Affiliation: Texas A and M University
Zhou L, Liu J, Xiang M, Olson P, Guzzetta A, Zhang K, et al
. Gata4 potentiates second heart field proliferation and Hedgehog signaling for cardiac septation. Proc Natl Acad Sci U S A. 2017;114:E1422-E1431 pubmed publisher
..Thus, both the cell-cycle and Hh-signaling defects caused by dominant Gata4 mutations were required for CHD pathogenesis, suggesting a combinatorial model of disease causation by transcription factor haploinsufficiency. ..
Zhou Y, Peng H, Liu Z, Zhang K, Jendrusch C, Drake M, et al
. Sex-associated preventive effects of low-dose aspirin on obesity and non-alcoholic fatty liver disease in mouse offspring with over-nutrition in utero. Lab Invest. 2018;: pubmed publisher
..In summary, our study demonstrates a sex-associated effect of low-dose aspirin on obesity and NAFLD prevention in female but not in male mice. ..
Xu H, Fu Q, Zhou Y, Xue C, Olson P, Lynch E, et al
. A long-term maternal diet intervention is necessary to avoid the obesogenic effect of maternal high-fat diet in the offspring. J Nutr Biochem. 2018;62:210-220 pubmed publisher
..In summary, we showed that a long-term maternal diet intervention effectively released the intergenerational obesogenic effect of maternal HF diet independent of maternal weight management. ..
Zhang K, Xiang M, Zhou L, Liu J, Curry N, Heine SuÃ±er D, et al
. Gene network and familial analyses uncover a gene network involving Tbx5/Osr1/Pcsk6 interaction in the second heart field for atrial septation. Hum Mol Genet. 2016;25:1140-51 pubmed publisher
..In summary, our study implicated a gene network involving Tbx5, Osr1 and Pcsk6 interaction in SHF for atrial septation, providing a molecular framework for understanding the role of Tbx5 in CHD ontogeny. ..