JOHN D SWEATT

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    J D Sweatt
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurochem 76:1-10. 2001
  2. ncbi Hippocampal function in cognition
    J David Sweatt
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Psychopharmacology (Berl) 174:99-110. 2004
  3. ncbi Mitogen-activated protein kinases in synaptic plasticity and memory
    J David Sweatt
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
    Curr Opin Neurobiol 14:311-7. 2004
  4. ncbi Structure and function of Kv4-family transient potassium channels
    Shari G Birnbaum
    Div of Neuroscience, S607, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Physiol Rev 84:803-33. 2004
  5. ncbi The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurobiol 25:51-66. 2002
  6. ncbi Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway
    Li Lian Yuan
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:4860-8. 2002
  7. ncbi Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents
    Andrew W Varga
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:3643-54. 2004
  8. ncbi Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo
    Cynthia D Galvan
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannim St, MC 3 6365, Houston, TX 77030, USA
    Eur J Neurosci 18:1861-72. 2003
  9. ncbi MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time
    Karen A Bell
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 91:349-61. 2004
  10. ncbi Integrin requirement for hippocampal synaptic plasticity and spatial memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:7107-16. 2003

Collaborators

Detail Information

Publications66

  1. ncbi The neuronal MAP kinase cascade: a biochemical signal integration system subserving synaptic plasticity and memory
    J D Sweatt
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurochem 76:1-10. 2001
    ..Finally, I will speculate on what the critical downstream effectors of the erks are in neurons, and how they might provide a readout of the integrated signal...
  2. ncbi Hippocampal function in cognition
    J David Sweatt
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 3498, USA
    Psychopharmacology (Berl) 174:99-110. 2004
    ..This review will describe emerging models for the cellular basis of cognitive processing in the hippocampus...
  3. ncbi Mitogen-activated protein kinases in synaptic plasticity and memory
    J David Sweatt
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
    Curr Opin Neurobiol 14:311-7. 2004
    ..These topics are discussed within the context of an emerging role for ERKs in a wide variety of forms of synaptic plasticity and memory formation in the behaving animal...
  4. ncbi Structure and function of Kv4-family transient potassium channels
    Shari G Birnbaum
    Div of Neuroscience, S607, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Physiol Rev 84:803-33. 2004
    ..Finally, the pathophysiology that may arise from dysregulation of these channels is also reviewed...
  5. ncbi The other half of Hebb: K+ channels and the regulation of neuronal excitability in the hippocampus
    Laura A Schrader
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Neurobiol 25:51-66. 2002
    ..In conclusion, we provide a model for an alternative form of coincidence detection through K+ channels in the hippocampus...
  6. ncbi Protein kinase modulation of dendritic K+ channels in hippocampus involves a mitogen-activated protein kinase pathway
    Li Lian Yuan
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:4860-8. 2002
    ..2 subunits...
  7. ncbi Calcium-calmodulin-dependent kinase II modulates Kv4.2 channel expression and upregulates neuronal A-type potassium currents
    Andrew W Varga
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:3643-54. 2004
    ..Thus CaMKII can directly modulate neuronal excitability by increasing cell-surface expression of A-type K(+) channels...
  8. ncbi Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo
    Cynthia D Galvan
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannim St, MC 3 6365, Houston, TX 77030, USA
    Eur J Neurosci 18:1861-72. 2003
    ..Postsynaptic changes are likely to be the major contributors to the hippocampal network hyperexcitability and should enhance both excitatory synaptic efficacy and plasticity...
  9. ncbi MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time
    Karen A Bell
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurochem 91:349-61. 2004
    ..These data indicate the existence of differential coupling of alpha7 to downstream targets depending on the type of ligand that leads to receptor activation...
  10. ncbi Integrin requirement for hippocampal synaptic plasticity and spatial memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:7107-16. 2003
    ..These results demonstrate that several different integrins are involved in physiological plasticity and provide the first evidence of their requirement for behavioral plasticity in vertebrates...
  11. ncbi beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:25056-61. 2002
    ..Thus, when beta-amyloid peptide activation of alpha7 receptors occurs, these currents are comprised, at least in part, of Ca(2+)...
  12. pmc c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation
    Hyung Jin Ahn
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 15:539-49. 2008
    ..Together, our results demonstrate that c-Rel is necessary for long-term synaptic potentiation in vitro and hippocampus-dependent memory formation in vivo...
  13. ncbi Molecular psychology: roles for the ERK MAP kinase cascade in memory
    J Paige Adams
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Pharmacol Toxicol 42:135-63. 2002
    ....
  14. ncbi Kinase suppressor of Ras1 compartmentalizes hippocampal signal transduction and subserves synaptic plasticity and memory formation
    Sara C Shalin
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Neuron 50:765-79. 2006
    ..Our report provides novel insight into the endogenous scaffolding role of KSR1 in controlling kinase activation within the nervous system...
  15. ncbi Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning
    Edwin J Weeber
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:39944-52. 2002
    ..Thus, the impairment of apoE receptor-dependent neuromodulation may contribute to cognitive impairment and synaptic loss in Alzheimer disease...
  16. pmc Alpha3-integrins are required for hippocampal long-term potentiation and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 14:606-15. 2007
    ..The impairment in LTP and working memory is similar to that observed in beta1-integrin conditional knockout mice, suggesting that alpha3-integrin is the functional binding partner for beta1 for these processes in the forebrain...
  17. ncbi Neuronal MEK is important for normal fear conditioning in mice
    Sara C Shalin
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci Res 75:760-70. 2004
    ..These findings indicate that the MEK1/ERK1/2 cascade within neurons plays an important role in the processes of learning and memory...
  18. pmc ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning
    Wilson B Chwang
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 13:322-8. 2006
    ..These results demonstrate that changes in histone phosphorylation in the hippocampus are regulated by ERK/MAPK following a behavioral fear conditioning paradigm...
  19. ncbi Molecular genetics of human cognition
    Edwin J Weeber
    Division of Neuroscience, Baylor College of Medicine 1 Baylor Plaza, Houston, TX 77030, USA
    Mol Interv 2:376-91, 339. 2002
    ....
  20. ncbi Regulation of histone acetylation during memory formation in the hippocampus
    Jonathan M Levenson
    Baylor College of Medicine, Department of Neuroscience, Houston, Texas 77030, USA
    J Biol Chem 279:40545-59. 2004
    ..Mimicking memory-associated changes in heterochromatin enhances a cellular process thought to underlie long term memory formation, hippocampal long term potentiation, and memory formation itself...
  21. pmc Beta 1-integrins are required for hippocampal AMPA receptor-dependent synaptic transmission, synaptic plasticity, and working memory
    Chi Shing Chan
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:223-32. 2006
    ..These observations suggest a new function of beta1-integrins as regulators of synaptic glutamate receptor function and working memory...
  22. ncbi Epigenetic mechanisms in memory formation
    Jonathan M Levenson
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, S607, Houston, Texas 77030, USA
    Nat Rev Neurosci 6:108-18. 2005
    ..Strikingly, the relevant data from the few extant neurobiology-related studies have already indicated a theme - epigenetic mechanisms probably have an important role in synaptic plasticity and memory formation...
  23. ncbi Mitochondrial regulation of synaptic plasticity in the hippocampus
    Michael Levy
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:17727-34. 2003
    ..The data suggest a role for the mitochondrial permeability transition pore and voltage-dependent anion channels in mitochondrial synaptic calcium buffering and in hippocampal synaptic plasticity...
  24. ncbi Glutamate uptake in synaptic plasticity: from mollusc to mammal
    Jonathan M Levenson
    Baylor College of Medicine, Division of Neuroscience, Houston, TX 77030, USA
    Curr Mol Med 2:593-603. 2002
    ..These new findings indicate that glutamate transporters most likely play a more active role in neurotransmission than previously believed...
  25. ncbi SCA7 knockin mice model human SCA7 and reveal gradual accumulation of mutant ataxin-7 in neurons and abnormalities in short-term plasticity
    Seung Yun Yoo
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 37:383-401. 2003
    ..These data demonstrate that glutamine expansion stabilizes mutant ataxin-7, provide an explanation for selective neuronal vulnerability, and show that mutant ataxin-7 impairs posttetanic potentiation (PTP)...
  26. ncbi The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity
    Edwin J Weeber
    Division of Neuroscience, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:18891-7. 2002
    ..These results demonstrate a dynamic functional role for mitochondrial porins and the permeability transition pore in learning and synaptic plasticity...
  27. ncbi Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins
    Kelly T Dineley
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 277:22768-80. 2002
    ..These findings provide two robust and rapid assays for beta-amyloid-associated effects that can be performed on young animals: impaired contextual fear learning and up-regulation of alpha 7 nicotinic receptors...
  28. ncbi The nuclear kinase mitogen- and stress-activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation
    Wilson B Chwang
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 27:12732-42. 2007
    ..This suggests that CREB phosphorylation and histone acetylation represent parallel targets of MSK1 function. Our study identifies MSK1 as an important regulator of chromatin remodeling in long-term memory...
  29. ncbi Evidence that DNA (cytosine-5) methyltransferase regulates synaptic plasticity in the hippocampus
    Jonathan M Levenson
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:15763-73. 2006
    ..Considered together, these results suggest that DNMT activity is dynamically regulated in the adult nervous system and that DNMT may play a role in regulating the induction of synaptic plasticity in the mature CNS...
  30. ncbi ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit
    Laura A Schrader
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Cell Physiol 290:C852-61. 2006
    ..Overall these studies provide new insights into the structure-function relationships for MAPK regulation of membrane ion channels...
  31. pmc The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning
    Jon C Alexander
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 16:167-77. 2009
    ..These data suggest a role for regulation of gene expression by KChIP3/DREAM/calsenilin in consolidation of contextual fear conditioning memories...
  32. ncbi Molecular neurobiology of human cognition
    Edwin J Weeber
    Division of Neuroscience, Department of Molecular Physiology and Biophysics, Mental Retardation Research Center, Baylor College of Medicine, Houston, TX 77030, USA
    Neuron 33:845-8. 2002
    ..We focus on this cascade because of recent exciting discoveries concerning the basis of neurofibromatosis type 1 (NF1) mental retardation, which link cognitive defects in this syndrome to disruptions of ras and its intracellular targets...
  33. pmc A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1
    Joel C Selcher
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Learn Mem 10:26-39. 2003
    ..Overall, our data indicate that the progressive increase in spiking observed during TBS represents a form of physiologic temporal integration that is dependent on ERK MAPK activity...
  34. ncbi Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome
    Paolo Moretti
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:319-27. 2006
    ..These data demonstrate a requirement for MeCP2 in learning and memory and suggest that functional and ultrastructural synaptic dysfunction is an early event in the pathogenesis of RTT...
  35. ncbi Genetics of childhood disorders: LI. Learning and memory, Part 4: Human cognitive disorders and the ras/ERK/CREB pathway
    J David Sweatt
    Division of Neurscience, Baylor College of Medicine, Houston, USA
    J Am Acad Child Adolesc Psychiatry 42:741-4. 2003
  36. ncbi Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome
    Edwin J Weeber
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 23:2634-44. 2003
    ..These findings are the first to implicate misregulation of CaMKII as a molecular cause for the neurobehavioral deficits in a human learning disorder...
  37. ncbi A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel
    Jonathan M Levenson
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 24:3933-43. 2004
    ..Using a knock-out mouse, we found that c-rel, one of the transcription factors identified in our bioinformatics study, is necessary for hippocampus-dependent long-term memory formation...
  38. ncbi Signal transduction mechanisms in memory disorders
    Sara C Shalin
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Prog Brain Res 157:25-41. 2006
    ....
  39. ncbi Developmental regulation of Eed complex composition governs a switch in global histone modification in brain
    Se Young Kim
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:9962-72. 2007
    ..Thus, this study suggests dynamic regulation of chromatin complex composition as a molecular mechanism to co-opt constituents of developmental pathways into the regulation of neuronal memory formation in adult brain...
  40. ncbi Genetics of childhood disorders: LII. Learning and memory, part 5: human cognitive disorders and the ras/ERK/CREB pathway
    J David Sweatt
    Division of Neuroscience, Baylor College of Medicine, Houston, USA
    J Am Acad Child Adolesc Psychiatry 42:873-6. 2003
  41. ncbi Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory
    Patrick R Cox
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Neurosci 23:1-12. 2003
    ..Electrophysiological analysis revealed enhanced LTP in Tmod2(lacZ-/-) mice. These studies suggest that Tmod2 plays a role in behavior, learning, memory, and synaptic plasticity...
  42. ncbi Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice
    Yanghong Gu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:2753-63. 2002
    ..Thus, although a number of studies have suggested that diminished LTP is associated with memory impairment, our data suggest that increased LTP may be a mechanism that leads to impaired cognitive processing as well...
  43. ncbi Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors
    Kenneth J O'Riordan
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:4870-9. 2006
    ....
  44. ncbi Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake
    Jonathan Levenson
    University of Houston, Department of Biology and Biochemistry, Houston, Texas 77204, USA
    Nat Neurosci 5:155-61. 2002
    ..These results indicate that regulation of glutamate uptake may be important for maintaining the level of synaptic strength during long-term changes in synaptic efficacy...
  45. ncbi Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice
    Valerie Bracchi-Ricard
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurochem 104:611-23. 2008
    ..These findings indicate that astroglial NF-kappaB is an important regulator of learning/memory and synaptic plasticity...
  46. ncbi Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory
    Alexei Morozov
    Howard Hughes Medical Institute, Columbia University, College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 39:309-25. 2003
    ..These results indicate that Rap1 couples cAMP signaling to a selective membrane-associated pool of p42/44MAPK to control excitability of pyramidal cells, the early and late phases of LTP, and the storage of spatial memory...
  47. ncbi Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 47:567-79. 2005
    ..Thus, alternative splicing of Apoer2, a novel component of the NMDA receptor complex, controls the modulation of NMDA receptor activity, synaptic neurotransmission, and memory by Reelin...
  48. pmc Secretin receptor-deficient mice exhibit impaired synaptic plasticity and social behavior
    Ichiko Nishijima
    Center for Molecular and Human Genetics, Columbus Children s Research Institute, The Ohio State University, Columbus, OH 43205, USA
    Hum Mol Genet 15:3241-50. 2006
    ..Furthermore, secretin receptor-deficient mice show abnormal social and cognitive behaviors. These findings suggest that the secretin receptor system has an important role in the central nervous system relating to social behavior...
  49. ncbi Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission
    Uwe Beffert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Neurosci 24:1897-906. 2004
    ..Taken together, these findings suggest that both pathways function together in a parallel, rather than a simple, linear manner to coordinate neuronal migration and neurotransmission in the developing and mature brain...
  50. ncbi A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
    Riichi Shibata
    Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 278:36445-54. 2003
    ..2 hydrophobic domain. These studies point to an essential role for KChIPs in determining both the biophysical and molecular characteristics of Kv4 channels and provide a molecular basis for the dramatic phenotype of KChIP knockout mice...
  51. pmc Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1
    Peter Marschang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell Biol 24:3782-93. 2004
    ..Analysis of LRP1b knockout mice may provide further insights into the role of LRP1b as a tumor suppressor and into the mechanisms of cancer development...
  52. ncbi Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition
    Ype Elgersma
    Department of Neuroscience, Erasmus Medical Center, 3000 DR, Rotterdam, The Netherlands
    J Neurosci 24:8410-5. 2004
  53. ncbi Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons
    Xixi Chen
    Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 26:12143-51. 2006
    ..2 knock-out and wild-type neurons. Our results support the hypothesis that dendritic A-type K+ channels, composed of Kv4.2 subunits, regulate action potential backpropagation and the induction of specific forms of synaptic plasticity...
  54. doi Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function
    IVY S SAMUELS
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106 4928, USA
    J Neurosci 28:6983-95. 2008
    ..These findings demonstrate an important role for ERK2 in cellular proliferation and differentiation during neural development as well as in cognition and memory formation...
  55. doi Striatal histone modifications in models of levodopa-induced dyskinesia
    Anthony P Nicholas
    Center for Neurodegeneration and Experimental Therapeutics, Department of Neurology, University of Alabama at Birmingham, AL 35294 0017, USA
    J Neurochem 106:486-94. 2008
    ..However, both models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing LDID...
  56. pmc Altered protein synthesis is a trigger for long-term memory formation
    Eric Klann
    Center for Neural Science, New York University, New York, NY, USA
    Neurobiol Learn Mem 89:247-59. 2008
    ..We feel that a clear delineation of these three principles will assist in interpreting the available experimental data, and propose that the available data are consistent with a role for protein synthesis in memory...
  57. pmc Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory
    Farah D Lubin
    Department of Neurobiology, The Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 28:10576-86. 2008
    ..These results suggest epigenetic modification of the bdnf gene as a mechanism for isoform-specific gene readout during memory consolidation...
  58. pmc The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories
    Farah D Lubin
    The Evelyn F McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 55:942-57. 2007
    ..These data provide insights into IKK-regulated transcriptional mechanisms in hippocampus that are necessary for memory reconsolidation...
  59. ncbi Behavioural neuroscience: Down memory lane
    J David Sweatt
    Nature 447:151-2. 2007
  60. ncbi An atomic switch for memory
    J David Sweatt
    Department of Neurobiology and McKnight Brain Institute, University of Alabama Birmingham, Birmingham, AL 35294, USA
    Cell 129:23-4. 2007
    ..An excellent example of this is provided in this issue of Cell by Costa-Mattioli et al. (2007), whose results implicate a single protein dephosphorylation event in the control of long-term memory formation in mice...
  61. ncbi Covalent modification of DNA regulates memory formation
    Courtney A Miller
    Department of Neurobiology and the Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neuron 53:857-69. 2007
    ..These results demonstrate that DNA methylation is dynamically regulated in the adult nervous system and that this cellular mechanism is a crucial step in memory formation...
  62. ncbi Translating prions at the synapse
    Jonathan M Levenson
    Nat Cell Biol 6:184-7. 2004
  63. ncbi Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation
    Courtney A Miller
    Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Learn Mem 13:498-505. 2006
    ....
  64. pmc Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice
    Petra May
    Zentrum für Neurowissenschaften, University of Freiburg, Albertstrabetae 23, 79104 Freiburg, Germany
    Mol Cell Biol 24:8872-83. 2004
    ..Together, these findings suggest that LRP1, like other ApoE receptors, can modulate synaptic transmission in the brain...
  65. ncbi Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior
    Timothy J Hendricks
    Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    Neuron 37:233-47. 2003
    ..These findings indicate that Pet-1 is a critical determinant of 5-HT neuron identity and implicate a Pet-1-dependent program in serotonergic modulation of behavior...
  66. pmc DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity
    Courtney A Miller
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham, 1074 Shelby Building, 1825 University Boulevard, Birmingham, AL, USA
    Neurobiol Learn Mem 89:599-603. 2008
    ....