Research Topics
| G StoicaSummaryAffiliation: Texas A and M University Country: USA Publications
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Detail Information
Publications
A line of Berlin Druckrey IV rats proposed as a new model for human hereditary ataxiaCheryl L Guyer
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University College Station, TX 77843-4467, USA
In Vivo 16:255-63. 2002..The authors propose that this disease accompanying a new variant of the BD IV rat (to be designated "shaker" rat) provides a new and unique research model for ataxia with features in common with some human hereditary ataxias...- In vivo imaging and characterization of hypoxia-induced neovascularization and tumor invasionGina F Lungu
Department of Pathobiology, College of Veterinary Medicine, Optical Imaging Laboratory, Texas A and M University, College Station, TX, USA
Int J Oncol 30:45-54. 2007..Moreover this report validates our hypothesis that a novel noninvasive technology (SPAT) developed in our laboratory is suitable for detection of tumors, hypoxia, and angiogenesis... - Limitations of quantitative photoacoustic measurements of blood oxygenation in small vesselsMathangi Sivaramakrishnan
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University 3120 TAMU, College Station, TX 77843 3120, USA
Phys Med Biol 52:1349-61. 2007.... 
Potential role of α-synuclein in neurodegeneration: studies in a rat animal modelGeorge Stoica
Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
J Neurochem 122:812-22. 2012....- Canine astrocytic tumors: a comparative reviewG Stoica
Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
Vet Pathol 48:266-75. 2011..Traditional veterinary histologic typing and grading of astrocytic tumors must be updated and supplemented with molecular data so that future studies directed toward therapeutic intervention and outcome can be optimized... - Identification of cancer stem cells in dog glioblastomaG Stoica
Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
Vet Pathol 46:391-406. 2009..This cloned cell line is aneuploid, forms neurospheres in culture, possesses CSC markers, and reproduces the original dog GBM when inoculated into the nude mouse brain... - Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathyGeorge Stoica
Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
Brain Res 1208:204-16. 2008..This study provides new in vivo insights into the possible role of proNGF and its receptors in ts1-induced neurodegeneration... - Motor neuronal loss and neurofilament-ubiquitin alteration in MoMuLV-ts1 encephalopathyG Stoica
Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
Acta Neuropathol 99:238-44. 2000..Together, these results suggest that significant neuronal loss occurs at the end of the disease process and that Lewy body-like formation and protein ubiquitination are part of the pathogenic process in ts1-induced encephalopathy... - Inherited tertiary hypothyroidism in Sprague-Dawley ratsGeorge Stoica
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Brain Res 1148:205-16. 2007..These data suggest that we discovered a tertiary form of inherited hypothyroidism involving the hypothalamus... - Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat modelOdete Mendes
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
Clin Exp Metastasis 22:237-46. 2005..In addition, PD 166793 decreased the in vitro invasive cell behavior of ENU1546. Together our results suggest that MMP-2, -3 and -9 may be involved in the process of metastasis of breast cancer to the brain... - Morphology, immunohistochemistry, and genetic alterations in dog astrocytomasG Stoica
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
Vet Pathol 41:10-9. 2004..The purpose of this study was to further characterize astrocytomas in dogs and to determine whether there are genetic changes similar to those in the human counterpart... - Point mutation of neu oncogene in animal peripheral nerve sheath tumorsG Stoica
Texas A and M University, Department of Veterinary Pathobiology, College Station 77843, USA
Vet Pathol 38:679-88. 2001..The finding of neu oncogene mutation could be a useful diagnostic genetic marker in the malignant form of peripheral nerve sheath tumors in animals... - Detection of Moloney murine sarcoma virus in tissues and cultured cells by the polymerase chain reactionS I Tasca
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843
J Virol Methods 41:255-63. 1993..This reproducible method could be useful for diagnostic and for pathogenetic investigations of MoMuSV infections... 
Moloney murine sarcoma virus 349 induces Kaposi's sarcomalike lesions in Balb/c miceG Stoica
Department of Veterinary Pathology, College of Veterinary Medicine, Texas A and M University, College Station
Am J Pathol 136:933-47. 1990..Erythrophagocytosis by the endothelial and spindlelike cells was demonstrated by light and electron microscopy. The widely disseminated lesions appear to have developed simultaneously as a consequence of viremia rather than metastasis...- Multiple-bandwidth photoacoustic tomographyGeng Ku
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843-3120, USA
Phys Med Biol 49:1329-38. 2004..The higher frequency detectors provided better image resolution while the lower frequency detectors delineated the major structural traits with a higher signal-noise ratio... - Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activationH T Kim
Department of Veterinary Pathobiology, Texas A and M University, College Station, Texas 77843, USA
J Neurovirol 7:466-75. 2001.... - Monosodium luminol upregulates the expression of Bcl-2 and VEGF in retrovirus-infected mice through downregulation of corresponding miRNAsG Lungu
Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
Acta Virol 54:27-32. 2010..The data showed that GVT treatment prevented ts1-induced ND at least in part by upregulating Bcl-2 and VEGF expression, what likely occurred as a consequence of downregulation of their corresponding miRNAs... - Combined photoacoustic and molecular fluorescence imaging in vivoLihong Wang
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX email tel 979 847 9040 fax 979 845 4450
Conf Proc IEEE Eng Med Biol Soc 1:190-2. 2005..The coregistration between the PAT and fluorescence images was used to visualize tumor location, angiogenesis, and brain structure simultaneously... - In vivo three-dimensional photoacoustic tomography of a whole mouse headKwang Hyun Song
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
Opt Lett 31:2453-5. 2006..Deeply seated arterial and venous vessels in the head measuring up to 1.7 cm in diameter were simultaneously imaged in vivo with 804 nm wavelength laser excitation of photoacoustic waves... - Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomographyGeng Ku
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
Appl Opt 44:770-5. 2005..This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research... - Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopyJung-Taek Oh
Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, 77843-3120, USA
J Biomed Opt 11:34032. 2006..The vascular system surrounding the melanoma is also imaged with visible light (584 nm) and the tumor-feeding vessels found. This technique can potentially be used for melanoma diagnosis, prognosis, and treatment planning... - MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2Odete Mendes
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
Clin Exp Metastasis 24:341-51. 2007..Furthermore, our results suggest that astrocyte factors and the ERK1/2 signaling pathway may be associated with BC brain metastasis development; and that ERK1/2 may regulate MMP2 in a way that is modifiable by astrocyte factors... - Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomographyXueding Wang
Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843-3120, USA
J Biomed Opt 11:024015. 2006..This technique, with its prominent sensitivity to endogenous contrast, can potentially contribute to the understanding of the interrelationship between neural, hemodynamic, and metabolic activities in the brain... - Sarcoma viruses containing the mos oncogene induce lesions resembling Kaposi's sarcomaG Stoica
Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843
In Vivo 8:43-7. 1994.... - Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imagingHao F Zhang
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843-3120, USA
Nat Biotechnol 24:848-51. 2006..fPAM is demonstrated with in vivo imaging of angiogenesis, melanoma, hemoglobin oxygen saturation (sO2) of single vessels in animals and total hemoglobin concentration in humans... - Activation of endoplasmic reticulum stress signaling pathway is associated with neuronal degeneration in MoMuLV-ts1-induced spongiform encephalomyelopathyHun-Taek Kim
Department of Pathobiology, Texas A and M University, College Station, TX 77843, USA
Lab Invest 84:816-27. 2004..Our findings highlight the importance of the ER stress signaling pathway in ts1 infection-induced neuronal degeneration and death... - FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1Gina Lungu
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
Mol Carcinog 47:424-35. 2008.... - Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intactXueding Wang
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843-3120, USA
Opt Lett 28:1739-41. 2003..The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well... - Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirusHun-Taek Kim
Department of Pathobiology, Texas A and M University, College Station, Texas 78957, USA
J Neurovirol 11:166-79. 2005..Because COX-2 inhibitors are now widely used to treat inflammatory conditions in animals and humans, this finding suggests that these drugs may be useful for therapeutic intervention in neurodegenerative syndromes as well... - Induction of p53 accumulation by Moloney murine leukemia virus-ts1 infection in astrocytes via activation of extracellular signal-regulated kinases 1/2Hun Taek Kim
Department of Veterinary Pathobiology, Texas A and M University, College Station, Texas
Lab Invest 82:693-702. 2002..Our studies suggest that ts1 neuropathology in mice may result from changes in expression and activity of p53, brought about in part by ts1 activation of ERK... - Fiber-based polarization-sensitive Mueller matrix optical coherence tomography with continuous source polarization modulationShuliang Jiao
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843-3120, USA
Appl Opt 44:5463-7. 2005..The system was successfully tested by imaging both standard polarization elements and biological samples... - Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brainXueding Wang
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843-3120, USA
Nat Biotechnol 21:803-6. 2003..We also imaged hyperoxia- and hypoxia-induced cerebral hemodynamic changes. This neuroimaging modality holds promise for applications in neurophysiology, neuropathology and neurotherapy... - Down-regulation of Jab1, HIF-1alpha, and VEGF by Moloney murine leukemia virus-ts1 infection: a possible cause of neurodegenerationGina F Lungu
Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas, USA
J Neurovirol 14:239-51. 2008..This study suggested that ts1-mediated neuropathology in mice may result from changes in expression and activity of Jab1, p53, and HIF-1alpha, with a final target on VEGF expression and neuronal degeneration... - In vivo burn imaging using Mueller optical coherence tomographyMilos Todorović
Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
Opt Express 16:10279-84. 2008..By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system's potential for in vivo burn-depth determination... - Optical-fiber-based Mueller optical coherence tomographyShuliang Jiao
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843-3120, USA
Opt Lett 28:1206-8. 2003..A new rigorous algorithm was then used to retrieve the calibrated polarization properties of the sample. This algorithm was validated with experimental data. The skin of a rat was imaged with this fiber-based system... - Imaging acute thermal burns by photoacoustic microscopyHao F Zhang
Department of Biomedical Engineering, Optical Imaging Laboratory, Texas A and M University, 3120 TAMU, College Station, Texas 77843-3120, USA
J Biomed Opt 11:054033. 2006..73+/-0.07 mm. In burns treated at 150 degrees C for 5, 10, 20, and 30 s, respectively, the trend of increasing maximum burn depth with longer thermal exposure is demonstrated... - Contrast mechanisms in polarization-sensitive Mueller-matrix optical coherence tomography and application in burn imagingShuliang Jiao
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843-3120, USA
Appl Opt 42:5191-7. 2003..Thus, Mueller OCT has significant potential for application in the noninvasive assessment of burn depth... - Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agentXueding Wang
Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843-3120, USA
Opt Lett 29:730-2. 2004..This new technology demonstrates the potential for dynamic and molecular biomedical imaging... - Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducerRoger J Zemp
Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, Saint Louis, Missouri 63130, USA
J Biomed Opt 12:010501. 2007..It is anticipated that the system can be used for studying and diagnosing a number of diseases including cancer, atherosclerosis, dermatological disorders, and peripheral microvascular complications in diabetes... - Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanismEugenio Gaudio
Division of Anatomy, University La Sapienza, Rome, Italy
Gastroenterology 130:1270-82. 2006..The role of VEGF in cholangiocyte pathophysiology is unknown. We evaluated the role of VEGF in the regulation of cholangiocyte proliferation in rats that underwent bile duct ligation... - Photoacoustic imaging of lacZ gene expression in vivoLi Li
Washington University in St Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St Louis, Missouri 63130, USA
J Biomed Opt 12:020504. 2007..With the future development of new absorption-based reporter gene systems, it is anticipated that photoacoustic technology will provide a valuable tool for molecular imaging research... - ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytesNa Liu
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
Lab Invest 85:1471-80. 2005..ERK1/2 activation and astrogliosis are also found in other parts of the brain, for example, the cortex. We conclude that ATM deficiency induces intrinsic growth defects, oxidative stress, ER stress, and ERKs activation in astrocytes... - Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in MoMuLV-ts1-induced apoptosis in astrocytesNa Liu
Department of Carcinogenesis, University of Texas, MD Anderson Cancer Center, Science Park-Research Division, Smithville, 78957, USA
J Neurovirol 10:189-98. 2004..Together the data imply that both ER stress- and mitochondrial stress-related apoptotic pathways are involved in ts1-induced astrocyte death...