L V Wang

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc Formulation of photon diffusion from spherical bioluminescent sources in an infinite homogeneous medium
    Wenxiang Cong
    CT Micro CT Laboratory University of Iowa Iowa City, Iowa 52242, USA
    Biomed Eng Online 3:12. 2004
  2. ncbi request reprint CONV--convolution for responses to a finite diameter photon beam incident on multi-layered tissues
    L Wang
    Bioengineering Program, Texas A and M University, College Station 77843 3120, USA
    Comput Methods Programs Biomed 54:141-50. 1997
  3. ncbi request reprint Ultrasonic modulation of scattered light in turbid media and a potential novel tomography in biomedicine
    L V Wang
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843 3120, USA
    Photochem Photobiol 67:41-9. 1998
  4. ncbi request reprint Mechanisms of ultrasonic modulation of multiply scattered coherent light: an analytic model
    L V Wang
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Phys Rev Lett 87:043903. 2001
  5. ncbi request reprint Combined photoacoustic and molecular fluorescence imaging in vivo
    Lihong Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX email tel 979 847 9040 fax 979 845 4450
    Conf Proc IEEE Eng Med Biol Soc 1:190-2. 2005
  6. ncbi request reprint Ultrasound-mediated biophotonic imaging: a review of acousto-optical tomography and photo-acoustic tomography
    Lihong V Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843 3120, USA
    Dis Markers 19:123-38. 2003
  7. ncbi request reprint Scanning microwave-induced thermoacoustic tomography: signal, resolution, and contrast
    G Ku
    Optical Imaging Laboratory, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:4-10. 2001
  8. ncbi request reprint Signal processing in scanning thermoacoustic tomography in biological tissues
    Y Xu
    Optical Imaging Laboratory, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:1519-24. 2001
  9. ncbi request reprint Microwave-induced thermoacoustic tomography using multi-sector scanning
    M Xu
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:1958-63. 2001
  10. ncbi request reprint Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture
    D Feng
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:2427-31. 2001

Collaborators

Detail Information

Publications73

  1. pmc Formulation of photon diffusion from spherical bioluminescent sources in an infinite homogeneous medium
    Wenxiang Cong
    CT Micro CT Laboratory University of Iowa Iowa City, Iowa 52242, USA
    Biomed Eng Online 3:12. 2004
    ..The numerical solutions to the diffusion equation take large amounts of computational time, and the studies for its analytic solutions have attracted more attention in biomedical engineering applications...
  2. ncbi request reprint CONV--convolution for responses to a finite diameter photon beam incident on multi-layered tissues
    L Wang
    Bioengineering Program, Texas A and M University, College Station 77843 3120, USA
    Comput Methods Programs Biomed 54:141-50. 1997
    ..The program, including the source code, has been in the public domain since 1992 and can be downloaded from the web site at http:(/)/biomed.tamu.edu/-lw...
  3. ncbi request reprint Ultrasonic modulation of scattered light in turbid media and a potential novel tomography in biomedicine
    L V Wang
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843 3120, USA
    Photochem Photobiol 67:41-9. 1998
    ..The mechanisms of ultrasonic modulation of scattered light are discussed. A theory based on the field autocorrelation function is reviewed as well...
  4. ncbi request reprint Mechanisms of ultrasonic modulation of multiply scattered coherent light: an analytic model
    L V Wang
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Phys Rev Lett 87:043903. 2001
    ..0890) of the acoustic wavelength, and it becomes increasingly more important beyond this point. This model agrees well with an independent Monte Carlo model...
  5. ncbi request reprint Combined photoacoustic and molecular fluorescence imaging in vivo
    Lihong Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX email tel 979 847 9040 fax 979 845 4450
    Conf Proc IEEE Eng Med Biol Soc 1:190-2. 2005
    ..The coregistration between the PAT and fluorescence images was used to visualize tumor location, angiogenesis, and brain structure simultaneously...
  6. ncbi request reprint Ultrasound-mediated biophotonic imaging: a review of acousto-optical tomography and photo-acoustic tomography
    Lihong V Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843 3120, USA
    Dis Markers 19:123-38. 2003
    ..Potential clinical applications of ultrasound-mediated biophotonic imaging include early cancer detection, functional imaging, and molecular imaging...
  7. ncbi request reprint Scanning microwave-induced thermoacoustic tomography: signal, resolution, and contrast
    G Ku
    Optical Imaging Laboratory, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:4-10. 2001
    ..Gain compensation, counteracting the microwave attenuation, was applied to enhance the image contrast...
  8. ncbi request reprint Signal processing in scanning thermoacoustic tomography in biological tissues
    Y Xu
    Optical Imaging Laboratory, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:1519-24. 2001
    ..A numerical simulation validated our signal-processing approach...
  9. ncbi request reprint Microwave-induced thermoacoustic tomography using multi-sector scanning
    M Xu
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:1958-63. 2001
    ..Each detected signal is converted into a one-dimensional (1D) image along the acoustic axis of the transducer. The cross-sectional images of the tissue samples are calculated by combining all of the 1D images acquired in the same planes...
  10. ncbi request reprint Microwave-induced thermoacoustic tomography: reconstruction by synthetic aperture
    D Feng
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843-3120, USA
    Med Phys 28:2427-31. 2001
    ..The 3 GHz system had a much larger imaging depth but a lower signal-noise ratio than the 9 GHz system in near-surface imaging...
  11. pmc Realtime photoacoustic microscopy of murine cardiovascular dynamics
    R J Zemp
    Department of Biomedical Engineering, Washington University, Optical Imaging Laboratory, St Louis, MO 63130, USA
    Opt Express 16:18551-6. 2008
    ..To our knowledge this is the first report of realtime photoacoustic imaging of physiological dynamics...
  12. ncbi request reprint Effects of ageing on the biomechanical properties of rat articular cartilage
    L Wang
    Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
    Proc Inst Mech Eng H 220:573-8. 2006
    ..However, and more intriguingly, it is also possible that ageing does not affect the biomechanical properties of articular cartilage in the absence of cartilage pathology...
  13. ncbi request reprint Image distortion in thermoacoustic tomography caused by microwave diffraction
    Changhui Li
    Biomedical Engineering Department, Washington University in St Louis, St Louis, Missouri 63130, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 77:031923. 2008
    ..Both numerical simulations and phantom experiments demonstrate this phenomenon. A method of partial correction is also provided...
  14. ncbi request reprint Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy
    Jung Taek Oh
    Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, 77843 3120, USA
    J Biomed Opt 11:34032. 2006
    ..The vascular system surrounding the melanoma is also imaged with visible light (584 nm) and the tumor-feeding vessels found. This technique can potentially be used for melanoma diagnosis, prognosis, and treatment planning...
  15. pmc Design and evaluation of a novel breast cancer detection system combining both thermoacoustic (TA) and photoacoustic (PA) tomography
    Manojit Pramanik
    Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
    Med Phys 35:2218-23. 2008
    ..Here we present the design of the breast scanner along with initial tissue phantom study results as a precursor to an actual patient study...
  16. pmc Effects of acoustic heterogeneities on transcranial brain imaging with microwave-induced thermoacoustic tomography
    Xing Jin
    Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Med Phys 35:3205-14. 2008
    ..This work is important for obtaining good brain images when the thickness of the skull cannot be ignored...
  17. ncbi request reprint Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography
    Xueding Wang
    Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 11:024015. 2006
    ..This technique, with its prominent sensitivity to endogenous contrast, can potentially contribute to the understanding of the interrelationship between neural, hemodynamic, and metabolic activities in the brain...
  18. ncbi request reprint Rhesus monkey brain imaging through intact skull with thermoacoustic tomography
    Yuan Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 53:542-8. 2006
    ..Brain features that are 3 cm deep in the head are imaged clearly. Our results demonstrate that TAT has potential for use in portable, cost-effective imagers for pediatric brains...
  19. doi request reprint Photoacoustic imaging of biological tissue with intensity-modulated continuous-wave laser
    Konstantin Maslov
    Washington University in St Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St Louis, Missouri 63130 4899, USA
    J Biomed Opt 13:024006. 2008
    ..85 and resonance frequency is 2.45 MHz, we image biological tissues with a lateral resolution of 0.45 mm, an axial resolution of 1 mm, and an SNR as high as 43 dB...
  20. ncbi request reprint Weighted expectation maximization reconstruction algorithms for thermoacoustic tomography
    Jin Zhang
    IEEE Trans Med Imaging 24:817-20. 2005
    ..Using simulated and experimental TAT measurement data, we demonstrate that suitable choices of weighted EM algorithms can effectively mitigate image artifacts that are attributable to temporal truncation of the TAT data function...
  21. ncbi request reprint Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging
    Hao F Zhang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Nat Biotechnol 24:848-51. 2006
    ..fPAM is demonstrated with in vivo imaging of angiogenesis, melanoma, hemoglobin oxygen saturation (sO2) of single vessels in animals and total hemoglobin concentration in humans...
  22. ncbi request reprint In vivo three-dimensional photoacoustic tomography of a whole mouse head
    Kwang Hyun Song
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Opt Lett 31:2453-5. 2006
    ..Deeply seated arterial and venous vessels in the head measuring up to 1.7 cm in diameter were simultaneously imaged in vivo with 804 nm wavelength laser excitation of photoacoustic waves...
  23. doi request reprint Sentinel lymph node detection ex vivo using ultrasound-modulated optical tomography
    Chulhong Kim
    Washington University in Saint Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, Campus Box 1097, One Brookings Drive, Saint Louis, Missouri 63130 4899, USA
    J Biomed Opt 13:020507. 2008
    ....
  24. ncbi request reprint Deep reflection-mode photoacoustic imaging of biological tissue
    Kwang Hyun Song
    Washington University in St Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Campus Box 1097, One Brookings Drive, St Louis, Missouri 63130 4899, USA
    J Biomed Opt 12:060503. 2007
    ..At the 19-mm depth, the axial resolution is 144 microm and the transverse resolution is 560 microm. Internal organs of small animals were imaged clearly...
  25. ncbi request reprint Photoacoustic tomography of a rat cerebral cortex in vivo with au nanocages as an optical contrast agent
    Xinmai Yang
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, MO 63130, USA
    Nano Lett 7:3798-802. 2007
    ..A gradual enhancement of the optical absorption in the cerebral cortex, by up to 81%, was observed over the course of the experiment...
  26. pmc Realtime photoacoustic microscopy in vivo with a 30-MHz ultrasound array transducer
    Roger J Zemp
    Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, Saint Louis, Missouri 63130, USA
    Opt Express 16:7915-28. 2008
    ..Realtime imaging performance is demonstrated on phantoms and in vivo with absorbing structures identified to depths of 2.5-3 mm. This work represents the first high-frequency realtime photoacoustic imaging system to our knowledge...
  27. ncbi request reprint Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer
    Roger J Zemp
    Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, Saint Louis, Missouri 63130, USA
    J Biomed Opt 12:010501. 2007
    ..It is anticipated that the system can be used for studying and diagnosing a number of diseases including cancer, atherosclerosis, dermatological disorders, and peripheral microvascular complications in diabetes...
  28. ncbi request reprint Photorefractive detection of tissue optical and mechanical properties by ultrasound modulated optical tomography
    Xiao Xu
    Department of Biomedical Engineering, Texas A and M University, College Station 77843, USA
    Opt Lett 32:656-8. 2007
    ....
  29. ncbi request reprint In vivo burn imaging using Mueller optical coherence tomography
    Milos Todorović
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
    Opt Express 16:10279-84. 2008
    ..By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system's potential for in vivo burn-depth determination...
  30. ncbi request reprint Thermoacoustic tomography with correction for acoustic speed variations
    Xing Jin
    Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Phys Med Biol 51:6437-48. 2006
    ..In this paper we develop a correction method based on ultrasonic transmission tomography (UTT) to improve the image quality of TAT. Numerical simulations and phantom experiments verify the effectiveness of this correction method...
  31. ncbi request reprint Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography
    Geng Ku
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 44:770-5. 2005
    ..This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research...
  32. ncbi request reprint Imaging of high-intensity focused ultrasound-induced lesions in soft biological tissue using thermoacoustic tomography
    Xing Jin
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Med Phys 32:5-11. 2005
    ..Gross pathologic photographs of the tissue samples confirmed the TAT images. This work demonstrates that TAT may potentially be used to image HIFU-induced lesions in biological tissues...
  33. ncbi request reprint Half-time image reconstruction in thermoacoustic tomography
    Mark A Anastasio
    Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL 60616, USA
    IEEE Trans Med Imaging 24:199-210. 2005
    ..Reconstructed images and numerical results produced from simulated and experimental TAT measurement data are employed to demonstrate these effects...
  34. ncbi request reprint Photoacoustic tomography of biological tissues with high cross-section resolution: reconstruction and experiment
    Xueding Wang
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University 3120 TAMU, College Station, Texas 77843 3120, USA
    Med Phys 29:2799-805. 2002
    ....
  35. ncbi request reprint Jones-matrix imaging of biological tissues with quadruple-channel optical coherence tomography
    Shuliang Jiao
    Texas A and M University, Optical Imaging Laboratory, Biomedical Engineering Program, College Station, Texas 77843 3120, USA
    J Biomed Opt 7:350-8. 2002
    ..Birefringence is sensitive to changes in tissue because it is based on phase contrast...
  36. ncbi request reprint Analytic explanation of spatial resolution related to bandwidth and detector aperture size in thermoacoustic or photoacoustic reconstruction
    Minghua Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843 3120, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 67:056605. 2003
    ..The bandwidth affects both axial and lateral resolutions; in contrast, the detector aperture blurs the lateral resolution greatly but the axial resolution only slightly...
  37. ncbi request reprint Multiple-bandwidth photoacoustic tomography
    Geng Ku
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843 3120, USA
    Phys Med Biol 49:1329-38. 2004
    ..The higher frequency detectors provided better image resolution while the lower frequency detectors delineated the major structural traits with a higher signal-noise ratio...
  38. ncbi request reprint Methods for parallel-detection-based ultrasound-modulated optical tomography
    Jun Li
    Optical Imaging Laboratory, Biomedical Engineering Program, Texas A and M University, College Station 77843 3120, USA
    Appl Opt 41:2079-84. 2002
    ..The image quality obtained with these methods was comparable with that obtained with the four-phase method; in addition, these methods have advantages in reducing acquisition time and improving the signal-to-noise ratio...
  39. ncbi request reprint Transmission- and side-detection configurations in ultrasound-modulated optical tomography of thick biological tissues
    Jun Li
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 42:4088-94. 2003
    ..Experimental results implied feasibility of applying the ultrasound-modulation technique to characterize optical properties in inhomogeneous biological tissues...
  40. ncbi request reprint High-resolution ultrasound-modulated optical tomography in biological tissues
    Sava Sakadzic
    Optical Imaging Laboratory, Department of Biomedical Engineering, 3120 TAMU, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 29:2770-2. 2004
    ..This technology is complementary to other imaging technologies, such as confocal microscopy and optical-coherence tomography, and has the potential for broad biomedical applications...
  41. ncbi request reprint Universal back-projection algorithm for photoacoustic computed tomography
    Minghua Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 71:016706. 2005
    ..A method for implementing this algorithm is described. Numerical simulation is used to demonstrate the performance of the algorithm...
  42. ncbi request reprint Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact
    Xueding Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 28:1739-41. 2003
    ..The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well...
  43. ncbi request reprint Imaging optically scattering objects with ultrasound-modulated optical tomography
    Sri Rajasekhar Kothapalli
    Department of Biomedical Engineering, Optical Imaging Laboratory, Washington University in St Louis, One Brookings Drive, St Louis, MO 63130 4899, USA
    Opt Lett 32:2351-3. 2007
    ..This study complements previous UOT experiments that demonstrated optical absorption contrast...
  44. ncbi request reprint Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study
    Chulhong Kim
    Department of Biomedical Engineering, Optical Imaging Laboratory, Washington University in St Louis, One Brookings Drive, St Louis, MO 63130, USA
    Opt Lett 32:2285-7. 2007
    ..The results suggest that UOT can potentially provide noninvasive functional imaging of the total concentration and oxygen saturation of hemoglobin in biological tissue...
  45. ncbi request reprint Multiple-source optical diffusion approximation for a multilayer scattering medium
    Joseph L Hollmann
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 46:6004-9. 2007
    ..This multisource method is found to be significantly more accurate than the previous single-source method...
  46. ncbi request reprint Photoacoustic tomography of a rat cerebral cortex with a ring-based ultrasonic virtual point detector
    Xinmai Yang
    Washington University in Saint Louis, Department of Biomedical Engineering, Optical Imaging Laboratory, Saint Louis, Missouri 63130, USA
    J Biomed Opt 12:060507. 2007
    ..Furthermore, the virtual point detector can be scanned inside the brain to improve the local signal-to-noise ratio...
  47. ncbi request reprint Fiber-based polarization-sensitive Mueller matrix optical coherence tomography with continuous source polarization modulation
    Shuliang Jiao
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 44:5463-7. 2005
    ..The system was successfully tested by imaging both standard polarization elements and biological samples...
  48. pmc Curved array photoacoustic tomographic system for small animal imaging
    John Gamelin
    University of Connecticut, Department of Electrical Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 13:024007. 2008
    ..For the first time, according to our knowledge, resolution of sub-200-microm vessels with an overlying turbid medium of greater than 2 cm depth is demonstrated using only intrinsic biological contrast...
  49. ncbi request reprint Ultrasound-modulated optical tomography of biological tissue by use of contrast of laser speckles
    Jun Li
    Optical Imaging Laboratory, Texas A and M University, College Station 77843 3120, USA
    Appl Opt 41:6030-5. 2002
    ..The technique was experimentally compared with speckle-contrast-based, purely optical imaging and with parallel-detection imaging techniques, and the advantages over each were demonstrated...
  50. ncbi request reprint Time-domain reconstruction for thermoacoustic tomography in a spherical geometry
    Minghua Xu
    Department of Biomedical Engineering, Texas A and M University, College Station 77843 3120, USA
    IEEE Trans Med Imaging 21:814-22. 2002
    ..Experiments demonstrate that the reconstructed images agree well with the original samples. The spatial resolution of the system reaches 0.5 mm...
  51. ncbi request reprint Propagation of polarized light in birefringent turbid media: a Monte Carlo study
    Xueding Wang
    Texas A and M University, Optical Imaging Laboratory, Biomedical Engineering Program, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 7:279-90. 2002
    ....
  52. pmc Detection of ultrasound-modulated diffuse photons using spectral-hole burning
    Youzhi Li
    Biomedical Engineering Department, Washington University in St Louis, St Louis, MO 63130, USA
    Opt Express 16:14862-74. 2008
    ..It is also immune to speckle decorrelation, potentially allowing real-time in vivo imaging. Both theory and experiments are presented...
  53. pmc Negative lens concept for photoacoustic tomography
    Changhui Li
    Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 78:021901. 2008
    ..Phantom experiments demonstrate that use of this concept greatly increases the detection region for PAT with high sensitivity...
  54. ncbi request reprint In vivo imaging of subcutaneous structures using functional photoacoustic microscopy
    Hao F Zhang
    Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri 63130, USA
    Nat Protoc 2:797-804. 2007
    ..The data acquisition time, however, can be significantly reduced by using a laser system with a higher pulse repetition rate...
  55. ncbi request reprint Photoacoustic imaging of lacZ gene expression in vivo
    Li Li
    Washington University in St Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St Louis, Missouri 63130, USA
    J Biomed Opt 12:020504. 2007
    ..With the future development of new absorption-based reporter gene systems, it is anticipated that photoacoustic technology will provide a valuable tool for molecular imaging research...
  56. ncbi request reprint Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain
    Xueding Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Nat Biotechnol 21:803-6. 2003
    ..We also imaged hyperoxia- and hypoxia-induced cerebral hemodynamic changes. This neuroimaging modality holds promise for applications in neurophysiology, neuropathology and neurotherapy...
  57. ncbi request reprint Deeply penetrating photoacoustic tomography in biological tissues enhanced with an optical contrast agent
    Geng Ku
    Optical Imaging Laboratory, Department of Biomedical Engineering, 3120 TAMU, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 30:507-9. 2005
    ..The resolution was found to deteriorate slowly with increasing imaging depth. The effects of detection bandwidth on the quality of images acquired simultaneously by four different ultrasonic transducers are described...
  58. ncbi request reprint Thermoacoustic and photoacoustic tomography of thick biological tissues toward breast imaging
    Geng Ku
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843 3120, USA
    Technol Cancer Res Treat 4:559-66. 2005
    ..Based on the intrinsic optical contrast between blood and chicken breast muscle, an embedded blood object that was 5 cm deep in the tissue was also detected using PAT at a wavelength of 1064 nm...
  59. ncbi request reprint A mouse optical simulation environment (MOSE) to investigate bioluminescent phenomena in the living mouse with the Monte Carlo method
    Hui Li
    Medical Image Processing Group, Key Laboratory of Complex Systems and Intelligence Science, Institute of Automation, Chinese Academy of Science, Beijing, China
    Acad Radiol 11:1029-38. 2004
    ..This simulator is dedicated to small animal optical imaging based on bioluminescence...
  60. ncbi request reprint Correlation transfer and diffusion of ultrasound-modulated multiply scattered light
    Sava Sakadzic
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Phys Rev Lett 96:163902. 2006
    ..These equations should be applicable to a wide spectrum of conditions for ultrasound-modulated optical tomography of soft biological tissues...
  61. ncbi request reprint Reconstructions in limited-view thermoacoustic tomography
    Yuan Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Med Phys 31:724-33. 2004
    ..Computations are conducted for both numerically simulated and experimental data. The reconstructions confirm our theoretical predictions...
  62. ncbi request reprint Temperature distribution in selective laser-tissue interaction
    Jared J Crochet
    University of Central Oklahoma, Department of Physics and Engineering, Biomedical Engineering Program, Edmond, 73034, USA
    J Biomed Opt 11:34031. 2006
    ..It may also provide guidance for laser immunotherapy in cancer treatment, since the immunological responses are believed to be related to tissue temperature changes...
  63. ncbi request reprint Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent
    Xueding Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 29:730-2. 2004
    ..This new technology demonstrates the potential for dynamic and molecular biomedical imaging...
  64. ncbi request reprint Signal dependence and noise source in ultrasound-modulated optical tomography
    Gang Yao
    Department of Biological Engineering, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Appl Opt 43:1320-6. 2004
    ..We studied this effect by incorporating a Brownian motion factor in the simulation...
  65. ncbi request reprint Intense acoustic bursts as a signal-enhancement mechanism in ultrasound-modulated optical tomography
    Chulhong Kim
    Optical Imaging Laboratory, Department of Biomedical Engineering, 3120 TAMU, Texas A and M University, College Station, TX 77843 3120, USA
    Opt Lett 31:2423-5. 2006
    ..Because of the substantially improved SNR, the use of intense acoustic bursts is a promising signal enhancement strategy for UOT...
  66. ncbi request reprint Time reversal and its application to tomography with diffracting sources
    Yuan Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Phys Rev Lett 92:033902. 2004
    ..The algorithm is verified by a numerical simulation. Extension to the case using Green's function in a heterogeneous medium is discussed...
  67. ncbi request reprint Stochastic explanation of speckle contrast detection in ultrasound-modulated optical tomography
    Roger Zemp
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 73:061920. 2006
    ..The theory predicts that speckle contrast changes linearly with applied acoustic intensity. This prediction is experimentally validated for both 1 and ultrasound. Signal dependence on ultrasound frequency is discussed...
  68. ncbi request reprint Effects of acoustic heterogeneity in breast thermoacoustic tomography
    Yuan Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 50:1134-46. 2003
    ..An approach to implement the compensation using only TAT data is proposed. Lastly, the differences in the effects of acoustic heterogeneity and the generation of speckles in breast TAT and breast ultrasound imaging are discussed...
  69. ncbi request reprint Degree of polarization in laser speckles from turbid media: implications in tissue optics
    Jun Li
    Texas A and M University, Optical Imaging Laboratory, Biomedical Engineering Program, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 7:307-12. 2002
    ..A numerical simulation explained the experimental observation. These results are important for the understanding of polarization phenomena in turbid media such as biological tissue...
  70. ncbi request reprint Time-domain reconstruction algorithms and numerical simulations for thermoacoustic tomography in various geometries
    Minghua Xu
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
    IEEE Trans Biomed Eng 50:1086-99. 2003
    ..We refer to these reconstruction formulas as modified back projections. Numerical results are given to illustrate the validity of these algorithms...
  71. ncbi request reprint Boundary conditions in photoacoustic tomography and image reconstruction
    Lihong V Wang
    Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 12:014027. 2007
    ..Analogously to the method of images of sources, which is commonly used in forward problems, the ultrasonic detectors are imaged about the boundary to satisfy the boundary condition in the inverse problem...
  72. ncbi request reprint Ultrasound-modulated optical tomography with intense acoustic bursts
    Roger J Zemp
    Otical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, Texas 77843 3120, USA
    Appl Opt 46:1615-23. 2007
    ..Additionally, we maintain high-resolution images representative of optical and not mechanical contrast. Signal-to-noise levels are sufficiently high so as to enable acquisition of 2D images of phantoms with one acoustic burst per pixel...
  73. ncbi request reprint Looking and listening to light: the evolution of whole-body photonic imaging
    Vasilis Ntziachristos
    Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School CNY149, 13th Street 5406, Charlestown, Massachusetts 02129, USA
    Nat Biotechnol 23:313-20. 2005
    ..For photonic imaging to fully realize its potential, however, further progress will be needed in refining optical inversion methods and data acquisition techniques...