JOHN WILLIAM SWANN

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo
    Cynthia D Galvan
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannim St, MC 3 6365, Houston, TX 77030, USA
    Eur J Neurosci 18:1861-72. 2003
  2. ncbi request reprint Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system
    J W Swann
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Ment Retard Dev Disabil Res Rev 6:258-67. 2000
  3. ncbi request reprint Recent experimental studies of the effects of seizures on brain development
    John W Swann
    Cain Foundation Laboratories, Department of Pediatrics, Division of Neuroscience, Baylor College of Medicine, 6621 Fannin Street, MC3 6365, Houston, TX 77030, USA
    Prog Brain Res 135:391-3. 2002
  4. ncbi request reprint The effects of seizures on the connectivity and circuitry of the developing brain
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Ment Retard Dev Disabil Res Rev 10:96-100. 2004
  5. ncbi request reprint The impact of seizures on developing hippocampal networks
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannin Street, MC 3 6365, Houston, TX 77030, USA
    Prog Brain Res 147:347-54. 2005
  6. ncbi request reprint The impact of chronic network hyperexcitability on developing glutamatergic synapses
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Houston, TX 77030, USA
    Eur J Neurosci 26:975-91. 2007
  7. ncbi request reprint Recurrent seizures and the molecular maturation of hippocampal and neocortical glutamatergic synapses
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Neurosci 29:168-78. 2007
  8. ncbi request reprint A new animal model of infantile spasms with unprovoked persistent seizures
    Chong L Lee
    The Cain Foundation Laboratories, and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Epilepsia 49:298-307. 2008
  9. ncbi request reprint Distally directed dendrotoxicity induced by kainic Acid in hippocampal interneurons of green fluorescent protein-expressing transgenic mice
    Anthony A Oliva
    The Cain Foundation Laboratories, Division of Neuroscience, and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:8052-62. 2002
  10. pmc Effects of chronic network hyperexcitability on the growth of hippocampal dendrites
    Masataka Nishimura
    The Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Neurobiol Dis 29:267-77. 2008

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo
    Cynthia D Galvan
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannim St, MC 3 6365, Houston, TX 77030, USA
    Eur J Neurosci 18:1861-72. 2003
    ..Postsynaptic changes are likely to be the major contributors to the hippocampal network hyperexcitability and should enhance both excitatory synaptic efficacy and plasticity...
  2. ncbi request reprint Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system
    J W Swann
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Ment Retard Dev Disabil Res Rev 6:258-67. 2000
    ..In experimental cortical dysplasia, alterations in the molecular composition of postsynaptic receptor are observed that favor subunit combinations characteristic of infancy...
  3. ncbi request reprint Recent experimental studies of the effects of seizures on brain development
    John W Swann
    Cain Foundation Laboratories, Department of Pediatrics, Division of Neuroscience, Baylor College of Medicine, 6621 Fannin Street, MC3 6365, Houston, TX 77030, USA
    Prog Brain Res 135:391-3. 2002
    ..However, the creation of new animal models is altering this view. This chapter briefly summarizes these new findings and suggests avenues for future study...
  4. ncbi request reprint The effects of seizures on the connectivity and circuitry of the developing brain
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Ment Retard Dev Disabil Res Rev 10:96-100. 2004
    ....
  5. ncbi request reprint The impact of seizures on developing hippocampal networks
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics and Division of Neuroscience, Baylor College of Medicine, 6621 Fannin Street, MC 3 6365, Houston, TX 77030, USA
    Prog Brain Res 147:347-54. 2005
  6. ncbi request reprint The impact of chronic network hyperexcitability on developing glutamatergic synapses
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Houston, TX 77030, USA
    Eur J Neurosci 26:975-91. 2007
    ....
  7. ncbi request reprint Recurrent seizures and the molecular maturation of hippocampal and neocortical glutamatergic synapses
    John W Swann
    The Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Neurosci 29:168-78. 2007
    ....
  8. ncbi request reprint A new animal model of infantile spasms with unprovoked persistent seizures
    Chong L Lee
    The Cain Foundation Laboratories, and Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Epilepsia 49:298-307. 2008
    ..Progress toward understanding the pathophysiology of this disorder and the development of effective therapies has been hindered by the lack of a relevant animal model. We report here the creation of such a model...
  9. ncbi request reprint Distally directed dendrotoxicity induced by kainic Acid in hippocampal interneurons of green fluorescent protein-expressing transgenic mice
    Anthony A Oliva
    The Cain Foundation Laboratories, Division of Neuroscience, and Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 22:8052-62. 2002
    ..The discovery of this phenomenon will likely be important in understanding interneuronal dysfunction following excitotoxic injury...
  10. pmc Effects of chronic network hyperexcitability on the growth of hippocampal dendrites
    Masataka Nishimura
    The Cain Foundation Laboratories, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Neurobiol Dis 29:267-77. 2008
    ..Taken together, our results suggest that chronic hippocampal network hyperexcitability limits dendritic growth...
  11. ncbi request reprint Abnormal laminar position and dendrite development of interneurons in the reeler forebrain
    Odessa Yabut
    The Cain Foundation Laboratories, Texas Children s Hospital, Baylor College of Medicine, Houston, TX 77030, USA
    Brain Res 1140:75-83. 2007
    ..Thus, the lack of Reelin signaling results in abnormal positioning and altered morphology of forebrain interneurons...
  12. ncbi request reprint Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia
    M Cecilia Ljungberg
    Cain Foundation Laboratories, Texas Children s Hospital, Houston, TX, USA
    Ann Neurol 60:420-9. 2006
    ....
  13. ncbi request reprint Models of pediatric epilepsies: strategies and opportunities
    Carl E Stafstrom
    University of Wisconsin, USA
    Epilepsia 47:1407-14. 2006

Research Grants36

  1. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 2007
    ..By identifying these pathways, novel therapies may eventually be developed to prevent NMDA receptor downregulation and hopefully prevent the learning deficits produced by recurring seizures in infancy. ..
  2. Multidisciplinary Training in Brain Disorders and Development
    John Swann; Fiscal Year: 2007
    ..By training outstanding research scientists, we feel new understandings and treatments for the devastating developmental disorders in infants and young children will emerge. ..
  3. DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSY
    John Swann; Fiscal Year: 2007
    ..Since there are so few animal models of early-onset epilepsy, the studies proposed here offer a unique opportunity to further an understanding of the biological origins of seizure disorders in infancy. ..
  4. IONIC HOMEOSTASIS AND SEIZURE REGULATION
    John Swann; Fiscal Year: 2009
    ..This hypothesis will be directly tested by measuring changes in intracellular calcium in glial cells and neurons during stimulus trains in hippocampal slices while measuring extracellular calcium. ..
  5. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    JOHN WILLIAM SWANN; Fiscal Year: 2010
    ..Results suggest that developing neurons grow abnormally slow after seizures. We are studying why this happens so therapies can be developed to prevent learning disabilities. ..
  6. IMMATURE HIPPOCAMPUS--EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 1999
    ....
  7. IMMATURE HIPPOCAMPUS--EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 1993
    ....
  8. IMMATURE HIPPOCAMPUS--EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 1992
    ..Experiments will further test the hypothesis that the sustained depolarization of seizure-like discharges is a separate physiologic process and that it is synaptically mediated...
  9. DEVELOPMENTAL PLASTICITY AND CHRONIC EPILEPSY
    John Swann; Fiscal Year: 2002
    ..Other experiments will attempt to prevent the development of epilepsy by chronically treating rats with NMDA receptor antagonists. ..
  10. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 2003
    ..The newly created GAD-EGFP transgenic mouse that selectively expresses EGFP in a subset of hippocampal inhibitory interneurons will be an important experimental tool in these studies. ..
  11. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    John Swann; Fiscal Year: 2009
    ..Results suggest that developing neurons grow abnormally slow after seizures. We are studying why this happens so therapies can be developed to prevent learning disabilities. ..