Fen Wang


Affiliation: Texas A and M Health Science Center
Country: USA


  1. Liu J, Chen G, Liu Z, Liu S, Cai Z, You P, et al. Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer. Cancer Res. 2018;78:4459-4470 pubmed publisher
    ..b>Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/16/4459/F1.large.jpg Cancer Res; 78(16); 4459-70. ©2018 AACR. ..
  2. Wang C, Ke Y, Liu S, Pan S, Liu Z, Zhang H, et al. Ectopic fibroblast growth factor receptor 1 promotes inflammation by promoting nuclear factor-?B signaling in prostate cancer cells. J Biol Chem. 2018;293:14839-14849 pubmed publisher
    ..As inflammation plays an important role in PCa initiation and progression, these findings suggest that ectopically expressed FGFR1 promotes PCa progression, at least in part, by increasing inflammation in the tumor microenvironment. ..
  3. Huang Y, Hamana T, Liu J, Wang C, An L, You P, et al. Prostate Sphere-forming Stem Cells Are Derived from the P63-expressing Basal Compartment. J Biol Chem. 2015;290:17745-52 pubmed publisher
    ..Understanding the contribution of the two types of P-SCs to prostate development and prostate cancer stem cells and how to manipulate them may open new avenues for control of prostate cancer progression and relapse. ..
  4. Li X, Wang C, Xiao J, McKeehan W, Wang F. Fibroblast growth factors, old kids on the new block. Semin Cell Dev Biol. 2016;53:155-67 pubmed publisher
  5. Yang C, Lu W, Lin T, You P, Ye M, Huang Y, et al. Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress. BMC Gastroenterol. 2013;13:67 pubmed publisher
    ..This study therefore provides a rationale for clinical biomarker studies in humans. ..
  6. Zhang Y, McKeehan K, Lin Y, Zhang J, Wang F. Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2alpha (FRS2alpha) but not FRS2 to the receptor. Mol Endocrinol. 2008;22:167-75 pubmed
    ..The results, for the first time, demonstrate the specific signals mediated by the Grb2-binding sites and further our understanding of FGF signal transmission at the adaptor level. ..
  7. Ho T, Liu X, Huang Y, Warneke C, Johnson M, Hoang A, et al. The impact of FGFR1 and FRS2? expression on sorafenib treatment in metastatic renal cell carcinoma. BMC Cancer. 2015;15:304 pubmed publisher
    ..The results suggest that FGF pathway activation may impact intrinsic resistance to VEGF receptor inhibition. ..
  8. Huang Y, Hamana T, Liu J, Wang C, An L, You P, et al. Type 2 Fibroblast Growth Factor Receptor Signaling Preserves Stemness and Prevents Differentiation of Prostate Stem Cells from the Basal Compartment. J Biol Chem. 2015;290:17753-61 pubmed publisher
    ..In addition, ablation of Fgfr2 in P63(+) cells causes defective postnatal development of the prostate. Therefore, the data indicate that FGFR2 signaling is critical for preserving stemness and preventing differentiation of P-bSCs. ..