KATHY K SVOBODA

Summary

Affiliation: Texas A and M Health Science Center
Country: USA

Publications

  1. ncbi ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium
    Kathy K H Svoboda
    Department of Biomedical Science, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 229:579-90. 2004
  2. ncbi Embryonic chick corneal epithelium: a model system for exploring cell-matrix interactions
    Kathy K H Svoboda
    Department of Biomedical Science, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 237:2667-75. 2008
  3. ncbi Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells
    Symone M San Miguel
    Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX 75246, USA
    J Periodontol 81:1675-90. 2010
  4. ncbi Parathyroid hormone/parathyroid hormone-related peptide modulates growth of avian sternal cartilage via chondrocytic proliferation
    Erik Kern Harrington
    Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Anat Rec (Hoboken) 290:155-67. 2007
  5. ncbi PI-3 kinase activity is required for epithelial-mesenchymal transformation during palate fusion
    Pei Kang
    Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 225:316-21. 2002
  6. ncbi PTH stimulated growth and decreased Col-X deposition are phosphotidylinositol-3,4,5 triphosphate kinase and mitogen activating protein kinase dependent in avian sterna
    Erik Kern Harrington
    Department of Biomedical Sciences, Texas A and M Health Sciences Center, Dallas, 75246, USA
    Anat Rec (Hoboken) 293:225-34. 2010
  7. ncbi The role of twist during palate development
    Wenli Yu
    Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 237:2716-25. 2008
  8. ncbi Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts
    Yiyu Fang
    Graduate Orthodontics, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75266, USA
    J Cell Biochem 95:1108-19. 2005
  9. ncbi Chondrocyte terminal differentiation, apoptosis, and type X collagen expression are downregulated by parathyroid hormone
    Erik Kern Harrington
    Department of Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Anat Rec A Discov Mol Cell Evol Biol 281:1286-95. 2004
  10. ncbi The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs
    Michiko Watanabe
    Department of Pediatrics UHC, Case Western Reserve University, Cleveland, OH 44106, USA
    Microsc Microanal 8:375-91. 2002

Research Grants

  1. BIOLOGY OF THE EMBRYONIC CORNEAL EPITHELIUM
    Kathy Svoboda; Fiscal Year: 2001
  2. Plasmid Delivery & Expression in Embryonic Eye Tissues
    Kathy Svoboda; Fiscal Year: 2005
  3. ICP-MS Instrument for Baylor College of Dentistry
    Kathy Svoboda; Fiscal Year: 2006

Collaborators

  • L A Opperman
  • Edie C Goldsmith
  • Erik Kern Harrington
  • Symone M San Miguel
  • Wenli Yu
  • Yiyu Fang
  • Pei Kang
  • Wende R Reenstra
  • Michiko Watanabe
  • Jan Zielinski
  • Matthew F Kern
  • Edward P Allen
  • David J Coon
  • Harold Kamara
  • Randy West
  • Gavin W Roddy
  • Leif E Lunsford
  • Florence Rothenberg
  • Kathy van der Wee
  • Steven A Fisher
  • Daniel L Orlow
  • Anna-Liisa Nieminen
  • Kaisa M Heiskanen
  • Midori Hitomi
  • Anna Liisa Nieminen
  • Robert Zucker

Detail Information

Publications11

  1. ncbi ROCK inhibitor (Y27632) increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium
    Kathy K H Svoboda
    Department of Biomedical Science, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 229:579-90. 2004
    ..In conclusion, ECM molecules decreased apoptosis markers and inhibiting the ROCK pathway blocked ECM stimulated actin cortical mat reformation and increased apoptosis in embryonic corneal epithelial cells...
  2. ncbi Embryonic chick corneal epithelium: a model system for exploring cell-matrix interactions
    Kathy K H Svoboda
    Department of Biomedical Science, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 237:2667-75. 2008
    ....
  3. ncbi Antioxidants counteract nicotine and promote migration via RacGTP in oral fibroblast cells
    Symone M San Miguel
    Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX 75246, USA
    J Periodontol 81:1675-90. 2010
    ..The aim of this study is to address the hypothesis that nicotine impairs wound healing by increasing reactive oxygen species and inhibiting cell migration, and antioxidants (AOs) may counteract nicotine effects...
  4. ncbi Parathyroid hormone/parathyroid hormone-related peptide modulates growth of avian sternal cartilage via chondrocytic proliferation
    Erik Kern Harrington
    Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Anat Rec (Hoboken) 290:155-67. 2007
    ..In conclusion, these experiments demonstrated that PTH increased cartilage growth by upregulating cell proliferation or other extracellular matrix components...
  5. ncbi PI-3 kinase activity is required for epithelial-mesenchymal transformation during palate fusion
    Pei Kang
    Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 225:316-21. 2002
    ..The MFS was significantly less in the 1 and 10 microM LY294002-treated tissues at 2.08 and 1.33, respectively. Our results demonstrate that EMT during palatal fusion in vitro is dependent on PI-3 kinase activity...
  6. ncbi PTH stimulated growth and decreased Col-X deposition are phosphotidylinositol-3,4,5 triphosphate kinase and mitogen activating protein kinase dependent in avian sterna
    Erik Kern Harrington
    Department of Biomedical Sciences, Texas A and M Health Sciences Center, Dallas, 75246, USA
    Anat Rec (Hoboken) 293:225-34. 2010
    ..All three inhibitors moderately disrupted Col-II and Col-IX deposition. These results suggest that PTH can activate multiple pathways during chondrocyte differentiation...
  7. ncbi The role of twist during palate development
    Wenli Yu
    Biomedical Sciences, Texas A and M Health Science Center, Baylor College of Dentistry, Dallas, Texas 75246, USA
    Dev Dyn 237:2716-25. 2008
    ..However, decreasing Twist with siRNA did not completely block palate fusion, indicating that the function of Twist may be duplicated by other transcription factors...
  8. ncbi Nicotine inhibits myofibroblast differentiation in human gingival fibroblasts
    Yiyu Fang
    Graduate Orthodontics, Texas A and M University System, Baylor College of Dentistry, Dallas, Texas 75266, USA
    J Cell Biochem 95:1108-19. 2005
    ....
  9. ncbi Chondrocyte terminal differentiation, apoptosis, and type X collagen expression are downregulated by parathyroid hormone
    Erik Kern Harrington
    Department of Biomedical Sciences, Texas A and M University System, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA
    Anat Rec A Discov Mol Cell Evol Biol 281:1286-95. 2004
    ..Type X collagen mRNA expression was downregulated by PTH in this organ culture model, but cell size, another marker for terminal differentiation, increased...
  10. ncbi The pros and cons of apoptosis assays for use in the study of cells, tissues, and organs
    Michiko Watanabe
    Department of Pediatrics UHC, Case Western Reserve University, Cleveland, OH 44106, USA
    Microsc Microanal 8:375-91. 2002
    ..Understanding the strengths and limitations of the assays would allow investigators to select the best methods for their needs...
  11. ncbi ECM-stimulated signaling and actin reorganization in embryonic corneal epithelia are Rho dependent
    Wende R Reenstra
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 43:3181-9. 2002
    ..CONCLUSIONS: Decreasing Rho protein or blocking its function inhibited ECM-stimulated actin reorganization and signal transduction, as measured by tyrosine phosphorylation...

Research Grants5

  1. BIOLOGY OF THE EMBRYONIC CORNEAL EPITHELIUM
    Kathy Svoboda; Fiscal Year: 2001
    ..In summary, these experiments in our well defined corneal epithelial model will focus on how ECM mediated signal transduction stimulates actin bundle formation and also save the cells from programmed cell death. ..
  2. Plasmid Delivery & Expression in Embryonic Eye Tissues
    Kathy Svoboda; Fiscal Year: 2005
    ..This project has a high risk because neither "two-in-one" vectors, nor transfection into whole tissues has been accomplished. ..
  3. ICP-MS Instrument for Baylor College of Dentistry
    Kathy Svoboda; Fiscal Year: 2006
    ..Previous experiments were completed by collaborating with investigators in Japan. We have identified two laboratories in the Dallas area that have appropriate instruments, but they cannot analyze our samples (see correspondence). ..