Haoquan Wu

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. pmc Alternative processing of primary microRNA transcripts by Drosha generates 5' end variation of mature microRNA
    Haoquan Wu
    Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 4:e7566. 2009
  2. doi request reprint MicroRNA cloning from cells of the immune system
    Haoquan Wu
    Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA
    Methods Mol Biol 667:67-77. 2010
  3. pmc Improved siRNA/shRNA functionality by mismatched duplex
    Haoquan Wu
    Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e28580. 2011
  4. pmc Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model
    Chunting Ye
    Center of Excellence in Infectious Disease, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Proc Natl Acad Sci U S A 109:21052-7. 2012
  5. pmc Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi
    Shuiping Chen
    Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e27551. 2011
  6. pmc Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitis
    Chunting Ye
    Paul L Foster School of Medicine, Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e17889. 2011
  7. pmc Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site
    Hongming Ma
    Center of Excellence for Infectious Diseases, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905
    Proc Natl Acad Sci U S A 110:20687-92. 2013
  8. pmc Targeted delivery of siRNA to macrophages for anti-inflammatory treatment
    Sang Soo Kim
    Center of Excellence in Infectious Diseases, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Mol Ther 18:993-1001. 2010
  9. pmc Lentiviral delivery of short hairpin RNAs
    N Manjunath
    Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Adv Drug Deliv Rev 61:732-45. 2009

Collaborators

Detail Information

Publications9

  1. pmc Alternative processing of primary microRNA transcripts by Drosha generates 5' end variation of mature microRNA
    Haoquan Wu
    Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 4:e7566. 2009
    ..Neither the significance nor the mechanism behind the generation of such miRNA polymorphism is understood. miR-142 is an abundantly expressed miRNA in hematopoietic cells and exhibits a high frequency of 5' end polymorphism...
  2. doi request reprint MicroRNA cloning from cells of the immune system
    Haoquan Wu
    Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA
    Methods Mol Biol 667:67-77. 2010
    ..The small RNAs cloned with this protocol will have a 5'-PO(4) and 3'-OH group, typical features of miRNAs, so majority of the cloned small RNAs will be miRNAs...
  3. pmc Improved siRNA/shRNA functionality by mismatched duplex
    Haoquan Wu
    Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e28580. 2011
    ....
  4. pmc Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model
    Chunting Ye
    Center of Excellence in Infectious Disease, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Proc Natl Acad Sci U S A 109:21052-7. 2012
    ....
  5. pmc Ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of RNAi
    Shuiping Chen
    Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e27551. 2011
    ..We conclude that Ago-2 slicer activity is essential for anti-viral efficacy of siRNAs and miRNA-mediated translational repression/transcript destabilization is too weak to suppress the abundantly expressed flaviviral proteins...
  6. pmc Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitis
    Chunting Ye
    Paul L Foster School of Medicine, Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e17889. 2011
    ..These studies suggest that early suppression of viral replication in macrophages and dendritic cells by RVG-9R-mediated siRNA delivery is key to preventing the development of a fatal neurological disease...
  7. pmc Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site
    Hongming Ma
    Center of Excellence for Infectious Diseases, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905
    Proc Natl Acad Sci U S A 110:20687-92. 2013
    ..If the distances are not optimal, Drosha tends to cleave at multiple sites, which can, in turn, generate multiple 5' isomiRs. Thus, our results also reveal a mechanism of 5' isomiR generation...
  8. pmc Targeted delivery of siRNA to macrophages for anti-inflammatory treatment
    Sang Soo Kim
    Center of Excellence in Infectious Diseases, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Mol Ther 18:993-1001. 2010
    ..These results demonstrate that RVG-9dR provides a tool for siRNA delivery to macrophages and microglia and that suppression of TNF-alpha can potentially be used to suppress neuroinflammation in vivo...
  9. pmc Lentiviral delivery of short hairpin RNAs
    N Manjunath
    Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Adv Drug Deliv Rev 61:732-45. 2009
    ..In this review we describe some of these advances, focusing on the progress made in the development of lentiviral shRNA delivery strategies to combat viral infections...