Hong Wang

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Biomimetic surface modification of poly (L-lactic acid) with gelatin and its effects on articular chondrocytes in vitro
    Yuan Lu Cui
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, People s Republic of China
    J Biomed Mater Res A 66:770-8. 2003
  2. ncbi request reprint Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth
    Xiao ming Liu
    Michael E DeBakey VA Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 18:768-70. 2004
  3. pmc PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:2311-6. 2004
  4. ncbi request reprint Human urotensin II modulates collagen synthesis and the expression of MMP-1 in human endothelial cells
    Hong Wang
    Renhe Hospital, Shanghai, China
    J Cardiovasc Pharmacol 44:577-81. 2004
  5. ncbi request reprint Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition
    Hong Wang
    Department of Medicine, Baylor College of Medicine, 2002 Holcombe Ave 109 129, Houston, TX 77030, USA
    Blood 99:939-45. 2002
  6. ncbi request reprint Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation
    Hong Wang
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Blood 101:3901-7. 2003
  7. ncbi request reprint Hyperhomocysteinemia inhibits post-injury reendothelialization in mice
    Hongmei Tan
    Department of Medicine, Baylor College of Medicine, USA
    Cardiovasc Res 69:253-62. 2006
  8. ncbi request reprint Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance
    Dan Liao
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 99:598-606. 2006
  9. ncbi request reprint Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation
    Xiaohua Jiang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 25:2515-21. 2005
  10. pmc Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
    Hong Wang
    The Geriatric Research, Education and Clinical Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Lipid Res 52:2159-68. 2011

Detail Information

Publications91

  1. ncbi request reprint Biomimetic surface modification of poly (L-lactic acid) with gelatin and its effects on articular chondrocytes in vitro
    Yuan Lu Cui
    Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, People s Republic of China
    J Biomed Mater Res A 66:770-8. 2003
    ..These results implied that gelatin used to modify the PLLA surface through entrapment and coupling could enhance chondrocyte adhesion, proliferation, and function...
  2. ncbi request reprint Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth
    Xiao ming Liu
    Michael E DeBakey VA Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    FASEB J 18:768-70. 2004
    ..The capacity of vascular mitogens to induce LAT1 expression may represent a basic mechanism by which tho acid transport * apoptosis..
  3. pmc PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells
    Ming Zhi Zhang
    Department of Medicine, Vanderbilt University, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 101:2311-6. 2004
    ..Reduced PKHD1 levels in pck rat kidneys and its colocalization with polycystins may underlie the pathogenic basis for cystogenesis in polycystic kidney diseases...
  4. ncbi request reprint Human urotensin II modulates collagen synthesis and the expression of MMP-1 in human endothelial cells
    Hong Wang
    Renhe Hospital, Shanghai, China
    J Cardiovasc Pharmacol 44:577-81. 2004
    ..This study was designed to study the role of hU-II in the expression of matrix metalloproteinase-1 (MMP-1) and collagen-1 in human umbilical vein endothelial cells (HUVECs) and underlying intracellular signaling mechanisms...
  5. ncbi request reprint Cyclin A transcriptional suppression is the major mechanism mediating homocysteine-induced endothelial cell growth inhibition
    Hong Wang
    Department of Medicine, Baylor College of Medicine, 2002 Holcombe Ave 109 129, Houston, TX 77030, USA
    Blood 99:939-45. 2002
    ..Taken together, these findings indicate that cyclin A is a critical functional target of Hcy-mediated EC growth inhibition...
  6. ncbi request reprint Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation
    Hong Wang
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Blood 101:3901-7. 2003
    ..These results suggest that isolated hyperhomocysteinemia is atherogenic and alters hepatic and macrophage lipoprotein metabolism, in part, by enhancing uptake of modified LDL...
  7. ncbi request reprint Hyperhomocysteinemia inhibits post-injury reendothelialization in mice
    Hongmei Tan
    Department of Medicine, Baylor College of Medicine, USA
    Cardiovasc Res 69:253-62. 2006
    ..In this study, we established a mouse model of endothelial injury and reendothelialization and examined the role and mechanism of HHcy in endothelial repair...
  8. ncbi request reprint Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance
    Dan Liao
    Department of Medicine, Baylor College of Medicine, Houston, TX, USA
    Circ Res 99:598-606. 2006
    ..These findings indicate that HHcy inhibits reverse cholesterol transport by reducing circulating HDL via inhibiting apoA-I protein synthesis and enhancing HDL-C clearance...
  9. ncbi request reprint Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation
    Xiaohua Jiang
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Arterioscler Thromb Vasc Biol 25:2515-21. 2005
    ..A risk factor for cardiovascular disease, hyperhomocystinemia (HHcy), is associated with endothelial dysfunction. In this study, we examined the mechanistic role of HHcy in endothelial dysfunction...
  10. pmc Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
    Hong Wang
    The Geriatric Research, Education and Clinical Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Lipid Res 52:2159-68. 2011
    ..These results suggest that Plin5 regulates oxidative LD hydrolysis and controls local FA flux to protect mitochondria against excessive exposure to FA during physiological stress...
  11. pmc Bcl-xL inhibits T-cell apoptosis induced by expression of SARS coronavirus E protein in the absence of growth factors
    Yu Yang
    Department of Medicine, Laboratory of Immunopathology, Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, U S A
    Biochem J 392:135-43. 2005
    ..These results demonstrate, for the first time, a novel molecular mechanism of T-cell apoptosis that contributes to the SARS-CoV-induced lymphopenia observed in most SARS patients...
  12. ncbi request reprint Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival
    Xiao ming Liu
    Houston Veterans Affairs Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:872-7. 2005
    ..The capacity of ER stress to stimulate the HO-1/CO system provides a novel mechanism by which this organelle regulates cell survival...
  13. ncbi request reprint An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity
    Yu Yang
    Department of Medicine, Laboratory of Immunopathology, Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA
    Oncogene 24:4778-88. 2005
    ..In conclusion, this study has demonstrated that an N-terminal region of a cytosolic protein, TCTP, is required for its binding to Bcl-xL and for its antiapoptotic activity...
  14. pmc Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism
    Florian W Kiefer
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Endocrinology 153:3089-99. 2012
    ..Taken together, this work establishes a role for retinoid metabolism in glucose homeostasis in vivo and for Aldh1a1 as a novel determinant of gluconeogenesis and lipid metabolism independent of adiposity...
  15. pmc Thyroid hormone receptor-α and vascular function
    Ayako Makino
    Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    Am J Physiol Cell Physiol 302:C1346-52. 2012
    ..These data suggest that TRα in SMCs has prominent effects on regulation of vascular tone and TH treatment helps decrease coronary vascular tone by increasing K(+) channel activity through TRα in SMCs...
  16. doi request reprint Effects of high-dose IFNalpha2b on regional lymph node metastases of human melanoma: modulation of STAT5, FOXP3, and IL-17
    Wenjun Wang
    Department of Medicine, Division of Hematology Oncology, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213 2584, USA
    Clin Cancer Res 14:8314-20. 2008
    ..The effects of IFNalpha on STAT signaling in relation to tumor tissue Treg and Th17 have not been documented in humans beyond the observations that IFNalpha2b down-regulates STAT3...
  17. pmc Regulation of mitochondrial morphology and function by O-GlcNAcylation in neonatal cardiac myocytes
    Ayako Makino
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1296-302. 2011
    ....
  18. pmc Excess protein O-GlcNAcylation and the progression of diabetic cardiomyopathy
    Eduardo S Fricovsky
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0618, USA
    Am J Physiol Regul Integr Comp Physiol 303:R689-99. 2012
    ..The nature and time course of changes observed in cardiac function suggest that protein O-GlcNAcylation plays a mechanistic role in the triggering of diabetic cardiomyopathy in DM2...
  19. pmc Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
    Zheng Sun
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:934-42. 2012
    ....
  20. ncbi request reprint Cyclic strain stimulates L-proline transport in vascular smooth muscle cells
    Sylvia V Reyna
    Michael E DeBakey VA Medical Center, Houston, Texas 77030, USA
    Am J Hypertens 17:712-7. 2004
    ..Because L-proline is essential for the synthesis of collagen and cell growth, we examined whether cyclic strain regulates the transcellular transport of L-proline by vascular SMC...
  21. ncbi request reprint Hyperhomocysteinemia and high-density lipoprotein metabolism in cardiovascular disease
    Dan Liao
    Department of Surgery, Baylor College of Medicine, Houston, TX, USA
    Clin Chem Lab Med 45:1652-9. 2007
    ..These studies suggest that Hcy-induced HDL-C and apoA-I inhibition represent a novel mechanism by which Hcy induces atherosclerotic CVD...
  22. ncbi request reprint Insulin signaling stimulates insulin transport by bovine aortic endothelial cells
    Hong Wang
    Department of Medicine, University of Virginia, Box 801410, Charlottesville, VA 22908, USA
    Diabetes 57:540-7. 2008
    ..Here, we addressed whether insulin signaling within the endothelial cell is required for the first step of transendothelial insulin transport: its uptake by the endothelial cell...
  23. pmc Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose
    Yong Hu
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:547-55. 2009
    ....
  24. ncbi request reprint Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth
    Kelly J Peyton
    Houston VA Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Blood 99:4443-8. 2002
    ..The capacity of vascular mitogens to induce CO synthesis may provide a novel mechanism by which these agents modulate cell growth...
  25. ncbi request reprint Single perivascular delivery of mitomycin C stimulates p21 expression and inhibits neointima formation in rat arteries
    Juan F Granada
    The Methodist Research Institute, Houston, Texas, USA
    Arterioscler Thromb Vasc Biol 25:2343-8. 2005
    ....
  26. ncbi request reprint ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes
    Haibing Peng
    Department of Medicine, Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Boston, Massachusetts, USA
    J Cell Physiol 215:562-73. 2008
    ..Intracellular ESE-1 staining in chondrocytes in cartilage from patients with osteoarthritis (OA), but not in normal cartilage, further suggests a fundamental role for ESE-1 in cartilage degeneration and suppression of repair...
  27. pmc Sorcin modulates mitochondrial Ca(2+) handling and reduces apoptosis in neonatal rat cardiac myocytes
    Jorge Suarez
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Am J Physiol Cell Physiol 304:C248-56. 2013
    ..In contrast, antisense sorcin induced caspase-3 activation. Thus, sorcin antiapoptotic properties may be due to modulation of mitochondrial Ca(2+) handling in cardiac myocytes...
  28. pmc Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes
    Thomas Gawlowski
    Department of Medicine, University of California, San Diego, La Jolla, CA 92039, USA
    J Biol Chem 287:30024-34. 2012
    ..In conclusion, this report shows, for the first time, that O-GlcNAcylation modulates DRP1 functionality in cardiac muscle cells...
  29. ncbi request reprint Physiologic cyclic stretch inhibits apoptosis in vascular endothelium
    Xiao ming Liu
    VA Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    FEBS Lett 541:52-6. 2003
    ..The ability of physiologic cyclic stretch to inhibit EC apoptosis may provide a previously unrecognized mechanism by which hemodynamic forces exert an anti-atherogenic effect...
  30. pmc Unique regulation of adipose triglyceride lipase (ATGL) by perilipin 5, a lipid droplet-associated protein
    Hong Wang
    Geriatric Research, Education, and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Biol Chem 286:15707-15. 2011
    ..Our studies establish perilipin 5 as a novel ATGL partner and provide evidence that the protein composition of perilipins at the LD surface regulates lipolytic activity of ATGL...
  31. pmc Oxidative tissue: perilipin 5 links storage with the furnace
    Hong Wang
    The Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, and Division of Endocrinology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    Trends Endocrinol Metab 22:197-203. 2011
    ..This review examines the results of studies on one of the newest members of the perilipin family, perilipin 5, which has emerged as a putative key player in LD function in oxidative tissues...
  32. pmc Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance
    Ming Bell
    Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Division of Gerontology, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland, USA
    Diabetes 57:2037-45. 2008
    ..Our hypothesis is that PAT proteins modulate LD metabolism and therefore insulin resistance...
  33. pmc Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature
    Eugene J Barrett
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Endocrinol Metab 301:E252-63. 2011
    ....
  34. pmc Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction
    Hong Wang
    Department of Medicine, School of Medicine, University of Maryland, Baltimore, MD, USA
    J Lipid Res 54:953-65. 2013
    ..Perilipin 5 regulates the formation and stabilization of cardiac LDs, and it promotes cardiac steatosis without major heart function impairment...
  35. pmc The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development
    Suman Verma
    Department of Medicine, University of California, Irvine, USA
    Dev Biol 369:249-60. 2012
    ..The pro-proliferative effects of Agr2 may explain its actions in early tumorigenesis...
  36. pmc Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy
    Ayako Makino
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0618, USA
    Endocrinology 150:2008-15. 2009
    ..These data suggest that TRbeta in the coronary ECs regulates capillary density during cardiac development, and down-regulation of TRbeta results in coronary microvascular rarefaction during pathological hypertrophy...
  37. pmc Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia
    Huaizhu Wu
    Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Circulation 119:2708-17. 2009
    ....
  38. pmc Inhibitory phosphorylation of GSK-3β by AKT, PKA, and PI3K contributes to high NaCl-induced activation of the transcription factor NFAT5 (TonEBP/OREBP)
    Xiaoming Zhou
    Department of Medicine, Uniformed Services University, 4301 Jones Bridge Rd, Bethesda, MD 20814, USA
    Am J Physiol Renal Physiol 304:F908-17. 2013
    ..When activated by high NaCl, PKA, PI3K, and AKT1, but not p38α, increase phosphorylation of GSK-3β-S9, which reduces the inhibitory effect of GSK-3β on NFAT5, and thus contributes to activation of NFAT5...
  39. ncbi request reprint Adenovirus-mediated heme oxygenase-1 gene expression stimulates apoptosis in vascular smooth muscle cells
    Xiao ming Liu
    Houston VA Medical Center and the Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Circulation 105:79-84. 2002
    ..Although HO-1 is induced in vascular smooth muscle cells (SMCs), the biological role of HO-1 in these cells has not been completely characterized...
  40. ncbi request reprint Reduced progression of endometrial hyperplasia with oral mTOR inhibition in the Pten heterozygote murine model
    Michael R Milam
    Department of Gynecologic Oncology, M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Obstet Gynecol 196:247.e1-5. 2007
    ..The objective of this study was to evaluate an oral mTOR inhibitor (mTOR-I) on the reduction of endometrial hyperplasia in an animal model...
  41. pmc Efficient processing of TFO-directed psoralen DNA interstrand crosslinks by the UvrABC nuclease
    Laura A Christensen
    Department of Carcinogenesis, Science Park Research Division, University of Texas MD Anderson Cancer Center, Smithville, TX, USA
    Nucleic Acids Res 36:7136-45. 2008
    ..As mutagenesis by TFO-directed ICLs requires nucleotide excision repair, the efficient processing of these lesions supports the use of triplex technology to direct DNA damage for genome modification...
  42. doi request reprint STAT3 as a biomarker of progression in atypical nevi of patients with melanoma: dose-response effects of systemic IFNalpha therapy
    Wenjun Wang
    Division of Hematology Oncology, Department of Medicine, University of Pittsburgh, Melanoma and Skin Cancer Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 2584, USA
    J Invest Dermatol 128:1997-2002. 2008
    ..pSTAT3 is a potential biomarker of melanocytic transformation and progression and is modulated by IFNalpha dose-dependently. STAT3 is a potential target for chemoprevention of melanoma...
  43. ncbi request reprint ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation
    Courtney Brown
    Beth Israel Deaconess Medical Center, Department of Medicine, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, 4 Blackfan Circle, Boston, MA 02115, USA
    J Biol Chem 279:12794-803. 2004
    ..Our results support a novel paradigm for the ETS factor ESE-1 as a transcriptional mediator of angiogenesis in the setting of inflammation...
  44. doi request reprint Lipoprotein lipase in the brain and nervous system
    Hong Wang
    Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, School of Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045, USA
    Annu Rev Nutr 32:147-60. 2012
    ..Overall, the time is ripe for new insights into how LPL-mediated lipoprotein metabolism in the brain impacts CNS processes and systems biology...
  45. ncbi request reprint Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes
    Bernard Ng
    Biology of Inflammation Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Allergy Clin Immunol 114:1463-70. 2004
    ..Alternative splicing is important for increasing the complexity of the human proteome from a limited genome. Previous studies have shown that for some autoantigens, there is differential immunogenicity among alternatively spliced isoforms...
  46. ncbi request reprint Hyperhomocysteinemia, DNA methylation and vascular disease
    Md S Jamaluddin
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Clin Chem Lab Med 45:1660-6. 2007
    ..We hypothesize that DNA hypomethylation is a key biochemical mechanism responsible for Hcy-induced cyclin A suppression and growth inhibition in EC and contributes to CVD...
  47. ncbi request reprint Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia
    Victor Vitvitsky
    Biochemistry Dept, Univ of Nebraska, Lincoln, NE 68588 0664, USA
    Am J Physiol Regul Integr Comp Physiol 287:R39-46. 2004
    ....
  48. ncbi request reprint Temporal progression of gene expression responses to salt shock in maize roots
    Hong Wang
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Plant Mol Biol 52:873-91. 2003
    ..Within this framework, 16 signaling molecules, including six protein kinases, two protein phosphatases and eight transcription factors, were regulated with distinct expression patterns by high salinity...
  49. ncbi request reprint Distribution of variant genotypes of Fc gamma receptor IIIa in healthy Chinese population of Zhengzhou City
    Jun Wang
    Department of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 23:239-41. 2003
    ..3%, 48.9% and 8.8% respectively. The distribution of Fc gamma R IIIa-158 in healthy Chinese population of Zhengzhou city was polymorphic and different from that of African Americans (AA) and Caucasian Americans (CA)...
  50. ncbi request reprint Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates
    John M Sanders
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Med Chem 47:375-84. 2004
    ....
  51. doi request reprint Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair
    Mark P Marriott
    Howard Florey Institute, The University of Melbourne, Victoria, Australia
    Glia 56:686-98. 2008
    ..Thus endogenous LIF receptor signaling is not only protective of oligodendrocytes but can also enhance remyelination, and exogenous LIF has therapeutic potential in limiting the consequences of oligodendrocyte damage...
  52. ncbi request reprint Thrombin signaling in the brain: the role of protease-activated receptors
    Hong Wang
    Institut fur Neurobiochemie, Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Biol Chem 384:193-202. 2003
    ....
  53. ncbi request reprint [Neuronal differentiation and TrkA expression of neuroblastoma induced by the combination treatment of interferon-gamma and NGF]
    Hong Wang
    Department of Pediatrics, The Second Affiliated Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Er Ke Za Zhi 42:180-3. 2004
    ..A small percentage of NB has been found to undergo spontaneous or chemotherapeutically induced regression or differentiation into benign ganglioneuromas. The differentiation therapy is a respective method in the clinical treatment of NB...
  54. ncbi request reprint Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas
    Charles T Miller
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Oncogene 22:7950-7. 2003
    ..05). This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers...
  55. ncbi request reprint Neurokinin-1 receptor-expressing cells regulate depressor region of rat ventrolateral medulla
    Hong Wang
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Heart Circ Physiol 285:H2757-69. 2003
    ....
  56. pmc The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins
    Chuan Ju Liu
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8024, USA
    Mol Cell Biol 22:2893-905. 2002
    ....
  57. ncbi request reprint Control of petal and pollen development by the plant cyclin-dependent kinase inhibitor ICK1 in transgenic Brassica plants
    Yongming Zhou
    Saskatoon Reseach Centre, 107 Science Place, Saskatoon, SK S7N 0X2, Canada
    Planta 215:248-57. 2002
    ..In those plants, the ability of pollen to germinate and pollen nuclear number were affected. These results are discussed in relation to the cell cycle and plant development...
  58. ncbi request reprint Globin attenuates the innate immune response to endotoxin
    Huan Yang
    Laboratory of Biomedical Science, North Shore University Hospital New York University School of Medicine, New York 11030, USA
    Shock 17:485-90. 2002
    ..Thus, the heme-iron moiety of hemoglobin, and not the binding of LPS to globin, enhanced macrophage responses to LPS...
  59. ncbi request reprint Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
    Hong Wang
    Otto von Guericke Universitat Magdeburg, Medizinische Fakultat, Institut fur Neurobiochemie, 39120 Magdeburg, Germany
    Am J Physiol Cell Physiol 283:C1351-64. 2002
    ..EGF receptor activation was detected by the receptor autophosphorylation site, tyrosine 1068. Our data suggest that thrombin-induced mitogenic action in astrocytes occurs independently of EGF receptor transphosphorylation...
  60. ncbi request reprint The role of the Ca2+-sensitive tyrosine kinase Pyk2 and Src in thrombin signalling in rat astrocytes
    Hong Wang
    Medizinische Fakultät der Otto von Guericke Universität Magdeburg, Institut fur Neurobiochemie, Magdeburg, Germany
    J Neurochem 84:1349-57. 2003
    ..From these data we conclude that PAR-1 uses Ca2+- and PKC-dependent Pyk2 to activate Src, thereby leading to ERK1/2 activation, which predominantly recruits Grb2 in rat astrocytes...
  61. ncbi request reprint Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas
    Guoan Chen
    Department of Surgery, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Mol Cell Proteomics 2:107-16. 2003
    ....
  62. ncbi request reprint IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Beatriz Rendon-Mitchell
    Center of Immunology and Inflammation, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol 170:3890-7. 2003
    ..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism...
  63. pmc Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
    ..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics...
  64. ncbi request reprint The effects of different donor cells and passages on development of reconstructed embryos
    Lei Lei
    State Key Laboratory of Reproductive Biology, Institute of Zoology, The Chinese Academy of Sciences, Beijing 100080, China
    Yi Chuan Xue Bao 30:215-20. 2003
    ..We could conclude that culture and passage of donor cells might be benefit to nucleus reprogramming...
  65. pmc Transient neonatal estrogen exposure to estrogen-deficient mice (aromatase knockout) reduces prostate weight and induces inflammation in late life
    Joseph John Bianco
    Monash Institute of Reproduction and Development, Monash University, Clayton, Victoria 3168, Australia
    Am J Pathol 168:1869-78. 2006
    ..Finally, this study establishes the ArKO mouse model of estrogen deficiency as a unique approach to study the effects of estrogens, estrogenic factors, and endocrine disruptors on prostate development...
  66. doi request reprint Iptakalim inhibited endothelin-1-induced proliferation of human pulmonary arterial smooth muscle cells through the activation of K(ATP) channel
    Yuming Zhu
    Department of Respiratory Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Vascul Pharmacol 48:92-9. 2008
    ..This study provides further evidence that iptakalim may serve as another candidate drug to treat pulmonary hypertension...
  67. doi request reprint Angiotensin II induces matrix metalloproteinase-9 expression via a nuclear factor-kappaB-dependent pathway in vascular smooth muscle cells
    Rui wei Guo
    Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Yunnan, 650032, China
    Regul Pept 147:37-44. 2008
    ..In summary, this study demonstrates that AngII stimulates NF-kappaB nuclear translocation in VSMC via AT1 and AT2. AngII increases the expression of MMP-9 in VSMC, and AT1 and NF-kappaB pathways have an important role in this response...
  68. pmc Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1
    Chih Ching Lin
    Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    Arterioscler Thromb Vasc Biol 28:739-45. 2008
    ..In this study, we evaluated whether there is an interaction between FIR radiation and HO-1 in regulating vascular inflammation...
  69. ncbi request reprint [Serotonin transporter gene polymorphisms in irritable bowel syndrome and their impact on tegaserod treatment]
    Yu Yuan Li
    Department of Gastroenterology, First People s Hospital of Guangzhou, 510180, China
    Zhonghua Nei Ke Za Zhi 45:552-5. 2006
    ....
  70. ncbi request reprint Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice
    Hong Wang
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 4975, USA
    J Neurosci 26:10911-5. 2006
    ..These findings are the first examples of abnormal neuropeptide and catecholamine secretion in a mouse model of RTT...
  71. ncbi request reprint [Effects of iptakalim on the proliferation of cultured rabbit pulmonary arterial smooth muscle cells induced by endothelin-1]
    Wei Ping Xie
    Department of Respiratory Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
    Zhonghua Jie He He Hu Xi Za Zhi 27:752-5. 2004
    ..To explore the effects of iptakalim on the proliferation of rabbit pulmonary arterial smooth muscle cell(PASMC) induced by endothelin-1(ET-1) in vitro...
  72. ncbi request reprint Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens
    Fan Yang
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Medical Research Building, Suite 300, Philadelphia, PA 19140, USA
    Clin Immunol 121:121-33. 2006
    ....
  73. pmc Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
    Yun Wu Zhang
    Center for Neuroscience and Aging, The Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 280:17020-6. 2005
    ....
  74. ncbi request reprint Phenylketonuria mutations in Northern China
    Fang Song
    Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, PR China
    Mol Genet Metab 86:S107-18. 2005
    ..The study enables us to construct a national database in China serving as a valuable tool for genetic counseling and prognostic evaluation of future cases of PKU...
  75. ncbi request reprint Anti-proliferating effect of iptakalim, a novel KATP channel opener, in cultured rabbit pulmonary arterial smooth muscle cells
    Weiping Xie
    Department of Pharmacology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China
    Eur J Pharmacol 511:81-7. 2005
    ..These findings suggest that iptakalim might be a promising candidate for the treatment of pulmonary arterial remodeling in pulmonary hypertension...
  76. ncbi request reprint Tanshinone: an inhibitor of proliferation of vascular smooth muscle cells
    Hong Wang
    Research Center of Traditional Chinese Medicine, Tianjin College of Traditional Chinese Medicine, Tianjin 300193, PR China
    J Ethnopharmacol 99:93-8. 2005
    ..The data suggest that the anti-proliferative effect of Tan on VSMCs proliferation was associated with ERK1/2 signaling pathway...
  77. ncbi request reprint The relaxin gene knockout mouse: a model of progressive scleroderma
    Chrishan S Samuel
    Relaxin Group, Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria, Australia
    J Invest Dermatol 125:692-9. 2005
    ....
  78. ncbi request reprint Mesangial cell-reduced Ca2+ signaling in high glucose is due to inactivation of phospholipase C-beta3 by protein kinase C
    Helena Frecker
    Institute of Medical Science, University Health Network, University of Toronto, ON, Canada M5S 1A8
    Am J Physiol Renal Physiol 289:F1078-87. 2005
    ..We conclude that reduced Ca(2+) signaling in HG cannot be explained by reduced Ca(2+) stores but is due to conventional PKC-dependent phosphorylation and inactivation of PLC-beta(3)...
  79. ncbi request reprint Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    In Vivo 20:573-82. 2006
    ..The data show that the reduced in vitro and in vivo migratory capacity of Smad3-/- bone marrow stromal cells correlates with decreased radiation pulmonary fibrosis observed in mice chimeric for Smad3-/- marrow...
  80. ncbi request reprint [Detection of the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase gene by PCR-RFLP analysis in Chinese patients]
    Yu jin Qu
    Department of Medical Genetics, Capital Institute of Pediatrics, Beijing, 100020, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:680-2. 2006
    ..To establish a single and rapid method for detecting the prevalent mutations of 6-pyruvoyl-tetrahydropterin synthase (PTPS) gene in Chinese patients with 6-pyruvoyl-tetrahydropterin synthase deficiency (PTPSD)...
  81. ncbi request reprint Effect of continuous positive airway pressure treatment on vascular endothelial function in patients with obstructive sleep apnea hypopnea syndrome and coronary artery disease
    Xi long Zhang
    Department of Respiratory Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
    Chin Med J (Engl) 117:844-7. 2004
    ..This research was carried out to investigate the effects of CPAP treatment on vascular endothelial function in patients with OSAHS and CHD...
  82. ncbi request reprint Genetic polymorphisms analysis of glutathione S-transferase M1 and T1 in children with acute lymphoblastic leukemia
    Jun Wang
    Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 24:243-4. 2004
    ..19% versus 49.32%, OR=1.621, P>0.05). It was suggested that GSTM1 null genotype might be a risk genotype of childhood ALL, while there as no correlation between GSTT1 null genotype and childhood ALL...
  83. ncbi request reprint Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome
    Michael Ogier
    Department of Neurosciences, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 27:10912-7. 2007
    ..These data demonstrate that BDNF expression remains plastic in Mecp2 null mice and raise the possibility that ampakine compounds could be of therapeutic value in the treatment of RTT...
  84. pmc Resistin, an adipocytokine, offers protection against acute myocardial infarction
    Jinping Gao
    Cecile Cox Quillen Laboratory of Geriatrics, James H Quillen College of Medicine East Tennessee State University, and James H Quillen Veterans Affairs Medical Center, Johnson City, TN 37614, USA
    J Mol Cell Cardiol 43:601-9. 2007
    ..There were significantly fewer in situ oligo ligation-positive myocyte nuclei in mice treated with resistin. Our results show that resistin can dramatically reduce apoptosis and infarct size, thus protecting the heart against I/R injury...
  85. ncbi request reprint Differential regulation of homocysteine transport in vascular endothelial and smooth muscle cells
    Xiaohua Jiang
    Temple University School of Medicine, Department of Pharmacology, 3420 North Broad Street, Philadelphia, PA 19140, USA
    Arterioscler Thromb Vasc Biol 27:1976-83. 2007
    ..This study characterized and directly compared Hcy transport in cultured human aortic ECs (HAECs) and smooth muscle cells (HASMCs)...
  86. pmc Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin A gene
    M D S Jamaluddin
    Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood 110:3648-55. 2007
    ..In conclusion, Hcy inhibits cyclin A transcription and cell growth by inhibiting DNA methylation through suppression of DNMT1 in ECs...
  87. pmc PRDM6 is enriched in vascular precursors during development and inhibits endothelial cell proliferation, survival, and differentiation
    Yaxu Wu
    Carolina Cardiovascular Biology Center, University of North Carolina, Chapel Hill, NC 27599 7126, USA
    J Mol Cell Cardiol 44:47-58. 2008
    ....
  88. pmc Nitric oxide stimulates heme oxygenase-1 gene transcription via the Nrf2/ARE complex to promote vascular smooth muscle cell survival
    Xiao ming Liu
    Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA
    Cardiovasc Res 75:381-9. 2007
    ..In the present study, we determined the signaling pathway responsible for the induction of HO-1 and its biological significance...
  89. ncbi request reprint Downregulation of connexin 43 in nasopharyngeal carcinoma cells is related to promoter methylation
    Zong Chun Yi
    Department of Biological Engineering, Beijing University of Aeronautics and Astronautics, 37 Xueyuan Road, Beijing 100083, PR China
    Oral Oncol 43:898-904. 2007
    ..These results indicate the promoter methylation as an important role in inactivation of Cx43 in CNE-1 cells...
  90. ncbi request reprint [Association of paraoxonase polymorphisms and serum homocysteine thiolactone complex with coronary heart disease]
    Qin Qin
    Tianjin Cardiovascular Institute, Tianjin Chest Hospital, Tianjin 300051, China
    Zhonghua Xin Xue Guan Bing Za Zhi 34:803-7. 2006
    ..To investigate the relationship between paraoxonase (PON) polymorphisms and serum homocysteine thiolactone (HTL) and coronary heart diseases...
  91. ncbi request reprint Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells
    Guolian Li
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Virginia Health System, P O Box 801410, Charlottesville, Virginia 22908 1410, USA
    Endocrinology 146:4690-6. 2005
    ....