G Wu

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats
    Wenjiang J Fu
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 135:714-21. 2005
  2. pmc Uterine biology in pigs and sheep
    Fuller W Bazer
    Department of Animal Science, 442D Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX, 77843 2471, USA
    J Anim Sci Biotechnol 3:23. 2012
  3. doi request reprint Functional amino acids in nutrition and health
    Guoyao Wu
    Department of Animal Science, Department of Veterinary Integrative Biosciences, and Faculty of Nutrition, Texas A and M University, College Station, TX, 77845, USA
    Amino Acids 45:407-11. 2013
  4. doi request reprint Impacts of arginine nutrition on embryonic and fetal development in mammals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, 77843, USA
    Amino Acids 45:241-56. 2013
  5. doi request reprint Dietary requirements of "nutritionally non-essential amino acids" by animals and humans
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Amino Acids 44:1107-13. 2013
  6. pmc Biochemical and physiological bases for utilization of dietary amino acids by young Pigs
    Reza Rezaei
    Department of Animal Science, Texas A and M University, College Station, Texas, 77843, USA
    J Anim Sci Biotechnol 4:7. 2013
  7. doi request reprint Biological mechanisms for nutritional regulation of maternal health and fetal development
    Guoyao Wu
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Paediatr Perinat Epidemiol 26:4-26. 2012
  8. pmc L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells
    Bie Tan
    Hunan Engineering Technology Research Center of Healthy Animal Husbandry and Laboratory for Agro ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, 410125, Hunan, China
    Amino Acids 38:1227-35. 2010
  9. ncbi request reprint Glutathione metabolism and its implications for health
    Guoyao Wu
    Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    J Nutr 134:489-92. 2004
  10. doi request reprint Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production
    G Wu
    Department of Animal Science and of Veterinary Integrative Biosciences, Texas A and M University, College Station, 77843, USA
    J Anim Sci 89:2017-30. 2011

Research Grants

Collaborators

Detail Information

Publications118 found, 100 shown here

  1. ncbi request reprint Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats
    Wenjiang J Fu
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 135:714-21. 2005
    ..In sum, arginine treatment may provide a potentially novel and useful means to enhance NO synthesis and reduce fat mass in obese subjects with type-II diabetes mellitus...
  2. pmc Uterine biology in pigs and sheep
    Fuller W Bazer
    Department of Animal Science, 442D Kleberg Center, 2471 TAMU, Texas A and M University, College Station, TX, 77843 2471, USA
    J Anim Sci Biotechnol 3:23. 2012
    ....
  3. doi request reprint Functional amino acids in nutrition and health
    Guoyao Wu
    Department of Animal Science, Department of Veterinary Integrative Biosciences, and Faculty of Nutrition, Texas A and M University, College Station, TX, 77845, USA
    Amino Acids 45:407-11. 2013
    ..g., obesity, diabetes, and cardiovascular disorders), intrauterine growth restriction, infertility, intestinal and neurological dysfunction, and infectious disease (including viral infections). ..
  4. doi request reprint Impacts of arginine nutrition on embryonic and fetal development in mammals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, 77843, USA
    Amino Acids 45:241-56. 2013
    ..Collectively, enhancement of uterine as well as placental growth and function through dietary arginine supplementation provides an effective solution to improving embryonic and fetal survival and growth. ..
  5. doi request reprint Dietary requirements of "nutritionally non-essential amino acids" by animals and humans
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Amino Acids 44:1107-13. 2013
    ....
  6. pmc Biochemical and physiological bases for utilization of dietary amino acids by young Pigs
    Reza Rezaei
    Department of Animal Science, Texas A and M University, College Station, Texas, 77843, USA
    J Anim Sci Biotechnol 4:7. 2013
    ....
  7. doi request reprint Biological mechanisms for nutritional regulation of maternal health and fetal development
    Guoyao Wu
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Paediatr Perinat Epidemiol 26:4-26. 2012
    ..Future studies are necessary to develop effective nutritional interventions to enhance fetal growth and development and alleviate the burden of maternal morbidity and mortality in low- and middle-income countries...
  8. pmc L-Arginine stimulates proliferation and prevents endotoxin-induced death of intestinal cells
    Bie Tan
    Hunan Engineering Technology Research Center of Healthy Animal Husbandry and Laboratory for Agro ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, 410125, Hunan, China
    Amino Acids 38:1227-35. 2010
    ..These results demonstrate a protective effect of Arg against LPS-induced enterocyte damage through mechanisms involving mTOR and TLR4 signaling pathways, as well as intracellular protein turnover...
  9. ncbi request reprint Glutathione metabolism and its implications for health
    Guoyao Wu
    Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    J Nutr 134:489-92. 2004
    ..New knowledge of the nutritional regulation of GSH metabolism is critical for the development of effective strategies to improve health and to treat these diseases...
  10. doi request reprint Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production
    G Wu
    Department of Animal Science and of Veterinary Integrative Biosciences, Texas A and M University, College Station, 77843, USA
    J Anim Sci 89:2017-30. 2011
    ..Thus, adequate amounts of dietary Gln, a major nutrient, are necessary to support the maximum growth, development, and production performance of swine...
  11. ncbi request reprint Pharmacokinetics and safety of arginine supplementation in animals
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 137:1673S-1680S. 2007
    ....
  12. pmc Proline and hydroxyproline metabolism: implications for animal and human nutrition
    Guoyao Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    Amino Acids 40:1053-63. 2011
    ..Further research is warranted to develop effective strategies of dietary supplementation with proline or hydroxyproline to benefit health, growth, and development of animals and humans...
  13. ncbi request reprint Polyamine synthesis from proline in the developing porcine placenta
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 72:842-50. 2005
    ..Our novel findings provide a new base of information for future studies to define the role of proline in fetoplacental growth and development...
  14. doi request reprint Amino acids: metabolism, functions, and nutrition
    Guoyao Wu
    Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX, 77843, USA
    Amino Acids 37:1-17. 2009
    ..Thus, AA have important functions in both nutrition and health...
  15. doi request reprint Proline metabolism in the conceptus: implications for fetal growth and development
    G Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 35:691-702. 2008
    ....
  16. ncbi request reprint Arginine nutrition in neonatal pigs
    Guoyao Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    J Nutr 134:2783S-2790S; discussion 2796S-2797S. 2004
    ..Our findings not only generate new fundamental knowledge about amino acid utilization by neonatal pigs, but they also have important practical implications for improving the efficiency of pork production...
  17. doi request reprint Impacts of amino acid nutrition on pregnancy outcome in pigs: mechanisms and implications for swine production
    G Wu
    Departments of Animal Science and of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    J Anim Sci 88:E195-204. 2010
    ..By regulating syntheses of nitric oxide, polyamines, and proteins, functional AA stimulate placental growth and the transfer of nutrients from mother to embryo or fetus to promote conceptus survival, growth, and development...
  18. pmc Arginine metabolism and nutrition in growth, health and disease
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 37:153-68. 2009
    ..The effect of Arg in treating many developmental and health problems is unique among AAs, and offers great promise for improved health and wellbeing of humans and animals...
  19. doi request reprint Nitric oxide and vascular insulin resistance
    Guoyao Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    Biofactors 35:21-7. 2009
    ..Modulation of the arginine-NO pathway by BH4 and arginine is beneficial for ameliorating vascular insulin resistance in obesity and diabetes...
  20. ncbi request reprint Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications
    Guoyao Wu
    Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr Biochem 15:442-51. 2004
    ..This new knowledge will be beneficial for designing the next generation of enteral and parenteral amino acid solutions to optimize nutrition and health in this compromised population...
  21. ncbi request reprint Board-invited review: intrauterine growth retardation: implications for the animal sciences
    G Wu
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Anim Sci 84:2316-37. 2006
    ....
  22. ncbi request reprint Regulation of nitric oxide synthesis by dietary factors
    Guoyao Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University College Station, Texas 77843, USA
    Annu Rev Nutr 22:61-86. 2002
    ....
  23. ncbi request reprint Dietary supplementation with watermelon pomace juice enhances arginine availability and ameliorates the metabolic syndrome in Zucker diabetic fatty rats
    Guoyao Wu
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 137:2680-5. 2007
    ....
  24. ncbi request reprint Glutamine metabolism in endothelial cells: ornithine synthesis from glutamine via pyrroline-5-carboxylate synthase
    G Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843, USA
    Comp Biochem Physiol A Mol Integr Physiol 126:115-23. 2000
    ..This new knowledge of glutamine metabolism may pave a new path for understanding the physiological role of glutamine in vascular function...
  25. ncbi request reprint A cortisol surge mediates the enhanced polyamine synthesis in porcine enterocytes during weaning
    G Wu
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station 77843, USA
    Am J Physiol Regul Integr Comp Physiol 279:R554-9. 2000
    ..Our results demonstrate an essential role for a cortisol surge in enhancing intestinal polyamine synthesis during weaning, which may be of physiological importance for intestinal adaptation and remodeling...
  26. pmc Glutamine metabolism to glucosamine is necessary for glutamine inhibition of endothelial nitric oxide synthesis
    G Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, 2471 TAMUS, College Station, TX 77843 2471, USA
    Biochem J 353:245-52. 2001
    ..Glucosamine reduces the cellular availability of NADPH (an essential cofactor for NOS) by inhibiting pentose cycle activity, and this may be a metabolic basis for the inhibition of endothelial NO synthesis by glucosamine...
  27. ncbi request reprint Arginine nutrition in development, health and disease
    G Wu
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station 77843 2471, USA
    Curr Opin Clin Nutr Metab Care 3:59-66. 2000
    ..The effect of L-arginine in treating many common health problems is unique among amino acids, and offers great promise for improved health and well-being in the future...
  28. ncbi request reprint Amino acid concentrations in fluids from the bovine oviduct and uterus and in KSOM-based culture media
    Y M Elhassan
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 2471, USA
    Theriogenology 55:1907-18. 2001
    ..The particular pattern of amino acid concentrations may be an important factor to be considered for the improvement of embryo culture media...
  29. pmc Arginine metabolism: nitric oxide and beyond
    G Wu
    Departments of Animal Science, Medical Physiology, and Veterinary Anatomy and Public Health, and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Biochem J 336:1-17. 1998
    ..The ongoing development of new cell lines and animal models using cDNA clones and genes for key arginine metabolic enzymes will provide new approaches more clearly elucidating the physiological roles of these enzymes...
  30. ncbi request reprint Enhanced intestinal synthesis of polyamines from proline in cortisol-treated piglets
    G Wu
    Faculty of Nutrition, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Endocrinol Metab 279:E395-402. 2000
    ....
  31. ncbi request reprint Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells
    H Li
    Department of Animal Science, Texas A and M University, College Station, Texas 77843, USA
    Am J Physiol Endocrinol Metab 280:E75-82. 2001
    ....
  32. pmc Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
    C J Meininger
    Cardiovascular Research Institute and Department of Medical Physiology, The Texas A and M University System Health Science Center, College Station, TX 77843 1114, USA
    Biochem J 349:353-6. 2000
    ..GTP-cyclohydrolase activity was low because of a decreased expression of the protein in the diabetic cells...
  33. ncbi request reprint Presence of glutamine:fructose-6-phosphate amidotransferase for glucosamine-6-phosphate synthesis in endothelial cells: effects of hyperglycaemia and glutamine
    G Wu
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843 2471, USA
    Diabetologia 44:196-202. 2001
    ..As glucosamine inhibits endothelial nitric oxide synthesis, these findings could have important implications for impaired endothelium-dependent relaxation and vascular dysfunction in diabetes mellitus...
  34. doi request reprint Select nutrients in the ovine uterine lumen. V. Nitric oxide synthase, GTP cyclohydrolase, and ornithine decarboxylase in ovine uteri and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 81:67-76. 2009
    ..Thus, biosynthesis of NO and polyamines in ovine uterine endometria and conceptuses is potentially regulated at transcriptional, translational, and posttranslational levels to favor conceptus development and implantation...
  35. pmc Dietary supplementation with cholesterol and docosahexaenoic acid increases the activity of the arginine-nitric oxide pathway in tissues of young pigs
    Peng Li
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843 2471, USA
    Nitric Oxide 19:259-65. 2008
    ..05) arginine concentrations in brain (35-42%), but not in liver or muscle. These tissue-specific effects of cholesterol and DHA on NO synthesis may play an important role in postnatal growth and development...
  36. ncbi request reprint Activities of arginase I and II are limiting for endothelial cell proliferation
    Hui Li
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, Texas 77843 2471, USA
    Am J Physiol Regul Integr Comp Physiol 282:R64-9. 2002
    ..These results demonstrate that either arginase isoform can potentially play a role in modulating EC proliferation by regulating polyamine synthesis...
  37. ncbi request reprint Baggs ewes adapt to maternal undernutrition and maintain conceptus growth by maintaining fetal plasma concentrations of amino acids
    W S Jobgen
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843, USA
    J Anim Sci 86:820-6. 2008
    ....
  38. ncbi request reprint Glucosamine inhibits inducible nitric oxide synthesis
    C J Meininger
    Cardiovascular Research Institute, Texas A and M University System Health Science Center, College Station, 77843, USA
    Biochem Biophys Res Commun 279:234-9. 2000
    ....
  39. ncbi request reprint Arginine catabolism in lactating porcine mammary tissue
    P R O'Quinn
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station 77843 2471, USA
    J Anim Sci 80:467-74. 2002
    ....
  40. pmc Feto-placental adaptations to maternal obesity in the baboon
    D Farley
    Center of Pregnancy related and Newborn Research, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    Placenta 30:752-60. 2009
    ..In summary, these data demonstrate that in obese baboons in the absence of increased fetal weight, placental and fetal phenotype are consistent with those described for large-for-gestational age human fetuses...
  41. doi request reprint Select nutrients in the ovine uterine lumen. III. Cationic amino acid transporters in the ovine uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:602-9. 2009
    ..These results indicate that coordinate changes in SLC7A1, SLC7A2, and SLC7A3 expression in uterine endometria and conceptuses are likely important in transport of arginine that is critical to conceptus growth, development, and survival...
  42. ncbi request reprint Dietary L-arginine supplementation enhances endothelial nitric oxide synthesis in streptozotocin-induced diabetic rats
    Ripla Kohli
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 134:600-8. 2004
    ..Thus, dietary L-arginine supplementation stimulates endothelial NO synthesis by increasing BH(4) provision, which is beneficial for vascular function and glucose homeostasis in diabetic subjects...
  43. ncbi request reprint Regulation of L-arginine synthesis from L-citrulline by L-glutamine in endothelial cells
    G Wu
    Department of Animal Science, Texas A and M University, College Station 77843
    Am J Physiol 265:H1965-71. 1993
    ..This cycle may function to efficiently scavenge the carbon and alpha-amino group of L-arginine and to maintain a sufficient cellular concentration of L-arginine during prolonged synthesis of NO in EC. (ABSTRACT TRUNCATED AT 250 WORDS)..
  44. ncbi request reprint Regulatory role for the arginine-nitric oxide pathway in metabolism of energy substrates
    Wenjuan Shi Jobgen
    Texas A and M University, College Station, TX 77843, USA
    J Nutr Biochem 17:571-88. 2006
    ....
  45. doi request reprint Dietary supplementation with 0.8% L-arginine between days 0 and 25 of gestation reduces litter size in gilts
    Xilong Li
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 140:1111-6. 2010
    ..These results indicate that dietary supplementation with 0.8% L-arginine between d 0 and 25 of gestation, while increasing placental vascularity, adversely affects the reproductive performance of gilts...
  46. pmc Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats
    Wenjuan Jobgen
    Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:230-7. 2009
    ..Thus, dietary arginine supplementation shifts nutrient partitioning to promote muscle over fat gain and may provide a useful treatment for improving the metabolic profile and reducing body white fat in diet-induced obese rats...
  47. ncbi request reprint Developmental changes in nitric oxide synthesis in the ovine placenta
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 70:679-86. 2004
    ....
  48. doi request reprint Select nutrients in the ovine uterine lumen. ii. glucose transporters in the uterus and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 80:94-104. 2009
    ....
  49. doi request reprint Select nutrients in the ovine uterine lumen. VI. Expression of FK506-binding protein 12-rapamycin complex-associated protein 1 (FRAP1) and regulators and effectors of mTORC1 and mTORC2 complexes in ovine uteri and conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 81:87-100. 2009
    ..These results suggest that the FRAP1 cell signaling pathway mediates interactions between the maternal uterus and peri-implantation conceptuses and that P4 and IFNT affect this pathway by regulating expression of RHEB and EIF4EBP1...
  50. ncbi request reprint Developmental changes in polyamine levels and synthesis in the ovine conceptus
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 69:1626-34. 2003
    ..Our findings may have important implications for both intrauterine growth retardation and fetal origins of diseases in adults...
  51. ncbi request reprint Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses
    G A Johnson
    Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843 4458, USA
    Soc Reprod Fertil Suppl 66:321-32. 2009
    ....
  52. doi request reprint Select nutrients in the ovine uterine lumen. IV. Expression of neutral and acidic amino acid transporters in ovine uteri and peri-implantation conceptuses
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 80:1196-208. 2009
    ..These results document coordinate changes in expression of transporters that are likely responsible for increases in amounts of neutral and acidic amino acids in the uterine lumen to support conceptus growth, development, and survival...
  53. doi request reprint Secreted phosphoprotein 1 binds integrins to initiate multiple cell signaling pathways, including FRAP1/mTOR, to support attachment and force-generated migration of trophectoderm cells
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, TX 77843, USA
    Matrix Biol 29:369-82. 2010
    ..These cell signaling pathways, acting in concert, mediate adhesion, migration and cytoskeletal remodeling of Tr cells essential for expansion and elongation of conceptuses and attachment to uterine LE for implantation...
  54. doi request reprint Select nutrients in the ovine uterine lumen. I. Amino acids, glucose, and ions in uterine lumenal flushings of cyclic and pregnant ewes
    Haijun Gao
    Center for Animal Biotechnology and Genomics, Departments of Animal Science and Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 80:86-93. 2009
    ....
  55. ncbi request reprint Ornithine aminotransferase messenger RNA expression and enzymatic activity in fetal porcine intestine
    C M Dekaney
    Department of Veterinary Anatomy and Public Health, Institute of Biosciences and Technology, Texas A and M University, College Station, Texas 77843-4458 USA
    Pediatr Res 50:104-9. 2001
    ..This capability may be important for synthesis of arginine, proline, ornithine, and polyamines for development and metabolic activity of the intestine during gestation or for somatic growth of the fetus...
  56. ncbi request reprint Tetrahydrobiopterin levels regulate endothelial cell proliferation
    R S Marinos
    Cardiovascular Research Institute and Department of Medical Physiology, Texas A and M University System Health Science Center, Texas A and M University, College Station, Texas 77843-1114, USA
    Am J Physiol Heart Circ Physiol 281:H482-9. 2001
    ..Our results suggest that BH4 levels regulate proliferation of normal EC and that a BH4 deficiency impairs NO-dependent proliferation of BBd EC...
  57. pmc Novel pathways for implantation and establishment and maintenance of pregnancy in mammals
    Fuller W Bazer
    Departments of Animal Science, Texas A and M Health Sciences Center, College Station, TX 77843, USA
    Mol Hum Reprod 16:135-52. 2010
    ..Understanding the roles of the variety of hormones, growth factors and endogenous retroviral proteins in uterine receptivity for implantation is essential to enhancing reproductive health and fertility in humans and domestic animals...
  58. ncbi request reprint Interferons and progesterone for establishment and maintenance of pregnancy: interactions among novel cell signaling pathways
    Fuller W Bazer
    Texas A and M University, College Station, TX 77843 2471, USA
    Reprod Biol 8:179-211. 2008
    ..The magnitude of the LH surge was reduced in cows receiving endotoxin...
  59. pmc Chronic binge ethanol-mediated acidemia reduces availability of glutamine and related amino acids in maternal plasma of pregnant sheep
    Jayanth Ramadoss
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A and M University, College Station, TX 77843, USA
    Alcohol 42:657-66. 2008
    ..We also speculate that the consequent increase in fetal glutamate during critical periods of brain development may contribute to the pathogenesis of FAS...
  60. ncbi request reprint GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats
    Cynthia J Meininger
    Cardiovascular Research Institute, Department of Medical Physiology, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    FASEB J 18:1900-2. 2004
    ..05). This study demonstrates that GTPCH gene transfer can reverse BH4 deficiency in both type I and type II diabetes and provides an experimental basis for using gene therapy to treat cardiovascular complications in diabetic patients...
  61. ncbi request reprint Eph B4 receptor signaling mediates endothelial cell migration and proliferation via the phosphatidylinositol 3-kinase pathway
    Jena J Steinle
    Cardiovascular Research Institute and Department of Medical Physiology, College of Medicine, The Texas A and M University System Health Science Center, Temple 76504, USA
    J Biol Chem 277:43830-5. 2002
    ..Eph B4 receptor stimulation increased activation of both matrix metalloproteinase-2 and -9. The results from these studies indicate that Eph B4 stimulates migration and proliferation and may play a role in angiogenesis...
  62. doi request reprint New developments in fish amino acid nutrition: towards functional and environmentally oriented aquafeeds
    Peng Li
    Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Amino Acids 37:43-53. 2009
    ..Functional amino acids hold great promise for development of balanced aquafeeds to enhance the efficiency and profitability of global aquaculture production...
  63. doi request reprint Comparative aspects of implantation
    Fuller W Bazer
    Department of Animal Science Veterinary Integrative Biosciences, Texas A and M University, 2471 TAMU, College Station, TX 77843 2471, USA
    Reproduction 138:195-209. 2009
    ....
  64. doi request reprint Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health
    Jason R McKnight
    Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 39:349-57. 2010
    ..g., glucose and fatty acids) Thus, L-arginine holds great promise as a safe and cost-effective nutrient to reduce adiposity, increase muscle mass, and improve the metabolic profile in animals and humans...
  65. doi request reprint Sildenafil citrate treatment enhances amino acid availability in the conceptus and fetal growth in an ovine model of intrauterine growth restriction
    M Carey Satterfield
    Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    J Nutr 140:251-8. 2010
    ..These findings may lead to the clinical use of sildenafil citrate in human pregnancies suspected to be at risk for intrauterine fetal growth retardation...
  66. doi request reprint Select nutrients and their associated transporters are increased in the ovine uterus following early progesterone administration
    M Carey Satterfield
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 82:224-31. 2010
    ..Thus, select nutrients are increased in the uterine lumen by P4 concomitant with the upregulation of epithelial transporters for glucose and basic amino acids, suggesting that these nutrients stimulate blastocyst growth and development...
  67. ncbi request reprint Obesity in pregnancy: problems and potential solutions
    Jason R McKnight
    Faculty of Nutrition, Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Front Biosci (Elite Ed) 3:442-52. 2011
    ..Because of ethical concerns over human studies, animal models (e.g., sheep, pigs, baboons, rats, and mice) are warranted to test novel hypotheses with enormous biological significance and clinical applications...
  68. ncbi request reprint Brown adipose tissue growth and development: significance and nutritional regulation
    Michael Carey Satterfield
    Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    Front Biosci (Landmark Ed) 16:1589-608. 2011
    ..This review will attempt to meld the wealth of new information regarding BAT development with established literature to provide an up to date synopsis of what is known and thus a framework for future research directions...
  69. doi request reprint Cellular regulation of bovine intramuscular adipose tissue development and composition
    S B Smith
    Department of Animal Science, Texas A and M University, College Station, TX 77843 2471, USA
    J Anim Sci 87:E72-82. 2009
    ..m. adipose tissue development. Conversely, supplementation with vitamin C or zinc may promote the development of i.m. adipose tissue...
  70. pmc Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs
    Peng Li
    Department of Animal Science, Texas A and M University, College Station, TX, 77843, USA
    Amino Acids 37:709-16. 2009
    ..These novel findings have important implications for designing the next generation of infant formula to optimize neonatal growth and development...
  71. ncbi request reprint Developmental changes of amino acids in ovine fetal fluids
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station 77843 2471, USA
    Biol Reprod 68:1813-20. 2003
    ..These novel findings of the unusual abundance of traditionally classified nonessential amino acids in allantoic fluid raise important questions regarding their roles in ovine conceptus development...
  72. ncbi request reprint Maternal nutrition and fetal development
    Guoyao Wu
    Department of Animal Science, Texas A and M University, Health Science Center, College Station, TX 77843, USA
    J Nutr 134:2169-72. 2004
    ..Promoting optimal nutrition will not only ensure optimal fetal development, but will also reduce the risk of chronic diseases in adults...
  73. doi request reprint Insulin-like growth factor II activates phosphatidylinositol 3-kinase-protooncogenic protein kinase 1 and mitogen-activated protein kinase cell Signaling pathways, and stimulates migration of ovine trophectoderm cells
    JinYoung Kim
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Endocrinology 149:3085-94. 2008
    ..Collectively, these results support the hypothesis that IGF-II coordinately activates multiple cell signaling pathways critical to survival, growth, and differentiation of the ovine conceptus during early pregnancy...
  74. pmc Intravenous administration of L-citrulline to pregnant ewes is more effective than L-arginine for increasing arginine availability in the fetus
    Arantzatzu Lassala
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:660-5. 2009
    ..These novel findings provide support for studies of the clinical use of arginine and citrulline as therapeutic means to prevent or ameliorate fetal growth retardation in mammals...
  75. doi request reprint High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue
    Wenjuan Jobgen
    Department of Animal Science, Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 37:187-98. 2009
    ..Our findings provide a molecular mechanism to explain a beneficial effect of Arg on ameliorating diet-induced obesity in mammals...
  76. doi request reprint Effect of amino acids supply in reduced crude protein diets on performance, efficiency of mammary uptake, and transporter gene expression in lactating sows
    R Manjarin
    Department of Animal Science, Michigan State University, East Lansing 48824, USA
    J Anim Sci 90:3088-100. 2012
    ..This increase was associated with a decrease in plasma concentration of BCAA:Lys, suggesting a competitive mechanism between cationic and BCAA for transport of AA across mammary cells...
  77. ncbi request reprint Glutamine synthesis in the developing porcine placenta
    Jon T Self
    Department of Animal Science, Texas A and M University, College Station, Texas 77843 2471, USA
    Biol Reprod 70:1444-51. 2004
    ....
  78. doi request reprint Dietary supplementation of L-arginine and conjugated linoleic acid reduces retroperitoneal fat mass and increases lean body mass in rats
    Jennifer L Nall
    Intercollegiate Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:1279-85. 2009
    ..We conclude that CLA and arginine modulated adipose tissue metabolism by separate, but not additive, effects. Also, CLA and arginine may have depressed muscle protein turnover...
  79. ncbi request reprint Maternal nutrient restriction reduces concentrations of amino acids and polyamines in ovine maternal and fetal plasma and fetal fluids
    Hyukjung Kwon
    Department of Animal Science and Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, Texas 77843, USA
    Biol Reprod 71:901-8. 2004
    ..The results have important implications for understanding the mechanisms responsible for both intrauterine growth retardation and developmental origins of adult disease...
  80. doi request reprint Regulation of ornithine aminotransferase gene expression and activity by all-transretinoic acid in Caco-2 intestinal epithelial cells
    Christopher M Dekaney
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, TX 77843, USA
    J Nutr Biochem 19:674-81. 2008
    ..These novel findings indicate a functional role for OAT in regulating intestinal polyamine synthesis and growth...
  81. doi request reprint Amino acids and gaseous signaling
    Xilong Li
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 37:65-78. 2009
    ....
  82. ncbi request reprint Amino acids and immune function
    Peng Li
    Faculty of Nutrition and Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Br J Nutr 98:237-52. 2007
    ..These nutrients hold great promise in improving health and preventing infectious diseases in animals and humans...
  83. doi request reprint Analysis of citrulline, arginine, and methylarginines using high-performance liquid chromatography
    Guoyao Wu
    Department of Animal Science, Texas A and M University, College Station, Texas, USA
    Methods Enzymol 440:177-89. 2008
    ..1 and 10 microM for methylarginines. These chromatographic methods are highly sensitive, specific, accurate, and easily automated and provide a useful tool to study the regulation of the arginine-nitric oxide pathway...
  84. doi request reprint L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes
    Tony E Haynes
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    Amino Acids 37:131-42. 2009
    ..The findings support addition of Gln or Ala-Gln to current Gln-free pediatric amino acid solutions to prevent intestinal oxidative injury and inflammatory disease in neonates...
  85. ncbi request reprint Inadequate intakes of indispensable amino acids among homebound older adults
    Mou Dasgupta
    Department of Animal Science, Texas A and M University, USA
    J Nutr Elder 24:85-99. 2005
    ....
  86. pmc Parenteral administration of L-arginine prevents fetal growth restriction in undernourished ewes
    Arantzatzu Lassala
    Department of Animal Science, Texas A and M University, College Station, TX 77843, USA
    J Nutr 140:1242-8. 2010
    ..The findings also lay a new framework for studying cellular and molecular mechanisms responsible for the beneficial effects of Arg in regulating conceptus growth and development...
  87. pmc Lactating porcine mammary tissue catabolizes branched-chain amino acids for glutamine and aspartate synthesis
    Peng Li
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Nutr 139:1502-9. 2009
    ....
  88. ncbi request reprint Analysis of nitrite and nitrate in biological samples using high-performance liquid chromatography
    Wenjuan S Jobgen
    Department of Animal Science and Faculty of Nutrition, Texas A and M University, College Station, TX 77843, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 851:71-82. 2007
    ..HPLC methods provide a useful research tool for studying NO biochemistry, physiology and pharmacology...
  89. ncbi request reprint Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs
    Deyuan Ou
    National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100094, PR China
    J Nutr Biochem 18:820-6. 2007
    ..These findings may have important implications for the prevention of weaning-associated diarrhea in piglets...
  90. ncbi request reprint Gene expression and activity of enzymes in the arginine biosynthetic pathway in porcine fetal small intestine
    Chirstopher M Dekaney
    Department of Veterinary Anatomy and Public Health, Institute of Biosciences and Technology
    Pediatr Res 53:274-80. 2003
    ..This ability of the fetal small intestine to synthesize amino acids may be important for development and metabolic activity of the intestine during somatic growth of the fetus...
  91. ncbi request reprint Watermelon consumption increases plasma arginine concentrations in adults
    Julie K Collins
    USDA ARS, South Central Agricultural Research Laboratory, Lane, Oklahoma, USA
    Nutrition 23:261-6. 2007
    ..This study investigated if watermelon juice consumption increases fasting concentrations of plasma arginine, ornithine, and citrulline in healthy adult humans...
  92. ncbi request reprint Dietary L-arginine supplementation enhances the reproductive performance of gilts
    Ronaldo D Mateo
    Texas Tech University, Lubbock, TX 79409, USA
    J Nutr 137:652-6. 2007
    ..032) and live litter birth weight of piglets by 24% (16.38 vs. 13.19 kg, P = 0.016). This exciting finding provides the first evidence for a marked increase of live-born piglets by 2 per litter through nutritional intervention in gilts...
  93. ncbi request reprint Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway
    Shehla Pervin
    Departments of Obstetrics and Gynecology and Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA, USA
    Cancer Res 67:289-99. 2007
    ....
  94. ncbi request reprint Arginine stimulates cdx2-transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and phosphorylation of p70 S6 kinase
    J Marc Rhoads
    Department of Pediatrics, University of Texas Health Science Center, Houston, TX 77030, USA
    J Nutr 138:1652-7. 2008
    ....
  95. ncbi request reprint Intestinal ribosomal p70(S6K) signaling is increased in piglet rotavirus enteritis
    J Marc Rhoads
    Department of Pediatrics, Ochsner Clinic Foundation and Ochsner Children s Research Institute, New Orleans, Louisiana, USA
    Am J Physiol Gastrointest Liver Physiol 292:G913-22. 2007
    ..In conclusion, intestinal activation of p70(S6K) was not inhibited by malnutrition but was strongly activated during an active state of mucosal regeneration...
  96. ncbi request reprint Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA)
    Kaye M Reid
    Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 292:G512-7. 2007
    ..Arginase blockade represents a potentially novel strategy to combat hepatic I/R injury associated with liver transplantation...
  97. ncbi request reprint Regulation of endothelial cell proliferation by nitric oxide
    Cynthia J Meininger
    Cardiovascular Research Institute, Department of Medical Physiology, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    Methods Enzymol 352:280-95. 2002
  98. ncbi request reprint A deficiency or excess of dietary threonine reduces protein synthesis in jejunum and skeletal muscle of young pigs
    Xu Wang
    National Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China
    J Nutr 137:1442-6. 2007
    ..The findings provide a mechanism for the low growth performance of animals fed a threonine-imbalanced diet...
  99. ncbi request reprint Nebivolol inhibits vascular smooth muscle cell proliferation by mechanisms involving nitric oxide but not cyclic GMP
    Louis J Ignarro
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 1735, USA
    Nitric Oxide 7:83-90. 2002
    ..These observations confirm previous findings that DFMO and NO interfere with RASMC proliferation by inhibiting ODC and polyamine production and provide evidence that nebivolol works by the same mechanism...
  100. ncbi request reprint Gene expression is altered in piglet small intestine by weaning and dietary glutamine supplementation
    Junjun Wang
    State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China
    J Nutr 138:1025-32. 2008
    ..These findings reveal coordinate alterations of gene expression in response to weaning and aid in providing molecular mechanisms for the beneficial effect of dietary glutamine supplementation to improve nutrition status in young mammals...
  101. pmc Arginase blockade protects against hepatic damage in warm ischemia-reperfusion
    Geetha Jeyabalan
    Department of Surgery, University of Pittsburgh, Starzl Transplantation Institute, 3459 Fifth Avenue, MUH 7 South, Pittsburgh, PA 15213, USA
    Nitric Oxide 19:29-35. 2008
    ..The purpose of this study was to determine if nor-NOHA, a novel arginase inhibitor, would be able to increase circulating arginine levels and decrease hepatic damage following warm I/R...

Research Grants1

  1. Arginine and Ovine Model for Fetal Growth Restriction
    Guoyao Wu; Fiscal Year: 2007
    ..This will ultimately promote favorable pregnancy outcomes while saving billions of healthcare dollars in the U.S. and worldwide. ..