R F Smith

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. ncbi request reprint BCM Search Launcher--an integrated interface to molecular biology data base search and analysis services available on the World Wide Web
    R F Smith
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 6:454-62. 1996
  2. ncbi request reprint Developments in ghrelin biology and potential clinical relevance
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 16:436-42. 2005
  3. ncbi request reprint Molecular endocrinology and physiology of the aging central nervous system
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
    Endocr Rev 26:203-50. 2005
  4. ncbi request reprint Growth hormone secretagogues: prospects and potential pitfalls
    Roy G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza N704, M320, Houston, TX 77030 3498, USA
    Best Pract Res Clin Endocrinol Metab 18:333-47. 2004
  5. ncbi request reprint Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, MS BCM M230, Houston, TX 77030, USA
    Ann N Y Acad Sci 1119:147-64. 2007
  6. ncbi request reprint Huffington Center on Aging
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, N704, Houston, TX 77030 3498, USA
    Exp Gerontol 37:963-9. 2002
  7. ncbi request reprint Growth hormone secretagogue receptor family members and ligands
    R G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Endocrine 14:9-14. 2001
  8. ncbi request reprint Adenosine: A partial agonist of the growth hormone secretagogue receptor
    R G Smith
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA
    Biochem Biophys Res Commun 276:1306-13. 2000
  9. ncbi request reprint The aging process: where are the drug opportunities?
    R G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Chem Biol 4:371-6. 2000
  10. ncbi request reprint Growth hormone releasing substances: types and their receptors
    R G Smith
    Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Horm Res 51:1-8. 1999

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint BCM Search Launcher--an integrated interface to molecular biology data base search and analysis services available on the World Wide Web
    R F Smith
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 6:454-62. 1996
    ..The BCM Search Launcher and batch client are available on the WWW at URL http:@gc.bcm.tmc.edu:8088/search-launcher.html...
  2. ncbi request reprint Developments in ghrelin biology and potential clinical relevance
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Trends Endocrinol Metab 16:436-42. 2005
    ....
  3. ncbi request reprint Molecular endocrinology and physiology of the aging central nervous system
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
    Endocr Rev 26:203-50. 2005
    ....
  4. ncbi request reprint Growth hormone secretagogues: prospects and potential pitfalls
    Roy G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza N704, M320, Houston, TX 77030 3498, USA
    Best Pract Res Clin Endocrinol Metab 18:333-47. 2004
    ..Ghrelin levels are reported to decline during ageing, therefore long-acting GHSs are ideal candidates for ghrelin replacement therapy...
  5. ncbi request reprint Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, MS BCM M230, Houston, TX 77030, USA
    Ann N Y Acad Sci 1119:147-64. 2007
    ..We speculate that aging is associated with deficient endogenous ghrelin signaling that can be rescued by intervention with GHS-R1a agonists to improve quality of life and maintain independence...
  6. ncbi request reprint Huffington Center on Aging
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, N704, Houston, TX 77030 3498, USA
    Exp Gerontol 37:963-9. 2002
  7. ncbi request reprint Growth hormone secretagogue receptor family members and ligands
    R G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Endocrine 14:9-14. 2001
    ..We also confirmed that the endogenous ligand ghrelin is a full agonist of the GHS-R...
  8. ncbi request reprint Adenosine: A partial agonist of the growth hormone secretagogue receptor
    R G Smith
    Huffington Center on Aging, Baylor College of Medicine, Houston, Texas, USA
    Biochem Biophys Res Commun 276:1306-13. 2000
    ..We propose, that adenosine is a physiologically important endogenous GHS-R ligand and speculate that GHS-R ligands modulate dopamine release from hypothalamic neurons...
  9. ncbi request reprint The aging process: where are the drug opportunities?
    R G Smith
    Huffington Center on Aging and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Curr Opin Chem Biol 4:371-6. 2000
    ..The orphan nuclear receptor Nurr1 appears to be a target for treatment of Parkinson's disease, and propargylamines are emerging as inhibitors of oxidative damage in neurons...
  10. ncbi request reprint Growth hormone releasing substances: types and their receptors
    R G Smith
    Huffington Center on Aging and Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Horm Res 51:1-8. 1999
    ..This new information is consistent with a natural ligand for the GHS-R playing a fundamentally important and conserved role in physiology...
  11. pmc Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:4679-84. 2004
    ..Our results suggest that chronic treatment with ghrelin antagonists will have little effect on growth or appetite...
  12. ncbi request reprint BEAUTY: an enhanced BLAST-based search tool that integrates multiple biological information resources into sequence similarity search results
    K C Worley
    Department of Molecular and Human Genetics, W M Keck Center for Computational Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 5:173-84. 1995
    ..BEAUTY searches can be performed remotely on our system using the "BCM Search Launcher" World-Wide Web pages (URL is < http:/ /gc.bcm.tmc.edu:8088/ search-launcher/launcher.html > )...
  13. ncbi request reprint Growth hormone corrects proliferation and transcription of phosphoenolpyruvate carboxykinase in livers of old mice via elimination of CCAAT/enhancer-binding protein alpha-Brm complex
    Guo Li Wang
    Huffington Center on Aging and Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 282:1468-78. 2007
    ..GH-dependent elimination of the complex is mediated by the inhibition of cyclin D3-CDK4 activity and by elevation of a phosphatase, protein phosphatase 2A, which dephosphorylates C/EBPalpha and dissociates the complex...
  14. ncbi request reprint Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cell Metab 3:379-86. 2006
    ..Hence, chronically, ghrelin controls glucose homeostasis by regulating pancreatic Ucp2 expression and insulin sensitivity...
  15. ncbi request reprint Ghrelin and growth hormone secretagogue receptor expression in mice during aging
    Yuxiang Sun
    Huffington Center on Aging, Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, M320, Houston, TX 77030, USA
    Endocrinology 148:1323-9. 2007
    ..In the brain, Ghsr1a mRNA levels remained stable during aging. Hence, in C57BL/6J male mice, aging is not associated with changes in circulating ghrelin levels or changes in ghrelin receptor expression in the pituitary gland and brain...
  16. ncbi request reprint Central and peripheral roles of ghrelin on glucose homeostasis
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Neuroendocrinology 86:215-28. 2007
    ..This review focuses on the newly emerging role of ghrelin in glucose homeostasis and exploration of whether ghrelin is a potential therapeutic target for diabetes...
  17. pmc Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes
    Guo Li Wang
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Cell Biol 26:2570-82. 2006
    ..The inhibition of cyclin D3 blocks the formation of these complexes. Thus, these studies provide a new function of cyclin D3, which is to support the growth-inhibitory activity of C/EBPalpha...
  18. ncbi request reprint The steroidogenic acute regulatory protein is expressed in steroidogenic cells of the day-old brain
    Steven R King
    Room N730, Scott Department of Urology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030 3498, USA
    Endocrinology 145:4775-80. 2004
    ..Importantly, StAR protein is present in cells that also express P450scc. These data suggest that, as with the adult, neurosteroid production during development occurs through a StAR-mediated pathway...
  19. ncbi request reprint Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia
    Jose M Garcia
    Department of Medicine, Division of Diabetes, Endocrinology, and Metabolism and The Huffington Center on Aging, Baylor College of Medicine, and Michael E DeBakey Veterans Affairs Medical Center, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 90:2920-6. 2005
    ..Changes in the active to total ghrelin ratio suggest that a mechanism other than increased secretion must be responsible for the increase in active ghrelin levels. PYY is unlikely to play an important role in cancer-induced cachexia...
  20. ncbi request reprint Mutations in NR4A2 associated with familial Parkinson disease
    Wei Dong LE
    Department of Neurology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Genet 33:85-9. 2003
    ..Additionally, mutations in NR4A2 affect transcription of the gene encoding tyrosine hydroxylase. These data suggest that mutations in NR4A2 can cause dopaminergic dysfunction, associated with Parkinson disease...
  21. ncbi request reprint BEAUTY-X: enhanced BLAST searches for DNA queries
    K C Worley
    Human Genome Center, Department of Molecular and Human Genetics, Baylor College of Medicine, N 1519 08, One Baylor Plaza, Houston, TX 77030, USA
    Bioinformatics 14:890-1. 1998
    ..6) (ftp://gc.bcm.tmc. edu/pub/software/search-launcher/). SUPPLEMENTARY INFORMATION: Example figures are available at http://dot.bcm.tmc. edu:9331/papers/beautypp.html CONTACT: (kworley,culpep)@bcm.tmc.edu..
  22. pmc Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia
    Jose M Garcia
    Division of Endocrinology, Diabetes and Metabolism, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
    Endocrinology 149:455-60. 2008
    ..Attenuation of mechanical hyperalgesia in the rat by the hormone ghrelin provides a unique model for elucidating the mechanisms involved, which are essential toward our understanding of these complications...
  23. ncbi request reprint Development of growth hormone secretagogues
    Roy G Smith
    Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Room M320, Houston, Texas 77030 3498, USA
    Endocr Rev 26:346-60. 2005
    ..Reverse pharmacology was completed when the cloned GHS-R was exploited to identify an endogenous agonist (ghrelin) and a partial agonist (adenosine); ghsr-knockout mice studies confirmed that GHS are ghrelin mimetics...
  24. ncbi request reprint Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers
    Hong Jiang
    Huffington Center of Aging, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 20:1772-85. 2006
    ..Most importantly, these results indicate that ghrelin has the potential to amplify dopamine signaling selectively in neurons that coexpress D1R and GHS-R...
  25. pmc Deletion of ghrelin impairs neither growth nor appetite
    Yuxiang Sun
    Department of Molecular and Cellular Biology, Huffington Center on Aging, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 23:7973-81. 2003
    ..Therefore, antagonists of ghrelin are unlikely to have broad utility as antiobesity agents...
  26. ncbi request reprint A comparative transcription map of the murine bare patches (Bpa) and striated (Str) critical regions and human Xq28
    M L Levin
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genome Res 6:465-77. 1996
    ....
  27. ncbi request reprint Perspectives: sequence data base searching in the era of large-scale genomic sequencing
    R F Smith
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030 USA
    Genome Res 6:653-60. 1996
    ..Improved data base annotation tools and construction of smaller data bases of representative and highly-annotated sequences for first-pass analyses will be essential to deal with the impending flood of new genomic sequence...
  28. pmc Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance
    Yuxiang Sun
    Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA
    Endocrinology 149:843-50. 2008
    ..These results support our hypothesis that the primary metabolic function of ghrelin in adult mice is to modulate glucose sensing and insulin sensitivity, rather than directly regulate energy intake and energy expenditure...
  29. ncbi request reprint An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain
    Steven R King
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Neurosci 22:10613-20. 2002
    ..These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain...
  30. ncbi request reprint The growth hormone secretagogue receptor
    Conrad Russell Young Cruz
    Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA
    Vitam Horm 77:47-88. 2008
    ..But science has barely scratched the surface, and we can be assured that the mysteries surrounding the precise nature of ghrelin and its receptor(s) are only beginning to unravel...
  31. ncbi request reprint The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    Michael A Cowley
    The Vollum Institute, Oregon Health and Science University, Portland, OR 97201, USA
    Neuron 37:649-61. 2003
    ..We propose that at these sites, release of ghrelin may stimulate the release of orexigenic peptides and neurotransmitters, thus representing a novel regulatory circuit controlling energy homeostasis...
  32. ncbi request reprint Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    Koji Toshinai
    Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Endocrinology 147:2306-14. 2006
    ..Central des-acyl ghrelin may activate orexin-expressing neurons, perhaps functioning in feeding regulation through interactions with a target protein distinct from the GHS-R...
  33. ncbi request reprint Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine
    Marcos C Carreira
    Department of Medicine, Research Area, Molecular Endocrinology Laboratory, Complejo Hospitalario Universitario de Santiago CHUS and University of Santiago de Compostela, Santiago de Compostela, Spain
    Neuroendocrinology 79:13-25. 2004
    ..The regulation of the ghrelin-activated earliest signaling pathways by adenosine may have unexpected implications in the GHSR-1a actions...
  34. ncbi request reprint Nonhereditary enhancement of progeny growth
    Amir S Khan
    Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 143:3561-7. 2002
    ..These unique findings demonstrate that enhanced GH-releasing hormone expression in pregnant dams can result in intergenerational growth promotion by altering development of the pituitary gland in the offspring...
  35. pmc Ghrelin promotes thymopoiesis during aging
    Vishwa Deep Dixit
    Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA
    J Clin Invest 117:2778-90. 2007
    ....
  36. ncbi request reprint Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice
    Eva Szentirmai
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Program in Neuroscience, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6520, USA
    Am J Physiol Regul Integr Comp Physiol 293:R510-7. 2007
    ..It is possible that redundancy in the arousal systems of the brain or activation of compensatory mechanisms during development allow for normal sleep-wake regulation in ghrelin KO mice...
  37. pmc Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor
    Sabata Pierno
    Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Italy
    Br J Pharmacol 139:575-84. 2003
    ..This peripheral action may account for the lack of restoration of skeletal muscle function in long-term GHS-treated aged animals...
  38. ncbi request reprint Antidiabetic activity of a highly potent and selective nonpeptide somatostatin receptor subtype-2 agonist
    Mathias Z Strowski
    Medizinische Klinik m S Hepatologie, Gastroenterologie, Endokrinologie und Stoffwechsel, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany
    Endocrinology 147:4664-73. 2006
    ..In summary, small-molecule sst(2)-selective agonists that suppress glucagon secretion offer a novel approach toward the development of orally bioavailable drugs for treatment of type 2 diabetes...
  39. ncbi request reprint Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a
    Jesús P Camiña
    Molecular and Cellular Endocrinology Laboratory, Department of Medicine, Complejo Hospitalario Universitario de Santiago Universidad de Santiago de Compostela, P O Box 56, E 15780 Santiago de Compostela, Spain
    Endocrinology 145:930-40. 2004
    ..The GHSR-1a internalization may explain the characteristic physiological responses mediated by this receptor...

Research Grants2

  1. Regulatory Role of Growth Hormone Secretagogue Receptor
    Roy Smith; Fiscal Year: 2007
    ..We hypothesize that clinical use of ghrelin mimetics will translate to improved cognitive function in the elderly. ..