A C Swann

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. doi Does a rat's exposure to cocaine during adolescence affect its response to cocaine in adulthood?
    Lindsey N King
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA
    Int J Neurosci 119:879-907. 2009
  2. pmc Norepinephrine and impulsivity: effects of acute yohimbine
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1941 East Road, Room 3216, Houston, TX 77054, USA
    Psychopharmacology (Berl) 229:83-94. 2013
  3. doi Activated depression: mixed bipolar disorder or agitated unipolar depression?
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1941 East Road, Room 3216, Houston, TX 77054, USA
    Curr Psychiatry Rep 15:376. 2013
  4. pmc Antisocial personality disorder and borderline symptoms are differentially related to impulsivity and course of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX, USA
    J Affect Disord 148:384-90. 2013
  5. doi Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA
    Am J Psychiatry 170:31-42. 2013
  6. doi Multivariate analysis of bipolar mania: retrospectively assessed structure of bipolar I manic and mixed episodes in randomized clinical trial participants
    Alan C Swann
    University of Texas, Houston Health Science Center, Houston, TX, USA
    J Affect Disord 144:59-64. 2013
  7. pmc Impulsivity: differential relationship to depression and mania in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center Houston, Texas 77030, USA
    J Affect Disord 106:241-8. 2008
  8. ncbi Neuroreceptor mechanisms of aggression and its treatment
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School, Houston, TX 77030, USA
    J Clin Psychiatry 64:26-35. 2003
  9. ncbi Impulsivity and phase of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Mental Sciences Institute, University of Texas Health Science Center, Houston, TX, USA
    J Affect Disord 73:105-11. 2003
  10. pmc Increased trait-like impulsivity and course of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    Bipolar Disord 11:280-8. 2009

Research Grants

  1. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2005
  2. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2006
  3. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2007
  4. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2008
  5. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2009

Collaborators

Detail Information

Publications100

  1. doi Does a rat's exposure to cocaine during adolescence affect its response to cocaine in adulthood?
    Lindsey N King
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, TX 77225, USA
    Int J Neurosci 119:879-907. 2009
    ..5 mg/kg cocaine and failed to respond significantly to the 15 mg/kg cocaine dose. The results of this study indicate that chronic cocaine exposure during adolescence alters the same rats' responses to cocaine during their adulthood...
  2. pmc Norepinephrine and impulsivity: effects of acute yohimbine
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1941 East Road, Room 3216, Houston, TX 77054, USA
    Psychopharmacology (Berl) 229:83-94. 2013
    ..Rapid-response impulsivity, characterized by inability to withhold response to a stimulus until it is adequately appraised, is associated with risky behavior and may be increased in a state-dependent manner by norepinephrine...
  3. doi Activated depression: mixed bipolar disorder or agitated unipolar depression?
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1941 East Road, Room 3216, Houston, TX 77054, USA
    Curr Psychiatry Rep 15:376. 2013
    ....
  4. pmc Antisocial personality disorder and borderline symptoms are differentially related to impulsivity and course of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX, USA
    J Affect Disord 148:384-90. 2013
    ..We investigated relationships among antisocial personality disorder (ASPD) or borderline personality disorder symptoms, impulsivity, and course of illness in bipolar disorder...
  5. doi Bipolar mixed states: an international society for bipolar disorders task force report of symptom structure, course of illness, and diagnosis
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, USA
    Am J Psychiatry 170:31-42. 2013
    ..However, definitions of mixed states, especially those with prominent depression, are not well established...
  6. doi Multivariate analysis of bipolar mania: retrospectively assessed structure of bipolar I manic and mixed episodes in randomized clinical trial participants
    Alan C Swann
    University of Texas, Houston Health Science Center, Houston, TX, USA
    J Affect Disord 144:59-64. 2013
    ..Mixed states may differ in important clinical characteristics from other manic episodes. However, it has not been established whether mixed states are a distinct type of episodes, or a common basic structure exists across manic episodes...
  7. pmc Impulsivity: differential relationship to depression and mania in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences University of Texas Health Science Center Houston, Texas 77030, USA
    J Affect Disord 106:241-8. 2008
    ..Impulsivity is a complex construct, and it may be related differently to depression and to mania...
  8. ncbi Neuroreceptor mechanisms of aggression and its treatment
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School, Houston, TX 77030, USA
    J Clin Psychiatry 64:26-35. 2003
    ..Drugs acting on nicotine receptors may deserve further attention. Nonpharmacologic measures include behavioral techniques aimed at reducing impulsivity, relapse prevention techniques for substance abuse, and anger management techniques...
  9. ncbi Impulsivity and phase of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Mental Sciences Institute, University of Texas Health Science Center, Houston, TX, USA
    J Affect Disord 73:105-11. 2003
    ..Impulsivity is prominent in bipolar disorder, but there is little quantitative information relating it to phase of illness...
  10. pmc Increased trait-like impulsivity and course of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    Bipolar Disord 11:280-8. 2009
    ..We have investigated relationships between trait-like impulsivity, measured by the Barratt Impulsiveness Scale (BIS-11), and demographic and illness-course characteristics of bipolar disorder...
  11. pmc Severity of bipolar disorder is associated with impairment of response inhibition
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030, USA
    J Affect Disord 116:30-6. 2009
    ..We measured two complementary aspects of response inhibition: attention-based and reward-based...
  12. pmc Interacting mechanisms of impulsivity in bipolar disorder and antisocial personality disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, BBSB, 1941 East Road, Room 3216, Houston, TX 77054, USA
    J Psychiatr Res 45:1477-82. 2011
    ..Impulsivity is prominent in both, but there is little information on how specific mechanisms of impulsivity differentiate, bridge, or underlie the disorders...
  13. ncbi Long-term treatment in bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School, Houston, TX 77030, USA
    J Clin Psychiatry 66:7-12. 2005
    ..Successful long-term treatment of bipolar disorder requires integrated pharmacologic and nonpharmacologic treatments combined with a therapeutic alliance that facilitates a proactive, preventive approach to the illness...
  14. ncbi Acute yohimbine increases laboratory-measured impulsivity in normal subjects
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas 77030, USA
    Biol Psychiatry 57:1209-11. 2005
    ....
  15. ncbi Impulsivity in mania
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    Curr Psychiatry Rep 11:481-7. 2009
    ..Manic episodes must be viewed in the context of the life course of bipolar disorder...
  16. doi The strong relationship between bipolar and substance-use disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Ann N Y Acad Sci 1187:276-93. 2010
    ..Studies of potential treatments for bipolar substance-use disorder have paid scant attention to the combined disorders. The most promising treatment strategies are those that address their shared mechanisms...
  17. ncbi Mechanisms of impulsivity in bipolar disorder and related illness
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, 1300 Moursund Street, Room 270, Houston, Texas 77030, USA
    Epidemiol Psichiatr Soc 19:120-30. 2010
    ..This paper reviews studies integrating behavioral and physiological mechanisms in impulsivity and their role in severity and course of bipolar and related disorders...
  18. ncbi Psychosis in mania: specificity of its role in severity and treatment response
    Alan C Swann
    University of Texas Medical School, Houston 77030, USA
    J Clin Psychiatry 65:825-9. 2004
    ..Psychosis is a prominent characteristic of manic episodes. We investigated relationships between the presence of psychotic features, the severity of the manic syndrome, and syndrome severity's response to treatment...
  19. pmc Manic symptoms and impulsivity during bipolar depressive episodes
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX 77030, USA
    Bipolar Disord 9:206-12. 2007
    ..Therefore, we investigated the prevalence of manic symptoms and their relationships to impulsivity and clinical characteristics in patients with bipolar depressive episodes...
  20. ncbi Impulsivity: a link between bipolar disorder and substance abuse
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, Mental Sciences Institute, Harris County Psychiatric Hospital, University of Texas Health Science Center, Houston, 77030, USA
    Bipolar Disord 6:204-12. 2004
    ..Substance abuse is present in most patients with bipolar disorder and associated with poor treatment outcome and increased risk of suicide. Increased impulsivity may be a link between bipolar disorder and substance abuse...
  21. pmc Criminal conviction, impulsivity, and course of illness in bipolar disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1941 East Road, Houston, TX 77054, USA
    Bipolar Disord 13:173-81. 2011
    ..We investigated relationships among impulsivity, antisocial personality disorder (ASPD) or borderline personality disorder symptoms, substance use disorder, course of illness, and history of criminal behavior in bipolar disorder...
  22. ncbi Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School at Houston, 1300 Moursund, Rm 270, Houston, TX 77030, USA
    Am J Psychiatry 162:1680-7. 2005
    ..The purpose of this study was to investigate the relationship between impulsivity and severity of past suicidal behavior, a potential predictor of eventual suicide, in patients with bipolar disorder...
  23. pmc Trait impulsivity and response inhibition in antisocial personality disorder
    Alan C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    J Psychiatr Res 43:1057-63. 2009
    ..We investigated these models in terms of the diagnosis and severity of antisocial personality disorder...
  24. ncbi Measurement of inter-episode impulsivity in bipolar disorder
    A C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, 77030, USA
    Psychiatry Res 101:195-7. 2001
    ..Laboratory measurements of impulsivity correlated with a BIS-11 score or severity of manic symptoms. Impulsivity in bipolar disorder may have both stable and state-dependent aspects...
  25. pmc Interactions between bipolar disorder and antisocial personality disorder in trait impulsivity and severity of illness
    A C Swann
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center, Houston, TX 77030, USA
    Acta Psychiatr Scand 121:453-61. 2010
    ..We investigated trait impulsivity in bipolar disorder and antisocial personality disorder (ASPD) with respect to severity and course of illness...
  26. ncbi Major system toxicities and side effects of anticonvulsants
    A C Swann
    Department of Psychiatry, University of Texas Medical School at Houston, 77030, USA
    J Clin Psychiatry 62:16-21. 2001
    ..In general, anticonvulsants are well tolerated and their effectiveness greatly outweighs risk or annoyance from side effects, but side effects must be kept in mind when choosing and monitoring treatment...
  27. ncbi Structure of mania: depressive, irritable, and psychotic clusters with different retrospectively-assessed course patterns of illness in randomized clinical trial participants
    A C Swann
    Department of Psychiatry, University of Texas Houston Health Science Center, 1300 Moursund Street, Room 270, Houston, TX 77030, USA
    J Affect Disord 67:123-32. 2001
    ..We investigated the structure of manic episodes by determining whether there was evidence for distinct groups of patients differing in clinical characteristics and course of illness...
  28. ncbi Psychiatric aspects of impulsivity
    F G Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, 77030, USA
    Am J Psychiatry 158:1783-93. 2001
    ..The authors discuss the relationship of impulsivity to psychiatric disorders and present selected hypotheses regarding the reasons for these relationships...
  29. ncbi A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group
    C L Bowden
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78284 7792, USA
    Arch Gen Psychiatry 57:481-9. 2000
    ..This study compared the efficacy of divalproex, lithium, and placebo as prophylactic therapy...
  30. pmc Descending glutamatergic pathways of PFC are involved in acute and chronic action of methylphenidate
    S J Wanchoo
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, The University of Texas Health Science Center, Houston, USA
    Brain Res 1301:68-79. 2009
    ....
  31. ncbi Mania: gender, transmitter function, and response to treatment
    A C Swann
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, 77030, USA
    Psychiatry Res 88:55-61. 1999
    ..These data suggest that GABA and norepinephrine may be related to different aspects of the manic state and to its pharmacologic sensitivity...
  32. ncbi Endogenous plasma testosterone levels and commission errors in women: A preliminary report
    J M Bjork
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas-Houston Medical School, 1300 Moursund, Houston, TX 77030, USA
    Physiol Behav 73:217-21. 2001
    ..In light of the fact previous studies find commission errors on the CPT are associated with impulsivity, the results of this study support a positive relationship between testosterone and impulsivity...
  33. ncbi Laboratory measures of aggression and impulsivity in women with borderline personality disorder
    D M Dougherty
    Department of Psychiatry and Behavioral Sciences, Harris County Psychiatric Center, University of Texas, Houston 77030, USA
    Psychiatry Res 85:315-26. 1999
    ..Aggressive responding rates correlated positively with BDHI scores. These results extend previous findings that negative affect in women is reflected in laboratory behavioral measures...
  34. ncbi The Brief Psychiatric Rating Scale as an acute inpatient outcome measurement tool: a pilot study
    R V Varner
    Department of Psychiatry and Behavioral Sciences, The University of Texas Medical School, Houston, USA
    J Clin Psychiatry 61:418-21. 2000
    ..This study examines the utility of the Brief Psychiatric Rating Scale (BPRS) as such a tool...
  35. ncbi Thyroid hormone and norepinephrine: effects on alpha-2, beta, and reuptake sites in cerebral cortex and heart
    A C Swann
    Department of Psychiatry, University of Texas Medical School, Houston
    J Neural Transm 71:195-205. 1988
    ..Heart was more sensitive than brain to these effects. These data are consistent with reduced noradrenergic activity during hyperthyroidism, possibly mediated by an increase in autoreceptor function...
  36. ncbi Generalized anxiety disorder in older adults: examining the relation between clinician severity ratings and patient self-report measures
    D R Hopko
    University of Texas Medical Center, Mental Sciences Institute, 1300 Moursund Avenue, Houston, TX 77030 3497, USA
    Depress Anxiety 12:217-25. 2000
    ..Specifically, the BDI and the PSWQ are identified as particularly useful screening instruments that may be helpful in conceptualizing GAD severity within an older adult population...
  37. ncbi Impact of trait impulsivity and state aggression on divalproex versus placebo response in borderline personality disorder
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, 1 Gustave L Levy Place, Box 1230, New York, NY 10029 6574, USA
    Am J Psychiatry 162:621-4. 2005
    ....
  38. ncbi A randomized, placebo-controlled, multicenter study of divalproex sodium extended release in the treatment of acute mania
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, San Antonio 78284 7792, USA
    J Clin Psychiatry 67:1501-10. 2006
    ..The efficacy and safety of divalproex sodium extended release (divalproex ER) were evaluated in patients hospitalized for acute mania associated with bipolar I disorder, manic or mixed type (DSM-IV-TR criteria)...
  39. ncbi Pattern of response to divalproex, lithium, or placebo in four naturalistic subtypes of mania
    Alan C Swann
    University of Texas Houston Health Science Center, P O Box 20708, Houston, TX 77225, USA
    Neuropsychopharmacology 26:530-6. 2002
    ..These data suggest that there are naturalistic subtypes of manic episodes with different responses to treatment...
  40. ncbi Ipsapirone neuroendocrine challenge: relationship to aggression as measured in the human laboratory
    F G Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, 77030, USA
    Psychiatry Res 81:31-8. 1998
    ..This study supports a relationship between serotonin function and aggression as measured in the human laboratory, similar to the well-documented association between self-reported aggression and serotonin...
  41. ncbi Subacute noradrenergic agonist infusions in vivo increase Na+, K+-ATPase and ouabain binding in rat cerebral cortex
    A C Swann
    Department of Psychiatry, University of Texas Medical School, Houston 77225
    J Neurochem 52:1598-604. 1989
    ..These results suggest that stimulation of both alpha 1- and beta-noradrenergic receptors may be necessary for optimal Na+, K+-ATPase, and that clonidine reduces Na+, K+-ATPase indirectly through decreased norepinephrine release...
  42. ncbi The impact of impulsivity on cocaine use and retention in treatment
    F G Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, Houston, TX 77030, USA
    J Subst Abuse Treat 21:193-8. 2001
    ..This study shows that impulsivity is a significant predictor of cocaine use and treatment retention, and suggests the need for targeting impulsivity in cocaine dependence treatment...
  43. ncbi Low dose zolmitriptan as a 5-HT neuroendocrine challenge agent in humans
    F G Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Houston Health Science Center, Houston 77030, USA
    Psychoneuroendocrinology 25:607-18. 2000
    ..The neuroendocrine effects of 2.5 mg of orally administered zolmitriptan are similar to previously reported effects of sumatriptan, with minimal side effects...
  44. ncbi Psychostimulant treatment for ADHD is modulated by prefrontal cortex manipulation
    A Tang
    Department of Neurobiology, University of Texas Medical School at Houston, Houston, TX, United States
    Brain Res Bull 80:353-8. 2009
    ..The results suggest that PFC lesion enhance the acute effects of amphetamine on locomotor activity and is required for development of behavior sensitization...
  45. ncbi Maintenance efficacy of divalproex in the prevention of bipolar depression
    Laszlo Gyulai
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1374-82. 2003
    ....
  46. ncbi Noradrenaline and thyroid function regulate (Na+,K+)-adenosine triphosphatase independently in vivo
    A C Swann
    Department of Psychiatry, University of Texas Medical School, Houston 77225
    Eur J Pharmacol 169:275-83. 1989
    ..These results show that noradrenaline and thyroid hormone regulate (Na+,K+)-ATPase by largely independent mechanisms, and may regulate different populations of enzyme molecules...
  47. ncbi The influence of menstrual-cycle phase on the relationship between testosterone and aggression
    D M Dougherty
    Department of Psychiatry and Behavioral Sciences, The University of Texas, Houston 77030, USA
    Physiol Behav 62:431-5. 1997
    ..self-report of perimenstrual symptomatology is a more consistent predictor of aggressive behavior across the menstrual cycle than plasma testosterone; and 3. perimenstrual emotional symptomatology is not related to testosterone levels...
  48. ncbi Evaluation of heterogeneity in pharmacotherapy trials for drug dependence: a Bayesian approach
    C E Green
    Center for Clinical Research and Evidence Based Medicine, University of Texas, Houston, 77030, USA
    Am J Drug Alcohol Abuse 35:95-102. 2009
    ..Well-attested methodological difficulties associated with these analyses recommend the use of Bayesian statistical reasoning for evaluation of salient interaction effects...
  49. ncbi Relationship of mania symptomatology to maintenance treatment response with divalproex, lithium, or placebo
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuropsychopharmacology 30:1932-9. 2005
    ..Dysphoric mania appeared to predispose patients to more side effects when treated with either divalproex or lithium during maintenance therapy...
  50. pmc A randomized, double-blind, placebo-controlled pilot study of naltrexone in outpatients with bipolar disorder and alcohol dependence
    E Sherwood Brown
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Alcohol Clin Exp Res 33:1863-9. 2009
    ..In this pilot study, the efficacy of naltrexone in reducing alcohol use and on mood symptoms was assessed in bipolar disorder and alcohol dependence...
  51. pmc A pilot study revealing impaired P50 gating in antisocial personality disorder
    Marijn Lijffijt
    Department of Psychiatry and Behavioral Sciences, University of Texas, Houston, USA
    J Neuropsychiatry Clin Neurosci 21:328-31. 2009
    ..Relative to 15 comparison subjects, gating was impaired in ASPD, suggesting abnormal pre-attentive filtering in pathological impulsivity...
  52. ncbi Sensory-evoked potentials recordings from the ventral tegmental area, nucleus accumbens, prefrontal cortex, and caudate nucleus and locomotor activity are modulated in dose-response characteristics by methylphenidate
    Pamela B Yang
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225, USA
    Brain Res 1073:164-74. 2006
    ..e., as MPD dose increased, evoked sensory inputs decreased. These opposite effects (motor activation and sensory input suppression) were further discussed...
  53. pmc P50, N100, and P200 sensory gating: relationships with behavioral inhibition, attention, and working memory
    Marijn Lijffijt
    Department of Psychiatry and Behavioral Sciences, University of Texas at Houston, Houston, Texas 77030, USA
    Psychophysiology 46:1059-68. 2009
    ..These findings suggest that P50, N100, and P200 gating could be involved in protecting cognition by affecting response bias, behavioral inhibition, working memory, or attention...
  54. pmc Diminished P50, N100 and P200 auditory sensory gating in bipolar I disorder
    Marijn Lijffijt
    Department of Psychiatry and Behavioral Sciences, Mental Sciences Institute, University of Texas, Houston, TX 77030, USA
    Psychiatry Res 167:191-201. 2009
    ..These findings extend the existing evidence on impaired sensory gating in bipolar I disorder beyond the P50, suggesting impaired filtering at both pre-attentive and early attentive levels in bipolar I disorder...
  55. ncbi MDMA (ecstasy) modulates locomotor and prefrontal cortex sensory evoked activity
    Kristal Atkins
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, Houston, TX 77225, USA
    Brain Res 1302:175-82. 2009
    ....
  56. ncbi Diffusion tensor imaging in MDMA users and controls: association with decision making
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 33:777-89. 2007
    ..There was a significant positive correlation between lambda(1) in the rostral body of the corpus callosum and advantageous choices on the IGT. Further research on the etiology of these findings is warranted...
  57. ncbi Diffusion tensor imaging eigenvalues: preliminary evidence for altered myelin in cocaine dependence
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
    Psychiatry Res 154:253-8. 2007
    ....
  58. ncbi Citalopram combined with behavioral therapy reduces cocaine use: a double-blind, placebo-controlled trial
    F Gerard Moeller
    Department of Psychiatry and Behavioral Science, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Am J Drug Alcohol Abuse 33:367-78. 2007
    ..Results of this study support further examination of citalopram in combination with behavioral therapy as a treatment for cocaine dependence...
  59. ncbi Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, 1300 Moursund, Houston, TX 77030, USA
    Drug Alcohol Depend 68:105-11. 2002
    ..This study supports the hypothesis that the increased impulsivity as measured by the BIS-11 in cocaine dependent individuals is not exclusively due to concomitant increases in aggression or ASPD...
  60. ncbi Familial transmission of Continuous Performance Test behavior: attentional and impulsive response characteristics
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030, USA
    J Gen Psychol 130:5-21. 2003
    ..e., BIS) was correlated with commission errors for parents, but not for adolescents. The findings of this study support the use of an objective behavioral measure of impulsivity to assess familial relationships of impulsivity...
  61. ncbi Cognitive-behavioral treatment of late-life generalized anxiety disorder
    Melinda A Stanley
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 77030, USA
    J Consult Clin Psychol 71:309-19. 2003
    ..Most gains for patients in CBT were maintained or enhanced over 1-year follow-up. However, posttreatment scores for patients in CBT failed to indicate return to normative functioning...
  62. ncbi Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 28:1186-97. 2003
    ....
  63. ncbi Two models of impulsivity: relationship to personality traits and psychopathology
    Alan C Swann
    Department of Psychiatry, University of Texas Medical School, Houston, Texas, USA
    Biol Psychiatry 51:988-94. 2002
    ....
  64. ncbi Behavioral impulsivity paradigms: a comparison in hospitalized adolescents with disruptive behavior disorders
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 77030 3406, USA
    J Child Psychol Psychiatry 44:1145-57. 2003
    ..As a result, comparisons between measures are difficult, with little consensus regarding which method may be most sensitive to individual impulsivity differences of different populations...
  65. ncbi P300 event-related potential amplitude and impulsivity in cocaine-dependent subjects
    F Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center Houston, Moursund, Houston, Texas, USA
    Neuropsychobiology 50:167-73. 2004
    ..This study supports the hypothesis that the basic neurophysiology responsible for the P300 amplitude in cocaine-dependent individuals is associated with impulsivity independent of a history of childhood conduct disorder symptoms...
  66. pmc Relationship between impulsivity and decision making in cocaine dependence
    Kimberly L Kjome
    Department of Psychiatry and Behavioral Science, University of Texas Health Science Center at Houston, TX, USA
    Psychiatry Res 178:299-304. 2010
    ..These results suggest that in cocaine-dependent subjects there is little overlap between decision making as measured by the IGT and impulsivity/behavioural inhibition as measured by the BIS and IMT...
  67. ncbi Measures of self-efficacy and optimism in older adults with generalized anxiety
    Melinda A Stanley
    University of Texas Houston Medical School, 77030, USA
    Assessment 9:70-81. 2002
    ....
  68. ncbi Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging
    Frederick Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Neuropsychopharmacology 30:610-7. 2005
    ....
  69. pmc Baseline neurocognitive profiles differentiate abstainers and non-abstainers in a cocaine clinical trial
    Joy M Schmitz
    University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Addict Dis 28:250-7. 2009
    ..Neurocognitive profiles may be useful in understanding population heterogeneity and predicting differential outcomes in subgroups of cocaine abusers...
  70. ncbi Extended-release carbamazepine capsules as monotherapy for acute mania in bipolar disorder: a multicenter, randomized, double-blind, placebo-controlled trial
    Richard H Weisler
    Department of Psychiatry and Behavioral Sciences, Duke University, 700 Spring Forest, Suite 125, Raleigh, NC 27609, USA
    J Clin Psychiatry 66:323-30. 2005
    ..In the present study, we further evaluated the efficacy and safety of monotherapy with beaded, extended-release carbamazepine capsules (ERC-CBZ) in patients with bipolar I disorder experiencing manic or mixed episodes...
  71. ncbi The Texas implementation of medication algorithms: update to the algorithms for treatment of bipolar I disorder
    Trisha Suppes
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9121, USA
    J Clin Psychiatry 66:870-86. 2005
    ..The guidelines for evaluating possible medications, the criteria for selection and ranking, and the updated algorithms are described...
  72. ncbi Texas Medication Algorithm Project: development and feasibility testing of a treatment algorithm for patients with bipolar disorder
    T Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
    J Clin Psychiatry 62:439-47. 2001
    ....
  73. pmc Bilateral six-hydroxydopamine administration to PFC prevents the expression of behavioral sensitization to methylphenidate
    S J Wanchoo
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, Houston, TX, USA
    Brain Res 1312:89-100. 2010
    ..It was found that the 6-OHDA lesion group failed to exhibit behavioral sensitization to MPD. The involvement of the dopaminergic afferents of PFC in behavioral sensitization to MPD is discussed...
  74. ncbi Serotonin 2a receptor T102C polymorphism and impaired impulse control
    James M Bjork
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, University of Texas Houston Medical School, Houston, Texas 77030, USA
    Am J Med Genet 114:336-9. 2002
    ..These preliminary data suggest that the T102C 5-HT2a receptor polymorphism may be a marker for impaired behavior control-perhaps in the context of psychiatric disorder history...
  75. ncbi Chronic methylphenidate modulates locomotor activity and sensory evoked responses in the VTA and NAc of freely behaving rats
    Pamela B Yang
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, Houston, TX 77225, USA
    Neuropharmacology 51:546-56. 2006
    ..Such further attenuation can be interpreted as electrophysiological sensitization...
  76. ncbi A multivantaged behavioural method for measuring onset and sequence of the clinical actions of antidepressants
    Martin M Katz
    Department of Psychiatry, University of Texas Health Science Center, San Antonio, TX, USA
    Int J Neuropsychopharmacol 7:471-9. 2004
    ..Thus, the Brief MV, in uncovering underlying behavioural actions, represents an important addition to the current unidimensional HAMD approach in drug research...
  77. ncbi Suicidal behaviors and drug abuse: impulsivity and its assessment
    Donald M Dougherty
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
    Drug Alcohol Depend 76:S93-S105. 2004
    ..To better account for influence of impulsivity in these psychiatric disturbances, no single source of measurement should be used without the consideration of other types of instruments...
  78. ncbi [Prediction of treatment response in acute mania: controlled clinical trials with divalproex]
    A C Swann
    University of Texas, Houston Medical Scholl, USA
    Encephale 27:277-9. 2001
    ..CONCLUSION: Specific features of the disease history and of the semiology of individual episodes help predict therapeutic response to mood stabilisers...
  79. ncbi Impulsivity and BOLD fMRI activation in MDMA users and healthy control subjects
    Ignacio H Valdes
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund, Houston, TX 77030, USA
    Psychiatry Res 147:239-42. 2006
    ..A significant correlation between BIS scores and DLPFC activation was found, supporting a role for the DLPFC in BIS-measured impulsivity...
  80. ncbi Strain differences in the behavioral responses of male rats to chronically administered methylphenidate
    Pamela B Yang
    Department of Neurobiology and Anatomy, The University of Texas Houston Medical School, PO Box 20708, Houston, TX 77225, USA
    Brain Res 971:139-52. 2003
    ..In conclusion, rat strains play a significant role in the response to acute and chronic administration of MPD...
  81. ncbi Development of ethanol tolerance not altered by 6-OHDA lesions of dorsal bundle
    J D Steketee
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston
    Pharmacol Biochem Behav 33:729-31. 1989
    ..0005) shorter sleeptimes after ETOH diet. Our data suggest that destruction of the DB does not alter development of ETOH tolerance as measured by the sleeptime test...
  82. doi Adolescent and adult male spontaneous hyperactive rats (SHR) respond differently to acute and chronic methylphenidate (Ritalin)
    Elyssa Barron
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, Houston, TX 77225, USA
    Int J Neurosci 119:40-58. 2009
    ..6 mg/kg dose of MPD failed to cause sensitization in the adolescent group but caused sensitization in the adult group, while the 2.5 and 10 mg/kg both caused sensitization in the adolescent and adult groups...
  83. ncbi Valproate prevents the induction and the expression of MK-801 sensitization
    Pamela B Yang
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, PO Box 20708, Houston, TX 77225, USA
    Brain Res 954:151-9. 2002
    ..Results of their locomotor responses demonstrated that valproate disrupted the development/induction and the expression of sensitization to MK-801, as it did to methylphenidate...
  84. ncbi Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine
    Pamela B Yang
    Department of Neurobiology and Anatomy, The University of Texas Houston Medical School, PO Box 20708, Houston, TX 77225, USA
    Life Sci 73:2899-911. 2003
    ..e., whether subjects were juvenile or adult rats when they received drugs, but rather it depended on the behavioral index examined...
  85. ncbi Differential locomotor responses in male rats from three strains to acute methylphenidate
    Behrang Amini
    Department of Neurobiology and Anatomy, University of Texas Medical School at Houston, University of Texas Graduate School of Biomedical Sciences, Houston, Texas, USA
    Int J Neurosci 114:1063-84. 2004
    ..In conclusion, the dose-response experiment on the acute effects of MPD demonstrated that there are genetic differences in the responses to MPD...
  86. ncbi Zolmitriptan and human aggression: interaction with alcohol
    Joshua L Gowin
    Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center Houston, Houston, TX, USA
    Psychopharmacology (Berl) 210:521-31. 2010
    ..The 5-HT1(B/D) agonist zolmitriptan's ability to reduce aggressive behavior in humans and its interaction with the well-known aggression-enhancing drug alcohol were examined...
  87. ncbi Laboratory-measured aggressive behavior of women: acute tryptophan depletion and augmentation
    Dawn M Marsh
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77030, USA
    Neuropsychopharmacology 26:660-71. 2002
    ..These findings indicate that both T+ and T- can influence aggressive behavior and that certain subgroups of women may be more susceptible to serotonin manipulation...
  88. doi Prolonged methylphenidate treatment alters the behavioral diurnal activity pattern of adult male Sprague-Dawley rats
    Mohamed F Algahim
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    Pharmacol Biochem Behav 92:93-9. 2009
    ..0 mg/kg MPD group exhibited changes during the washout and re-challenge periods (p<0.01, p<0.001), respectively. In conclusion, prolonged administration of MPD modulated the diurnal HA pattern in a dose-dependent manner...
  89. ncbi Disruption of sensitization to methylphenidate by a single administration of MK-801
    Osvaldo Gaytan
    Department of Neurobiology and Anatomy, The University of Texas Health Science Center at Houston, 77030, USA
    Life Sci 70:2271-85. 2002
    ..In conclusion, a single injection of MK-801 persistently blocks the development of sensitization to methylphenidate only if it is given with methylphenidate on the first day of the repetitive treatment phase...
  90. ncbi Report of the Texas Consensus Conference Panel on medication treatment of bipolar disorder 2000
    Trisha Suppes
    Department of Psychiatry The University of Texas Southwestern Medical Center Dallas, 75390 9070, USA
    J Clin Psychiatry 63:288-99. 2002
    ....
  91. ncbi A comparison of the efficacy, safety, and tolerability of divalproex sodium and olanzapine in the treatment of bipolar disorder
    John M Zajecka
    Rush Presbyterian St Luke s Medical Center, Chicago, Ill 60612 3824, USA
    J Clin Psychiatry 63:1148-55. 2002
    ..This study compared the efficacy, safety, and tolerability of divalproex and olanzapine in the treatment of acute mania associated with bipolar disorder...
  92. ncbi Divalproex sodium versus olanzapine in the treatment of acute mania in bipolar disorder: health-related quality of life and medical cost outcomes
    Dennis A Revicki
    Center for Outcomes Research, MEDTAP International, Bethesda, MD 20814, USA
    J Clin Psychiatry 64:288-94. 2003
    ..This study compares the clinical, health-related quality of life (HRQL), and economic outcomes of divalproex and olanzapine in the treatment of acute mania associated with bipolar disorder...
  93. doi Methylphenidate sensitization is prevented by prefrontal cortex lesion
    Min J Lee
    Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, P O Box 20708, Houston, TX 77225, United States
    Brain Res Bull 76:131-40. 2008
    ..These results suggest that the PFC does not interfere with the acute effects of MPD on locomotor activity but is required for development of behavioral sensitization to MPD...
  94. pmc Characterizing aggressive behavior with the Impulsive/Premeditated Aggression Scale among adolescents with conduct disorder
    Charles W Mathias
    Neurobehavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychiatry Res 151:231-42. 2007
    ..As in the adult and child literature, characterization of aggressive behavior into two subtypes appears to be relevant to understanding individual differences among adolescents with Conduct Disorder...
  95. ncbi Laboratory measured behavioral impulsivity relates to suicide attempt history
    Donald M Dougherty
    Neuro behavioral Research Laboratory and Clinic, Department of Psychiatry and Behavioral Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Suicide Life Threat Behav 34:374-85. 2004
    ..This study helps to demonstrate how laboratory behavioral measures of impulsivity can be used to discriminate groups based on suicidal histories among samples not currently exhibiting significant suicidal behaviors...
  96. pmc Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains
    Pamela B Yang
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, 740 Westwood Blvd, Room A8 144, Los Angeles, CA 90024, USA
    Brain Res Bull 71:301-10. 2006
    ..These results suggest that the animal's age at time of drug treatment and strain/genetic variability play a crucial role in the acute and chronic effect of MPD and in the development of behavioral sensitization...
  97. ncbi Differentiating anxiety and depression in older adults with generalized anxiety disorder
    J Gayle Beck
    Department of Psychology, University at Buffalo, State University of New York, Park Hall, Buffalo, New York 14260, USA
    Psychol Assess 15:184-92. 2003
    ..Hierarchical regression suggested that the CCL-D subscale was a significant predictor of self-reported depression...
  98. ncbi What is bipolar disorder?
    Alan C Swann
    Am J Psychiatry 163:177-9. 2006
  99. ncbi Involvement in physical activity and risk for nearly lethal suicide attempts
    Thomas R Simon
    Division of Violence Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Am J Prev Med 27:310-5. 2004
    ..This study compared reports of recent physical activity among those surviving a nearly lethal suicide attempt to reports from community controls...
  100. pmc Chronic administration of methylphenidate produces neurophysiological and behavioral sensitization
    Pamela B Yang
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, 740 Westwood Blvd, Room A8 144, Los Angeles, CA 90024, USA
    Brain Res 1145:66-80. 2007
    ..In PFC, the baseline and effect of methylphenidate expressed electrophysiological sensitization on experimental day 10, while recording from CN did not exhibit any electrophysiological sensitization...

Research Grants5

  1. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2005
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..
  2. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2006
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..
  3. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2007
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..
  4. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2008
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..
  5. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2009
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..