Farida Sohrabji

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. ncbi request reprint Estrogen: a neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models
    Farida Sohrabji
    Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University Health Science Center, College Station, TX 77843, USA
    Ann N Y Acad Sci 1052:75-90. 2005
  2. pmc Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 195:47-59. 2008
  3. ncbi request reprint Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen
    Adam B Johnson
    Department of Anatomy and Medical Neurobiology, TAMUS Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Neuroimmunol 174:82-91. 2006
  4. ncbi request reprint Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?
    Farida Sohrabji
    Neuroscience and Experimental Therapeutics, Department of Human Anatomy and Medical Neurobiology, TAMHSC College of Medicine, College Station, TX 77843 1114, USA
    Endocrine 29:191-7. 2006
  5. pmc A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics and Women s Health in Neuroscience Program, TAM Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 223:31-8. 2010
  6. pmc The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    Amutha Selvamani
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843, USA
    J Neurosci 30:6852-61. 2010
  7. pmc Estrogen-BDNF interactions: implications for neurodegenerative diseases
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    Front Neuroendocrinol 27:404-14. 2006
  8. ncbi request reprint Estrogen's effects on central and circulating immune cells vary with reproductive age
    Adam B Johnson
    Department of Anatomy and Medical Neurobiology, TAMUS Health Science Center, College of Medicine, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Neurobiol Aging 26:1365-74. 2005
  9. doi request reprint Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function
    Danielle K Lewis
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Neurobiol Aging 33:1123.e1-16. 2012
  10. ncbi request reprint Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, TX 77843, USA
    Gene Expr 13:311-9. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Estrogen: a neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models
    Farida Sohrabji
    Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University Health Science Center, College Station, TX 77843, USA
    Ann N Y Acad Sci 1052:75-90. 2005
    ..The paper will also review aging and reproductive age-related changes in the estrogen receptor (ER) systems, specifically ER-alpha, as a potential mechanism for estrogen's deleterious effects in the reproductive senescent animal...
  2. pmc Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 195:47-59. 2008
    ....
  3. ncbi request reprint Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen
    Adam B Johnson
    Department of Anatomy and Medical Neurobiology, TAMUS Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Neuroimmunol 174:82-91. 2006
    ..These data suggest that the central inflammatory response to a systemic insult can be modulated by estrogen although the mechanism underlying the initiation of this response varies with reproductive age...
  4. ncbi request reprint Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?
    Farida Sohrabji
    Neuroscience and Experimental Therapeutics, Department of Human Anatomy and Medical Neurobiology, TAMHSC College of Medicine, College Station, TX 77843 1114, USA
    Endocrine 29:191-7. 2006
    ....
  5. pmc A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics and Women s Health in Neuroscience Program, TAM Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 223:31-8. 2010
    ....
  6. pmc The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    Amutha Selvamani
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843, USA
    J Neurosci 30:6852-61. 2010
    ..These data support the hypothesis that stroke severity in older females is associated with decreased IGF-1 and further indicate that short-term postischemic IGF-1 therapy may be beneficial for stroke...
  7. pmc Estrogen-BDNF interactions: implications for neurodegenerative diseases
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    Front Neuroendocrinol 27:404-14. 2006
    ..This review describes the distribution of BDNF and trkB expressing cells in the forebrain, and the roles of estrogen and the BDNF-trkB neurotrophin system in Parkinson's disease, Alzheimer's disease and multiple sclerosis...
  8. ncbi request reprint Estrogen's effects on central and circulating immune cells vary with reproductive age
    Adam B Johnson
    Department of Anatomy and Medical Neurobiology, TAMUS Health Science Center, College of Medicine, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Neurobiol Aging 26:1365-74. 2005
    ....
  9. doi request reprint Age-related severity of focal ischemia in female rats is associated with impaired astrocyte function
    Danielle K Lewis
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Neurobiol Aging 33:1123.e1-16. 2012
    ..These studies show that the aging astrocyte may directly contribute to infarct severity by inefficient glutamate clearance and enhanced cytokine production and suggest a cellular target for improved stroke therapy among older females...
  10. ncbi request reprint Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, TX 77843, USA
    Gene Expr 13:311-9. 2007
    ..This article considers the disruption of the blood-brain barrier in Alzheimer's disease and forwards the hypothesis that estrogen may preserve neural health by maintaining the integrity of the blood-brain barrier...
  11. pmc Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats
    Amutha Selvamani
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Neurobiol Aging 31:1618-28. 2010
    ....
  12. ncbi request reprint Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals
    Vanessa L Nordell
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System, Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Neurobiol Aging 24:733-43. 2003
    ....
  13. pmc Vitamin D deficiency exacerbates experimental stroke injury and dysregulates ischemia-induced inflammation in adult rats
    Robyn Balden
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, 228 Reynolds Medical Building, College Station, Texas 77843 1114, USA
    Endocrinology 153:2420-35. 2012
    ..Our data indicate that VDD exacerbates stroke severity, involving both a dysregulation of the inflammatory response as well as suppression of known neuroprotectants such as IGF-I...
  14. pmc The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats
    Vanessa L Nordell
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System Health Science Center College of Medicine, College Station, TX 77843 USA
    BMC Neurosci 6:58. 2005
    ..Previously, we reported that estrogen attenuated local increases of interleukin(IL)-1beta in the NMDA-lesioned olfactory bulb, while further increasing NGF expression...
  15. pmc Astrocytes from acyclic female rats exhibit lowered capacity for neuronal differentiation
    Danielle K Lewis
    TAMU Health Science Center, Department of Neuroscience and Experimental Therapeutics, College Station, TX 77843 1114, USA
    Aging Cell 7:836-49. 2008
    ....
  16. pmc Estrogen receptor-alpha overexpression suppresses 17beta-estradiol-mediated vascular endothelial growth factor expression and activation of survival kinases
    Shameena Bake
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843 1114, USA
    Endocrinology 149:3881-9. 2008
    ..The present data also support the hypothesis that 17beta-estradiol treatment to an ERalpha overexpressing system, such as the senescent brain, could reverse the normally observed beneficial effect of estrogen...
  17. ncbi request reprint Estrogen enhances retrograde transport of brain-derived neurotrophic factor in the rodent forebrain
    Melinda K Jezierski
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    Endocrinology 144:5022-9. 2003
    ..These studies support the hypothesis that estrogen facilitates neurotrophin transport in forebrain circuits...
  18. pmc Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins
    Shameena Bake
    Department of Neuroscience and Experimental Therapeutics, TAMHSC College of Medicine, College Station, TX 77843, USA
    Microvasc Res 78:413-24. 2009
    ..Collectively, these data support the hypothesis that constitutive loss of barrier integrity in the forebrain during reproductive senescence may be due, in part, to the selective loss of tight junction proteins in endothelial junctions...
  19. pmc Revisiting the timing hypothesis: biomarkers that define the therapeutic window of estrogen for stroke
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, Women s Health in Neuroscience Program, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Horm Behav 63:222-30. 2013
    ..Together, age-related decline of these factors differentially affects stroke risk, severity, and outcome, and may provide a novel therapeutic adjunct to traditional HT practices...
  20. pmc Ethanol regulates angiogenic cytokines during neural development: evidence from an in vitro model of mitogen-withdrawal-induced cerebral cortical neuroepithelial differentiation
    Cynthia Camarillo
    Texas A and M Health Science Center, College of Medicine, Department Neuroscience and Experimental Therapeutics, College Station, USA
    Alcohol Clin Exp Res 31:324-35. 2007
    ..Emerging evidence suggests that cytokines play a crucial growth-promoting role in the developing neural tube...
  21. pmc Adverse effects of incorporating ketoprofen into established rodent studies
    Tennille K Lamon
    Texas A and M University, College Station, TX, USA
    J Am Assoc Lab Anim Sci 47:20-4. 2008
    ..These results suggest that the adverse effects seen after administration of ketoprofen were due to differences between barriers...
  22. ncbi request reprint 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats
    Shameena Bake
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University Health Science Center College of Medicine, College Station, Texas 77843 1114, USA
    Endocrinology 145:5471-5. 2004
    ..These results support the hypothesis that the hormonal decline that marks reproductive senescence leads to increased permeability of the blood-brain barrier, which is further exacerbated by estrogen treatment in specific regions...
  23. doi request reprint Vascular and metabolic dysfunction in Alzheimer's disease: a review
    Ian V J Murray
    Neuroscience and Experimental Therapeutics, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Exp Biol Med (Maywood) 236:772-82. 2011
    ..The common denominator between vascular and metabolic dysfunction emerging from this review appears to be oxidative stress and Aβ. This review also provides a framework for evaluation of current and future therapeutics for AD...
  24. ncbi request reprint Neurodegeneration in women
    Farida Sohrabji
    Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas, USA
    Alcohol Res Health 26:316-8. 2002