Research Topics
Species | Chwan Li ShenSummaryAffiliation: Texas Tech University Health Sciences Center Country: USA Publications
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Publications
Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese ratsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 8115, USA
Nutr Res 32:448-57. 2012..This study shows that GTP supplementation benefited body composition and bone properties in obese rats possibly through enhancing antioxidant capacity and suppressing inflammation...- Fruits and dietary phytochemicals in bone protectionChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
Nutr Res 32:897-910. 2012.... - Dietary polyphenols and mechanisms of osteoarthritisChwan Li Shen
Department of Pathology and Physiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
J Nutr Biochem 23:1367-77. 2012.... - Green tea polyphenols and 1-α-OH-vitamin D₃ attenuate chronic inflammation-induced myocardial fibrosis in female ratsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
J Med Food 15:269-77. 2012..In summary, both 1-α-OH-vitamin D₃ administration and GTPs supplementation mitigate myocardial fibrosis through suppression of a chronic inflammation innate immune response... 
Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trialC L Shen
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
Osteoporos Int 23:1541-52. 2012..Tai Chi exercise increased serum parathyroid hormone. GTP supplementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia...- Green tea and bone metabolismChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
Nutr Res 29:437-56. 2009..In general, tea and its bioactive components might decrease the risk of fracture by improving bone mineral density and supporting osteoblastic activities while suppressing osteoclastic activities... - Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trialChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
BMC Musculoskelet Disord 10:110. 2009.... - Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female ratsC L Shen
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
Osteoporos Int 21:1841-52. 2010.... - Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammationC L Shen
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
Osteoporos Int 22:327-37. 2011..GTP supplementation sustained microarchitecture and improved bone quality via a decrease in inflammation. Findings suggest a significant role for GTP in skeletal health of patients with chronic inflammation... - Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammationChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
J Nutr Biochem 22:673-80. 2011..A combination of both showed to sustain bone microarchitecture and strength. We conclude that a protective impact of GTP and alfacalcidol in bone microarchitecture during chronic inflammation may be due to a suppression of TNF-α... - Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life reportChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
BMC Complement Altern Med 10:76. 2010..This study was to evaluate the safety of 24 weeks of GTP supplementation combined with TC exercise in postmenopausal osteopenic women, along with effects on quality of life in this population... - Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female ratsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
Inflamm Res 60:665-72. 2011..This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation... - Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized ratsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, 79430, USA
Calcif Tissue Int 88:455-63. 2011..We conclude that GTP supplementation attenuates trabecular and cortical bone loss through increasing bone formation while suppressing bone resorption due to its antioxidant capacity... - Green tea and bone health: Evidence from laboratory studiesChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
Pharmacol Res 64:155-61. 2011.... - Green tea polyphenols mitigate deterioration of bone microarchitecture in middle-aged female ratsChwan Li Shen
BB 198, 3601 4th Street, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
Bone 44:684-90. 2009.... 
Effects of Tai Chi on gait kinematics, physical function, and pain in elderly with knee osteoarthritis--a pilot studyChwan Li Shen
Department of Pathology, School of Medicine, Texas Tech University Health Sciences Center, Texas 79430, USA
Am J Chin Med 36:219-32. 2008....- Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acidsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
Lipids 39:161-6. 2004..The fact that CLA alone or in combination with other PUFA modulated PGE2 and NO production in human OC cultures suggests that these 18:2 isomers may have the potential to influence OA pathogenesis... - Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male ratsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
Br J Nutr 95:462-8. 2006..These findings indicate a protective action of LC n-3 PUFA on ageing-induced bone loss in gonad-intact middle-aged male rats through a modulation of local factors and systemic calcitrophic hormones... - Short-term supplementation of COX-2 inhibitor suppresses bone turnover in gonad-intact middle-aged male ratsChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430 9790, USA
J Bone Miner Metab 24:461-6. 2006..Such action was through modulating local factors and systemic hormones... - Improvement of bone quality in gonad-intact middle-aged male rats by long-chain n-3 polyunsaturated fatty acidC L Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Calcif Tissue Int 80:286-93. 2007.... - Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss modelChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
J Nutr Biochem 21:968-74. 2010..We conclude that GTP mitigates bone loss in a chronic inflammation-induced bone loss model by reducing oxidative stress-induced damage and inflammation... - Effect of long-chain n-3 polyunsaturated fatty acid on inflammation mediators during osteoblastogenesisChwan Li Shen
Department of Pathology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
J Med Food 11:105-10. 2008..Our investigation has corroborated that the protective action of EPA on osteoblastogenesis was mediated by the modulation of PGE(2) and the NO pathway... - Protective effect of green tea polyphenols on bone loss in middle-aged female ratsC L Shen
Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX, 79430 9097, USA
Osteoporos Int 19:979-90. 2008.... - Comparison of the effects of Tai Chi and resistance training on bone metabolism in the elderly: a feasibility studyChwan Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
Am J Chin Med 35:369-81. 2007..In conclusion, these findings support that TC is beneficial for increasing bone formation in elderly, and long-term application is needed to substantiate the effect of TC as an alternative exercise in promotion of bone health... - A gel-based proteomic analysis of the effects of green tea polyphenols on ovariectomized ratsChangxia Shao
Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA
Nutrition 27:681-6. 2011..This may lead to understanding the mechanisms of GTPs in promoting bone health... - Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesisXingJia Wang
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
Endocrinology 146:4202-8. 2005..The present study suggests a novel mechanism in male aging involving COX2 and a potential application of the mechanism to delay the age-related decline in testosterone biosynthesis... - Effects of tai chi exercise on posturography, gait, physical function and quality of life in postmenopausal women with osteopaenia: a randomized clinical studyMing Chien Chyu
Department of Mechanical Engineering, Texas Tech University and Department of Pathology, Texas, USA
Clin Rehabil 24:1080-90. 2010..to evaluate the effects of tai chi exercise on risk factors for falls in postmenopausal women with osteopaenia through measurements of balance, gait, physical function and quality of life... - Group and home-based tai chi in elderly subjects with knee osteoarthritis: a randomized controlled trialJean Michel Brismee
Department of Rehabilitation Sciences, School of Allied Health Sciences, Texas Tech University Health Sciences Center, Texas 79430, USA
Clin Rehabil 21:99-111. 2007..To evaluate the effects of tai chi consisting of group and home-based sessions in elderly subjects with knee osteoarthritis... - Complementary and alternative exercises for management of osteoarthritisMing Chien Chyu
Graduate Healthcare Engineering, Whitacre College of Engineering, Texas Tech University, Lubbock, TX 79409, USA
Arthritis 2011:364319. 2011..Findings from the literature suggest that CAM exercises demonstrate considerable promise in the management of OA. Future studies require rigorous randomized controlled trials with larger sample sizes... - Training Self-Administered Acupressure Exercise among Postmenopausal Women with Osteoarthritic Knee Pain: A Feasibility Study and Lessons LearnedYan Zhang
Department of Family and Community Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 8143, Lubbock, TX 79430, USA
Evid Based Complement Alternat Med 2012:570431. 2012..Due to the limitations of this study such as small sample size and high attrition rate, acupressure's efficacy needs to be further explored in larger scale studies with more rigorous design... - The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expressionXingJia Wang
Department of Neuropsychiatry, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
J Endocrinol 190:871-8. 2006..This study suggests that cAMP stimulation of MA-10 cells increases epoxygenase-generated AA metabolites and the co-action of these metabolites with PKA significantly increases StAR gene expression and steroid hormone production... - Green tea polyphenols improve bone microarchitecture in high-fat-diet-induced obese female rats through suppressing bone formation and erosionChwan Li Shen
1 Department of Pathology, Texas Tech University, Lubbock, Texas, USA
J Med Food 16:421-7. 2013..We concluded that GTP supplementation in drinking water improves bone microarchitecture in the HFD-induced obese female rats, possibly through suppressing bone turnover, resulting in a larger net bone volume... - The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive functionLee T Ferris
Department of Physiology, Texas Tech University Health Sciences Center Texas Tech University, Lubbock, TX 79409 3011, USA
Med Sci Sports Exerc 39:728-34. 2007..Previous studies using animals have demonstrated that acute and chronic exercise leads to increases in BDNF in various brain regions... - Green tea polyphenols reduce body weight in rats by modulating obesity-related genesChuanwen Lu
Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
PLoS ONE 7:e38332. 2012..Collectively, this study revealed the beneficial effects of GTP on body weight via regulating obesity-related genes, anti-inflammation, anti-oxidant capacity, and estrogen-related actions in high-fat-induced obese rats... - Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytesChwan-Li Shen
Department of Pathology, Texas Tech University, Lubbock, Texas 79409-2141, USA
J Med Food 8:149-53. 2005..The inhibitory effects of GRE on NO and PGE2 production by sow OC observed in this study suggest an important role for GRE as an anti-arthritic agent... - Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explantsChwan-Li Shen
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79409, USA
J Med Food 6:323-8. 2003..The inhibitory effects of GRE on NO and PGE(2) production by sow osteoarthrotic cartilage explants observed in this study suggest an important role for GRE as an anti-arthritic agent in osteoarthrosis in the sow... - Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cellsKee-Jong Hong
Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
Phytother Res 18:768-70. 2004....
Research Grants
- GTP and Tai Chi for Bone Health: a Pilot StudyChwan Li Shen; Fiscal Year: 2007..Significance: The study will result in a new alternative rehabilitation treatment with proven anti-osteoporotic benefits for postmenopausal women with low bone mass. ..