F Sohrabji

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats
    Vanessa L Nordell
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System Health Science Center College of Medicine, College Station, TX 77843 USA
    BMC Neurosci 6:58. 2005
  2. ncbi request reprint Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?
    Farida Sohrabji
    Neuroscience and Experimental Therapeutics, Department of Human Anatomy and Medical Neurobiology, TAMHSC College of Medicine, College Station, TX 77843 1114, USA
    Endocrine 29:191-7. 2006
  3. ncbi request reprint Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen
    F Sohrabji
    Department of Human Anatomy and Neurobiology, 228, Reynolds Medical Building, Texas A and M System Health Science Center, College Station, Texas 77843 1114, USA
    J Neurobiol 45:61-74. 2000
  4. pmc Estrogen-BDNF interactions: implications for neurodegenerative diseases
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    Front Neuroendocrinol 27:404-14. 2006
  5. ncbi request reprint Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, TX 77843, USA
    Gene Expr 13:311-9. 2007
  6. ncbi request reprint Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation
    M K Jezierski
    Department of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843-1114, USA
    Neurobiol Aging 22:309-19. 2001
  7. ncbi request reprint Region- and peptide-specific regulation of the neurotrophins by estrogen
    M K Jezierski
    Department of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, 228 Reynolds Medical Building, College Station, Texas, TX 77843 1114, USA
    Brain Res Mol Brain Res 85:77-84. 2000
  8. ncbi request reprint Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals
    Vanessa L Nordell
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System, Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Neurobiol Aging 24:733-43. 2003
  9. pmc Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 195:47-59. 2008
  10. ncbi request reprint Estrogen enhances retrograde transport of brain-derived neurotrophic factor in the rodent forebrain
    Melinda K Jezierski
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    Endocrinology 144:5022-9. 2003

Collaborators

Detail Information

Publications23

  1. pmc The neurotrophin receptor p75NTR mediates early anti-inflammatory effects of estrogen in the forebrain of young adult rats
    Vanessa L Nordell
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System Health Science Center College of Medicine, College Station, TX 77843 USA
    BMC Neurosci 6:58. 2005
    ..Previously, we reported that estrogen attenuated local increases of interleukin(IL)-1beta in the NMDA-lesioned olfactory bulb, while further increasing NGF expression...
  2. ncbi request reprint Age-related changes in neuroprotection: is estrogen pro-inflammatory for the reproductive senescent brain?
    Farida Sohrabji
    Neuroscience and Experimental Therapeutics, Department of Human Anatomy and Medical Neurobiology, TAMHSC College of Medicine, College Station, TX 77843 1114, USA
    Endocrine 29:191-7. 2006
    ....
  3. ncbi request reprint Local and cortical effects of olfactory bulb lesions on trophic support and cholinergic function and their modulation by estrogen
    F Sohrabji
    Department of Human Anatomy and Neurobiology, 228, Reynolds Medical Building, Texas A and M System Health Science Center, College Station, Texas 77843 1114, USA
    J Neurobiol 45:61-74. 2000
    ..Furthermore, these data also indicate that estrogen selectively attenuates certain lesion-induced deficits...
  4. pmc Estrogen-BDNF interactions: implications for neurodegenerative diseases
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    Front Neuroendocrinol 27:404-14. 2006
    ..This review describes the distribution of BDNF and trkB expressing cells in the forebrain, and the roles of estrogen and the BDNF-trkB neurotrophin system in Parkinson's disease, Alzheimer's disease and multiple sclerosis...
  5. ncbi request reprint Guarding the blood-brain barrier: a role for estrogen in the etiology of neurodegenerative disease
    Farida Sohrabji
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, TX 77843, USA
    Gene Expr 13:311-9. 2007
    ..This article considers the disruption of the blood-brain barrier in Alzheimer's disease and forwards the hypothesis that estrogen may preserve neural health by maintaining the integrity of the blood-brain barrier...
  6. ncbi request reprint Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation
    M K Jezierski
    Department of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843-1114, USA
    Neurobiol Aging 22:309-19. 2001
    ..Changes in the proportion or ratio of steroid receptor/coactivator systems in the aging forebrain may contribute to the refractory response to estrogen in the reproductively senescent animals...
  7. ncbi request reprint Region- and peptide-specific regulation of the neurotrophins by estrogen
    M K Jezierski
    Department of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, 228 Reynolds Medical Building, College Station, Texas, TX 77843 1114, USA
    Brain Res Mol Brain Res 85:77-84. 2000
    ..Since the two estrogen receptors have been shown to stimulate different signaling pathways, we hypothesize that estrogen acting through specific receptors may differentially influence the extent and direction of neurotrophin expression...
  8. ncbi request reprint Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals
    Vanessa L Nordell
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System, Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Neurobiol Aging 24:733-43. 2003
    ....
  9. pmc Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics, TAMU Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 195:47-59. 2008
    ....
  10. ncbi request reprint Estrogen enhances retrograde transport of brain-derived neurotrophic factor in the rodent forebrain
    Melinda K Jezierski
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University System Health Science Center, College Station, Texas 77843, USA
    Endocrinology 144:5022-9. 2003
    ..These studies support the hypothesis that estrogen facilitates neurotrophin transport in forebrain circuits...
  11. ncbi request reprint Nerve growth factor (NGF) regulation of estrogen receptors in explant cultures of the developing forebrain
    R Miranda
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurobiol 31:77-87. 1996
    ..Alterations in nuclear estrogen binding but not estrogen receptor mRNA levels suggests that NGF may regulate cortical estrogen receptors posttranscriptionally...
  12. ncbi request reprint Estrogen: a neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models
    Farida Sohrabji
    Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University Health Science Center, College Station, TX 77843, USA
    Ann N Y Acad Sci 1052:75-90. 2005
    ..The paper will also review aging and reproductive age-related changes in the estrogen receptor (ER) systems, specifically ER-alpha, as a potential mechanism for estrogen's deleterious effects in the reproductive senescent animal...
  13. pmc Adverse effects of incorporating ketoprofen into established rodent studies
    Tennille K Lamon
    Texas A and M University, College Station, TX, USA
    J Am Assoc Lab Anim Sci 47:20-4. 2008
    ..These results suggest that the adverse effects seen after administration of ketoprofen were due to differences between barriers...
  14. pmc Reproductive age modulates the impact of focal ischemia on the forebrain as well as the effects of estrogen treatment in female rats
    Amutha Selvamani
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    Neurobiol Aging 31:1618-28. 2010
    ....
  15. ncbi request reprint Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen
    Adam B Johnson
    Department of Anatomy and Medical Neurobiology, TAMUS Health Science Center, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    J Neuroimmunol 174:82-91. 2006
    ..These data suggest that the central inflammatory response to a systemic insult can be modulated by estrogen although the mechanism underlying the initiation of this response varies with reproductive age...
  16. ncbi request reprint Estrogen's effects on central and circulating immune cells vary with reproductive age
    Adam B Johnson
    Department of Anatomy and Medical Neurobiology, TAMUS Health Science Center, College of Medicine, 228 Reynolds Medical Building, College Station, TX 77843 1114, USA
    Neurobiol Aging 26:1365-74. 2005
    ....
  17. ncbi request reprint 17beta-estradiol differentially regulates blood-brain barrier permeability in young and aging female rats
    Shameena Bake
    Department of Human Anatomy and Medical Neurobiology, Texas A and M University Health Science Center College of Medicine, College Station, Texas 77843 1114, USA
    Endocrinology 145:5471-5. 2004
    ..These results support the hypothesis that the hormonal decline that marks reproductive senescence leads to increased permeability of the blood-brain barrier, which is further exacerbated by estrogen treatment in specific regions...
  18. pmc The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1
    Amutha Selvamani
    Women s Health in Neuroscience Program, Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843, USA
    J Neurosci 30:6852-61. 2010
    ..These data support the hypothesis that stroke severity in older females is associated with decreased IGF-1 and further indicate that short-term postischemic IGF-1 therapy may be beneficial for stroke...
  19. ncbi request reprint NGF stimulation increases JNK2 phosphorylation and reduces caspase-3 activity in the olfactory bulb of estrogen-replaced animals
    M K Jezierski
    Department of Human Anatomy and Medical Neurobiology, The Texas A and M University System Health Science Center, College Station 77843-1114, USA
    Endocrinology 142:2401. 2001
    ..In view of the disparate roles assigned to JNK, this latter finding suggests that estrogen pretreatment may preferentially direct neurotrophin-dependent JNK activation toward regeneration and plasticity rather than cell death...
  20. ncbi request reprint Neurodegeneration in women
    Farida Sohrabji
    Department of Human Anatomy and Medical Neurobiology, College of Medicine, Texas A and M University System Health Science Center, College Station, Texas, USA
    Alcohol Res Health 26:316-8. 2002
  21. pmc Reproductive age-related changes in the blood brain barrier: expression of IgG and tight junction proteins
    Shameena Bake
    Department of Neuroscience and Experimental Therapeutics, TAMHSC College of Medicine, College Station, TX 77843, USA
    Microvasc Res 78:413-24. 2009
    ..Collectively, these data support the hypothesis that constitutive loss of barrier integrity in the forebrain during reproductive senescence may be due, in part, to the selective loss of tight junction proteins in endothelial junctions...
  22. pmc A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats
    Danielle K Lewis
    Department of Neuroscience and Experimental Therapeutics and Women s Health in Neuroscience Program, TAM Health Science Center, College Station, TX 77843 1114, USA
    J Neuroimmunol 223:31-8. 2010
    ....
  23. pmc Estrogen receptor-alpha overexpression suppresses 17beta-estradiol-mediated vascular endothelial growth factor expression and activation of survival kinases
    Shameena Bake
    Department of Neuroscience and Experimental Therapeutics, Texas A and M Health Science Center College of Medicine, College Station, Texas 77843 1114, USA
    Endocrinology 149:3881-9. 2008
    ..The present data also support the hypothesis that 17beta-estradiol treatment to an ERalpha overexpressing system, such as the senescent brain, could reverse the normally observed beneficial effect of estrogen...