Rong Fu Wang

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Enhancement of antitumor immunity by prolonging antigen presentation on dendritic cells
    Rong Fu Wang
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nat Biotechnol 20:149-54. 2002
  2. ncbi request reprint Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    Guangyong Peng
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 309:1380-4. 2005
  3. ncbi request reprint Functional control of regulatory T cells and cancer immunotherapy
    Rong Fu Wang
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA
    Semin Cancer Biol 16:106-14. 2006
  4. ncbi request reprint Regulatory T cells and toll-like receptors in cancer therapy
    Rong Fu Wang
    The 2nd Hospital, Zhejiang University Medical School, Hangzhou, China
    Cancer Res 66:4987-90. 2006
  5. ncbi request reprint Regulatory T cells and innate immune regulation in tumor immunity
    Rong Fu Wang
    Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building, N1120 Houston, TX 77030, USA corrected
    Springer Semin Immunopathol 28:17-23. 2006
  6. pmc Identification of a mutated fibronectin as a tumor antigen recognized by CD4+ T cells: its role in extracellular matrix formation and tumor metastasis
    Helen Y Wang
    The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Exp Med 195:1397-406. 2002
  7. pmc Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes
    Kui Shin Voo
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Exp Med 199:459-70. 2004
  8. ncbi request reprint Regulatory T cells and Toll-like receptors in tumor immunity
    Rong Fu Wang
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Immunol 18:136-42. 2006
  9. ncbi request reprint Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer
    Rong Fu Wang
    Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA
    Semin Cancer Biol 16:73-9. 2006
  10. doi request reprint Toll-like receptors and immune regulation: implications for cancer therapy
    R F Wang
    Center for Cell and Gene Therapy and Department of Pathology and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 27:181-9. 2008

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Enhancement of antitumor immunity by prolonging antigen presentation on dendritic cells
    Rong Fu Wang
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Nat Biotechnol 20:149-54. 2002
    ..This CPP-based approach may be generally applicable to enhance the efficacy of DC-based peptide vaccines against cancer and other diseases...
  2. ncbi request reprint Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function
    Guangyong Peng
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Science 309:1380-4. 2005
    ..These results suggest that TLR8 signaling could play a critical role in controlling immune responses to cancer and other diseases...
  3. ncbi request reprint Functional control of regulatory T cells and cancer immunotherapy
    Rong Fu Wang
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA
    Semin Cancer Biol 16:106-14. 2006
    ..Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to shift the balance between CD4(+) T-helper and Treg cells, in ways that may improve the outcome of cancer immunotherapy...
  4. ncbi request reprint Regulatory T cells and toll-like receptors in cancer therapy
    Rong Fu Wang
    The 2nd Hospital, Zhejiang University Medical School, Hangzhou, China
    Cancer Res 66:4987-90. 2006
    ..Linking TLR signaling to the functional control of Treg cells may offer new opportunities to improve the outcome of cancer immunotherapy by coadminstration of certain TLR ligands...
  5. ncbi request reprint Regulatory T cells and innate immune regulation in tumor immunity
    Rong Fu Wang
    Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building, N1120 Houston, TX 77030, USA corrected
    Springer Semin Immunopathol 28:17-23. 2006
    ..Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to manipulate TLR signaling to control both innate and adaptive immunity against cancer...
  6. pmc Identification of a mutated fibronectin as a tumor antigen recognized by CD4+ T cells: its role in extracellular matrix formation and tumor metastasis
    Helen Y Wang
    The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    J Exp Med 195:1397-406. 2002
    ....
  7. pmc Evidence for the presentation of major histocompatibility complex class I-restricted Epstein-Barr virus nuclear antigen 1 peptides to CD8+ T lymphocytes
    Kui Shin Voo
    Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Exp Med 199:459-70. 2004
    ....
  8. ncbi request reprint Regulatory T cells and Toll-like receptors in tumor immunity
    Rong Fu Wang
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Semin Immunol 18:136-42. 2006
    ..Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to shift the balance between CD4(+) T-helper and Treg cells, in ways that may improve the outcome of cancer immunotherapy...
  9. ncbi request reprint Immune suppression by tumor-specific CD4+ regulatory T-cells in cancer
    Rong Fu Wang
    Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, ALKEK Building, N1120, Houston, TX 77030, USA
    Semin Cancer Biol 16:73-9. 2006
    ..This review will discuss the natural ligands and their potential roles of tumor-specific CD4+ regulatory T-cells in cancer therapy...
  10. doi request reprint Toll-like receptors and immune regulation: implications for cancer therapy
    R F Wang
    Center for Cell and Gene Therapy and Department of Pathology and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 27:181-9. 2008
    ..In this review, we focus on the current understanding of TLRs and Treg cells with emphasis on their roles in cancer immunity. Related information on non-TLR immune receptors will be briefly discussed...
  11. doi request reprint CD8+ regulatory T cells, their suppressive mechanisms, and regulation in cancer
    Rong Fu Wang
    Center for Cell and Gene Therapy, Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA
    Hum Immunol 69:811-4. 2008
    ....
  12. ncbi request reprint The role of MHC class II-restricted tumor antigens and CD4+ T cells in antitumor immunity
    R F Wang
    The Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Immunol 22:269-76. 2001
    ..To this end, the identification of MHC class II-restricted tumor antigens that can stimulate CD4+ T cells might provide opportunities for developing effective cancer vaccines...
  13. ncbi request reprint Identification of MHC class II-restricted tumor antigens recognized by CD4+ T cells
    Rong Fu Wang
    Department of Immunology, The Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building N1120, One Baylor Plaza, Houston, TX 77030, USA
    Methods 29:227-35. 2003
    ..Helper T peptides are subsequently identified by using synthetic peptides to test their ability to stimulate CD4+ T cells...
  14. ncbi request reprint Enhancing antitumor immune responses: intracellular peptide delivery and identification of MHC class II-restricted tumor antigens
    Rong Fu Wang
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Immunol Rev 188:65-80. 2002
    ....
  15. ncbi request reprint T cell-mediated immune responses in melanoma: implications for immunotherapy
    Rong Fu Wang
    Department of Immunology, The Center for Cell and Gene Therapy, Baylor College of Medicine, ALKEK Building, N1120, One Baylor Plaza, Houston, TX 77030, USA
    Crit Rev Oncol Hematol 43:1-11. 2002
    ..This review will summarize the current status of MHC class I and class II-restricted human tumor antigens, and their potential application to cancer treatment...
  16. ncbi request reprint Identification of HLA-DP3-restricted peptides from EBNA1 recognized by CD4(+) T cells
    Kui Shin Voo
    The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 62:7195-9. 2002
    ....
  17. ncbi request reprint Recognition of a new ARTC1 peptide ligand uniquely expressed in tumor cells by antigen-specific CD4+ regulatory T cells
    Helen Y Wang
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Immunol 174:2661-70. 2005
    ....
  18. pmc Identification of special AT-rich sequence binding protein 1 as a novel tumor antigen recognized by CD8+ T cells: implication for cancer immunotherapy
    Mingjun Wang
    Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Houston, Texas, USA
    PLoS ONE 8:e56730. 2013
    ....
  19. pmc Enhanced TLR-induced NF-κB signaling and type I interferon responses in NLRC5 deficient mice
    Yanzheng Tong
    The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Res 22:822-35. 2012
    ....
  20. ncbi request reprint Tumor-infiltrating gammadelta T cells suppress T and dendritic cell function via mechanisms controlled by a unique toll-like receptor signaling pathway
    Guangyong Peng
    The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 27:334-48. 2007
    ..These results provide new insights into the regulatory mechanisms of tumor-specific gammadelta T cells and identify a unique TLR8 signaling pathway linking to their functional regulation...
  21. pmc Critical role of EBNA1-specific CD4+ T cells in the control of mouse Burkitt lymphoma in vivo
    Tihui Fu
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    J Clin Invest 114:542-50. 2004
    ....
  22. pmc NLRX1 negatively regulates TLR-induced NF-κB signaling by targeting TRAF6 and IKK
    Xiaojun Xia
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 34:843-53. 2011
    ..Our study identifies a previously unrecognized role for NLRX1 in the negative regulation of TLR-induced NF-κB activation by dynamically interacting with TRAF6 and the IKK complex...
  23. pmc Induction of CD4(+) T cell-dependent antitumor immunity by TAT-mediated tumor antigen delivery into dendritic cells
    Helen Y Wang
    Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 109:1463-70. 2002
    ..These results suggest that a TAT-mediated antigen delivery system may have important clinical applications for cancer therapy...
  24. ncbi request reprint CD8+ Foxp3+ regulatory T cells mediate immunosuppression in prostate cancer
    Yukiko Kiniwa
    Department of Pathology, The Center for Cell and Gene Therapy, Baylor Colleg of Medicine, Houston, Texas 77030, USA
    Clin Cancer Res 13:6947-58. 2007
    ..In this study, we investigated prostate tumor-derived CD8(+) Treg cells and their function...
  25. ncbi request reprint Functional characterization of EBV-encoded nuclear antigen 1-specific CD4+ helper and regulatory T cells elicited by in vitro peptide stimulation
    Kui Shin Voo
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 65:1577-86. 2005
    ....
  26. ncbi request reprint Antigen-specific CD4+ regulatory T cells in cancer: implications for immunotherapy
    Helen Y Wang
    ALKEK Building, N1120, Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Microbes Infect 7:1056-62. 2005
    ..This review discusses the natural ligands and their potential roles of tumor-specific CD4(+) regulatory T cells in cancer therapy...
  27. pmc Identification of prostate-specific G-protein coupled receptor as a tumor antigen recognized by CD8(+) T cells for cancer immunotherapy
    Satoko Matsueda
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA
    PLoS ONE 7:e45756. 2012
    ..In this study, we describe the identification of PSGR-derived peptide epitopes recognized by CD8(+) T cells in an HLA-A2 dependent manner...
  28. ncbi request reprint CD4+ T-cell response to mitochondrial cytochrome B in human melanoma
    Kui Shin Voo
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, Texas, USA
    Cancer Res 66:5919-26. 2006
    ..These findings provide the first example of a mitochondrial immune target for CD4(+) T cells and therefore have implications for the immunosurveillance of mitochondrial aberrations in cancer patients...
  29. pmc NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4
    Jun Cui
    The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Nat Immunol 13:387-95. 2012
    ..Our results identify a previously unrecognized role for NLRP4 in the regulation of type I interferon signaling and provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation...
  30. doi request reprint Molecular cloning and characterization of MHC class I- and II-restricted tumor antigens recognized by T cells
    Rong Fu Wang
    The Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Curr Protoc Immunol . 2009
    ..This unit describes a cDNA expression system and a genetic targeting expression system for the cloning of genes encoding for MHC class I- and II-restricted antigens recognized by antigen-specific CD8(+) and CD4(+) T cells...
  31. pmc Tumor-associated galectin-3 modulates the function of tumor-reactive T cells
    Weiyi Peng
    The Center for Cell and Gene Therapy, Department of Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 68:7228-36. 2008
    ..These findings suggest that Gal-3 may function as an immune regulator to inhibit T-cell immune responses and promote tumor growth, thus providing a new mechanism for tumor immune tolerance...
  32. ncbi request reprint Tumor-specific human CD4+ regulatory T cells and their ligands: implications for immunotherapy
    Helen Y Wang
    The Center for Cell and Gene Therapy and Department of Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 20:107-18. 2004
    ..These findings suggest that the presence of tumor-specific CD4(+) Treg cells at tumor sites may have a profound effect on the inhibition of T cell responses against cancer...
  33. doi request reprint Cell type-specific function of TAK1 in innate immune signaling
    Adebusola A Ajibade
    Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, 6670 Bertner Avenue, Houston, TX 77030, USA
    Trends Immunol 34:307-16. 2013
    ..In this article, we discuss the latest progresses in our understanding of TAK1 regulation, function, and mechanisms in a cell-type specific manner. ..
  34. pmc Jmjd3 inhibits reprogramming by upregulating expression of INK4a/Arf and targeting PHF20 for ubiquitination
    Wei Zhao
    Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Cell 152:1037-50. 2013
    ..Our findings demonstrate, to the best of our knowledge, a previously unrecognized role of Jmjd3 in cellular reprogramming and provide molecular insight into the mechanisms by which the Jmjd3-PHF20 axis controls this process...
  35. pmc Enhancing cancer immunotherapy by intracellular delivery of cell-penetrating peptides and stimulation of pattern-recognition receptor signaling
    Helen Y Wang
    Department of Pathology and Immunology, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, USA
    Adv Immunol 114:151-76. 2012
    ..We will discuss the recent progress and novel strategies in cancer immunotherapy...
  36. pmc TAK1 negatively regulates NF-κB and p38 MAP kinase activation in Gr-1+CD11b+ neutrophils
    Adebusola Alagbala Ajibade
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Immunity 36:43-54. 2012
    ..Our findings identify a previously unrecognized role of TAK1 as a negative regulator of p38 and IKK activation in a cell type-specific manner...
  37. doi request reprint USP3 inhibits type I interferon signaling by deubiquitinating RIG-I-like receptors
    Jun Cui
    1 Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China 2 Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Houston, TX 77030, USA
    Cell Res 24:400-16. 2014
    ..Our findings identify a previously unrecognized role of USP3 in RIG-I activation and provide insights into the mechanisms by which USP3 inhibits RIG-I signaling and antiviral immunity. ..
  38. ncbi request reprint Regulatory T cells and cancer
    Helen Y Wang
    Center for Cell and Gene Therapy, Departments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Immunol 19:217-23. 2007
    ....
  39. pmc NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways
    Jun Cui
    Center for Cell and Gene Therapy, and Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 141:483-96. 2010
    ..Our findings identify NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity...
  40. pmc Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer
    Yoshihiro Miyahara
    Department of Pathology and Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:15505-10. 2008
    ..These findings should accelerate efforts to define the function of this important subset of CD4(+) T cells in the human immune response to cancer...
  41. doi request reprint HLA-restricted NY-ESO-1 peptide immunotherapy for metastatic castration resistant prostate cancer
    Guru Sonpavde
    Department of Medicine, Section of Medical Oncology, Baylor College of Medicine, Houston, TX, USA
    Invest New Drugs 32:235-42. 2014
    ..Given the immunogenicity of NY-ESO-1 peptides in prostate cancer, a phase I clinical trial was designed to evaluate HLA class-I and class-II restricted NY-ESO-1 peptides in metastatic castration-resistant prostate cancer (mCRPC)...
  42. pmc Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    Tuo Deng
    The Methodist Diabetes and Metabolism Institute, Center for Diabetes Research and Center for Inflammation and Epigenetics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA
    Cell Metab 17:411-22. 2013
    ..These investigations uncover a mechanism whereby a HFD-induced adipocyte/ART dialog involving MHCII instigates adipose inflammation and, together with ATM MHCII, escalates its progression...
  43. ncbi request reprint Revelation of a cryptic major histocompatibility complex class II-restricted tumor epitope in a novel RNA-processing enzyme
    Suzanne L Topalian
    Surgery Branch, National Cancer Institute, Center for Cancer Research, NIH, Bethesda, Maryland 20892 1502, USA
    Cancer Res 62:5505-9. 2002
    ..Genetic aberrations such as the described point mutation can have unexpected immunological consequences, in this case leading to immune recognition of a distant normal self epitope...
  44. pmc Generation of NY-ESO-1-specific CD4+ and CD8+ T cells by a single peptide with dual MHC class I and class II specificities: a new strategy for vaccine design
    Gang Zeng
    Surgery Branch, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 62:3630-5. 2002
    ..Dual-specific peptides containing both cytotoxic T-cell and helper T-cell epitopes may represent an attractive strategy of vaccine design aimed at generating tumor-reactive CD4+ and CD8+ T cells...
  45. ncbi request reprint [Study of clinical value of dual-phase imaging using single photon emission computed tomography with coincidence detection for differentiating benign from malignant lesions]
    Rong Fu Wang
    Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 37:287-91. 2005
    ....
  46. ncbi request reprint Microarray method to monitor 40 intestinal bacterial species in the study of azo dye reduction
    Rong Fu Wang
    Microbiology Division, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
    Biosens Bioelectron 20:699-705. 2004
    ..Results from this study showed 26-30 species are present in the cultured fecal samples. The representative bacteria were then examined for the azo dye reduction activity...
  47. ncbi request reprint [Prospect of hypoxia imaging of nuclear medicine in tumors]
    Gang Chen
    Department of Nuclear Medicine, Peking University First Hospital, Beijing 100034, China
    Beijing Da Xue Xue Bao 38:335-inside back cover. 2006
    ..Presenting a noninvasive approach in detecting hypoxic state in tumors, hypoxia imaging of nuclear medicine can be used in the differential diagnosis, prognosis evaluation and guiding therapy of malignant tumors...