Research Topics
| G WuSummaryAffiliation: Texas A and M University Country: USA Publications
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Publications
Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty ratsWenjiang J Fu
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Nutr 135:714-21. 2005..In sum, arginine treatment may provide a potentially novel and useful means to enhance NO synthesis and reduce fat mass in obese subjects with type-II diabetes mellitus...
Dietary requirements of "nutritionally non-essential amino acids" by animals and humansGuoyao Wu
Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
Amino Acids 44:1107-13. 2013....
Biochemical and physiological bases for utilization of dietary amino acids by young PigsReza Rezaei
Department of Animal Science, Texas A and M University, College Station, Texas, 77843, USA
J Anim Sci Biotechnol 4:7. 2013....- Biological mechanisms for nutritional regulation of maternal health and fetal developmentGuoyao Wu
Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
Paediatr Perinat Epidemiol 26:4-26. 2012..Future studies are necessary to develop effective nutritional interventions to enhance fetal growth and development and alleviate the burden of maternal morbidity and mortality in low- and middle-income countries... - L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cellsBie Tan
Hunan Engineering Technology Research Center of Healthy Animal Husbandry and Laboratory for Agro ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, 410125, Hunan, China
Amino Acids 38:1227-35. 2010..These results demonstrate a protective effect of Arg against LPS-induced enterocyte damage through mechanisms involving mTOR and TLR4 signaling pathways, as well as intracellular protein turnover... - Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthaseG Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843, USA
Comp Biochem Physiol A Mol Integr Physiol 126:115-23. 2000..This new knowledge of glutamine metabolism may pave a new path for understanding the physiological role of glutamine in vascular function... - Regulation of nitric oxide synthesis by dietary factorsGuoyao Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University College Station, Texas 77843, USA
Annu Rev Nutr 22:61-86. 2002.... - Arginine metabolism: nitric oxide and beyondG Wu
Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Biochem J 336:1-17. 1998..The ongoing development of new cell lines and animal models using cDNA clones and genes for key arginine metabolic enzymes will provide new approaches more clearly elucidating the physiological roles of these enzymes... - Arginine metabolism and nutrition in growth, health and diseaseGuoyao Wu
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Amino Acids 37:153-68. 2009..The effect of Arg in treating many developmental and health problems is unique among AAs, and offers great promise for improved health and wellbeing of humans and animals... - Proline metabolism in the conceptus: implications for fetal growth and developmentG Wu
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Amino Acids 35:691-702. 2008.... - Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty ratsGuoyao Wu
Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 137:2680-5. 2007.... - Board-invited review: intrauterine growth retardation: implications for the animal sciencesG Wu
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Anim Sci 84:2316-37. 2006.... - Pharmacokinetics and safety of arginine supplementation in animalsGuoyao Wu
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 137:1673S-1680S. 2007.... - Polyamine synthesis from proline in the developing porcine placentaGuoyao Wu
Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 72:842-50. 2005..Our novel findings provide a new base of information for future studies to define the role of proline in fetoplacental growth and development... - Arginine nutrition in neonatal pigsGuoyao Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
J Nutr 134:2783S-2790S; discussion 2796S-2797S. 2004..Our findings not only generate new fundamental knowledge about amino acid utilization by neonatal pigs, but they also have important practical implications for improving the efficiency of pork production... - Glutathione metabolism and its implications for healthGuoyao Wu
Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
J Nutr 134:489-92. 2004..New knowledge of the nutritional regulation of GSH metabolism is critical for the development of effective strategies to improve health and to treat these diseases... - Amino acids: metabolism, functions, and nutritionGuoyao Wu
Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
Amino Acids 37:1-17. 2009..Thus, AA have important functions in both nutrition and health... - Nitric oxide and vascular insulin resistanceGuoyao Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
Biofactors 35:21-7. 2009..Modulation of the arginine-NO pathway by BH4 and arginine is beneficial for ameliorating vascular insulin resistance in obesity and diabetes... - Arginine nutrition in development, health and diseaseG Wu
Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station 77843 2471, USA
Curr Opin Clin Nutr Metab Care 3:59-66. 2000..The effect of L-arginine in treating many common health problems is unique among amino acids, and offers great promise for improved health and well-being in the future... - Enhanced intestinal synthesis of polyamines from proline in cortisol-treated pigletsG Wu
Faculty of Nutrition, Texas A and M University, College Station, Texas 77843, USA
Am J Physiol Endocrinol Metab 279:E395-402. 2000.... - A cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaningG Wu
Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station 77843, USA
Am J Physiol Regul Integr Comp Physiol 279:R554-9. 2000..Our results demonstrate an essential role for a cortisol surge in enhancing intestinal polyamine synthesis during weaning, which may be of physiological importance for intestinal adaptation and remodeling... - Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesisG Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University, 2471 TAMUS, College Station, TX 77843 2471, USA
Biochem J 353:245-52. 2001..Glucosamine reduces the cellular availability of NADPH (an essential cofactor for NOS) by inhibiting pentose cycle activity, and this may be a metabolic basis for the inhibition of endothelial NO synthesis by glucosamine... - Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implicationsGuoyao Wu
Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Nutr Biochem 15:442-51. 2004..This new knowledge will be beneficial for designing the next generation of enteral and parenteral amino acid solutions to optimize nutrition and health in this compromised population... - Amino acid concentrations in fluids from the bovine oviduct and uterus and in KSOM-based culture mediaY M Elhassan
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 2471, USA
Theriogenology 55:1907-18. 2001..The particular pattern of amino acid concentrations may be an important factor to be considered for the improvement of embryo culture media... - Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and productionG Wu
Department of Animal Science and of Veterinary Integrative Biosciences, Texas A and M University, College Station, 77843, USA
J Anim Sci 89:2017-30. 2011..Thus, adequate amounts of dietary Gln, a major nutrient, are necessary to support the maximum growth, development, and production performance of swine... - Proline and hydroxyproline metabolism: implications for animal and human nutritionGuoyao Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
Amino Acids 40:1053-63. 2011..Further research is warranted to develop effective strategies of dietary supplementation with proline or hydroxyproline to benefit health, growth, and development of animals and humans... - Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine productionG Wu
Departments of Animal Science and of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
J Anim Sci 88:E195-204. 2010..By regulating syntheses of nitric oxide, polyamines, and proteins, functional AA stimulate placental growth and the transfer of nutrients from mother to embryo or fetus to promote conceptus survival, growth, and development... - Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cellsH Li
Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
Am J Physiol Endocrinol Metab 280:E75-82. 2001.... - Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiencyC J Meininger
Cardiovascular Research Institute and Department of Medical Physiology, The Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
Biochem J 349:353-6. 2000..GTP-cyclohydrolase activity was low because of a decreased expression of the protein in the diabetic cells... - Presence of glutamine:fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells: effects of hyperglycaemia and glutamineG Wu
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843 2471, USA
Diabetologia 44:196-202. 2001..As glucosamine inhibits endothelial nitric oxide synthesis, these findings could have important implications for impaired endothelium-dependent relaxation and vascular dysfunction in diabetes mellitus... - Select nutrients in the ovine uterine lumen. V. Nitric oxide synthase, GTP cyclohydrolase, and ornithine decarboxylase in ovine uteri and peri-implantation conceptusesHaijun Gao
Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 81:67-76. 2009..Thus, biosynthesis of NO and polyamines in ovine uterine endometria and conceptuses is potentially regulated at transcriptional, translational, and posttranslational levels to favor conceptus development and implantation... - Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigsPeng Li
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
Nitric Oxide 19:259-65. 2008..05) arginine concentrations in brain (35-42%), but not in liver or muscle. These tissue-specific effects of cholesterol and DHA on NO synthesis may play an important role in postnatal growth and development... - Activities of arginase I and II are limiting for endothelial cell proliferationHui Li
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2471, USA
Am J Physiol Regul Integr Comp Physiol 282:R64-9. 2002..These results demonstrate that either arginase isoform can potentially play a role in modulating EC proliferation by regulating polyamine synthesis... - Glucosamine inhibits inducible nitric oxide synthesisC J Meininger
Cardiovascular Research Institute, Texas A and M University System Health Science Center, College Station, 77843, USA
Biochem Biophys Res Commun 279:234-9. 2000.... - Arginine catabolism in lactating porcine mammary tissueD A Knabe
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843-2471, USA
J Anim Sci 80:467-74. 2002.... - Feto-placental adaptations to maternal obesity in the baboonD Farley
Center of Pregnancy related and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
Placenta 30:752-60. 2009..In summary, these data demonstrate that in obese baboons in the absence of increased fetal weight, placental and fetal phenotype are consistent with those described for large-for-gestational age human fetuses... - Baggs ewes adapt to maternal undernutrition and maintain conceptus growth by maintaining fetal plasma concentrations of amino acidsW S Jobgen
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843, USA
J Anim Sci 86:820-6. 2008.... - Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic ratsRipla Kohli
Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 134:600-8. 2004..Thus, dietary L-arginine supplementation stimulates endothelial NO synthesis by increasing BH(4) provision, which is beneficial for vascular function and glucose homeostasis in diabetic subjects... - Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptusesHaijun Gao
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 80:602-9. 2009..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival... - Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cellsG Wu
Department of Animal Science, Texas A and M University, College Station 77843
Am J Physiol 265:H1965-71. 1993..This cycle may function to efficiently scavenge the carbon and alpha-amino group of L-arginine and to maintain a sufficient cellular concentration of L-arginine during prolonged synthesis of NO in EC. (ABSTRACT TRUNCATED AT 250 WORDS).. - Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese ratsWenjuan Jobgen
Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:230-7. 2009..Thus, dietary arginine supplementation shifts nutrient partitioning to promote muscle over fat gain and may provide a useful treatment for improving the metabolic profile and reducing body white fat in diet-induced obese rats... - Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substratesWenjuan Shi Jobgen
Texas A and M University, College Station, TX 77843, USA
J Nutr Biochem 17:571-88. 2006.... - Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in giltsXilong Li
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 140:1111-6. 2010..These results indicate that dietary supplementation with 0.8% L-arginine between d 0 and 25 of gestation, while increasing placental vascularity, adversely affects the reproductive performance of gilts... - Developmental changes in nitric oxide synthesis in the ovine placentaHyukjung Kwon
Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 70:679-86. 2004.... - Developmental changes in polyamine levels and synthesis in the ovine conceptusHyukjung Kwon
Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843-2471, USA
Biol Reprod 69:1626-34. 2003..Our findings may have important implications for both intrauterine growth retardation and fetal origins of diseases in adults... - Select nutrients in the ovine uterine lumen. ii. glucose transporters in the uterus and peri-implantation conceptusesHaijun Gao
Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
Biol Reprod 80:94-104. 2009.... - Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ovine uteri and conceptusesHaijun Gao
Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 81:87-100. 2009..These results suggest that the FRAP1 cell signaling pathway mediates interactions between the maternal uterus and peri-implantation conceptuses and that P4 and IFNT affect this pathway by regulating expression of RHEB and EIF4EBP1... - Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptusesG A Johnson
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
Soc Reprod Fertil Suppl 66:321-32. 2009.... - Select nutrients in the ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenal flushings of cyclic and pregnant ewesHaijun Gao
Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
Biol Reprod 80:86-93. 2009.... - Select nutrients in the ovine uterine lumen. IV. Expression of neutral and acidic amino acid transporters in ovine uteri and peri-implantation conceptusesHaijun Gao
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 80:1196-208. 2009..These results document coordinate changes in expression of transporters that are likely responsible for increases in amounts of neutral and acidic amino acids in the uterine lumen to support conceptus growth, development, and survival... - Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cellsJinYoung Kim
Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
Matrix Biol 29:369-82. 2010..These cell signaling pathways, acting in concert, mediate adhesion, migration and cytoskeletal remodeling of Tr cells essential for expansion and elongation of conceptuses and attachment to uterine LE for implantation... - Tetrahydrobiopterin levels regulate endothelial cell proliferationR S Marinos
Cardiovascular Research Institute and Department of Medical Physiology, Texas A and M University System Health Science Center, Texas A and M University, College Station, Texas 77843-1114, USA
Am J Physiol Heart Circ Physiol 281:H482-9. 2001..Our results suggest that BH4 levels regulate proliferation of normal EC and that a BH4 deficiency impairs NO-dependent proliferation of BBd EC... - Ornithine aminotransferase messenger RNA expression and enzymatic activity in fetal porcine intestineC M Dekaney
Department of Veterinary Anatomy and Public Health, Institute of Biosciences and Technology, Texas A and M University, College Station, Texas 77843-4458 USA
Pediatr Res 50:104-9. 2001..This capability may be important for synthesis of arginine, proline, ornithine, and polyamines for development and metabolic activity of the intestine during gestation or for somatic growth of the fetus... - Novel pathways for implantation and establishment and maintenance of pregnancy in mammalsFuller W Bazer
Departments of Animal Science, Texas A and M Health Sciences Center, College Station, TX 77843, USA
Mol Hum Reprod 16:135-52. 2010..Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals... - Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathwayJena J Steinle
Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple 76504, USA
J Biol Chem 277:43830-5. 2002..Eph B4 receptor stimulation increased activation of both matrix metalloproteinase-2 and -9. The results from these studies indicate that Eph B4 stimulates migration and proliferation and may play a role in angiogenesis... - Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheepJayanth Ramadoss
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
Alcohol 42:657-66. 2008..We also speculate that the consequent increase in fetal glutamate during critical periods of brain development may contribute to the pathogenesis of FAS... - Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathwaysFuller W Bazer
Texas A and M University, College Station, TX 77843 2471, USA
Reprod Biol 8:179-211. 2008..The magnitude of the LH surge was reduced in cows receiving endotoxin... - GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic ratsCynthia J Meininger
Cardiovascular Research Institute, Department of Medical Physiology, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
FASEB J 18:1900-2. 2004..05). This study demonstrates that GTPCH gene transfer can reverse BH4 deficiency in both type I and type II diabetes and provides an experimental basis for using gene therapy to treat cardiovascular complications in diabetic patients... - New developments in fish amino acid nutrition: towards functional and environmentally oriented aquafeedsPeng Li
Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
Amino Acids 37:43-53. 2009..Functional amino acids hold great promise for development of balanced aquafeeds to enhance the efficiency and profitability of global aquaculture production... - Comparative aspects of implantationFuller W Bazer
Department of Animal Science Veterinary Integrative Biosciences, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
Reproduction 138:195-209. 2009.... - Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administrationM Carey Satterfield
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Biol Reprod 82:224-31. 2010..Thus, select nutrients are increased in the uterine lumen by P4 concomitant with the upregulation of epithelial transporters for glucose and basic amino acids, suggesting that these nutrients stimulate blastocyst growth and development... - Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restrictionM Carey Satterfield
Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
J Nutr 140:251-8. 2010..These findings may lead to the clinical use of sildenafil citrate in human pregnancies suspected to be at risk for intrauterine fetal growth retardation... - Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human healthJason R McKnight
Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Amino Acids 39:349-57. 2010..g., glucose and fatty acids) Thus, L-arginine holds great promise as a safe and cost-effective nutrient to reduce adiposity, increase muscle mass, and improve the metabolic profile in animals and humans... - Obesity in pregnancy: problems and potential solutionsJason R McKnight
Faculty of Nutrition, Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
Front Biosci (Elite Ed) 3:442-52. 2011..Because of ethical concerns over human studies, animal models (e.g., sheep, pigs, baboons, rats, and mice) are warranted to test novel hypotheses with enormous biological significance and clinical applications... - Brown adipose tissue growth and development: significance and nutritional regulationMichael Carey Satterfield
Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
Front Biosci 16:1589-608. 2011..This review will attempt to meld the wealth of new information regarding BAT development with established literature to provide an up to date synopsis of what is known and thus a framework for future research directions... - Cellular regulation of bovine intramuscular adipose tissue development and compositionS B Smith
Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
J Anim Sci 87:E72-82. 2009..m. adipose tissue development. Conversely, supplementation with vitamin C or zinc may promote the development of i.m. adipose tissue... - Maternal nutrition and fetal developmentGuoyao Wu
Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
J Nutr 134:2169-72. 2004..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults... - High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissueWenjuan Jobgen
Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
Amino Acids 37:187-98. 2009..Our findings provide a molecular mechanism to explain a beneficial effect of Arg on ameliorating diet-induced obesity in mammals... - Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cellsJinYoung Kim
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
Endocrinology 149:3085-94. 2008..Collectively, these results support the hypothesis that IGF-II coordinately activates multiple cell signaling pathways critical to survival, growth, and differentiation of the ovine conceptus during early pregnancy... - Developmental changes of amino acids in ovine fetal fluidsHyukjung Kwon
Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station 77843-2471, USA
Biol Reprod 68:1813-20. 2003..These novel findings of the unusual abundance of traditionally classified nonessential amino acids in allantoic fluid raise important questions regarding their roles in ovine conceptus development... - Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetusArantzatzu Lassala
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:660-5. 2009..These novel findings provide support for studies of the clinical use of arginine and citrulline as therapeutic means to prevent or ameliorate fetal growth retardation in mammals... - Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigsPeng Li
Department of Animal Science, Texas A and M University, College Station, TX, 77843, USA
Amino Acids 37:709-16. 2009..These novel findings have important implications for designing the next generation of infant formula to optimize neonatal growth and development... - Effect of amino acids supply in reduced crude protein diets on performance, efficiency of mammary uptake, and transporter gene expression in lactating sowsR Manjarin
Department of Animal Science, Michigan State University, East Lansing 48824, USA
J Anim Sci 90:3088-100. 2012..This increase was associated with a decrease in plasma concentration of BCAA:Lys, suggesting a competitive mechanism between cationic and BCAA for transport of AA across mammary cells... - Dietary supplementation of L-arginine and conjugated linoleic acid reduces retroperitoneal fat mass and increases lean body mass in ratsJennifer L Nall
Intercollegiate Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:1279-85. 2009..We conclude that CLA and arginine modulated adipose tissue metabolism by separate, but not additive, effects. Also, CLA and arginine may have depressed muscle protein turnover... - Amino acids and gaseous signalingXilong Li
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Amino Acids 37:65-78. 2009.... - Regulation of ornithine aminotransferase gene expression and activity by all-transretinoic acid in Caco-2 intestinal epithelial cellsChristopher M Dekaney
Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
J Nutr Biochem 19:674-81. 2008..These novel findings indicate a functional role for OAT in regulating intestinal polyamine synthesis and growth... - Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluidsHyukjung Kwon
Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
Biol Reprod 71:901-8. 2004..The results have important implications for understanding the mechanisms responsible for both intrauterine growth retardation and developmental origins of adult disease... - Glutamine synthesis in the developing porcine placentaJon T Self
Department of Animal Science, Texas A and M University, College Station, Texas 77843-2471, USA
Biol Reprod 70:1444-51. 2004.... - Inadequate intakes of indispensable amino acids among homebound older adultsMou Dasgupta
Department of Animal Science, Texas A and M University, USA
J Nutr Elder 24:85-99. 2005.... - Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewesArantzatzu Lassala
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
J Nutr 140:1242-8. 2010..The findings also lay a new framework for studying cellular and molecular mechanisms responsible for the beneficial effects of Arg in regulating conceptus growth and development... - Amino acids and immune functionPeng Li
Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Br J Nutr 98:237-52. 2007..These nutrients hold great promise in improving health and preventing infectious diseases in animals and humans... - Analysis of citrulline, arginine, and methylarginines using high-performance liquid chromatographyGuoyao Wu
Department of Animal Science, Texas A and M University, College Station, Texas, USA
Methods Enzymol 440:177-89. 2008..1 and 10 microM for methylarginines. These chromatographic methods are highly sensitive, specific, accurate, and easily automated and provide a useful tool to study the regulation of the arginine-nitric oxide pathway... - L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytesTony E Haynes
Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
Amino Acids 37:131-42. 2009..The findings support addition of Gln or Ala-Gln to current Gln-free pediatric amino acid solutions to prevent intestinal oxidative injury and inflammatory disease in neonates... - Lactating porcine mammary tissue catabolizes branched-chain amino acids for glutamine and aspartate synthesisPeng Li
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Nutr 139:1502-9. 2009.... - Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatographyWenjuan S Jobgen
Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
J Chromatogr B Analyt Technol Biomed Life Sci 851:71-82. 2007..HPLC methods provide a useful research tool for studying NO biochemistry, physiology and pharmacology... - Dietary L-arginine supplementation enhances the reproductive performance of giltsRonaldo D Mateo
Texas Tech University, Lubbock, TX 79409, USA
J Nutr 137:652-6. 2007..032) and live litter birth weight of piglets by 24% (16.38 vs. 13.19 kg, P = 0.016). This exciting finding provides the first evidence for a marked increase of live-born piglets by 2 per litter through nutritional intervention in gilts... - Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathwayShehla Pervin
Departments of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA
Cancer Res 67:289-99. 2007.... - Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritisJ Marc Rhoads
Department of Pediatrics, Ochsner Clinic Foundation and Ochsner Children s Research Institute, New Orleans, Louisiana, USA
Am J Physiol Gastrointest Liver Physiol 292:G913-22. 2007..In conclusion, intestinal activation of p70(S6K) was not inhibited by malnutrition but was strongly activated during an active state of mucosal regeneration... - Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA)Kaye M Reid
Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Physiol Gastrointest Liver Physiol 292:G512-7. 2007..Arginase blockade represents a potentially novel strategy to combat hepatic I/R injury associated with liver transplantation... - Dietary arginine supplementation enhances the growth of milk-fed young pigsSung Woo Kim
Department of Animal and Food Sciences, Texas Tech University, Lubbock, TX 79409 2141, USA
J Nutr 134:625-30. 2004..Collectively, both the metabolic and growth data demonstrate unequivocally that arginine is deficient in milk-fed young pigs and that this arginine deficiency represents a major obstacle to maximal growth in piglets... - Linoleic acid-induced endothelial activation: role of calcium and peroxynitrite signalingViswanathan Saraswathi
Molecular and Cell Nutrition Laboratory, College of Agriculture, University of Kentucky, Lexington, KY 40546, USA
J Lipid Res 45:794-804. 2004..LA exposure resulted in increased nitrotyrosine levels, as observed by Western blotting and immunofluorescence. Our data suggest that the proinflammatory effects of LA can be mediated through calcium and peroxynitrite signaling... - Arginase blockade protects against hepatic damage in warm ischemia-reperfusionGeetha Jeyabalan
Department of Surgery, University of Pittsburgh, Starzl Transplantation Institute, 3459 Fifth Avenue, MUH 7 South, Pittsburgh, PA 15213, USA
Nitric Oxide 19:29-35. 2008..The purpose of this study was to determine if nor-NOHA, a novel arginase inhibitor, would be able to increase circulating arginine levels and decrease hepatic damage following warm I/R... - Role of ephrin B2 in human retinal endothelial cell proliferation and migrationJena J Steinle
Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, 702 SW HK Dodgen Loop, Medical Research Building, Room 202A, Temple, TX 76504, USA
Cell Signal 15:1011-7. 2003..Additionally, it appears that vascular growth may be modulated in the retina through activation of the PI3K pathway and its downstream components... - Citrulline can preserve proliferation and prevent the loss of CD3 zeta chain under conditions of low arginineVishal Bansal
Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
JPEN J Parenter Enteral Nutr 28:423-30. 2004..Therefore, citrulline has the potential to be a substitute for supplemental arginine in diseases associated with arginase-mediated T cell dysfunction... - Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementationJunjun Wang
State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China
J Nutr 138:1025-32. 2008..These findings reveal coordinate alterations of gene expression in response to weaning and aid in providing molecular mechanisms for the beneficial effect of dietary glutamine supplementation to improve nutrition status in young mammals... - Dietary arginine supplementation during early pregnancy enhances embryonic survival in ratsXiangfang Zeng
State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China 100094
J Nutr 138:1421-5. 2008..This novel finding has important implications for preventing early pregnancy loss and enhancing reproductive performance in mammals... - Watermelon consumption increases plasma arginine concentrations in adultsJulie K Collins
USDA ARS, South Central Agricultural Research Laboratory, Lane, Oklahoma, USA
Nutrition 23:261-6. 2007..This study investigated if watermelon juice consumption increases fasting concentrations of plasma arginine, ornithine, and citrulline in healthy adult humans... - Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arteriolesMichael D Delp
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
J Physiol 586:1161-8. 2008..Rather, the age-related deficit in flow-mediated vasodilatation appears to be the result, in part, of limited BH(4) bioavailability... - Intrauterine growth restriction affects the proteomes of the small intestine, liver, and skeletal muscle in newborn pigsJunjun Wang
State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China 100094
J Nutr 138:60-6. 2008.... - Gene expression and activity of enzymes in the arginine biosynthetic pathway in porcine fetal small intestineChirstopher M Dekaney
Department of Veterinary Anatomy and Public Health, Institute of Biosciences and Technology
Pediatr Res 53:274-80. 2003..This ability of the fetal small intestine to synthesize amino acids may be important for development and metabolic activity of the intestine during somatic growth of the fetus... - Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMPLouis J Ignarro
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1735, USA
Nitric Oxide 7:83-90. 2002..These observations confirm previous findings that DFMO and NO interfere with RASMC proliferation by inhibiting ODC and polyamine production and provide evidence that nebivolol works by the same mechanism...
Research Grants
- Arginine and Ovine Model for Fetal Growth RestrictionGuoyao Wu; Fiscal Year: 2007..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. ..