G Stoica

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint A line of Berlin Druckrey IV rats proposed as a new model for human hereditary ataxia
    Cheryl L Guyer
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University College Station, TX 77843 4467, USA
    In Vivo 16:255-63. 2002
  2. ncbi request reprint In vivo imaging and characterization of hypoxia-induced neovascularization and tumor invasion
    Gina F Lungu
    Department of Pathobiology, College of Veterinary Medicine, Optical Imaging Laboratory, Texas A and M University, College Station, TX, USA
    Int J Oncol 30:45-54. 2007
  3. ncbi request reprint Limitations of quantitative photoacoustic measurements of blood oxygenation in small vessels
    Mathangi Sivaramakrishnan
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University 3120 TAMU, College Station, TX 77843 3120, USA
    Phys Med Biol 52:1349-61. 2007
  4. doi request reprint Potential role of α-synuclein in neurodegeneration: studies in a rat animal model
    George Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
    J Neurochem 122:812-22. 2012
  5. doi request reprint Canine astrocytic tumors: a comparative review
    G Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Pathol 48:266-75. 2011
  6. doi request reprint Identification of cancer stem cells in dog glioblastoma
    G Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Pathol 46:391-406. 2009
  7. doi request reprint Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy
    George Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
    Brain Res 1208:204-16. 2008
  8. ncbi request reprint Motor neuronal loss and neurofilament-ubiquitin alteration in MoMuLV-ts1 encephalopathy
    G Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Acta Neuropathol 99:238-44. 2000
  9. ncbi request reprint Inherited tertiary hypothyroidism in Sprague-Dawley rats
    George Stoica
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Brain Res 1148:205-16. 2007
  10. ncbi request reprint Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model
    Odete Mendes
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Clin Exp Metastasis 22:237-46. 2005

Collaborators

Detail Information

Publications43

  1. ncbi request reprint A line of Berlin Druckrey IV rats proposed as a new model for human hereditary ataxia
    Cheryl L Guyer
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University College Station, TX 77843 4467, USA
    In Vivo 16:255-63. 2002
    ..The authors propose that this disease accompanying a new variant of the BD IV rat (to be designated "shaker" rat) provides a new and unique research model for ataxia with features in common with some human hereditary ataxias...
  2. ncbi request reprint In vivo imaging and characterization of hypoxia-induced neovascularization and tumor invasion
    Gina F Lungu
    Department of Pathobiology, College of Veterinary Medicine, Optical Imaging Laboratory, Texas A and M University, College Station, TX, USA
    Int J Oncol 30:45-54. 2007
    ..Moreover this report validates our hypothesis that a novel noninvasive technology (SPAT) developed in our laboratory is suitable for detection of tumors, hypoxia, and angiogenesis...
  3. ncbi request reprint Limitations of quantitative photoacoustic measurements of blood oxygenation in small vessels
    Mathangi Sivaramakrishnan
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University 3120 TAMU, College Station, TX 77843 3120, USA
    Phys Med Biol 52:1349-61. 2007
    ....
  4. doi request reprint Potential role of α-synuclein in neurodegeneration: studies in a rat animal model
    George Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
    J Neurochem 122:812-22. 2012
    ....
  5. doi request reprint Canine astrocytic tumors: a comparative review
    G Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Pathol 48:266-75. 2011
    ..Traditional veterinary histologic typing and grading of astrocytic tumors must be updated and supplemented with molecular data so that future studies directed toward therapeutic intervention and outcome can be optimized...
  6. doi request reprint Identification of cancer stem cells in dog glioblastoma
    G Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Pathol 46:391-406. 2009
    ..This cloned cell line is aneuploid, forms neurospheres in culture, possesses CSC markers, and reproduces the original dog GBM when inoculated into the nude mouse brain...
  7. doi request reprint Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy
    George Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
    Brain Res 1208:204-16. 2008
    ..This study provides new in vivo insights into the possible role of proNGF and its receptors in ts1-induced neurodegeneration...
  8. ncbi request reprint Motor neuronal loss and neurofilament-ubiquitin alteration in MoMuLV-ts1 encephalopathy
    G Stoica
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843 4467, USA
    Acta Neuropathol 99:238-44. 2000
    ..Together, these results suggest that significant neuronal loss occurs at the end of the disease process and that Lewy body-like formation and protein ubiquitination are part of the pathogenic process in ts1-induced encephalopathy...
  9. ncbi request reprint Inherited tertiary hypothyroidism in Sprague-Dawley rats
    George Stoica
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Brain Res 1148:205-16. 2007
    ..These data suggest that we discovered a tertiary form of inherited hypothyroidism involving the hypothalamus...
  10. ncbi request reprint Expression of MMP2, MMP9 and MMP3 in breast cancer brain metastasis in a rat model
    Odete Mendes
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Clin Exp Metastasis 22:237-46. 2005
    ..In addition, PD 166793 decreased the in vitro invasive cell behavior of ENU1546. Together our results suggest that MMP-2, -3 and -9 may be involved in the process of metastasis of breast cancer to the brain...
  11. ncbi request reprint Morphology, immunohistochemistry, and genetic alterations in dog astrocytomas
    G Stoica
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843 4467, USA
    Vet Pathol 41:10-9. 2004
    ..The purpose of this study was to further characterize astrocytomas in dogs and to determine whether there are genetic changes similar to those in the human counterpart...
  12. ncbi request reprint Point mutation of neu oncogene in animal peripheral nerve sheath tumors
    G Stoica
    Texas A and M University, Department of Veterinary Pathobiology, College Station 77843, USA
    Vet Pathol 38:679-88. 2001
    ..The finding of neu oncogene mutation could be a useful diagnostic genetic marker in the malignant form of peripheral nerve sheath tumors in animals...
  13. ncbi request reprint Detection of Moloney murine sarcoma virus in tissues and cultured cells by the polymerase chain reaction
    S I Tasca
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843
    J Virol Methods 41:255-63. 1993
    ..This reproducible method could be useful for diagnostic and for pathogenetic investigations of MoMuSV infections...
  14. pmc Moloney murine sarcoma virus 349 induces Kaposi's sarcomalike lesions in Balb/c mice
    G Stoica
    Department of Veterinary Pathology, College of Veterinary Medicine, Texas A and M University, College Station
    Am J Pathol 136:933-47. 1990
    ..Erythrophagocytosis by the endothelial and spindlelike cells was demonstrated by light and electron microscopy. The widely disseminated lesions appear to have developed simultaneously as a consequence of viremia rather than metastasis...
  15. ncbi request reprint Multiple-bandwidth photoacoustic tomography
    Geng Ku
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, TX 77843 3120, USA
    Phys Med Biol 49:1329-38. 2004
    ..The higher frequency detectors provided better image resolution while the lower frequency detectors delineated the major structural traits with a higher signal-noise ratio...
  16. ncbi request reprint Enhanced proteolysis of IkappaBalpha and IkappaBbeta proteins in astrocytes by Moloney murine leukemia virus (MoMuLV)-ts1 infection: a potential mechanism of NF-kappaB activation
    H T Kim
    Department of Veterinary Pathobiology, Texas A and M University, College Station, Texas 77843, USA
    J Neurovirol 7:466-75. 2001
    ....
  17. ncbi request reprint Monosodium luminol upregulates the expression of Bcl-2 and VEGF in retrovirus-infected mice through downregulation of corresponding miRNAs
    G Lungu
    Department of Veterinary Pathobiology, Texas A and M University, College Station, TX 77843, USA
    Acta Virol 54:27-32. 2010
    ..The data showed that GVT treatment prevented ts1-induced ND at least in part by upregulating Bcl-2 and VEGF expression, what likely occurred as a consequence of downregulation of their corresponding miRNAs...
  18. ncbi request reprint Combined photoacoustic and molecular fluorescence imaging in vivo
    Lihong Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX email tel 979 847 9040 fax 979 845 4450
    Conf Proc IEEE Eng Med Biol Soc 1:190-2. 2005
    ..The coregistration between the PAT and fluorescence images was used to visualize tumor location, angiogenesis, and brain structure simultaneously...
  19. ncbi request reprint In vivo three-dimensional photoacoustic tomography of a whole mouse head
    Kwang Hyun Song
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843, USA
    Opt Lett 31:2453-5. 2006
    ..Deeply seated arterial and venous vessels in the head measuring up to 1.7 cm in diameter were simultaneously imaged in vivo with 804 nm wavelength laser excitation of photoacoustic waves...
  20. ncbi request reprint Imaging of tumor angiogenesis in rat brains in vivo by photoacoustic tomography
    Geng Ku
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 44:770-5. 2005
    ..This research demonstrates that PAT can potentially provide a powerful tool for small-animal biological research...
  21. ncbi request reprint Three-dimensional imaging of skin melanoma in vivo by dual-wavelength photoacoustic microscopy
    Jung Taek Oh
    Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, 77843 3120, USA
    J Biomed Opt 11:34032. 2006
    ..The vascular system surrounding the melanoma is also imaged with visible light (584 nm) and the tumor-feeding vessels found. This technique can potentially be used for melanoma diagnosis, prognosis, and treatment planning...
  22. ncbi request reprint MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2
    Odete Mendes
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, TX 77843, USA
    Clin Exp Metastasis 24:341-51. 2007
    ..Furthermore, our results suggest that astrocyte factors and the ERK1/2 signaling pathway may be associated with BC brain metastasis development; and that ERK1/2 may regulate MMP2 in a way that is modifiable by astrocyte factors...
  23. ncbi request reprint Noninvasive imaging of hemoglobin concentration and oxygenation in the rat brain using high-resolution photoacoustic tomography
    Xueding Wang
    Texas A and M University, Department of Biomedical Engineering, Optical Imaging Laboratory, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 11:024015. 2006
    ..This technique, with its prominent sensitivity to endogenous contrast, can potentially contribute to the understanding of the interrelationship between neural, hemodynamic, and metabolic activities in the brain...
  24. ncbi request reprint Sarcoma viruses containing the mos oncogene induce lesions resembling Kaposi's sarcoma
    G Stoica
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station 77843
    In Vivo 8:43-7. 1994
    ....
  25. ncbi request reprint Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging
    Hao F Zhang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Nat Biotechnol 24:848-51. 2006
    ..fPAM is demonstrated with in vivo imaging of angiogenesis, melanoma, hemoglobin oxygen saturation (sO2) of single vessels in animals and total hemoglobin concentration in humans...
  26. ncbi request reprint Activation of endoplasmic reticulum stress signaling pathway is associated with neuronal degeneration in MoMuLV-ts1-induced spongiform encephalomyelopathy
    Hun Taek Kim
    Department of Pathobiology, Texas A and M University, College Station, TX 77843, USA
    Lab Invest 84:816-27. 2004
    ..Our findings highlight the importance of the ER stress signaling pathway in ts1 infection-induced neuronal degeneration and death...
  27. ncbi request reprint FGF-1-induced matrix metalloproteinase-9 expression in breast cancer cells is mediated by increased activities of NF-kappaB and activating protein-1
    Gina Lungu
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas 77843, USA
    Mol Carcinog 47:424-35. 2008
    ....
  28. ncbi request reprint Three-dimensional laser-induced photoacoustic tomography of mouse brain with the skin and skull intact
    Xueding Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 28:1739-41. 2003
    ..The spatial resolution is primarily diffraction limited by the received photoacoustic waves. Imaged structures of the brain at different depths match the corresponding histological pictures well...
  29. ncbi request reprint Up-regulation of astrocyte cyclooxygenase-2, CCAAT/enhancer-binding protein-homology protein, glucose-related protein 78, eukaryotic initiation factor 2 alpha, and c-Jun N-terminal kinase by a neurovirulent murine retrovirus
    Hun Taek Kim
    Department of Pathobiology, Texas A and M University, College Station, Texas 78957, USA
    J Neurovirol 11:166-79. 2005
    ..Because COX-2 inhibitors are now widely used to treat inflammatory conditions in animals and humans, this finding suggests that these drugs may be useful for therapeutic intervention in neurodegenerative syndromes as well...
  30. ncbi request reprint Induction of p53 accumulation by Moloney murine leukemia virus-ts1 infection in astrocytes via activation of extracellular signal-regulated kinases 1/2
    Hun Taek Kim
    Department of Veterinary Pathobiology, Texas A and M University, College Station, Texas
    Lab Invest 82:693-702. 2002
    ..Our studies suggest that ts1 neuropathology in mice may result from changes in expression and activity of p53, brought about in part by ts1 activation of ERK...
  31. ncbi request reprint Fiber-based polarization-sensitive Mueller matrix optical coherence tomography with continuous source polarization modulation
    Shuliang Jiao
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 44:5463-7. 2005
    ..The system was successfully tested by imaging both standard polarization elements and biological samples...
  32. ncbi request reprint Noninvasive laser-induced photoacoustic tomography for structural and functional in vivo imaging of the brain
    Xueding Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Nat Biotechnol 21:803-6. 2003
    ..We also imaged hyperoxia- and hypoxia-induced cerebral hemodynamic changes. This neuroimaging modality holds promise for applications in neurophysiology, neuropathology and neurotherapy...
  33. doi request reprint Down-regulation of Jab1, HIF-1alpha, and VEGF by Moloney murine leukemia virus-ts1 infection: a possible cause of neurodegeneration
    Gina F Lungu
    Department of Pathobiology, College of Veterinary Medicine, Texas A and M University, College Station, Texas, USA
    J Neurovirol 14:239-51. 2008
    ..This study suggested that ts1-mediated neuropathology in mice may result from changes in expression and activity of Jab1, p53, and HIF-1alpha, with a final target on VEGF expression and neuronal degeneration...
  34. ncbi request reprint In vivo burn imaging using Mueller optical coherence tomography
    Milos Todorović
    Department of Biomedical Engineering, Texas A and M University, College Station, TX 77843 3120, USA
    Opt Express 16:10279-84. 2008
    ..By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system's potential for in vivo burn-depth determination...
  35. ncbi request reprint Optical-fiber-based Mueller optical coherence tomography
    Shuliang Jiao
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Opt Lett 28:1206-8. 2003
    ..A new rigorous algorithm was then used to retrieve the calibrated polarization properties of the sample. This algorithm was validated with experimental data. The skin of a rat was imaged with this fiber-based system...
  36. ncbi request reprint Imaging acute thermal burns by photoacoustic microscopy
    Hao F Zhang
    Department of Biomedical Engineering, Optical Imaging Laboratory, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    J Biomed Opt 11:054033. 2006
    ..73+/-0.07 mm. In burns treated at 150 degrees C for 5, 10, 20, and 30 s, respectively, the trend of increasing maximum burn depth with longer thermal exposure is demonstrated...
  37. ncbi request reprint Contrast mechanisms in polarization-sensitive Mueller-matrix optical coherence tomography and application in burn imaging
    Shuliang Jiao
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, 3120 TAMU, College Station, Texas 77843 3120, USA
    Appl Opt 42:5191-7. 2003
    ..Thus, Mueller OCT has significant potential for application in the noninvasive assessment of burn depth...
  38. ncbi request reprint Noninvasive photoacoustic angiography of animal brains in vivo with near-infrared light and an optical contrast agent
    Xueding Wang
    Optical Imaging Laboratory, Department of Biomedical Engineering, Texas A and M University, College Station, Texas 77843 3120, USA
    Opt Lett 29:730-2. 2004
    ..This new technology demonstrates the potential for dynamic and molecular biomedical imaging...
  39. ncbi request reprint Photoacoustic imaging of the microvasculature with a high-frequency ultrasound array transducer
    Roger J Zemp
    Washington University, Optical Imaging Laboratory, Department of Biomedical Engineering, Saint Louis, Missouri 63130, USA
    J Biomed Opt 12:010501. 2007
    ..It is anticipated that the system can be used for studying and diagnosing a number of diseases including cancer, atherosclerosis, dermatological disorders, and peripheral microvascular complications in diabetes...
  40. ncbi request reprint Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism
    Eugenio Gaudio
    Division of Anatomy, University La Sapienza, Rome, Italy
    Gastroenterology 130:1270-82. 2006
    ..The role of VEGF in cholangiocyte pathophysiology is unknown. We evaluated the role of VEGF in the regulation of cholangiocyte proliferation in rats that underwent bile duct ligation...
  41. ncbi request reprint Photoacoustic imaging of lacZ gene expression in vivo
    Li Li
    Washington University in St Louis, Optical Imaging Laboratory, Department of Biomedical Engineering, St Louis, Missouri 63130, USA
    J Biomed Opt 12:020504. 2007
    ..With the future development of new absorption-based reporter gene systems, it is anticipated that photoacoustic technology will provide a valuable tool for molecular imaging research...
  42. ncbi request reprint ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes
    Na Liu
    Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park Research Division, Smithville, TX 78957, USA
    Lab Invest 85:1471-80. 2005
    ..ERK1/2 activation and astrogliosis are also found in other parts of the brain, for example, the cortex. We conclude that ATM deficiency induces intrinsic growth defects, oxidative stress, ER stress, and ERKs activation in astrocytes...
  43. ncbi request reprint Possible involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in MoMuLV-ts1-induced apoptosis in astrocytes
    Na Liu
    Department of Carcinogenesis, University of Texas, MD Anderson Cancer Center, Science Park Research Division, Smithville, 78957, USA
    J Neurovirol 10:189-98. 2004
    ..Together the data imply that both ER stress- and mitochondrial stress-related apoptotic pathways are involved in ts1-induced astrocyte death...