Research Topics
| Yan ShiSummaryAffiliation: Texas Tech University Health Sciences Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosisYan Shi
Department of Pharmaceutical Sciences and Cancer Biology Center, Texas Tech University Health Sciences Center, School of Pharmacy, Amarillo, Texas, USA
BMC Cancer 8:294. 2008..This study elucidates the molecular mechanism of Triphala against human pancreatic cancer in the cellular and in vivo model...- Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cellsRavi P Sahu
Department of Biomedical and Pharmaceutical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Suite 1103, Amarillo, TX 79106, USA
Carcinogenesis 30:1744-53. 2009..Taken together, our results suggest that BITC-mediated G(2)/M arrest is mediated through ERK activation, whereas apoptosis is via ERK, JNK and P38... 
Synthesis and SAR of novel, potent and orally bioavailable benzimidazole inhibitors of poly(ADP-ribose) polymerase (PARP) with a quaternary methylene-amino substituentGui Dong Zhu
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064, USA
Bioorg Med Chem Lett 18:3955-8. 2008..In vivo efficacy data in a B16F10 murine flank melanoma model in combination with temozolomide (TMZ) are described for two optimized analogs...
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor modelsCherrie K Donawho
Abbott Laboratories, Abbott Park, Illinois 60064 6074, USA
Clin Cancer Res 13:2728-37. 2007..To evaluate the preclinical pharmacokinetics and antitumor efficacy of a novel orally bioavailable poly(ADP-ribose) polymerase (PARP) inhibitor, ABT-888...- Morroniside and loganin extracted from Cornus officinalis have protective effects on rat mesangial cell proliferation exposed to advanced glycation end products by preventing oxidative stressHuiqin Xu
Department of Pharmacology, College of Pharmacy, Nanjing University of Traditional Chinese Medicine, 282 HanZhong Road, Nanjing 210029, China
Can J Physiol Pharmacol 84:1267-73. 2006..These results suggest that morroniside and loganin regulate MC growth by preventing oxidative stress. Thus, this study provides a molecular basis for the use of morroniside and loganin in the early stages of DN... - Adenosine deamination sustains dendritic cell activation in inflammationMelanie D Desrosiers
Department of Microbiology and Infectious Diseases, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
J Immunol 179:1884-92. 2007..Our findings suggest a mechanism that DCs maintain their hyperreactive state in inflammation despite the general state of suppression, and reveal a regulatory role of adenosine deaminase in DC innate immune responses... - Rapid detection of BCR-ABL fusion genes using a novel combined LUX primer, in-cell RT-PCR and flow cytometric methodYan Shi
Department of Hematology, Qilu Hospital, Shandong University, Jinan, 250012, People s Republic of China
Ann Hematol 87:35-41. 2008.... - Progress in the study of therapeutic effects of traditional Chinese medicine and extracts in treating severe acute pancreatitisXi Ping Zhang
Department of General Surgery, Hangzhou First People s Hospital, Hangzhou, Zhejiang Province, China
JOP 8:704-14. 2007..Therefore, the application of extracts of Chinese herbs for treating severe acute pancreatitis has significant clinical value and good prospects... - Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damageXuesong Liu
Department R47S, Cancer Research, Abbott Laboratories, Abbott Park, Illinois 60064, USA
Cancer Biol Ther 7:934-41. 2008..Unlike in HeLa cells, ABT-888 protected MNNG induced cell death in normal human fibroblasts. Our study provides evidence that PARP activity determines the fate of HeLa cells by regulating the level of ATP after treatment with MNNG... - Effects of simulated carbon dioxide and helium peumoperitoneum on proliferation and apoptosis of gastric cancer cellsYing Xue Hao
Department of General Surgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
World J Gastroenterol 14:2241-5. 2008..To investigate the effects of carbon dioxide (CO(2)) and helium insufflation administered at different pressures on the growth and apoptosis of cultured human gastric cancer cells... - Discovery and SAR of 2-(1-propylpiperidin-4-yl)-1H-benzimidazole-4-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancerThomas D Penning
Cancer Research, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Bioorg Med Chem 16:6965-75. 2008.... - Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expressionXuesong Liu
Department of R47S, GPRD, Abbott Laboratories, Abbott Park, IL 60064, USA
Neoplasia 10:828-37. 2008..Our studies suggest that that Akt may promote mitotic progression through the transcriptional regulation of Aurora A... - An enzyme-linked immunosorbent poly(ADP-ribose) polymerase biomarker assay for clinical trials of PARP inhibitorsXuesong Liu
Cancer Research, GPRD, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Anal Biochem 381:240-7. 2008..In summary, the ELISA assay described here is suitable for biomarker studies in clinical trials of PARP inhibitors... - Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaksXuesong Liu
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL, USA
Mol Cancer Res 6:1621-9. 2008..ABT-888 is well tolerated in animal models. ABT-888 is currently in clinical trials in combination with temozolomide... - Purification and some properties of beta-N-acetyl-D-glucosaminidase from the cabbage butterfly (Pieris rapae)Yan Shi
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, People s Republic of China
Biochimie 89:347-54. 2007..The results of chemical modification also suggested that carboxyl group was essential to the enzyme activity. Moreover, Zn(2+), Hg(2+), Cu(2+) had strongly inhibitory effects on the enzyme activity... - 96-well electroporation method for transfection of mammalian central neuronsWilliam J Buchser
University of Miami Miller School of Medicine, Miami, FL 33136, USA
Biotechniques 41:619-24. 2006..In addition to enabling the rapid optimization of experimental protocols with multiple parameters, this procedure enables the use of high content screening methods to characterize neuronal phenotypes... - Molecular cloning and characterization of human Aph2 gene, involved in AP-1 regulation by interaction with JAB1Fengrui Zhang
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute and Cancer Institute of Shanghai Jiaotong University, Shanghai 200032, PR China
Biochim Biophys Acta 1759:514-25. 2006..The expression level of c-jun was also down-regulated by overexpression of hAPH2 in COS-7 cells. These data showed some basic characterization and function of hAph2 (hAPH2), dependent or independent with JAB1... - [Clinical significance of serum S-100B protein in severe cerebral injury]Dian-lei Hu
Department of Neurosurgery, Xuzhou Third Hospital, Xuzhou 221005, Jiangsu, China
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:221-2. 2004..00 microg/L or higher, compared with 4 of 41 surviving patients (P<0.005). CONCLUSION: S-100B protein has a reliable value in diagnosis and prognostic after severe head injury... - Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acidYan Shi
Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, PR China
Stem Cells 23:656-62. 2005..The findings reported here offer a novel in vitro model to study the differentiation mechanism of pancreatic beta cells and a potential source of insulin-producing cells for transplantation therapy of type I diabetes mellitus... - Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivoYan Luo
Cancer Research, Abbott Laboratories, IL 60064-6117, USA
Mol Cancer Ther 4:977-86. 2005..These data show that direct Akt inhibition may be useful in cancer therapy, but significant metabolic toxicities are likely dose limiting... - [Cytogenetic and clinical study of Philadelphia chromosome positive adult acute leukemia]Jing-Ying Qiu
Institute of Hematology, People Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:358-63. 2005.... - Inactivation kinetics of guanidinium chloride on Penaeus vannamei beta-N-acetyl-D-glucosaminidase and the relationship of enzyme activity and its conformationXiao-Lan Xie
Department of Biochemistry and Biotechnology, School of Life Sciences, Xiamen University, Xiamen, 361005, China
Protein J 24:267-73. 2005..The rate constants of inactivation have been determined. The value of k(+0) is larger than that of k'(+0) which suggests that the enzyme is protected by substrate to a certain extent during guanidine denaturation... - Optimal classes of chemotherapeutic agents sensitized by specific small-molecule inhibitors of akt in vitro and in vivoYan Shi
Department R47S Cancer Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Neoplasia 7:992-1000. 2005..These findings provide important guidance in selecting appropriate classes of chemotherapeutic agents for combination with Akt inhibitors in cancer treatment... - Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluationQun Li
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
Bioorg Med Chem Lett 16:1679-85. 2006..The cellular activities including inhibition of cell growth and phosphorylation of downstream target GSK3 are also described. The X-ray structure of compound 2q complexed with PKA in the ATP binding site was determined... - Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancerQun Li
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064 6101, USA
Bioorg Med Chem Lett 16:2000-7. 2006..Inhibition of phosphorylation of the Akt downstream target GSK3 was also observed in FL5.12-Akt1 cells with an EC(50) of 1.5microM. The X-ray structures of 12 and 13a in complex with PKA in the ATP-binding site were determined... - Inhibitory effects of cis- and trans-isomers of 3,5-dihydroxystilbene on the activity of mushroom tyrosinaseKang-Kang Song
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, PR China
Biochem Biophys Res Commun 342:1147-51. 2006..This research may offer some references for designing and synthesizing some novel and effective tyrosinase inhibitors. Furthermore, it may improve the use of stilbenes on the field of food preservation and depigmentation... - Inhibition of the phosphatidylinositol 3-kinase/Akt pathway sensitizes MDA-MB468 human breast cancer cells to cerulenin-induced apoptosisXuesong Liu
Department R47S, AP9A, Cancer Research, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Mol Cancer Ther 5:494-501. 2006.... - Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activityGui Dong Zhu
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064, USA
Bioorg Med Chem Lett 16:3150-5. 2006..v. t(1/2) = 5.0 h, p.o. F = 51%) but resulted in >500-fold drop in potency. In a mouse MiaPaCa-2 xenograft model, an amino analog 10y significantly slowed the tumor growth, however was accompanied by toxicity... - Discovery and SAR of oxindole-pyridine-based protein kinase B/Akt inhibitors for treating cancersGui Dong Zhu
Cancer Research, GPRD, Abbott Laboratories, Abbott Park, IL 60064, USA
Bioorg Med Chem Lett 16:3424-9. 2006..In a mouse xenograft model, 9d, 11f, and 11n inhibited tumor growth but with accompanying toxicity... - Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditionsXuesong Liu
Department of Cancer Research R47S, Abbott L, Abbott Park, Illinois 60064, USA
J Biol Chem 281:31380-8. 2006..In addition, our data indicate that cells under stress require more Akt for its survival... - [Analysis of cytogenetic response in Ph+ chronic myeloid leukemia patients treated with interferon alpha]Hong Hong
Department of Cytogenetics, Institute of Hematology and People's Hospital, Peking University, Beijing 100044, China
Zhongguo Shi Yan Xue Ye Xue Za Zhi 11:269-73. 2003..Regular cytogenesis examination in CML patients is necessary during IFN-alpha therapy, which is useful to reflect curative effect and progression of the disease...