Charles E Wade

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Do-not-resuscitate orders in trauma patients may bias mortality-based effect estimates: an evaluation using the PROMMTT study
    Charles E Wade
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S89-96. 2013
  2. pmc Signals from fat after injury: plasma adipokines and ghrelin concentrations in the severely burned
    Charles E Wade
    University of Texas Health Science Center at Houston, 6431 Fannin St, MSB 5 204, Houston, TX 77030, USA
    Cytokine 61:78-83. 2013
  3. doi request reprint Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion
    Charles E Wade
    Department of Surgery, and The Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma 71:S389-93. 2011
  4. doi request reprint Use of recombinant factor VIIa in US military casualties for a five-year period
    Charles E Wade
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:353-9. 2010
  5. ncbi request reprint Prior exercise alters responses to hemorrhage
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, Houston, TX 77030, USA
    Shock 34:68-74. 2010
  6. pmc Admission hypo- or hyperthermia and survival after trauma in civilian and military environments
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Int J Emerg Med 4:35. 2011
  7. doi request reprint The impact of missing trauma data on predicting massive transfusion
    Amber W Trickey
    Department of Surgery, Inova Fairfax Hospital, Falls Church, Virginia, USA
    J Trauma Acute Care Surg 75:S68-74. 2013
  8. pmc A latent class model for defining severe hemorrhage: experience from the PROMMTT study
    Mohammad H Rahbar
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S82-8. 2013
  9. pmc Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia
    Bryce R H Robinson
    Division of Trauma Critical Care, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Trauma Acute Care Surg 75:S61-7. 2013
  10. pmc Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study
    Deborah J Del Junco
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S24-30. 2013

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. pmc Do-not-resuscitate orders in trauma patients may bias mortality-based effect estimates: an evaluation using the PROMMTT study
    Charles E Wade
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S89-96. 2013
    ..We determined the frequency, timing, and impact on mortality-based effect estimates for patients with DNR orders in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study...
  2. pmc Signals from fat after injury: plasma adipokines and ghrelin concentrations in the severely burned
    Charles E Wade
    University of Texas Health Science Center at Houston, 6431 Fannin St, MSB 5 204, Houston, TX 77030, USA
    Cytokine 61:78-83. 2013
    ..Adipokines are likely to play a role in these changes but have not been identified to date in burn patients...
  3. doi request reprint Variations between level I trauma centers in 24-hour mortality in severely injured patients requiring a massive transfusion
    Charles E Wade
    Department of Surgery, and The Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma 71:S389-93. 2011
    ..We hypothesized differences among centers in 24-hour mortality could predominantly be accounted for by differences in transfusion practices as well as patient characteristics...
  4. doi request reprint Use of recombinant factor VIIa in US military casualties for a five-year period
    Charles E Wade
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:353-9. 2010
    ..This study was undertaken to assess how deployed physicians are using rFVIIa and its impact on casualty outcomes...
  5. ncbi request reprint Prior exercise alters responses to hemorrhage
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, Houston, TX 77030, USA
    Shock 34:68-74. 2010
    ..Prior exercise alters responses to hemorrhage that mask the extent of hypovolemia and should be considered in the initial evaluation of a patient with hemorrhage caused by traumatic injuries...
  6. pmc Admission hypo- or hyperthermia and survival after trauma in civilian and military environments
    Charles E Wade
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Int J Emerg Med 4:35. 2011
    ..abstract:..
  7. doi request reprint The impact of missing trauma data on predicting massive transfusion
    Amber W Trickey
    Department of Surgery, Inova Fairfax Hospital, Falls Church, Virginia, USA
    J Trauma Acute Care Surg 75:S68-74. 2013
    ..Three blood transfusion prediction models were evaluated using an observational trauma data set with valid missing data...
  8. pmc A latent class model for defining severe hemorrhage: experience from the PROMMTT study
    Mohammad H Rahbar
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S82-8. 2013
    ..We show how a latent class model could improve the accuracy of identifying the SH patients...
  9. pmc Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia
    Bryce R H Robinson
    Division of Trauma Critical Care, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Trauma Acute Care Surg 75:S61-7. 2013
    ..Acute lung injury following trauma resuscitation remains a concern despite recent advances. With the use of the PROMMTT study population, the risk of hypoxemia and potential modifiable risk factors are studied...
  10. pmc Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study
    Deborah J Del Junco
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S24-30. 2013
    ..To differentiate the association of in-hospital mortality with early plasma or platelet transfusion from that with delayed but gradually balanced ratios, we developed a separate analytic approach...
  11. doi request reprint Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy
    Quinton M Hatch
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:1503-11. 2011
    ....
  12. doi request reprint Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 73:365-70; discussion 370. 2012
    ..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
  13. doi request reprint Heart-rate complexity for prediction of prehospital lifesaving interventions in trauma patients
    Leopoldo C Cancio
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 65:813-9. 2008
    ..To improve our ability to forecast the need for prehospital lifesaving interventions (LSIs), we applied heart-rate complexity (HRC) analysis to the electrocardiogram (ECG) of patients en route to trauma centers...
  14. doi request reprint The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    Philip C Spinella
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:286-93; discussion 293-4. 2008
    ....
  15. pmc Clinical and mechanistic drivers of acute traumatic coagulopathy
    Mitchell Jay Cohen
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 75:S40-7. 2013
    ..The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study provided a unique opportunity to characterize coagulation and the effects of resuscitation on ATC after severe trauma...
  16. doi request reprint Cryoprecipitate use in the PROMMTT study
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S31-9. 2013
    ..Our objectives were to identify patterns and predictors of cryoprecipitate use and determine whether transfusing cryoprecipitate was associated with improved survival...
  17. pmc Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study
    Elaheh Rahbar
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S16-23. 2013
    ....
  18. doi request reprint Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Surg 256:476-86. 2012
    ..We have previously shown that admission r-TEG results are available faster than CCTs and predict pulmonary embolism. We hypothesized that r-TEGs more reliably predict blood component transfusion than CCTs...
  19. doi request reprint Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 72:1470-5; discussion 1475-7. 2012
    ..The purpose of this study was to identify whether admission rapid-thrombelastography (r-TEG) could identify patients at risk of developing pulmonary embolism (PE) during their hospital stay...
  20. doi request reprint Fasciotomy rates in operations enduring freedom and iraqi freedom: association with injury severity and tourniquet use
    John F Kragh
    US Army Institute of Surgical Research USAISR, Fort Sam Houston, TX, USA
    J Orthop Trauma 25:134-9. 2011
    ..To compare fasciotomy rates and Injury Severity Scores (ISSs) before and after tourniquets were fielded for combat casualties in March 2005...
  21. doi request reprint Survey of trauma registry data on tourniquet use in pediatric war casualties
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    Pediatr Emerg Care 28:1361-5. 2012
    ....
  22. pmc The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, 6410 Fannin, Ste 1100, Houston, TX 77030, USA
    JAMA Surg 148:127-36. 2013
    ..To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios...
  23. doi request reprint Novel predictors of sepsis outperform the American Burn Association sepsis criteria in the burn intensive care unit patient
    Elizabeth A Mann-Salinas
    School of Nursing, University of Texas Health Science Center, Houston, Texas, USA
    J Burn Care Res 34:31-43. 2013
    ..Usefulness of the ABA criteria to predict sepsis is limited to the day before blood culture is obtained. A significant contribution of this research is the identification of six novel sepsis predictors for the burn patient...
  24. doi request reprint Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro
    Daniel N Darlington
    Damage Control Resuscitation and Blood Programs, US Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
    J Trauma 71:1152-63. 2011
    ..This study evaluates the effect of hemodilution by various common resuscitation fluids, and the efficacy of activated recombinant factor VII (rFVIIa) on coagulation parameters in human blood in vitro...
  25. doi request reprint A predictive model for massive transfusion in combat casualty patients
    Daniel F McLaughlin
    United States Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S57-63; discussion S63. 2008
    ..We postulated that evaluation of clinical variables routinely assessed upon admission would allow identification of these patients for earlier, more effective intervention...
  26. pmc Waiver of consent in noninterventional, observational emergency research: the PROMMTT experience
    Erin E Fox
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Trauma Acute Care Surg 75:S3-8. 2013
    ..The goal of this article was to examine the rationale and tradeoffs of using waiver of consent in PROMMTT...
  27. doi request reprint New hemostatic agents in the combat setting
    E Darrin Cox
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    Transfusion 49:248S-55S. 2009
    ..This article reports recent clinical observations regarding the efficacy and evolution of use of two new hemostatic bandages employed in the global war on terrorism...
  28. doi request reprint Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma
    Nena Matijevic
    Center for Translational Injury Research, Department of Surgery, University of Texas Health Science Center at Houston, Texas 77030, USA
    J Trauma Acute Care Surg 74:84-90; discussion 90-1. 2013
    ..We characterized changes in LQP hemostatic potential during 26 days of cold storage...
  29. doi request reprint Survival with emergency tourniquet use to stop bleeding in major limb trauma
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Ann Surg 249:1-7. 2009
    ..The purpose of this study was to determine if emergency tourniquet use saved lives...
  30. doi request reprint A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury
    Angel V Delgado
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:75-80. 2008
    ..This study evaluated the efficacy of a biologic hemostatic fibrin patch (FP) to control coagulopathic bleeding and prevent death in a porcine model of severe liver injury with hemodilution and hypothermia...
  31. pmc An emergency department thawed plasma protocol for severely injured patients
    Zayde A Radwan
    Center for Translational Injury Research, The University of Texas Health Science Center, 6410 Fannin St, 1100 20 UPB, Houston, TX 77030, USA
    JAMA Surg 148:170-5. 2013
    ....
  32. doi request reprint Differential expression of the immunoinflammatory response in trauma patients: burn vs. non-burn
    James E Mace
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Burns 38:599-606. 2012
    ..Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically...
  33. pmc Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage
    Phillip A Letourneau
    Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 71:1115-9. 2011
    ..We hypothesized that FFP5 would increase bleeding and mortality compared with FFP0 in a rodent bioassay model of uncontrolled liver hemorrhage...
  34. doi request reprint Predictors of early acute lung injury at a combat support hospital: a prospective observational study
    Jason W Edens
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S81-6. 2010
    ..The purpose of this study was to determine whether this strategy is associated with an increased incidence of ALI...
  35. doi request reprint Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit
    Ruben Gomez
    Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 208:348-54. 2009
    ..Approximately 5% of combat-related injuries include burns. Previous studies have shown similar mortality rates between military and civilian burn casualties; but causes of death were not detailed...
  36. ncbi request reprint The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  37. doi request reprint Glucose variability is associated with high mortality after severe burn
    Heather F Pidcoke
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas 78234 6315, USA
    J Trauma 67:990-5. 2009
    ..High glucose variability creates challenges to glycemic control and may be a marker of poor outcome. We wondered whether glycemic variability alone might identify patients at higher risk of death...
  38. ncbi request reprint Hypotension begins at 110 mm Hg: redefining "hypotension" with data
    Brian J Eastridge
    U S Army Institute for Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 63:291-7; discussion 297-9. 2007
    ..However, few data exist to support the rigid adherence to this arbitrary cutoff. We hypothesized that the physiologic hypoperfusion and mortality outcomes classically associated with hypotension were manifest at higher SBPs...
  39. ncbi request reprint The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers
    Elizabeth A Mann
    United States Army Institute of Surgical Research, Brooke Army Medical Center, San Antonio, TX, USA
    J Burn Care Res 29:718-23. 2008
    ..The combination of a higher prevalence of hypoglycemia in the presence of near universal anemia is concerning, particularly given the pervasiveness of glucometer use among burn centers...
  40. pmc Prehospital intravenous fluid is associated with increased survival in trauma patients
    David A Hampton
    Division of Trauma, Critical Care and Acute Care Surgery, Department of Surgery, School of Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Trauma Acute Care Surg 75:S9-15. 2013
    ..We hypothesized that receiving any prehospital IVF is associated with increased survival in trauma patients compared with receiving no prehospital IVF...
  41. doi request reprint Compartment syndrome performance improvement project is associated with increased combat casualty survival
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, Houston, Texas 78234 6315, USA
    J Trauma Acute Care Surg 74:259-63. 2013
    ..The program included educational alerts, classroom training, video instruction, and a research publication. We compared casualty data before and after the program implementation to determine whether the education altered outcomes...
  42. ncbi request reprint Computerized decision support system improves fluid resuscitation following severe burns: an original study
    Jose Salinas
    U S Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 39:2031-8. 2011
    ..The goal of this study was to analyze the efficacy of a computerized open-loop decision support system for burn resuscitation compared to historical controls...
  43. doi request reprint Burn hazards of the deployed environment in wartime: epidemiology of noncombat burns from ongoing United States military operations
    David S Kauvar
    United States Army Institute of Surgical Research, Clinical Division, Clinical Division, 3400 Rawley E Chambers Bldg 3611, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 209:453-60. 2009
    ..Examining these risks can assist in the development of military burn prevention measures. This study endeavored to examine noncombat burn epidemiology in the context of similar civilian data...
  44. doi request reprint Incidence of systemic fungal infection and related mortality following severe burns
    Clinton K Murray
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 34:1108-12. 2008
    ....
  45. doi request reprint Anemia causes hypoglycemia in intensive care unit patients due to error in single-channel glucometers: methods of reducing patient risk
    Heather F Pidcoke
    United States Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 38:471-6. 2010
    ..We hypothesized that point-of-care glucometer error due to anemia is prevalent, can be corrected mathematically, and correction uncovers occult hypoglycemia during intensive insulin therapy...
  46. doi request reprint Association of hemodilution and blood pressure in uncontrolled bleeding
    Nicholas S Pawelczyk
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas
    J Surg Res 184:959-65. 2013
    ..We investigated interactions of isovolumic hemodilution on hemodynamics, coagulation, and blood loss after injury...
  47. doi request reprint Influence of resuscitation fluids, fresh frozen plasma and antifibrinolytics on fibrinolysis in a thrombelastography-based, in-vitro, whole-blood model
    Vadim Kostousov
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Blood Coagul Fibrinolysis 24:489-97. 2013
    ..Low concentrations of TXA or ACA reversed hyperfibrinolysis, but the efficient concentrations were dependent on the degree of fibrinolysis and whole-blood dilution...
  48. doi request reprint Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma Association
    M Margaret Knudson
    Department of Surgery, University of California, San Francisco, USA
    J Am Coll Surg 212:87-95. 2011
    ..We hypothesized that we could describe the setting in which rFVIIa would be most successful in arresting hemorrhage after injury...
  49. pmc Defining when to initiate massive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients
    Rachael A Callcut
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California 94110, USA
    J Trauma Acute Care Surg 74:59-65, 67-8; discussion 66-7. 2013
    ..Early predictors of massive transfusion (MT) would prevent undertriage of patients likely to require MT. This study validates triggers using the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study...
  50. ncbi request reprint Patterns of exogenous insulin requirement reflect insulin sensitivity changes in trauma
    Heather F Pidcoke
    United States Army Institute of Surgical Research, Brooke Army Medical Center, 3400 Rawley E Chambers Ave, Fort Sam Houston, TX 78234 6315, USA
    Am J Surg 194:798-803; discussion 803. 2007
    ..We investigated patterns of blood glucose and exogenous insulin requirement in the intensive care unit, and questioned whether they reflect fluctuations in insulin activity...
  51. ncbi request reprint Minor morbidity with emergency tourniquet use to stop bleeding in severe limb trauma: research, history, and reconciling advocates and abolitionists
    John F Kragh
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Bldg 3611, Rm 282 4, Fort Sam Houston, TX 78234 6315, USA
    Mil Med 176:817-23. 2011
    ..To check these new and important results, we continued critical evaluation of tourniquet use for 6 more months in the current study to see if results were consistent...
  52. doi request reprint Battle casualty survival with emergency tourniquet use to stop limb bleeding
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Emerg Med 41:590-7. 2011
    ..In a previous study conducted at a combat support hospital in Iraq, we reported the major lifesaving benefits of emergency tourniquets to stop bleeding in major limb trauma. Morbidity associated with tourniquet use was minor...
  53. doi request reprint Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients
    Myung S Park
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S188-94. 2008
    ..We hypothesized that combining markers of these processes and standard clinical indices would improve early prediction of in- hospital mortality in burned and nonburned trauma patients...
  54. pmc Computer decision support software safely improves glycemic control in the burn intensive care unit: a randomized controlled clinical study
    Elizabeth A Mann
    US Army Burn Center, United States Army Institute of Surgical Research, Brooke Army Medical Center, San Antonio, Texas, USA
    J Burn Care Res 32:246-55. 2011
    ..Time in target range improved without increase in hypoglycemic events. CDSS enhanced consistency in practice, providing standardization among nursing staff...
  55. ncbi request reprint Contribution of bacterial and viral infections to attributable mortality in patients with severe burns: an autopsy series
    Laurie C D'Avignon
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 36:773-9. 2010
    ..aureus remain the most common cause of bacteria related mortality early in the hospital course. Viral infections are also associated with mortality and numbers have remained stable when compared to data from prior years...
  56. doi request reprint Prolonged prothrombin time after recombinant activated factor VII therapy in critically bleeding trauma patients is associated with adverse outcomes
    Neil R McMullin
    US Army Institute of Surgical Research, BAMC Fort Sam Houston, Texas, USA
    J Trauma 69:60-9. 2010
    ....
  57. doi request reprint Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    J Trauma 71:S318-28. 2011
    ..However, outcomes associated with platelet transfusions are poorly characterized. We hypothesized that increased platelet:red blood cells (RBC) ratios would decrease hemorrhagic death and improve survival after massive transfusion (MT)...
  58. pmc Do not resuscitate status, not age, affects outcomes after injury: an evaluation of 15,227 consecutive trauma patients
    Sasha D Adams
    Department of Surgery, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma Acute Care Surg 74:1327-30. 2013
    ..We hypothesized that the increased likelihood of DNR status in older patients alters age-adjusted mortality rates in trauma...
  59. doi request reprint Early femur fracture fixation is associated with a reduction in pulmonary complications and hospital charges: a decade of experience with 1,376 diaphyseal femur fractures
    John A Harvin
    Departments of Surgery, The University of Texas Health Science Center at Houston, Houston, Texas
    J Trauma Acute Care Surg 73:1442-8; discussion 1448-9. 2012
    ..We hypothesized that early IMN fixation of femur fractures would be associated with a decreased incidence of PC, hospital stay, and overall charges...
  60. pmc Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, TX, USA
    Ann Surg 254:598-605. 2011
    ..To determine whether implementation of damage control resuscitation (DCR) in patients undergoing damage control laparotomy (DCL) translates into improved survival...
  61. doi request reprint Closed-loop and decision-assist resuscitation of burn patients
    Jose Salinas
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 64:S321-32. 2008
    ....
  62. ncbi request reprint Burns sustained in combat explosions in Operations Iraqi and Enduring Freedom (OIF/OEF explosion burns)
    David S Kauvar
    United States Army Institute of Surgical Research, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 32:853-7. 2006
    ..Many OIF/OEF burns result from the enemy's detonation of explosives. We reviewed these to evaluate mission impact and provide recommendations for improved combat burn protection. Data were compared to those from the Vietnam War...
  63. ncbi request reprint Development and resuscitation of a sedated, mature male miniature swine severe hemorrhage model
    John W Burns
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    J Trauma 71:148-56. 2011
    ..A sedated, mature male miniature swine hemorrhage model has been specifically developed to evaluate resuscitation products for the Defense Advanced Research Projects Agency Surviving Blood Loss program...
  64. ncbi request reprint The military emergency tourniquet program's lessons learned with devices and designs
    John F Kragh
    U S Army Institute of Surgical Research, 3611 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Mil Med 176:1144-52. 2011
    ..The purpose of this study is to report the device lessons learned from an emergency tourniquet program and, in particular, to emphasize analysis of discarded devices recovered after clinical use...
  65. ncbi request reprint Comparison of combat and non-combat burns from ongoing U.S. military operations
    David S Kauvar
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Surg Res 132:195-200. 2006
    ..Military burns result from either combat or non-combat causes. We compared these etiologies from patients involved in ongoing conflicts to evaluate their impact and provide prevention recommendations...
  66. doi request reprint Hemostatically distinct FFPs equally improve abnormal TEG variables in an in vitro dilutional coagulopathy model
    Vadim Kostousov
    Department of Surgery, and Center for Translational Injury Research, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Thromb Res 130:429-34. 2012
    ..We hypothesized that smaller volumes of plasma with higher hemostatic potential (FFP-H) would be needed to restore normal thrombelastogram (TEG) values compared to plasma with lower hemostatic potential (FFP-L)...
  67. doi request reprint Posttraumatic stress disorder in combat casualties with burns sustaining primary blast and concussive injuries
    Alejandra G Mora
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 66:S178-85. 2009
    ..We hypothesized that the prevalence of PTSD in patients with burn was associated with primary blast injuries (PBIs) and mTBI...
  68. doi request reprint Continuous renal replacement therapy improves survival in severely burned military casualties with acute kidney injury
    Kevin K Chung
    United States Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, USA
    J Trauma 64:S179-85; discussion S185-7. 2008
    ..We wondered whether early use of continuous renal replacement therapy (CRRT) changes outcomes in severely burned military casualties with predetermined criteria for acute kidney injury...
  69. doi request reprint Joint Theater Trauma System implementation of burn resuscitation guidelines improves outcomes in severely burned military casualties
    Jody L Ennis
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S146-51; discussion S151-2. 2008
    ..To help standardize care, burn resuscitation guidelines (BRG) were devised along with a burn flow sheet (BFS) and disseminated via the new operational Joint Theater Trauma System to assist deployed providers...
  70. doi request reprint Practical use of emergency tourniquets to stop bleeding in major limb trauma
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 64:S38-49; discussion S49-50. 2008
    ..Previously we showed that tourniquets were lifesaving devices in the current war. Few studies, however, describe their actual morbidity in combat casualties. The purpose of this study was to measure tourniquet use and complications...
  71. doi request reprint Utilizing a trauma systems approach to benchmark and improve combat casualty care
    Brian J Eastridge
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 69:S5-9. 2010
    ..S. civilian trauma system models. The purpose of this analysis was to develop battlefield injury outcome benchmark metrics and to evaluate the impact of JTTS-driven performance improvement interventions...
  72. ncbi request reprint Incidence of primary blast injury in US military overseas contingency operations: a retrospective study
    Amber E Ritenour
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Ann Surg 251:1140-4. 2010
    ..The present retrospective study was performed to determine the incidence and outcome of primary blast injury and to identify possible changes over the course of the conflicts between 2003 and 2006...
  73. doi request reprint Prediction of mortality and of the need for massive transfusion in casualties arriving at combat support hospitals in Iraq
    Leopoldo C Cancio
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S51-5; discussion S55-6. 2008
    ....
  74. doi request reprint Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualties
    Claire R Larson
    Department of Surgery, United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S26-32. 2010
    ..The objective of this study was to compare the results of an MT prediction model and actual MT incidence in combat casualties...
  75. pmc Diabetes does not influence selected clinical outcomes in critically ill burn patients
    Chaitanya K Dahagam
    United States Army Institute of Surgical Research, Brooke Army Medical Center, San Antonio, Texas, USA
    J Burn Care Res 32:256-62. 2011
    ..Admission blood glucose is higher, and blood glucose is more difficult to control in diabetic burn ICU patients. A preexisting diagnosis of diabetes does not influence clinical outcomes in critically ill burn patients...
  76. ncbi request reprint Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  77. doi request reprint Combat wounds in operation Iraqi Freedom and operation Enduring Freedom
    Brett D Owens
    U S Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 64:295-9. 2008
    ..There have been no large cohort reports detailing the wounding patterns and mechanisms in the current conflicts in Iraq and Afghanistan...
  78. pmc Comparison between civilian burns and combat burns from Operation Iraqi Freedom and Operation Enduring Freedom
    Steven E Wolf
    Burn Center, United States Army Institute of Surgical Research, 3400 Rawley E Chambers, Fort Sam Houston, TX 79234, USA
    Ann Surg 243:786-92; discussion 792-5. 2006
    ..To assess outcome differences between locally burned civilians and military personnel burned in a distant combat zone treated in the same facility...
  79. doi request reprint Field triage score (FTS) in battlefield casualties: validation of a novel triage technique in a combat environment
    Brian J Eastridge
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Am J Surg 200:724-7; discussion 727. 2010
    ..The purpose of this analysis was to validate the predictive utility of the FTS in the battlefield trauma environment...
  80. doi request reprint Time and degree of glycemic derangement are associated with increased mortality in trauma patients in the setting of tight glycemic control
    Michael G Corneille
    Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Am J Surg 200:832-7; discussion 837-8. 2010
    ..Tight glucose control (TGC) may reduce mortality in critically ill trauma patients. We hypothesize that euglycemia is beneficial, and a measure considering time and degree of hyperglycemia is most associated with mortality...
  81. pmc Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma
    Nena Matijevic
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Thromb Res 128:35-41. 2011
    ..We report on MP changes in TP between its initial thaw (FFP-0) and five days (FFP-5) of storage...
  82. doi request reprint Hypotension is 100 mm Hg on the battlefield
    Brian J Eastridge
    Trauma and Surgical Critical Care, US Army Institute for Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    Am J Surg 202:404-8. 2011
    ..In this analysis, we sought to determine the relationship between SBP, hypoperfusion, and mortality in the combat casualty...
  83. doi request reprint Injury severity and causes of death from Operation Iraqi Freedom and Operation Enduring Freedom: 2003-2004 versus 2006
    Joseph F Kelly
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234 3611, USA
    J Trauma 64:S21-6; discussion S26-7. 2008
    ..We hypothesized that the severity of wounds has increased over time. Furthermore, we examined cause of death looking for opportunities of improvement for research and training...
  84. doi request reprint Comparison of mortality associated with sepsis in the burn, trauma, and general intensive care unit patient: a systematic review of the literature
    Elizabeth A Mann
    University of Texas Health Science Center, Houston, Texas, USA
    Shock 37:4-16. 2012
    ..Great variability of criteria to identify septic patients among studies compromises population comparisons...
  85. pmc Effect of diabetes mellitus on outcomes of hyperglycemia in a mixed medical surgical intensive care unit
    Andrew T Schlussel
    Department of Surgery, Tripler Army Medical Center, Tripler AMC, Hawaii, USA
    J Diabetes Sci Technol 5:731-40. 2011
    ..We hypothesized that diabetic patients who achieved tight glucose control with continuous insulin therapy would have less morbidity and lower mortality than diabetic patients with uncontrolled blood glucose...
  86. doi request reprint Thromboembolic complications following trauma
    Daniel F McLaughlin
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Transfusion 49:256S-63S. 2009
    ..Some studies have reported an increased incidence of thromboembolic complications following trauma...
  87. doi request reprint Initial resuscitation with plasma and other blood components reduced bleeding compared to hetastarch in anesthetized swine with uncontrolled splenic hemorrhage
    Jill L Sondeen
    US Army Institute of Surgical Research, Fort Sam, Houston, Texas 78234 6315, USA
    Transfusion 51:779-92. 2011
    ..The purpose of this study was to evaluate resuscitation with either blood components or conventional fluids on coagulation and blood loss...
  88. pmc Multiple levels of degradation diminish hemostatic potential of thawed plasma
    Nena Matijevic
    Department of Surgery and Center for Translational Injury Research, University of Texas Health Science Center Houston, Houston, Texas 77030, USA
    J Trauma 70:71-9; discussion 79-80. 2011
    ..However, there are no clinical data analyzing the effects of the approved 5-day storage on plasma. We hypothesize that the hemostatic potential (HP) of freshly thawed (FFP-0) was superior to plasma stored for 5 days (FFP-5)...
  89. ncbi request reprint Current use of damage-control laparotomy, closure rates, and predictors of early fascial closure at the first take-back
    Quinton M Hatch
    Department of Surgery and the Center for Translational Injury Research, The University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 70:1429-36. 2011
    ..The purpose of the current study was to determine (1) the current rate of DCL, (2) the percentage of DCLs that are closed at first take-back, and (3) possible physiologic and resuscitative parameters predicting early fascial closure...
  90. ncbi request reprint Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Ft Sam Houston, TX, USA
    Crit Care Med 35:1568-74. 2007
    ..To investigate the effect of tris-hydroxymethylaminomethane (THAM) pH neutralization on reversing coagulation abnormalities caused by acidosis...
  91. pmc Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004
    John B Holcomb
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Ann Surg 245:986-91. 2007
    ..Effective combat trauma management strategies depend upon an understanding of the epidemiology of death on the battlefield...
  92. doi request reprint Impact of policy change on US Army combat transfusion practices
    John W Simmons
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S75-80. 2010
    ..The objective of this study was to determine whether the CPG was associated with a change in the transfusion practices in combat-wounded patients...
  93. doi request reprint Died of wounds on the battlefield: causation and implications for improving combat casualty care
    Brian J Eastridge
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 71:S4-8. 2011
    ..The current analysis was undertaken to develop a comprehensive perspective of deaths that occurred after casualties reached a medical treatment facility...
  94. doi request reprint Tympanic membrane perforation and hearing loss from blast overpressure in Operation Enduring Freedom and Operation Iraqi Freedom wounded
    Amber E Ritenour
    United States Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:S174-8; discussion S178. 2008
    ..We wanted to determine the severity of perforation and its effect on hearing and combat readiness...
  95. doi request reprint Combat urologic trauma in US military overseas contingency operations
    Faye B Serkin
    Department of Urology, San Antonio Military Medical Center, Fort Sam Houston, Texas, USA
    J Trauma 69:S175-8. 2010
    ..This article reports on the occurrences and patterns of genitourinary (GU) trauma in the contemporary high-intensity conflict of the overseas contingency operations (OCOs)...
  96. ncbi request reprint Uncontrolled hemorrhage differs from volume- or pressure-matched controlled hemorrhage in swine
    Jill L Sondeen
    US Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
    Shock 28:426-33. 2007
    ..We suggest that the relationship of blood pressure to blood volume loss is modified in the presence of uncontrolled hemorrhage...
  97. ncbi request reprint Making sense of the preclinical literature on advanced hemostatic products
    Anthony E Pusateri
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, and the Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    J Trauma 60:674-82. 2006
    ..Mission and training requirements will dictate the use of these products by military and civilian prehospital care providers...
  98. doi request reprint High-frequency percussive ventilation and low tidal volume ventilation in burns: a randomized controlled trial
    Kevin K Chung
    U S Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Crit Care Med 38:1970-7. 2010
    ..The purpose of this study was to prospectively compare the two ventilator modalities in a burn intensive care unit setting...
  99. doi request reprint Error rates resulting from anemia can be corrected in multiple commonly used point-of-care glucometers
    Elizabeth A Mann
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:15-20; discussion 20-1. 2008
    ..The purpose of this study was to analyze error rates of three additional POC glucometer brands and determine mathematical correction formulas for each...
  100. ncbi request reprint Radiologic diagnosis of explosion casualties
    Brian J Eastridge
    US Army Institute for Surgical Research, Fort Sam Houston, Texas, USA
    Am J Disaster Med 3:301-5. 2008
    ..With this caveat, the appropriate utilization of radiology resources has the potential to impact in-hospital diagnosis and triage and is an essential element in optimizing the management of the explosive-injured patients...
  101. pmc Fungal wound infection (not colonization) is independently associated with mortality in burn patients
    Edward E Horvath
    U S Army Institute of Surgical Research, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Ann Surg 245:978-85. 2007
    ..To analyze the occurrence of fungal wound infection (FWI) after thermal injury and its relationship to mortality...