Yuxiang Sun

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint Central and peripheral roles of ghrelin on glucose homeostasis
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Neuroendocrinology 86:215-28. 2007
  2. ncbi request reprint Ghrelin and growth hormone secretagogue receptor expression in mice during aging
    Yuxiang Sun
    Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
    Endocrinology 148:1323-9. 2007
  3. ncbi request reprint Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex
    Guo Li Wang
    Huffington Center on Aging and Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:1468-78. 2007
  4. pmc Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice
    Xiaojun Ma
    US Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 303:E422-31. 2012
  5. ncbi request reprint Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, MS BCM M230, Houston, TX 77030, USA
    Ann N Y Acad Sci 1119:147-64. 2007
  6. ncbi request reprint Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 3:379-86. 2006
  7. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
  8. doi request reprint Thermogenic characterization of ghrelin receptor null mice
    Ligen Lin
    Department of Pediatrics, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA
    Methods Enzymol 514:355-70. 2012
  9. pmc Ghrelin: much more than a hunger hormone
    Geetali Pradhan
    aUSDA ARS Children s Nutrition Research Center, Department of Pediatrics bDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine cHuffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Clin Nutr Metab Care 16:619-24. 2013
  10. doi request reprint Effect of ghrelin on glucose regulation in mice
    Shaji K Chacko
    Department of Pediatrics, Baylor College of Medicine Children s Nutrition Research Center, United States Department of Agriculture Agricultural Research Service, Houston, TX, USA
    Am J Physiol Endocrinol Metab 302:E1055-62. 2012

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Central and peripheral roles of ghrelin on glucose homeostasis
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Neuroendocrinology 86:215-28. 2007
    ..This review focuses on the newly emerging role of ghrelin in glucose homeostasis and exploration of whether ghrelin is a potential therapeutic target for diabetes...
  2. ncbi request reprint Ghrelin and growth hormone secretagogue receptor expression in mice during aging
    Yuxiang Sun
    Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
    Endocrinology 148:1323-9. 2007
    ..In the brain, Ghsr1a mRNA levels remained stable during aging. Hence, in C57BL/6J male mice, aging is not associated with changes in circulating ghrelin levels or changes in ghrelin receptor expression in the pituitary gland and brain...
  3. ncbi request reprint Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex
    Guo Li Wang
    Huffington Center on Aging and Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:1468-78. 2007
    ..GH-dependent elimination of the complex is mediated by the inhibition of cyclin D3-CDK4 activity and by elevation of a phosphatase, protein phosphatase 2A, which dephosphorylates C/EBPalpha and dissociates the complex...
  4. pmc Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice
    Xiaojun Ma
    US Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Endocrinol Metab 303:E422-31. 2012
    ..The paradoxical effects of ghrelin ablation and Ghsr ablation in ob/ob mice highlight the complexity of the ghrelin-signaling pathway...
  5. ncbi request reprint Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, MS BCM M230, Houston, TX 77030, USA
    Ann N Y Acad Sci 1119:147-64. 2007
    ..We speculate that aging is associated with deficient endogenous ghrelin signaling that can be rescued by intervention with GHS-R1a agonists to improve quality of life and maintain independence...
  6. ncbi request reprint Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 3:379-86. 2006
    ..Hence, chronically, ghrelin controls glucose homeostasis by regulating pancreatic Ucp2 expression and insulin sensitivity...
  7. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
    ..Our results suggest that chronic treatment with ghrelin antagonists will have little effect on growth or appetite...
  8. doi request reprint Thermogenic characterization of ghrelin receptor null mice
    Ligen Lin
    Department of Pediatrics, USDA ARS Children s Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA
    Methods Enzymol 514:355-70. 2012
    ..Understanding the roles and molecular mechanisms of ghrelin/GHS-R in thermogenesis is of great significance. GHS-R antagonists might be a novel means of combating obesity by shifting adiposity balance from obesogenesis to thermogenesis...
  9. pmc Ghrelin: much more than a hunger hormone
    Geetali Pradhan
    aUSDA ARS Children s Nutrition Research Center, Department of Pediatrics bDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine cHuffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA
    Curr Opin Clin Nutr Metab Care 16:619-24. 2013
    ..However, ample recent literature indicates that the functions of ghrelin go well beyond its role as an orexigenic signal. Here, we have reviewed some of the most recent findings on ghrelin and its signalling in animals and humans...
  10. doi request reprint Effect of ghrelin on glucose regulation in mice
    Shaji K Chacko
    Department of Pediatrics, Baylor College of Medicine Children s Nutrition Research Center, United States Department of Agriculture Agricultural Research Service, Houston, TX, USA
    Am J Physiol Endocrinol Metab 302:E1055-62. 2012
    ..This study demonstrates that gluconeogenesis and glycogenolysis are increased and insulin sensitivity is improved by the ablation of the ghrelin or growth hormone secretagogue receptor in mice...
  11. pmc Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues
    Ligen Lin
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 10:996-1010. 2011
    ..Growth hormone secretagogue receptor antagonists may be a new means of combating obesity by shifting the energy balance from obesogenesis to thermogenesis...
  12. pmc Adipocyte expression of PU.1 transcription factor causes insulin resistance through upregulation of inflammatory cytokine gene expression and ROS production
    Ligen Lin
    US Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Houston, Texas, USA
    Am J Physiol Endocrinol Metab 302:E1550-9. 2012
    ..Therefore, PU.1 might be a mediator for obesity-induced adipose inflammation and insulin resistance...
  13. ncbi request reprint Growth hormone secretagogues: prospects and potential pitfalls
    Roy G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza N704, M320, Houston, TX 77030 3498, USA
    Best Pract Res Clin Endocrinol Metab 18:333-47. 2004
    ..Ghrelin levels are reported to decline during ageing, therefore long-acting GHSs are ideal candidates for ghrelin replacement therapy...
  14. pmc Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model
    Motoyuki Kohjima
    Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Endocrinology 151:1532-40. 2010
    ....
  15. pmc Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Endocrinology 149:843-50. 2008
    ..These results support our hypothesis that the primary metabolic function of ghrelin in adult mice is to modulate glucose sensing and insulin sensitivity, rather than directly regulate energy intake and energy expenditure...
  16. pmc Deletion of ghrelin impairs neither growth nor appetite
    Yuxiang Sun
    Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 23:7973-81. 2003
    ..Therefore, antagonists of ghrelin are unlikely to have broad utility as antiobesity agents...
  17. ncbi request reprint Molecular endocrinology and physiology of the aging central nervous system
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
    Endocr Rev 26:203-50. 2005
    ....
  18. pmc Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes
    Guo Li Wang
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 26:2570-82. 2006
    ..The inhibition of cyclin D3 blocks the formation of these complexes. Thus, these studies provide a new function of cyclin D3, which is to support the growth-inhibitory activity of C/EBPalpha...
  19. ncbi request reprint Developments in ghrelin biology and potential clinical relevance
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 16:436-42. 2005
    ....
  20. pmc Physiological roles revealed by ghrelin and ghrelin receptor deficient mice
    Rosie G Albarran-Zeckler
    Department of Metabolism and Aging, Scripps Research Institute Florida, 130 Scripps Way B3B, Jupiter, FL 33458, United States
    Peptides 32:2229-35. 2011
    ..In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice...
  21. ncbi request reprint Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice
    Eva Szentirmai
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 293:R510-7. 2007
    ..It is possible that redundancy in the arousal systems of the brain or activation of compensatory mechanisms during development allow for normal sleep-wake regulation in ghrelin KO mice...
  22. ncbi request reprint Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    Koji Toshinai
    Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Endocrinology 147:2306-14. 2006
    ..Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R...
  23. pmc Ghrelin promotes thymopoiesis during aging
    Vishwa Deep Dixit
    Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA
    J Clin Invest 117:2778-90. 2007
    ....

Research Grants2

  1. Ghrelin's role in glucose homestasis during aging
    Yuxiang Sun; Fiscal Year: 2007
    ..These studies will shed more light on the molecular mechanisms of diabetes and glucose homeostasis during aging, and may potentially lead to the discovery of new means for the prevention and/or treatment of aging-related diabetes. ..