Yang Xia

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsia
    Yang Xia
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77225, USA
    Hypertension 50:269-75. 2007
  2. pmc Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom
    Hypertension 51:1010-9. 2008
  3. pmc Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice
    Cissy Chenyi Zhou
    Department of Biochemistry, Texas A and M Health Science Center, Houston, Texas, United States of America
    PLoS ONE 7:e29236. 2012
  4. pmc Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia
    Wei Wang
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, TX 77030
    Hypertension 63:595-606. 2014
  5. pmc Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification
    Chen Liu
    Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas or
    Hypertension 63:353-61. 2014
  6. ncbi request reprint Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Circ Res 113:78-87. 2013
  7. ncbi request reprint Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia
    Wei Wang
    Department of Nephrology, Xiangya Hospital, Central South University, Hunan, China
    Hypertension 60:712-21. 2012
  8. pmc Angiotensin receptors, autoimmunity, and preeclampsia
    Yang Xia
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 179:3391-5. 2007
  9. pmc Is preeclampsia an autoimmune disease?
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas Houston, Medical School, Houston, TX 77030, USA
    Clin Immunol 133:1-12. 2009
  10. ncbi request reprint Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas, Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 278:13143-50. 2003

Collaborators

Detail Information

Publications55

  1. pmc Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsia
    Yang Xia
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77225, USA
    Hypertension 50:269-75. 2007
  2. pmc Autoantibody from women with preeclampsia induces soluble Fms-like tyrosine kinase-1 production via angiotensin type 1 receptor and calcineurin/nuclear factor of activated T-cells signaling
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, Medical School, University of Birmingham, Edgbaston, Birmingham, West Midlands, United Kingdom
    Hypertension 51:1010-9. 2008
    ..These autoantibodies represent potentially important targets for diagnosis and therapeutic intervention...
  3. pmc Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice
    Cissy Chenyi Zhou
    Department of Biochemistry, Texas A and M Health Science Center, Houston, Texas, United States of America
    PLoS ONE 7:e29236. 2012
    ..However, the lack of well-defined trophoblast-specific gene regulatory elements has hampered investigations regarding the role of specific genes in placental development and fetal growth...
  4. pmc Excess LIGHT contributes to placental impairment, increased secretion of vasoactive factors, hypertension, and proteinuria in preeclampsia
    Wei Wang
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, TX 77030
    Hypertension 63:595-606. 2014
    ....
  5. pmc Tissue transglutaminase contributes to the pathogenesis of preeclampsia and stabilizes placental angiotensin receptor type 1 by ubiquitination-preventing isopeptide modification
    Chen Liu
    Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas or
    Hypertension 63:353-61. 2014
    ....
  6. ncbi request reprint Angiotensin receptor agonistic autoantibodies and hypertension: preeclampsia and beyond
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA
    Circ Res 113:78-87. 2013
    ..These pathogenic autoantibodies could serve as presymptomatic biomarkers and therapeutic targets, thereby providing improved medical management for these conditions...
  7. ncbi request reprint Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia
    Wei Wang
    Department of Nephrology, Xiangya Hospital, Central South University, Hunan, China
    Hypertension 60:712-21. 2012
    ..These studies are the first to link angiotensin II type 1 receptor agonistic autoantibody with complement activation and to provide important new opportunities for therapeutic intervention in PE...
  8. pmc Angiotensin receptors, autoimmunity, and preeclampsia
    Yang Xia
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 179:3391-5. 2007
    ..The research reviewed here raises the intriguing possibility that preeclampsia may be a pregnancy-induced autoimmune disease...
  9. pmc Is preeclampsia an autoimmune disease?
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas Houston, Medical School, Houston, TX 77030, USA
    Clin Immunol 133:1-12. 2009
    ..Research reviewed here raises the intriguing possibility that preeclampsia may be a pregnancy-induced autoimmune condition characterized by the presence of disease-causing angiotensin receptor activating autoantibodies...
  10. ncbi request reprint Mammalian target of rapamycin and protein kinase A signaling mediate the cardiac transcriptional response to glutamine
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas, Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 278:13143-50. 2003
    ..These results highlight glutamine as a major nutrient regulator of cardiac gene expression and identify protein kinase A and mammalian target of rapamycin signaling pathways as mediators of the cardiomyocyte transcriptional response...
  11. pmc Receptor-activating autoantibodies and disease: preeclampsia and beyond
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, TX 77030, USA
    Expert Rev Clin Immunol 7:659-74. 2011
    ....
  12. pmc Angiotensin receptor agonistic autoantibody-mediated tumor necrosis factor-alpha induction contributes to increased soluble endoglin production in preeclampsia
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Circulation 121:436-44. 2010
    ....
  13. pmc Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A2B adenosine receptor signaling
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin St, MSB 6 200, Houston, TX 77030, USA
    FASEB J 24:740-9. 2010
    ..Dai, Y., Zhang, Y., Tang, Y., Sun, H., Mi, T., Phatarpekar, P. V., Kellems, R. E., Blackburn, M. R., Xia, Y. Increased adenosine contributes to penile fibrosis, a dangerous feature of priapism, via A(2B) adenosine receptor signaling...
  14. pmc Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
    Cissy C Zhou
    Department of Biochemistry, University of Texas Houston Medical School, 6431 Fannin, Houston, Texas 77030, USA
    Nat Med 14:855-62. 2008
    ..This hypothesis has obvious implications regarding pre-eclampsia screening, diagnosis and therapy...
  15. pmc Interleukin 6 underlies angiotensin II-induced hypertension and chronic renal damage
    Weiru Zhang
    Department of Biochemistry, University of Texas Houston Medical School, Houston, TX, USA
    Hypertension 59:136-44. 2012
    ..These findings immediately suggest that the IL-6 signaling is a novel therapeutic target to manage this devastating disorder affecting millions worldwide...
  16. pmc Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension
    Weiru Zhang
    Departments of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, TX 77030, USA
    Circ Res 112:1466-78. 2013
    ..Hypertension is the most prevalent life-threatening disease worldwide and is frequently associated with chronic kidney disease (CKD). However, the molecular basis underlying hypertensive CKD is not fully understood...
  17. pmc The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia
    Roxanna A Irani
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX, 77030, USA
    J Exp Med 206:2809-22. 2009
    ..Our findings highlight AT(1)-AAs as important therapeutic targets...
  18. ncbi request reprint Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1
    Shahrzad Abbasi
    Department of Biochemistry and Molecular Biology, The University of Texas Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 281:7717-26. 2006
    ....
  19. doi request reprint Detrimental effects of adenosine signaling in sickle cell disease
    Yujin Zhang
    Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    Nat Med 17:79-86. 2011
    ..Thus, excessive adenosine signaling through the A(2B)R has a pathological role in SCD. These findings may provide new therapeutic possibilities for this disease...
  20. pmc A2B adenosine receptor-mediated induction of IL-6 promotes CKD
    Yingbo Dai
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas, USA
    J Am Soc Nephrol 22:890-901. 2011
    ..Taken together, these data suggest that A(2B)R-mediated induction of IL-6 contributes to renal fibrogenesis and shows potential therapeutic targets for CKD...
  21. pmc Aqp2-expressing cells give rise to renal intercalated cells
    Hongyu Wu
    Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Am Soc Nephrol 24:243-52. 2013
    ..In conclusion, these data suggest that Dot1l deletion facilitates the differentiation of some α- and β-intercalated cells from Aqp2-expressing progenitor cells or mature principal cells...
  22. pmc A2B adenosine receptor contributes to penile erection via PI3K/AKT signaling cascade-mediated eNOS activation
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, 6431 Fannin St, MSB 6 200, Houston, TX 77030, USA
    FASEB J 25:2823-30. 2011
    ..These studies suggest that this signaling pathway may be a novel therapeutic target for erectile disorders...
  23. pmc Adenosine deaminase enzyme therapy prevents and reverses the heightened cavernosal relaxation in priapism
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Sex Med 7:3011-22. 2010
    ..Recent studies have revealed a novel role of excess adenosine in priapism caused by heightened cavernosal relaxation, and therefore present an intriguing mechanism-based therapeutic possibility...
  24. ncbi request reprint Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human trophoblast cells
    Yang Xia
    Department of Biochemistry and Molecular Biology, Houston, Texas 77303, USA
    J Soc Gynecol Investig 10:82-93. 2003
    ..We sought to evaluate the role of AT1 agonistic autoantibodies (AT1-AA) in two major features of preeclampsia-increased plasminogen activator inhibitor-1 (PAI-1) production and shallow trophoblast invasion...
  25. pmc Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling
    Roxanna A Irani
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin St, Houston, TX 77030, USA
    Hypertension 55:1246-53. 2010
    ..Overall, AT(1)-AA is a novel candidate that induces TNF-alpha, a cytokine that may play an important pathogenic role in preeclampsia...
  26. ncbi request reprint Angiotensin receptor agonistic autoantibody-mediated soluble fms-like tyrosine kinase-1 induction contributes to impaired adrenal vasculature and decreased aldosterone production in preeclampsia
    Athar H Siddiqui
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    Hypertension 61:472-9. 2013
    ..05). Overall, we revealed that angiotensin II type 1 receptor agonistic autoantibody-induced soluble Fms-like tyrosine kinase-1 elevation is a novel pathogenic mechanism underlying decreased aldosterone production in PE...
  27. pmc Angiotensin receptor agonistic autoantibody is highly prevalent in preeclampsia: correlation with disease severity
    Athar H Siddiqui
    Departments of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, Tex, USA
    Hypertension 55:386-93. 2010
    ..These data serve as compelling clinical evidence that AT(1)-AA is highly prevalent in PE, and its titer is strongly correlated to the severity of the disease...
  28. pmc Recombinant vascular endothelial growth factor 121 attenuates autoantibody-induced features of pre-eclampsia in pregnant mice
    Athar H Siddiqui
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, USA
    Am J Hypertens 24:606-12. 2011
    ..The research reported here used this autoantibody-injection model of PE to assess the therapeutic potential of recombinant VEGF(121), a relatively stable form of the natural ligand...
  29. pmc Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Immunol 186:6024-34. 2011
    ..Significantly, our findings revealed novel factors and signaling cascades involved in ET-1 production, subsequent disease symptom development, and possible therapeutic intervention in the management of PE...
  30. ncbi request reprint Antibodies from preeclamptic patients stimulate increased intracellular Ca2+ mobilization through angiotensin receptor activation
    Theingi M Thway
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Circulation 110:1612-9. 2004
    ..Recent studies have shown that antibodies directed against angiotensin II type I (AT1) receptors are also highly associated with preeclampsia...
  31. pmc Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling
    Tiejuan Mi
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Clin Invest 118:1491-501. 2008
    ..These findings provide insight regarding the molecular basis of priapism and suggest that strategies to either reduce adenosine or block A2BR activation may prove beneficial in the treatment of this disorder...
  32. pmc Af17 deficiency increases sodium excretion and decreases blood pressure
    Lihe Chen
    Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Am Soc Nephrol 22:1076-86. 2011
    ..Af17-mediated regulation of BP is largely, but not exclusively, the result of modulating ENaC, suggesting it has potential as a therapeutic target for the control of BP...
  33. pmc Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2
    Hongyu Wu
    Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, United States of America
    PLoS ONE 8:e53342. 2013
    ....
  34. pmc Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels
    Mary Rose Reisenauer
    Department of Internal Medicine, University of Texas Medical School at Houston, Houston, TX 77030, USA
    Am J Physiol Renal Physiol 299:F63-76. 2010
    ..In brief, Dot1a and AF9 downregulate Na(+) transport, most likely by regulating ENaC mRNA and subsequent protein expression and ENaC activity...
  35. ncbi request reprint Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice
    Amir Mohsenin
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, University of Texas, Houston, Texas 77030, USA
    Am J Physiol Lung Cell Mol Physiol 293:L753-61. 2007
    ..There were no compensatory changes in the other adenosine receptors in the lungs of ADA/A(2A)R double knockout mice. These findings suggest that the A(2A)R plays a protective role in the ADA-deficient model of pulmonary inflammation...
  36. ncbi request reprint Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression
    Chen Ning
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, Texas, USA Department of Urology and Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
    FASEB J 28:2725-35. 2014
    ..Dai, Y., Wang, W., Zhang, W., Qi, L., Grenz, A., Eltzschig, H. K., Blackburn, M. R., Kellems, R. E., Xia, Y. Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression. ..
  37. ncbi request reprint Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion
    Sol M Bobst
    Department of Biochemistry and Molecular Biology, University of Texas at Houston Medical School, 6431 Fannin, Houston, TX 77030, USA
    Am J Hypertens 18:330-6. 2005
    ..In this study, we investigated the role of AT(1) receptor-agonistic autoantibody (AT1-AA) regarding interleukin-6 (IL-6) and plasminogen activator inhibitor-1 (Pai-1) secretion in human mesangial cells...
  38. doi request reprint Adenosine signaling, priapism and novel therapies
    Yingbo Dai
    University of Texas at Houston Medical School, Biochemistry and Molecular Biology, Houston, TX 77030, USA
    J Sex Med 6:292-301. 2009
    ..Adenosine is a signaling nucleoside that elicits many pathophysiological effects by engaging membrane receptors. Recent evidence shows that adenosine may play an important role in priapism via adenosine receptor...
  39. pmc Impaired erectile function in CD73-deficient mice with reduced endogenous penile adenosine production
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, TX 77030, USA
    J Sex Med 8:2172-80. 2011
    ..Adenosine has been implicated in normal and abnormal penile erection. However, a direct role of endogenous adenosine in erectile physiology and pathology has not been established...
  40. pmc Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
    Cissy Chenyi Zhou
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, 6431 Fannin, MSB 6 200 Houston, TX 77030, USA
    Circ Res 100:88-95. 2007
    ....
  41. ncbi request reprint Angiotensin II inhibits human trophoblast invasion through AT1 receptor activation
    Yang Xia
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 277:24601-8. 2002
    ..These studies are the first to link the renin-angiotensin system with the fibrinolytic system to regulate trophoblast invasion...
  42. doi request reprint Adenosine signaling: good or bad in erectile function?
    Jiaming Wen
    Department of Biochemistry and Molecular Biology, UT Houston Medical School, Texas 77225, USA
    Arterioscler Thromb Vasc Biol 32:845-50. 2012
    ..This new insight highlights adenosine signaling pathways operating in penile tissue as significant therapeutic targets for the treatment of erectile disorders...
  43. pmc Role of adenosine signaling in penile erection and erectile disorders
    Prasad V Phatarpekar
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, Houston, TX, USA
    J Sex Med 7:3553-64. 2010
    ..Adenosine, a physiological vasorelaxant, has been shown to be a modulator of penile erection...
  44. ncbi request reprint The essential role of MEKK3 signaling in angiotensin II-induced calcineurin/nuclear factor of activated T-cells activation
    Shahrzad Abbasi
    Department of Biochemistry and Molecular Biology, University of Texas at Houston Medical School, Houston, Texas 77030, USA
    J Biol Chem 280:36737-46. 2005
    ..Taken together, our studies reveal a previously unrecognized novel essential regulatory role of MEKK3 signaling in calcineurin/NFAT activation...
  45. ncbi request reprint Adenosine-dependent pulmonary fibrosis in adenosine deaminase-deficient mice
    Janci L Chunn
    Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Medical School, Houston, TX 77030, USA
    J Immunol 175:1937-46. 2005
    ..These findings demonstrate that chronic adenosine elevations are associated with pulmonary fibrosis in ADA-deficient mice and suggest that the adenosine functions as a profibrotic signal in the lung...
  46. pmc Adenosine signaling during acute and chronic disease states
    Harry Karmouty-Quintana
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, 6431 Fannin Blvd, Suite 6 200, Houston, TX 77030, USA
    J Mol Med (Berl) 91:173-81. 2013
    ....
  47. pmc Renin angiotensin signaling in normal pregnancy and preeclampsia
    Roxanna A Irani
    Department of Biochemistry and Molecular Biology, University of Texas at Houston Medical School, 6431 Fannin Street, Houston, TX 77030, USA
    Semin Nephrol 31:47-58. 2011
    ..Here we review the functions of the RAS during normal pregnancy and PE, and highlight the role of AT(1)-AA in both animal models and in the human disorder...
  48. ncbi request reprint Pregnancy-induced changes in renin gene expression in mice
    Yang Xia
    Department of Biochemistry and Molecular Biology, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Biol Reprod 66:135-43. 2002
    ..However, these mice differ with regard to gestation-induced sites of increased renin gene expression. These studies suggest that mice are a convenient and valuable model for studying renin gene expression during pregnancy...
  49. pmc Widely expressed Af17 is likely not required for embryogenesis, hematopoiesis, and animal survival
    Zhijing Zhang
    Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Genesis 48:693-706. 2010
    ....
  50. pmc PMA induces SnoN proteolysis and CD61 expression through an autocrine mechanism
    Chonghua Li
    Department of Biochemistry and Molecular Biology, Medical School, United States
    Cell Signal 26:1369-78. 2014
    ..These results indicate that protein ubiquitination promotes megakaryopoiesis via degrading SnoN, an inhibitor of CD61 expression, strengths the roles of ubiquitination in cellular differentiation...
  51. doi request reprint New insights into sickle cell disease: a disease of hypoxia
    Kaiqi Sun
    Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, Texas 77030, USA
    Curr Opin Hematol 20:215-21. 2013
    ..Although the condition was first described more than a 100 years ago, treatment options remain scarce and unsatisfactory. This review summarizes recent findings that may provide novel insight into therapeutic approaches to SCD treatment...
  52. pmc Adenosine signaling in normal and sickle erythrocytes and beyond
    Yujin Zhang
    Biochemistry and Molecular Biology Department, University of Texas Houston Medical School, Houston, TX 77030, USA
    Microbes Infect 14:863-73. 2012
    ..Thus, adenosine signaling represents a potentially important therapeutic target for the treatment and prevention of disease...
  53. pmc The A2B adenosine receptor modulates pulmonary hypertension associated with interstitial lung disease
    Harry Karmouty-Quintana
    Department of Biochemistry and Molecular Biology, University of Texas Medical School at Houston, 6431 Fannin, Houston, TX 77030, USA
    FASEB J 26:2546-57. 2012
    ..These studies identify a novel mechanism of disease progression to pulmonary hypertension and support the development of A(2B)R antagonists for the treatment of pulmonary hypertension secondary to interstitial lung disease...
  54. ncbi request reprint [A preliminary study in establishment of mice model of experimental uveal melanoma]
    Hao Cheng
    Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China
    Zhonghua Yan Ke Za Zhi 42:733-7. 2006
    ..To explore the methods to establish a nude mice model of experimental uveal melanoma by the implantation the primary cultured cells into anterior chamber or subcutaneous injection...
  55. ncbi request reprint Mechanisms of transforming growth factor-alpha (TGF-alpha) induced gastroprotection against ethanol in the rat: roles of sensory neurons, sensory neuropeptides, and prostaglandins
    Verapan Vongthavaravat
    Department of Medicine, University of Oklahoma Health Sciences Center, and Oklahoma City Department of Veterans Affairs, Medical Center, Oklahoma City, Oklahoma, USA
    Dig Dis Sci 48:329-33. 2003
    ..In conclusion, TGF-alpha-mediated gastroprotection involves sensory neuron activation and CGRP release and this protective effect did not involve substance P or prostaglandin generation...

Research Grants7

  1. AT1 Receptor Activating Autoantibodies and Preeclampsia
    Yang Xia; Fiscal Year: 2007
    ..This hypothesis has the ability to explain many features of this complex life threatening condition and immediately suggests diagnostic and therapeutic opportunities. ..
  2. AT1 Receptor Activating Autoantibodies and Preeclampsia
    Yang Xia; Fiscal Year: 2006
    ..This hypothesis has the ability to explain many features of this complex life threatening condition and immediately suggests diagnostic and therapeutic opportunities. ..
  3. Adenosine Signaling and Priapsim
    Yang Xia; Fiscal Year: 2007
    ..By understanding the molecular events involved in the development of priapism, we seek to develop novel therapeutic strategies to treat this disease. ..
  4. Adenosine Signaling, Priapism and Sickle Cell Disease
    Yang Xia; Fiscal Year: 2009
    ..By understanding the molecular events involved in the development of priapism, we seek to develop novel therapeutic strategies to treat this disease. ..
  5. Adenosine Signaling, Priapism and Sickle Cell Disease
    Yang Xia; Fiscal Year: 2010
    ..By understanding the molecular events involved in the development of priapism, we seek to develop novel therapeutic strategies to treat this disease. ..