K Vinod Vijayan

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:33039-42. 2004
  2. ncbi request reprint The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    J Biol Chem 280:21756-62. 2005
  3. pmc Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions
    Nawaf Alrehani
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Thromb Haemost 109:118-26. 2013
  4. pmc Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen
    Subhashree Pradhan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:29059-68. 2010
  5. pmc The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function
    Francisca C Gushiken
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 4:e8304. 2009
  6. ncbi request reprint Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions
    Chalmette Ball
    Thrombosis Research Section, Department of Medicine, Medicine Baylor College of Medicine, BCM286, N1319 One Baylor Plaza, Houston, Texas 77030, USA
    Thromb Haemost 100:857-63. 2008
  7. ncbi request reprint PlA polymorphism of integrin beta 3 differentially modulates cellular migration on extracellular matrix proteins
    Mansoor Sajid
    Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Arterioscler Thromb Vasc Biol 22:1984-9. 2002
  8. ncbi request reprint Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    FEBS Lett 540:41-6. 2003
  9. pmc Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling
    Francisca C Gushiken
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 283:12862-9. 2008
  10. ncbi request reprint Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:3860-7. 2003

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 279:33039-42. 2004
    ..These studies reveal a previously unrecognized role for integrins whereby the alpha subunit cytoplasmic tail localizes the machinery for initiating and temporally maintaining the regulatory signaling activity of a phosphatase...
  2. ncbi request reprint The Pro33 isoform of integrin beta3 enhances outside-in signaling in human platelets by regulating the activation of serine/threonine phosphatases
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    J Biol Chem 280:21756-62. 2005
    ....
  3. pmc Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions
    Nawaf Alrehani
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Thromb Haemost 109:118-26. 2013
    ..Thus, PP1c isoforms have distinct contribution to the outside-in αIIbβ3 signalling-dependent functions in 293 αIIbβ3 cells. Moreover, PP1cα negatively regulates integrin function by suppressing the p38 pathway...
  4. pmc Cross-talk between serine/threonine protein phosphatase 2A and protein tyrosine phosphatase 1B regulates Src activation and adhesion of integrin αIIbβ3 to fibrinogen
    Subhashree Pradhan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:29059-68. 2010
    ..Moreover, these studies extend the notion that a cross-talk between Ser/Thr and Tyr phosphatases can fine-tune α(IIb)β(3) outside-in signaling...
  5. pmc The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function
    Francisca C Gushiken
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    PLoS ONE 4:e8304. 2009
    ..Although the catalytic subunit of protein phosphatase 1 (PP1c) interacts with alpha(IIb)beta(3), the role of PP1c in platelet reactivity is unclear...
  6. ncbi request reprint Glutathione regulates integrin alpha(IIb)beta(3)-mediated cell adhesion under flow conditions
    Chalmette Ball
    Thrombosis Research Section, Department of Medicine, Medicine Baylor College of Medicine, BCM286, N1319 One Baylor Plaza, Houston, Texas 77030, USA
    Thromb Haemost 100:857-63. 2008
    ..They further suggest that the HPA phenotype may be redox-regulated...
  7. ncbi request reprint PlA polymorphism of integrin beta 3 differentially modulates cellular migration on extracellular matrix proteins
    Mansoor Sajid
    Department of Medicine, Baylor College of Medicine, Houston, Tex 77030, USA
    Arterioscler Thromb Vasc Biol 22:1984-9. 2002
    ..We have addressed the possibility that the Leu33Pro polymorphism could modify the migratory behavior of Chinese hamster ovary (CHO) cells expressing the beta3-containing integrin complexes...
  8. ncbi request reprint Shear stress augments the enhanced adhesive phenotype of cells expressing the Pro33 isoform of integrin beta3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    FEBS Lett 540:41-6. 2003
    ..Thus, shear stress enhances the adhesive phenotype of the Pro33 cells to multiple physiologic substrates...
  9. pmc Protein phosphatase 2A negatively regulates integrin alpha(IIb)beta(3) signaling
    Francisca C Gushiken
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 283:12862-9. 2008
    ..These studies demonstrate that PP2Ac (alpha) can negatively regulate integrin alpha(IIb)beta(3) signaling by suppressing the ERK1/2 signaling pathway...
  10. ncbi request reprint Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:3860-7. 2003
    ..Post-integrin occupancy signaling through MAPK and MLCK after alpha(IIb)beta(3) cross-linking may explain in part the increased adhesive properties of the Pro(33) variant of integrin beta(3)...
  11. ncbi request reprint Molecular mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enhanced outside-in signaling through the Pro33 variant of integrin beta3
    K Vinod Vijayan
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, BCM 286, N1319, Houston, TX 77030, USA
    Exp Biol Med (Maywood) 231:505-13. 2006
    ..A detailed understanding of how polymorphisms modulate platelet physiology will be important for understanding individual differences in response to antiplatelet therapy...
  12. pmc Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibalpha and platelet activation under shear stress
    Matthew Auton
    Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 285:22831-9. 2010
    ..Therefore, the termination of A domain association within VWF in solution results in binding to GPIba and platelet activation under high shear stress...
  13. pmc Decline in platelet microparticles contributes to reduced hemostatic potential of stored plasma
    Nena Matijevic
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Thromb Res 128:35-41. 2011
    ..We report on MP changes in TP between its initial thaw (FFP-0) and five days (FFP-5) of storage...

Research Grants6

  1. Serine / Threonine Phosphatases and Platelet Physiology
    K Vinod Vijayan; Fiscal Year: 2010
    ..abstract_text> ..
  2. Serine / Threonine Phosphatases and Platelet Physiology
    K Vinod Vijayan; Fiscal Year: 2007
    ....