Carolyn Smith

Summary

Affiliation: Texas Medical Center
Country: USA

Publications

  1. pmc Marinobufagenin interferes with the function of the mineralocorticoid receptor
    Carolyn L Smith
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochem Biophys Res Commun 356:930-4. 2007
  2. pmc Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2
    Christopher C Williams
    1Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA
    BMC Biochem 10:36. 2009
  3. ncbi request reprint Cross-talk between peptide growth factor and estrogen receptor signaling pathways
    C L Smith
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Biol Reprod 58:627-32. 1998
  4. ncbi request reprint Transcriptional regulation by steroid receptor coactivator phosphorylation
    Ray Chang Wu
    Molecular and Cellular Biology, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Rev 26:393-9. 2005
  5. ncbi request reprint Coregulator function: a key to understanding tissue specificity of selective receptor modulators
    Carolyn L Smith
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocr Rev 25:45-71. 2004
  6. pmc Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction
    Carolyn L Smith
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Cell Biol 22:525-35. 2002
  7. ncbi request reprint Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains
    Martin Dutertre
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:1296-314. 2003
  8. pmc Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor
    Fuzhong F Zheng
    Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:8273-84. 2005
  9. pmc Implementation of Texas Senate Bill 19 to increase physical activity in elementary schools
    Steven H Kelder
    School of Public Health, University of Texas at Houston, Austin Regional Campus, Austin, TX 78701, USA
    J Public Health Policy 30:S221-47. 2009
  10. pmc Senate Bill 42: implementation and impact on physical activity in middle schools
    Cristina S Barroso
    Hispanic Health Research Center, Michael and Susan Dell Center for Advancement of Healthy Living, University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas 78520, USA
    J Adolesc Health 45:S82-90. 2009

Research Grants

Collaborators

Detail Information

Publications31

  1. pmc Marinobufagenin interferes with the function of the mineralocorticoid receptor
    Carolyn L Smith
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Biochem Biophys Res Commun 356:930-4. 2007
    ..Thus, the ability of MBG to cause a natriuresis may be due, not only to inhibition of Na+/K+-ATPase activity, but also to its ability to interfere with MR-dependent expression of the Na/K/H exchanger in the late distal nephron...
  2. pmc Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2
    Christopher C Williams
    1Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA, USA
    BMC Biochem 10:36. 2009
    ..To determine if additional ERalpha phosphorylation sites exist, COS-1 cells expressing human ERalpha were labeled with [32P]H3PO4 in vivo and ERalpha tryptic phosphopeptides were isolated to identify phosphorylation sites...
  3. ncbi request reprint Cross-talk between peptide growth factor and estrogen receptor signaling pathways
    C L Smith
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Biol Reprod 58:627-32. 1998
    ..Thus, steroid receptor function may be regulated by estrogenic ligands as well as by pathway "cross-talk" from membrane receptors for growth factors...
  4. ncbi request reprint Transcriptional regulation by steroid receptor coactivator phosphorylation
    Ray Chang Wu
    Molecular and Cellular Biology, One Baylor Plaza, Houston, Texas 77030, USA
    Endocr Rev 26:393-9. 2005
    ....
  5. ncbi request reprint Coregulator function: a key to understanding tissue specificity of selective receptor modulators
    Carolyn L Smith
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocr Rev 25:45-71. 2004
    ..Increased understanding of the effect of cellular environment on nuclear receptors and their coregulators has the potential to open the field of SRM discovery and research to many members of the nuclear receptor superfamily...
  6. pmc Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction
    Carolyn L Smith
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Cell Biol 22:525-35. 2002
    ....
  7. ncbi request reprint Ligand-independent interactions of p160/steroid receptor coactivators and CREB-binding protein (CBP) with estrogen receptor-alpha: regulation by phosphorylation sites in the A/B region depends on other receptor domains
    Martin Dutertre
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 17:1296-314. 2003
    ....
  8. pmc Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor
    Fuzhong F Zheng
    Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA
    Mol Cell Biol 25:8273-84. 2005
    ..Our results provide evidence for an early nongenomic action of ER on SRC-3 that supports the well-established downstream genomic roles of estrogen and coactivators...
  9. pmc Implementation of Texas Senate Bill 19 to increase physical activity in elementary schools
    Steven H Kelder
    School of Public Health, University of Texas at Houston, Austin Regional Campus, Austin, TX 78701, USA
    J Public Health Policy 30:S221-47. 2009
    ..Results underscore the importance of continued monitoring of enacted legislation, and that legislation for child health that focuses on school programs and policies requires funding and refinement to produce the intended effect...
  10. pmc Senate Bill 42: implementation and impact on physical activity in middle schools
    Cristina S Barroso
    Hispanic Health Research Center, Michael and Susan Dell Center for Advancement of Healthy Living, University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas 78520, USA
    J Adolesc Health 45:S82-90. 2009
    ..The purpose of this study was to assess awareness of and adherence to SB42 in Texas middle schools, and to assess the impact of SB42 on the frequency and quality of structured physical activity...
  11. pmc Unique roles of p160 coactivators for regulation of breast cancer cell proliferation and estrogen receptor-alpha transcriptional activity
    Sudipan Karmakar
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 150:1588-96. 2009
    ....
  12. ncbi request reprint SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity
    Kevin M Coleman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030 3498, USA
    Biochem Biophys Res Commun 323:332-8. 2004
    ..Thus, SRA is an ERalpha AF-1-specific coactivator that enhances the agonist activity of tamoxifen-bound ERalpha and may contribute to tamoxifen resistance...
  13. ncbi request reprint Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions
    David M Lonard
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Steroids 67:15-24. 2002
    ..These aspects of the molecular biology of estrogen receptor action may help clarify the mechanism(s) of SERM biologic action and will be addressed in further detail in this review...
  14. ncbi request reprint Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation
    Ilaria T R Cavarretta
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    Mol Endocrinol 16:253-70. 2002
    ....
  15. ncbi request reprint Mechanistic differences in the activation of estrogen receptor-alpha (ER alpha)- and ER beta-dependent gene expression by cAMP signaling pathway(s)
    Kevin M Coleman
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030 3498, USA
    J Biol Chem 278:12834-45. 2003
    ....
  16. pmc The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity
    Theresa J Peterson
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Cell Biol 27:5933-48. 2007
    ..Taken together, these data indicate that SMRT, in conjunction with gene-specific and cell-dependent factors, is required for positively regulating agonist-dependent ERalpha transcriptional activity...
  17. pmc Cooperative activation of cyclin D1 and progesterone receptor gene expression by the SRC-3 coactivator and SMRT corepressor
    Sudipan Karmakar
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Endocrinol 24:1187-202. 2010
    ....
  18. ncbi request reprint Evolutionary identification of a subtype specific functional site in the ligand binding domain of steroid receptors
    Michele Raviscioni
    W M Keck Center for Computational and Structural Biology, Baylor College of Medicine, Houston Texas 77030, USA
    Proteins 64:1046-57. 2006
    ..This highlights the power of evolutionary information for the identification of new functional sites even in a protein family as well studied as NRs...
  19. ncbi request reprint The pure estrogen receptor antagonist ICI 182,780 promotes a novel interaction of estrogen receptor-alpha with the 3',5'-cyclic adenosine monophosphate response element-binding protein-binding protein/p300 coactivators
    Basem M Jaber
    Molecular and Cellular Biology, One Baylor Plaza, Houston, Texas 77030, USA
    Mol Endocrinol 20:2695-710. 2006
    ..Taken together, these data indicate that recruitment of the CBP coactivator/cointegrator without steroid receptor coactivator 1 to ERalpha is insufficient to promote transcription of ERalpha target genes...
  20. pmc Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor
    Sudipan Karmakar
    Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Int J Cancer 124:1841-51. 2009
    ..The ability of E2-bound ERalpha and REA to suppress BTG2 expression indicates a positive role for this corepressor in regulation of breast cancer cell proliferation...
  21. ncbi request reprint Role of SRC-1 in the promotion of prostate cancer cell growth and tumor progression
    Irina U Agoulnik
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 65:7959-67. 2005
    ....
  22. ncbi request reprint Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL
    Chun yi Lee
    Department of Cell Biology, Baylor College of Medicine, Houston, TX, USA
    Biochem Biophys Res Commun 317:1221-5. 2004
    ..These findings suggest that estrogen may directly regulate ligament structure and function by alteration of Type I and III collagen synthesis. This regulation is dependent on mechanical loading...
  23. ncbi request reprint Expression of estrogen receptors-alpha and -beta in bladder cancer cell lines and human bladder tumor tissue
    Steven S Shen
    Department of Pathology, The Methodist Hospital and Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer 106:2610-6. 2006
    ..In a previous study the selective ER modulator raloxifene was shown to induce apoptosis in an ERbeta-positive bladder cancer cell line. However, the expression of ERbeta in human bladder cancer has not been thoroughly investigated...
  24. ncbi request reprint SKF-82958 is a subtype-selective estrogen receptor-alpha (ERalpha ) agonist that induces functional interactions between ERalpha and AP-1
    Marian R Walters
    Department of Physiology, Tulane Medical School, New Orleans, Louisiana 70112, USA
    J Biol Chem 277:1669-79. 2002
    ....
  25. ncbi request reprint Synthetic 19-nortestosterone derivatives as estrogen receptor alpha subtype-selective ligands induce similar receptor conformational changes and steroid receptor coactivator recruitment than natural estrogens
    Rocío García-Becerra
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Mexico City 14000, Mexico
    J Steroid Biochem Mol Biol 99:108-14. 2006
    ..Our data indicate that A-ring 3beta,5alpha-tetrahydro-reduced 19-nortestosterone-derived progestins behave as selective ERalpha agonists with ligand-receptor structural and functional responses similar to those induced with natural E(2)...
  26. pmc Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator
    Paul Labhart
    Genpathway, Inc, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 102:1339-44. 2005
    ....
  27. ncbi request reprint Efficacy of selective estrogen receptor modulators in nude mice bearing human transitional cell carcinoma
    Guru Sonpavde
    U S Oncology Research, Webster, Texas, USA
    Urology 69:1221-6. 2007
    ..To evaluate estrogen receptors as a therapeutic target for human bladder cancer...
  28. pmc The efficiency of protein compartmentalization into the secretory pathway
    Corinna G Levine
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Biol Cell 16:279-91. 2005
    ..These findings imply that protein compartmentalization can be modulated in a substrate-specific manner to generate biologically significant quantities of cytosolically available secretory and membrane proteins...
  29. ncbi request reprint Syntabulin is a microtubule-associated protein implicated in syntaxin transport in neurons
    Qingning Su
    Synaptic Function Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 3B203, MSC 3701, 35 Convent Drive, Bethesda, MD 20892 3701, USA
    Nat Cell Biol 6:941-53. 2004
    ..These findings suggest that syntabulin functions as a linker molecule that attaches syntaxin-cargo vesicles to kinesin I, enabling the transport of syntaxin-1 to neuronal processes...
  30. pmc Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes
    Diana A Stavreva
    Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute Light Imaging Facility, National Institute for Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA
    Mol Cell Biol 24:2682-97. 2004
    ..Moreover, our results reveal that longer GR residence times are consistently associated with greater transcriptional output, suggesting a new paradigm in which the rate of rapid exchange provides a means to tune transcriptional levels...
  31. pmc Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis
    Mariusz Karbowski
    Biochemistry Section, SNB, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 159:931-8. 2002
    ..Surprisingly, Drp1 and Mfn2, but not other proteins implicated in the regulation of mitochondrial morphology, colocalize with Bax in these foci. We suggest that Bax participates in apoptotic fragmentation of mitochondria...

Research Grants17

  1. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn Smith; Fiscal Year: 2009
    ..g. tissue selectivity) and pathophysiological scenarios (e.g. breast cancer), and ultimately provide new approaches for identification and characterization of ER-based therapeutics. ..
  2. Negative Regulation of Estrogen Receptors
    Carolyn Smith; Fiscal Year: 2007
    ..abstract_text> ..
  3. Negative Regulation of Estrogen Receptors
    Carolyn Smith; Fiscal Year: 2006
    ..abstract_text> ..
  4. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn Smith; Fiscal Year: 2005
    ..Our studies will therefore provide mechanistic information on 4HT's ability to modulate ERalpha activity in a gene or cell specific manner. ..
  5. Negative Regulation of Estrogen Receptors
    Carolyn Smith; Fiscal Year: 2005
    ..abstract_text> ..
  6. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn Smith; Fiscal Year: 2004
    ..Our studies will therefore provide mechanistic information on 4HT's ability to modulate ERalpha activity in a gene or cell specific manner. ..
  7. Negative Regulation of Estrogen Receptors
    Carolyn Smith; Fiscal Year: 2004
    ..abstract_text> ..
  8. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn Smith; Fiscal Year: 2003
    ..Our studies will therefore provide mechanistic information on 4HT's ability to modulate ERalpha activity in a gene or cell specific manner. ..
  9. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn Smith; Fiscal Year: 2002
    ..Our studies will therefore provide mechanistic information on 4HT's ability to modulate ERalpha activity in a gene or cell specific manner. ..
  10. ESTROGEN RECEPTOR COACTIVATOR FUNCTIONAL INTERACTIONS
    Carolyn Smith; Fiscal Year: 2001
    ..It is anticipated that these studies will further our understanding of the regulation of ER action and provide insight that may allow ER-coactivator interactions to be exploited in the development of new strategies to block ER action. ..
  11. ESTROGEN RECEPTOR COACTIVATOR FUNCTIONAL INTERACTIONS
    Carolyn Smith; Fiscal Year: 2000
    ..It is anticipated that these studies will further our understanding of the regulation of ER action and provide insight that may allow ER-coactivator interactions to be exploited in the development of new strategies to block ER action. ..
  12. ESTROGEN RECEPTOR COACTIVATOR FUNCTIONAL INTERACTIONS
    Carolyn Smith; Fiscal Year: 1999
    ..It is anticipated that these studies will further our understanding of the regulation of ER action and provide insight that may allow ER-coactivator interactions to be exploited in the development of new strategies to block ER action. ..
  13. Estrogen Receptor-Coregulator Functional Interactions
    Carolyn L Smith; Fiscal Year: 2010
    ..g. tissue selectivity) and pathophysiological scenarios (e.g. breast cancer), and ultimately provide new approaches for identification and characterization of ER-based therapeutics. ..