S Umar

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Dietary pectin and calcium inhibit colonic proliferation in vivo by differing mechanisms
    S Umar
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The University of Texas Medical School, Houston, Texas, USA
    Cell Prolif 36:361-75. 2003
  2. ncbi request reprint Murine colonic mucosa hyperproliferation. I. Elevated CFTR expression and enhanced cAMP-dependent Cl(-) secretion
    S Umar
    Department of Integrative Biology, Pharmacology and Physiology, Division of Gastroenterology, Hepatology and Nutrition, The University of Texas Health Science Center at Houston, Medical School, Houston 77030, USA
    Am J Physiol Gastrointest Liver Physiol 278:G753-64. 2000
  3. ncbi request reprint Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo
    J H Sellin
    Department of Internal Medicine, The University of Texas Medical School-Houston, 77030, USA
    Cancer Res 61:2899-906. 2001
  4. pmc Activation of NF-kappaB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo
    S Umar
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Oncogene 27:5599-611. 2008
  5. ncbi request reprint Increased nuclear translocation of catalytically active PKC-zeta during mouse colonocyte hyperproliferation
    S Umar
    Department of Integrative Biology, Pharmacology, and Physiology, University of Texas Health Science Center at Houston, Medical School, 77030, USA
    Am J Physiol Gastrointest Liver Physiol 279:G223-37. 2000

Collaborators

Detail Information

Publications5

  1. ncbi request reprint Dietary pectin and calcium inhibit colonic proliferation in vivo by differing mechanisms
    S Umar
    Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The University of Texas Medical School, Houston, Texas, USA
    Cell Prolif 36:361-75. 2003
    ..TMCH is thus a diet-sensitive model for examining the effect of specific nutrients on molecular characteristics of the pre-neoplastic colonic epithelium...
  2. ncbi request reprint Murine colonic mucosa hyperproliferation. I. Elevated CFTR expression and enhanced cAMP-dependent Cl(-) secretion
    S Umar
    Department of Integrative Biology, Pharmacology and Physiology, Division of Gastroenterology, Hepatology and Nutrition, The University of Texas Health Science Center at Houston, Medical School, Houston 77030, USA
    Am J Physiol Gastrointest Liver Physiol 278:G753-64. 2000
    ..This novel mode of CFTR regulation may explain why high endogenous levels of cellular CFTR mRNA and protein within the TMCH epithelium were not matched with larger increases in transmucosal CFTR Cl(-) current...
  3. ncbi request reprint Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo
    J H Sellin
    Department of Internal Medicine, The University of Texas Medical School-Houston, 77030, USA
    Cancer Res 61:2899-906. 2001
    ..These findings predict that an oncogenic signaling mechanism related to non-E-cadherin-bound beta-catenin is active in hyperproliferating native colonocytes and is similar to that recorded during the early stages of colon carcinogenesis...
  4. pmc Activation of NF-kappaB is required for mediating proliferative and antiapoptotic effects of progastrin on proximal colonic crypts of mice, in vivo
    S Umar
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555 1043, USA
    Oncogene 27:5599-611. 2008
    ..Thus, downregulation of NF-kappaB may significantly reduce the increased risk of colon carcinogenesis in response to PG...
  5. ncbi request reprint Increased nuclear translocation of catalytically active PKC-zeta during mouse colonocyte hyperproliferation
    S Umar
    Department of Integrative Biology, Pharmacology, and Physiology, University of Texas Health Science Center at Houston, Medical School, 77030, USA
    Am J Physiol Gastrointest Liver Physiol 279:G223-37. 2000
    ..These results suggest separate cellular and nuclear roles, respectively, for PKC-zeta in quiescent and mitotically active colonocytes. PKM-zeta may specifically act as a modulator of proliferation during TMCH...