J H Tinsley

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Involvement of PKCdelta and PKD in pulmonary microvascular endothelial cell hyperpermeability
    John H Tinsley
    Department of Surgery, Texas A and M University, System Health Science Center, 702 SW H K Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Cell Physiol 286:C105-11. 2004
  2. ncbi request reprint Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability
    J H Tinsley
    Departments of Surgery and Medical Physiology, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    Am J Physiol Cell Physiol 279:C1285-9. 2000
  3. ncbi request reprint Protein transfection of intact microvessels specifically modulates vasoreactivity and permeability
    J H Tinsley
    Department of Surgery, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, Tex 76504, USA
    J Vasc Res 38:444-52. 2001
  4. ncbi request reprint Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns
    John H Tinsley
    Dept of Medical Physiology, Texas A and M Univ System Health Science Center, 702 SW HK Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Lung Cell Mol Physiol 286:L841-7. 2004
  5. ncbi request reprint Src-dependent, neutrophil-mediated vascular hyperpermeability and beta-catenin modification
    John H Tinsley
    Department of Surgery, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    Am J Physiol Cell Physiol 283:C1745-51. 2002
  6. ncbi request reprint Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
    S Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Circ Res 87:412-7. 2000
  7. pmc p150Glued, the largest subunit of the dynactin complex, is nonessential in Neurospora but required for nuclear distribution
    J H Tinsley
    Department of Biology, Texas A and M University, College Station 77843 3258, USA
    Mol Biol Cell 7:731-42. 1996
  8. ncbi request reprint Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage
    Sarah Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University Health Science Center, Temple, Texas, USA yuan tamu edu
    Circ Res 90:1214-21. 2002
  9. ncbi request reprint PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells
    John H Tinsley
    Dept of Surgery, Scott and White Memorial Hospital, 702 SW HK Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Lung Cell Mol Physiol 289:L217-23. 2005
  10. ncbi request reprint Apoptotic signaling induces hyperpermeability following hemorrhagic shock
    Ed W Childs
    Department of Surgery, The Texas A and M University, HSC College of Medicine, Scott and White Memorial Hospital, 2401 South 31st St, Temple, TX 76508, USA
    Am J Physiol Heart Circ Physiol 292:H3179-89. 2007

Detail Information

Publications12

  1. ncbi request reprint Involvement of PKCdelta and PKD in pulmonary microvascular endothelial cell hyperpermeability
    John H Tinsley
    Department of Surgery, Texas A and M University, System Health Science Center, 702 SW H K Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Cell Physiol 286:C105-11. 2004
    ....
  2. ncbi request reprint Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability
    J H Tinsley
    Departments of Surgery and Medical Physiology, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    Am J Physiol Cell Physiol 279:C1285-9. 2000
    ..This study uses a novel technique to measure the effects of an activated kinase on both its substrate and cellular morphology and function through direct transference into endothelial cells...
  3. ncbi request reprint Protein transfection of intact microvessels specifically modulates vasoreactivity and permeability
    J H Tinsley
    Department of Surgery, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, Tex 76504, USA
    J Vasc Res 38:444-52. 2001
    ..By transfecting inhibitor peptides against NOS and PKC into coronary arterioles and venules, we have been able to determine the specific roles of these two enzymes in vasodilation and hyperpermeability responses...
  4. ncbi request reprint Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns
    John H Tinsley
    Dept of Medical Physiology, Texas A and M Univ System Health Science Center, 702 SW HK Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Lung Cell Mol Physiol 286:L841-7. 2004
    ..The results suggest that blocking MLC phosphorylation may provide therapeutic intervention in burn patients with the goal of alleviating systemic inflammation-induced endothelial dysfunction...
  5. ncbi request reprint Src-dependent, neutrophil-mediated vascular hyperpermeability and beta-catenin modification
    John H Tinsley
    Department of Surgery, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, Texas 76504, USA
    Am J Physiol Cell Physiol 283:C1745-51. 2002
    ....
  6. ncbi request reprint Protein kinase C activation contributes to microvascular barrier dysfunction in the heart at early stages of diabetes
    S Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University System Health Science Center, Temple, TX 76504, USA
    Circ Res 87:412-7. 2000
    ..The results suggest that endothelial barrier dysfunction attributed to the activation of PKC occurs at the coronary exchange vessels in early diabetes...
  7. pmc p150Glued, the largest subunit of the dynactin complex, is nonessential in Neurospora but required for nuclear distribution
    J H Tinsley
    Department of Biology, Texas A and M University, College Station 77843 3258, USA
    Mol Biol Cell 7:731-42. 1996
    ..crassa. We show that N. crassa cytoplasmic dynein and dynactin mutants have abnormal nuclear distribution but retain the ability to organize cytoplasmic microtubules and actin in anucleate hyphae...
  8. ncbi request reprint Myosin light chain phosphorylation in neutrophil-stimulated coronary microvascular leakage
    Sarah Y Yuan
    Departments of Surgery and Medical Physiology, Cardiovascular Research Institute, Texas A and M University Health Science Center, Temple, Texas, USA yuan tamu edu
    Circ Res 90:1214-21. 2002
    ..Taken together, the results suggest that endothelial MLCK activation and MLC phosphorylation play an important role in mediating endothelial barrier dysfunction during neutrophil activation...
  9. ncbi request reprint PKC-dependent, burn-induced adherens junction reorganization and barrier dysfunction in pulmonary microvascular endothelial cells
    John H Tinsley
    Dept of Surgery, Scott and White Memorial Hospital, 702 SW HK Dodgen Loop, Temple, TX 76504, USA
    Am J Physiol Lung Cell Mol Physiol 289:L217-23. 2005
    ..Furthermore, all the above responses to burn plasma were attenuated when cells were pretreated with the PKC inhibitor bisindolylmaleimide, suggesting that PKC is required for burn-induced pulmonary endothelial dysfunction...
  10. ncbi request reprint Apoptotic signaling induces hyperpermeability following hemorrhagic shock
    Ed W Childs
    Department of Surgery, The Texas A and M University, HSC College of Medicine, Scott and White Memorial Hospital, 2401 South 31st St, Temple, TX 76508, USA
    Am J Physiol Heart Circ Physiol 292:H3179-89. 2007
    ....
  11. ncbi request reprint Isoform-specific knockout of endothelial myosin light chain kinase: closing the gap on inflammatory lung disease
    John H Tinsley
    Department of Medical Physiology and Cardiovascular Research Institute, Texas A and M University System Health Science Center, College of Medicine, College Station, 77843, USA
    Trends Pharmacol Sci 25:64-6. 2004
    ..Recent studies show that mice with selective knockout of the endothelial MLCK are less susceptible to endotoxin-induced acute lung injury and that a new small-molecule inhibitor of MLCK also protects against lung injury...
  12. doi request reprint Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock
    Ed W Childs
    Department of Surgery, Texas A and M University System HSC College of Medicine, Scott and White Memorial Hospital, 2401 South 31st Street, Temple, TX 76508, USA
    Am J Physiol Heart Circ Physiol 294:H2285-95. 2008
    ..05). These findings suggest that Ang-1's role in maintaining microvascular endothelial barrier integrity involves the intrinsic apoptotic signaling cascade...