M H Wu

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules
    M H Wu
    Cardiovascular Research Institute, Department of Medical Physiology, Texas A and M University System Health Science Center, Temple, TX 76504, USA
    J Physiol 532:785-91. 2001
  2. ncbi Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor
    Mack H Wu
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 702 Southwest HK Dodgen Loop, Temple, TX 76504, USA
    J Physiol 552:691-9. 2003
  3. ncbi Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
    S Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Circ Res 87:412-7. 2000
  4. ncbi Protein transfection of intact microvessels specifically modulates vasoreactivity and permeability
    J H Tinsley
    Department of Surgery, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, Tex 76504, USA
    J Vasc Res 38:444-52. 2001
  5. ncbi Growth factor- and heparin-dependent regulation of constitutive and agonist-mediated human endothelial barrier function
    Alan B Moy
    Cellular Engineering Technologies, Inc, 2501 Crosspark Rd, Ste B105, Coralville, IA 52241, USA
    Am J Physiol Heart Circ Physiol 291:H2126-35. 2006
  6. ncbi Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability
    Hengrui Sun
    Department of Surgery, University of California at Davis School of Medicine, Sacramento, California, USA
    Microcirculation 13:237-47. 2006
  7. ncbi Toll-like receptor 4 contributes to microvascular inflammation and barrier dysfunction in thermal injury
    Jerome W Breslin
    Department of Surgery Division of Research, University of California Davis School of Medicine, Sacramento, California 95817, USA
    Shock 29:349-55. 2008
  8. ncbi Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage
    Jerome W Breslin
    UCDMC Dept of Surgery, Div of Research, 2805 50th St, Rm 2411, Sacramento, CA 95817, USA
    Am J Physiol Heart Circ Physiol 290:H741-50. 2006
  9. ncbi Focal adhesion kinase in neutrophil-induced microvascular hyperpermeability
    Mingzhang Guo
    Department of Surgery, Texas A and M University Health Science Center, Temple, Texas, USA
    Microcirculation 12:223-32. 2005
  10. ncbi The protein kinase MEK1/2 mediate vascular endothelial growth factor- and histamine-induced hyperpermeability in porcine coronary venules
    Mack H Wu
    Cardiovascular Research Institute, Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 702 Southwest HK Dodgen Loop, Temple, TX 76504, USA
    J Physiol 563:95-104. 2005

Collaborators

Detail Information

Publications22

  1. ncbi Integrin binding to fibronectin and vitronectin maintains the barrier function of isolated porcine coronary venules
    M H Wu
    Cardiovascular Research Institute, Department of Medical Physiology, Texas A and M University System Health Science Center, Temple, TX 76504, USA
    J Physiol 532:785-91. 2001
    ..It is likely that both fibronectin and vitronectin binding to integrins contribute to the maintenance of endothelial barrier function in venules...
  2. ncbi Focal adhesion kinase mediates porcine venular hyperpermeability elicited by vascular endothelial growth factor
    Mack H Wu
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 702 Southwest HK Dodgen Loop, Temple, TX 76504, USA
    J Physiol 552:691-9. 2003
    ..Taken together, the results suggest that FAK contributes to VEGF-elicited vascular hyperpermeability. Phosphorylation of FAK may play an important role in the signal transduction of vascular barrier response to VEGF...
  3. ncbi Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
    S Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Circ Res 87:412-7. 2000
    ..The results suggest that endothelial barrier dysfunction attributed to the activation of PKC occurs at the coronary exchange vessels in early diabetes...
  4. ncbi Protein transfection of intact microvessels specifically modulates vasoreactivity and permeability
    J H Tinsley
    Department of Surgery, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, Tex 76504, USA
    J Vasc Res 38:444-52. 2001
    ..By transfecting inhibitor peptides against NOS and PKC into coronary arterioles and venules, we have been able to determine the specific roles of these two enzymes in vasodilation and hyperpermeability responses...
  5. ncbi Growth factor- and heparin-dependent regulation of constitutive and agonist-mediated human endothelial barrier function
    Alan B Moy
    Cellular Engineering Technologies, Inc, 2501 Crosspark Rd, Ste B105, Coralville, IA 52241, USA
    Am J Physiol Heart Circ Physiol 291:H2126-35. 2006
    ..Taken together, these data demonstrate marked differential regulation of constitutive and agonist-mediated endothelial barrier function in response to mitogens and heparin stimulation...
  6. ncbi Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability
    Hengrui Sun
    Department of Surgery, University of California at Davis School of Medicine, Sacramento, California, USA
    Microcirculation 13:237-47. 2006
    ..They also investigated myosin light chain (MLC) phosphorylation and actin polymerization, two well-characterized targets of the Rho-ROCK pathway that are implicated in the regulation of endothelial barrier function...
  7. ncbi Toll-like receptor 4 contributes to microvascular inflammation and barrier dysfunction in thermal injury
    Jerome W Breslin
    Department of Surgery Division of Research, University of California Davis School of Medicine, Sacramento, California 95817, USA
    Shock 29:349-55. 2008
    ..Taken together, these data indicate that TLR-4 plays an important role in microvascular leakage and leukocyte adhesion under the inflammatory condition associated with nonseptic thermal injury...
  8. ncbi Involvement of ROCK-mediated endothelial tension development in neutrophil-stimulated microvascular leakage
    Jerome W Breslin
    UCDMC Dept of Surgery, Div of Research, 2805 50th St, Rm 2411, Sacramento, CA 95817, USA
    Am J Physiol Heart Circ Physiol 290:H741-50. 2006
    ..The data suggest that during neutrophil activation, ROCK promotes microvascular leakage in association with actin-myosin-mediated tension development in endothelial cells...
  9. ncbi Focal adhesion kinase in neutrophil-induced microvascular hyperpermeability
    Mingzhang Guo
    Department of Surgery, Texas A and M University Health Science Center, Temple, Texas, USA
    Microcirculation 12:223-32. 2005
    ..The aim of this study was to explore the potential contribution of FAK to neutrophil-dependent microvascular hyperpermeability...
  10. ncbi The protein kinase MEK1/2 mediate vascular endothelial growth factor- and histamine-induced hyperpermeability in porcine coronary venules
    Mack H Wu
    Cardiovascular Research Institute, Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, 702 Southwest HK Dodgen Loop, Temple, TX 76504, USA
    J Physiol 563:95-104. 2005
    ..The results suggest that activation of MEK1/2 may play a central role in the signal transduction of microvascular hyperpermeability in response to growth factors and inflammatory mediators...
  11. ncbi Transference of recombinant VE-cadherin cytoplasmic domain alters endothelial junctional integrity and porcine microvascular permeability
    Mingzhang Guo
    Cardiovascular Research Institute, Department of Surgery, Texas A and M University System Health Science Center, 702 Southwest H K Dodgen Loop, Temple, TX 76504, USA
    J Physiol 554:78-88. 2004
    ..The results suggest that the intracellular association of VE-cadherin with beta-catenin-linked cytoskeleton is essential to the maintenance of endothelial junctional integrity and microvascular permeability...
  12. ncbi Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway
    Jena J Steinle
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple 76504, USA
    J Biol Chem 277:43830-5. 2002
    ..Eph B4 receptor stimulation increased activation of both matrix metalloproteinase-2 and -9. The results from these studies indicate that Eph B4 stimulates migration and proliferation and may play a role in angiogenesis...
  13. ncbi Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage
    Sarah Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University Health Science Center, Temple, Texas, USA. yuan@ tamu.edu
    Circ Res 90:1214-21. 2002
    ..Taken together, the results suggest that endothelial MLCK activation and MLC phosphorylation play an important role in mediating endothelial barrier dysfunction during neutrophil activation...
  14. ncbi A role for endothelial-derived matrix metalloproteinase-2 in breast cancer cell transmigration across the endothelial-basement membrane barrier
    Hamed Kargozaran
    Department of Surgery, Division of Research, University of California Davis School of Medicine, 4625 2nd Avenue, Room 3006, Sacramento, CA 95817, USA
    Clin Exp Metastasis 24:495-502. 2007
    ..We suggest that the interaction between malignant cells and peritumoral benign tissues including the vascular endothelium may serve as an important mechanism in the regulation of tumor invasion and metastasis...
  15. ncbi VEGF-C alters barrier function of cultured lymphatic endothelial cells through a VEGFR-3-dependent mechanism
    Jerome W Breslin
    Department of Surgery, Division of Research, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
    Lymphat Res Biol 5:105-13. 2007
    ....
  16. ncbi VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
    Mingzhang Guo
    Department of Surgery, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Am J Physiol Cell Physiol 294:C977-84. 2008
    ..Taken together, these data suggest that inflammatory agents like histamine cause a transient and reversible disruption of binding between beta-catenin and VE-cadherin, during which endothelial permeability is elevated...
  17. ncbi Microvascular permeability in diabetes and insulin resistance
    Sarah Y Yuan
    Department of Surgery, University of California at Davis School of Medicine, Sacramento, California 95817, USA
    Microcirculation 14:363-73. 2007
    ..A deeper understanding of the molecular basis of diabetes-induced endothelial barrier dysfunction will provide a framework for the development of new therapeutic targets to treat this chronic and debilitating disease process...
  18. ncbi A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns
    Rashell Reynoso
    Division of Research, Department of Surgery, University of California at Davis School of Medicine, Sacramento, California 95817, USA
    Shock 28:589-95. 2007
    ..These results provide direct evidence for a role of MLCK-210 in mediating burn-induced microvascular barrier injury and validate MLCK-210 as a potential therapeutic target in the treatment of burn edema...
  19. ncbi Signaling pathways mediating VEGF165-induced calcium transients and membrane depolarization in human endothelial cells
    Nancy S Dawson
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas 77843 1114, USA
    FASEB J 20:991-3. 2006
    ..In addition, the depolarization is modulated by PI3 kinase in a ras-independent manner. In summary, intracellular calcium and membrane potential are influenced by several key signaling cascades of VEGFR-2 activation in HUVEC...
  20. ncbi Endothelial focal adhesions and barrier function
    Mack H Wu
    Department of Surgery, University of California at Davis School of Medicine, Sacramento, CA 95817, USA
    J Physiol 569:359-66. 2005
    ....
  21. ncbi Upregulation of PKC genes and isozymes in cardiovascular tissues during early stages of experimental diabetes
    Mingzhang Guo
    Cardiovascular Research Institute, Departments of Surgery and Medical Physiology, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    Physiol Genomics 12:139-46. 2003
    ....
  22. ncbi Counter regulatory effects of PKCbetaII and PKCdelta on coronary endothelial permeability
    Nathalie Gaudreault
    Department of Surgery, University of California Davis School of Medicine, 4625 2nd Avenue, Room 3006, Sacramento, CA 95817, USA
    Arterioscler Thromb Vasc Biol 28:1527-33. 2008
    ....