
    J Zhao
    Human Genetics Center, University of Texas-Houston, Houston, Texas, USA
    Genet Epidemiol 21:S655-9. 2001
  8. ncbi request reprint Combined linkage and linkage disequilibrium mapping for genome screens
    M Xiong
    Human Genetics Center, University of Texas, Houston Health Science Center, Houston, Texas 77225, USA
    Genet Epidemiol 19:211-34. 2000
  9. ncbi request reprint Haplotypes vs single marker linkage disequilibrium tests: what do we gain?
    J Akey
    Human Genetics Center, University of Texas Houston, Houston, Texas 77225, USA
    Eur J Hum Genet 9:291-300. 2001
  10. pmc Biomarker identification by feature wrappers
    M Xiong
    Human Genetics Center, University of Texas Houston, Houston, TX 77225, USA
    Genome Res 11:1878-87. 2001

Collaborators

Detail Information

Publications41

  1. pmc Generalized T2 test for genome association studies
    Momiao Xiong
    Human Genetics Center, University of Texas Houston, 77225, USA
    Am J Hum Genet 70:1257-68. 2002
    ..Finally, examples are given to evaluate the performance of the proposed T2 statistic for association studies using simulated and real data...
  2. ncbi request reprint Haplotype block linkage disequilibrium mapping
    Momiao Xiong
    Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
    Front Biosci 8:a85-93. 2003
    ..Our preliminary results of theoretic analysis further demonstrate that the haplotype block LD analysis is a breakthrough in LD mapping and is a promising tool for genome-wide association studies...
  3. ncbi request reprint Linkage disequilibrium mapping of quantitative trait loci under truncation selection
    M Xiong
    Human Genetics Center, University of Texas Houston, Houston, Tex 77225, USA
    Hum Hered 53:158-72. 2002
    ..Finally, the proposed methods are applied to mapping QTL influencing variation in systolic blood pressure in an isolated Chinese population...
  4. ncbi request reprint Network-based regulatory pathways analysis
    Momiao Xiong
    Human Genetic Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Bioinformatics 20:2056-66. 2004
    ..It is important to extend the concept of network-based metabolic pathways to genetic networks and develop mathematical procedures for network-based regulatory pathway analysis...
  5. pmc Identification of genetic networks
    Momiao Xiong
    Human Genetics Center, University of Texas, Houston Health Science Center, TX 77030, USA
    Genetics 166:1037-52. 2004
    ..To illustrate the concepts and methods for reconstruction of genetic networks and identification of association of genetic networks with function, we applied the proposed models and algorithms to three data sets...
  6. pmc The effect that genotyping errors have on the robustness of common linkage-disequilibrium measures
    J M Akey
    Human Genetics Center, School of Public Health, University of Texas Houston, Houston, TX, 77030, USA
    Am J Hum Genet 68:1447-56. 2001
    ..Finally, through stochastic simulations, we illustrate how genotyping errors can lead to erroneous inferences when measures of LD between two samples are compared...
  7. ncbi request reprint Population based linkage disequilibrium mapping of QTL: an application to simulated data in an isolated population
    J Zhao
    Human Genetics Center, University of Texas-Houston, Houston, Texas, USA
    Genet Epidemiol 21:S655-9. 2001
    ..The proposed method is applied to search for polymorphism sites within the candidate genes 2 and 6, which influence quantitative traits Q1 and Q2 or Q5, in a simulated data set in an isolated population...
  8. ncbi request reprint Combined linkage and linkage disequilibrium mapping for genome screens
    M Xiong
    Human Genetics Center, University of Texas, Houston Health Science Center, Houston, Texas 77225, USA
    Genet Epidemiol 19:211-34. 2000
    ..The proposed LLDM is applied to familial hemophagocytic lymphohistiocytosis (FHL) disease...
  9. ncbi request reprint Haplotypes vs single marker linkage disequilibrium tests: what do we gain?
    J Akey
    Human Genetics Center, University of Texas Houston, Houston, Texas 77225, USA
    Eur J Hum Genet 9:291-300. 2001
    ..Finally, published data from the Hereditary Hemochromatosis disease region is used to illustrate the utility of haplotypes...
  10. pmc Biomarker identification by feature wrappers
    M Xiong
    Human Genetics Center, University of Texas Houston, Houston, TX 77225, USA
    Genome Res 11:1878-87. 2001
    ..The preliminary results demonstrate that very high classification accuracy can be attained by identified composite classifiers with several biomarkers...
  11. ncbi request reprint Feature (gene) selection in gene expression-based tumor classification
    M Xiong
    Human Genetics Center, University of Texas Houston Health Science Center, Houston, Texas 77225, USA
    Mol Genet Metab 73:239-47. 2001
    ..In this report we also show that stepwise Fisher's linear discriminant function is a practicable method for gene expression-based tumor classification...
  12. pmc Comparison of the power and accuracy of biallelic and microsatellite markers in population-based gene-mapping methods
    M Xiong
    Human Genetics Center, University of Texas Houston Health Science Center, Houston, TX 77225, USA
    Am J Hum Genet 64:629-40. 1999
    ..These studies provide not only guidance in selection of the markers and in the design of the sample scheme for positional cloning but also insight into the biological bases of the mapping of human disease genes...
  13. ncbi request reprint Computational methods for gene expression-based tumor classification
    M Xiong
    University of Texas Houston Health Science Center, Houston, TX, USA
    Biotechniques 29:1264-8, 1270. 2000
    ..0%. The combined approach using principal components and discriminant analysis provided superior sensitivity and specificity compared to an approach using simple differences in the expression levels of individual genes...
  14. ncbi request reprint Systemic sclerosis (scleroderma): specific autoantigen genes are selectively overexpressed in scleroderma fibroblasts
    X Zhou
    Division of Rheumatology and Clinical Immunogenetics and Division of Medical Genetics, Department of Internal Medicine, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 167:7126-33. 2001
    ..Therefore, SSc-associated autoantigen genes are selectively overexpressed in SSc dermal fibroblasts, a major tissue involved in disease pathogenesis...
  15. ncbi request reprint Interaction between the melanocortin-1 receptor and P genes contributes to inter-individual variation in skin pigmentation phenotypes in a Tibetan population
    J M Akey
    Human Genetics Center, School of Public Health, University of Texas Houston, 77030, USA
    Hum Genet 108:516-20. 2001
    ..43; P=0.0105). We also discuss the possible mechanisms of how gene interactions arise in signal transduction pathways...
  16. ncbi request reprint Genome-wide association study for regions of systemic sclerosis susceptibility in a Choctaw Indian population with high disease prevalence
    Xiaodong Zhou
    University of Texas Houston Medical School
    Arthritis Rheum 48:2585-92. 2003
    ..The aim of this study was to localize chromosome regions associated with susceptibility to SSc in a relatively isolated and homogeneous population of Choctaw Indians with a high prevalence of SSc...
  17. ncbi request reprint cDNA microarrays reveal distinct gene expression clusters in idiopathic inflammatory myopathies
    Xiaodong Zhou
    Division of Rheumatology and Clinical Immunogenetics, Department of Internal Medicine, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Med Sci Monit 10:BR191-7. 2004
    ..This study was to use gene microarray analysis of muscle biopsies from PM and DM patients to obtain a comprehensive view of molecules participating in disease pathogenesis...
  18. ncbi request reprint High resolution T association tests of complex diseases based on family data
    Ruzong Fan
    The Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
    Ann Hum Genet 69:187-208. 2005
    ..The proposed paired Hotelling's T(2) statistic tests are potentially powerful in mapping complex diseases. A SAS Macro, Hotel_fam.sas, has been written to implement the method for data analysis...
  19. pmc An entropy-based statistic for genomewide association studies
    Jinying Zhao
    Human Genetic Center, University of Texas, Health Science Center at Houston, Houston, TX 77225, USA
    Am J Hum Genet 77:27-40. 2005
    ..The results show that the entropy-based statistic obtained smaller P values than did the standard chi2 statistic...
  20. pmc Nonlinear tests for genomewide association studies
    Jinying Zhao
    Human Genetics Center, University of Texas Health Science Center, Houston 77030, USA
    Genetics 174:1529-38. 2006
    ..To evaluate their performance, the nonlinear test statistics are also applied to three real data sets. Our study shows that nonlinear test statistics have great potential in association studies of complex diseases...
  21. pmc Test for interaction between two unlinked loci
    Jinying Zhao
    Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77225, USA
    Am J Hum Genet 79:831-45. 2006
    ..Our results showed that the P values of the LD-based statistic were smaller than those obtained by other approaches, including logistic regression models...
  22. ncbi request reprint An entropy-based genome-wide transmission/disequilibrium test
    Jinying Zhao
    Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Hum Genet 121:357-67. 2007
    ..Results show that the entropy-based TDT statistic can reach p-values that are small enough to establish genome-wide linkage or association analyses...
  23. ncbi request reprint Dissecting linkage disequilibrium in African-American genomes: roles of markers and individuals
    Shuhua Xu
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Mol Biol Evol 24:2049-58. 2007
    ....
  24. doi request reprint Composite measure of linkage disequilibrium for testing interaction between unlinked loci
    Xuesen Wu
    School of Life Science, Fudan University, Shanghai, China
    Eur J Hum Genet 16:644-51. 2008
    ..The preliminary results demonstrate that the composite LD-based statistic is a strong alternative to the logistic regressions and the intragametic LD-based statistic for the detection of interaction between two unlinked loci...
  25. ncbi request reprint Linkage and association studies of QTL for nuclear families by mixed models
    Ruzong Fan
    Department of Statistics, Texas A and M University, 447 Blocker Building, College Station, TX 77843 3143, USA
    Biostatistics 4:75-95. 2003
    ..1999) under moderate disequilibrium for nuclear families. Moreover, it has higher power than the TDT statistic which is constructed by randomly choosing a single offspring from each nuclear family...
  26. ncbi request reprint High resolution mapping of quantitative trait loci by linkage disequilibrium analysis
    Ruzong Fan
    Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas, TX 77843 3143, USA
    Eur J Hum Genet 10:607-15. 2002
    ..For a complex disease with heritability h(2)> or =0.15, a study with sample size of 250 can provide high power for QTL detection under moderate linkage disequilibria...
  27. ncbi request reprint The effect of single nucleotide polymorphism identification strategies on estimates of linkage disequilibrium
    Joshua M Akey
    Center for Genome Information, University of Cincinnati, Cincinnati, Ohio, USA
    Mol Biol Evol 20:232-42. 2003
    ..Finally, we validate our theoretical predictions by comparing our results to publicly available data from ten genes sequenced in 24 African American and 23 European American individuals...
  28. ncbi request reprint A mathematical programming approach for gene selection and tissue classification
    Minghe Sun
    Department of Management Science and Statistics, College of Business, The University of Texas at San Antonio, San Antonio, TX 78249 0632, USA
    Bioinformatics 19:1243-51. 2003
    ..Therefore, a mathematical programming approach is developed for gene selection and tissue classification using gene expression profiles...
  29. ncbi request reprint SamCluster: an integrated scheme for automatic discovery of sample classes using gene expression profile
    Wuju Li
    Beijing Institute of Basic Medical Sciences, PO Box 130 3, People s Republic of China
    Bioinformatics 19:811-7. 2003
    ..In contrast to class prediction, few statistical and computational methods for feature selection have been applied to clustering algorithms for pattern discovery...
  30. ncbi request reprint Combined high resolution linkage and association mapping of quantitative trait loci
    Ruzong Fan
    Department of Statistics, The Texas A and M University, 447 Blocker Building, College Station, Texas 77843 3143, USA
    Eur J Hum Genet 11:125-37. 2003
    ....
  31. ncbi request reprint Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift
    Kun Zhang
    Center for Genome Information, 130 Kettering, Department of Environmental Health, University of Cincinnati, OH 45215, Cincinnati, USA
    Hum Genet 113:51-9. 2003
    ..Our findings highlight the necessity of characterizing haplotype blocks in world-wide populations...
  32. ncbi request reprint Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis
    Eun Bong Lee
    Seoul National University, Seoul, Republic of Korea
    Arthritis Rheum 56:2443-8. 2007
    ..To examine genetic polymorphisms in the chemokine pathway, and to assess their interactions in relation to susceptibility to systemic sclerosis (SSc)...
  33. ncbi request reprint Multiple transporters associated with malaria parasite responses to chloroquine and quinine
    Jianbing Mu
    Laboratory of Malaria and Vector Research, National Institutes of Health, Bethesda, MD, USA
    Mol Microbiol 49:977-89. 2003
    ..This study provides specific leads for better understanding of complex drug resistances in malaria parasites...
  34. ncbi request reprint [Linkage analysis of 13 vasoactivity-regulating short tandem genes loci in essential hypertension in Chinese]
    Shaoli Chu
    Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Zhonghua Nei Ke Za Zhi 41:295-7. 2002
    ..To investigate whether linkage between essential hypertension (EH) and genetic loci near renin-angiotensin system, endothelin system, nitric oxide synthase, adrenergic receptor genes in Chinese...
  35. ncbi request reprint [Linkage analysis of cytokine and cytokine-related receptor gene loci and essential hypertension in Chinese]
    Shaoli Chu
    Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, Shanghai, 200025 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:221-4. 2002
    ..To investigate the genetic linkage between several cytokine and cytokine-related receptor gene loci and essential hypertension (EH) in Chinese...
  36. ncbi request reprint Linkage analysis of a region on chromosome 2 with essential hypertension in Chinese families
    Dingliang Zhu
    Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China
    Chin Med J (Engl) 115:654-7. 2002
    ..To verify the linkage of the candidate regions identified in a previous study (markers D2S168, D2S151, D2S142 on chromosome 2) with hypertension in Chinese families...
  37. ncbi request reprint Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profiles
    Jieruo Gu
    University of California Los Angeles, 90095, USA
    J Rheumatol 29:2159-64. 2002
    ....
  38. ncbi request reprint Monozygotic twins clinically discordant for scleroderma show concordance for fibroblast gene expression profiles
    Xiaodong Zhou
    University of Texas Medical School at Houston, USA
    Arthritis Rheum 52:3305-14. 2005
    ..To discover genetic versus nongenetic molecular pathways important to the pathogenesis of SSc, we compared global gene expression patterns in twins discordant for SSc...
  39. ncbi request reprint Discovery of Ca2+-relevant and differentiation-associated genes downregulated in esophageal squamous cell carcinoma using cDNA microarray
    Aiping Luo
    National Lab of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P R China
    Oncogene 23:1291-9. 2004
    ..This study provides new insights into the role of squamous cell differentiation-associated genes in ESCC initiation and progression...
  40. ncbi request reprint Comparison of gene expression between metastatic derivatives and their poorly metastatic parental cells implicates crucial tumor-environment interaction in metastasis of head and neck squamous cell carcinoma
    Zhuo Chen
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Exp Metastasis 20:335-42. 2003
    ....
  41. pmc Differential dynamic properties of scleroderma fibroblasts in response to perturbation of environmental stimuli
    Momiao Xiong
    Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston UTHSC H, Houston, Texas, USA
    PLoS ONE 3:e1693. 2008
    ..Our findings may open a new avenue in exploring the functions of cells and mechanism operative in disease development...