Chwan Li Shen

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. pmc Complementary and alternative exercises for management of osteoarthritis
    Ming Chien Chyu
    Graduate Healthcare Engineering, Whitacre College of Engineering, Texas Tech University, Lubbock, TX 79409, USA
    Arthritis 2011:364319. 2011
  2. pmc Green tea polyphenols reduce body weight in rats by modulating obesity-related genes
    Chuanwen Lu
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
    PLoS ONE 7:e38332. 2012
  3. ncbi request reprint Effects of dietary fat levels and feeding durations on musculoskeletal health in female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Food Funct 5:598-604. 2014
  4. ncbi request reprint Functions and mechanisms of green tea catechins in regulating bone remodeling
    Chwan Li Shen
    BB 198, 3601 4th Street, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430 9097, USA
    Curr Drug Targets 14:1619-30. 2013
  5. doi request reprint Energy-restricted diet benefits body composition but degrades bone integrity in middle-aged obese female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Nutr Res 33:668-76. 2013
  6. doi request reprint Green tea polyphenols improve bone microarchitecture in high-fat-diet-induced obese female rats through suppressing bone formation and erosion
    Chwan Li Shen
    Department of Pathology, Texas Tech University, Lubbock, Texas, USA
    J Med Food 16:421-7. 2013
  7. doi request reprint Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 8115, USA
    Nutr Res 32:448-57. 2012
  8. doi request reprint Fruits and dietary phytochemicals in bone protection
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Nutr Res 32:897-910. 2012
  9. doi request reprint Dietary polyphenols and mechanisms of osteoarthritis
    Chwan Li Shen
    Department of Pathology and Physiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Nutr Biochem 23:1367-77. 2012
  10. doi request reprint Green tea polyphenols and 1-α-OH-vitamin D₃ attenuate chronic inflammation-induced myocardial fibrosis in female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Med Food 15:269-77. 2012

Research Grants

  1. GTP and Tai Chi for Bone Health: a Pilot Study
    Chwan Li Shen; Fiscal Year: 2007

Collaborators

Detail Information

Publications47

  1. pmc Complementary and alternative exercises for management of osteoarthritis
    Ming Chien Chyu
    Graduate Healthcare Engineering, Whitacre College of Engineering, Texas Tech University, Lubbock, TX 79409, USA
    Arthritis 2011:364319. 2011
    ..Findings from the literature suggest that CAM exercises demonstrate considerable promise in the management of OA. Future studies require rigorous randomized controlled trials with larger sample sizes...
  2. pmc Green tea polyphenols reduce body weight in rats by modulating obesity-related genes
    Chuanwen Lu
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Texas Tech University Health Sciences Center, Lubbock, Texas, United States of America
    PLoS ONE 7:e38332. 2012
    ..Collectively, this study revealed the beneficial effects of GTP on body weight via regulating obesity-related genes, anti-inflammation, anti-oxidant capacity, and estrogen-related actions in high-fat-induced obese rats...
  3. ncbi request reprint Effects of dietary fat levels and feeding durations on musculoskeletal health in female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    Food Funct 5:598-604. 2014
    ..This study evaluates the effects of dietary fat levels and feeding durations on body composition, bone properties, and endocrine factors in female rats...
  4. ncbi request reprint Functions and mechanisms of green tea catechins in regulating bone remodeling
    Chwan Li Shen
    BB 198, 3601 4th Street, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430 9097, USA
    Curr Drug Targets 14:1619-30. 2013
    ..In light of the physical, economical, and social burdens due to osteoporosis, easily accessible and affordable preventive measures such as GTC deserves further clinical studies prior to its clinical application. ..
  5. doi request reprint Energy-restricted diet benefits body composition but degrades bone integrity in middle-aged obese female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Nutr Res 33:668-76. 2013
    ..Our data suggest that long-term RD has a negative impact on bone remodeling in obese female rats, probably through modification of endocrines and elevation of proinflammation. ..
  6. doi request reprint Green tea polyphenols improve bone microarchitecture in high-fat-diet-induced obese female rats through suppressing bone formation and erosion
    Chwan Li Shen
    Department of Pathology, Texas Tech University, Lubbock, Texas, USA
    J Med Food 16:421-7. 2013
    ..We concluded that GTP supplementation in drinking water improves bone microarchitecture in the HFD-induced obese female rats, possibly through suppressing bone turnover, resulting in a larger net bone volume...
  7. doi request reprint Green tea polyphenols benefits body composition and improves bone quality in long-term high-fat diet-induced obese rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 8115, USA
    Nutr Res 32:448-57. 2012
    ..This study shows that GTP supplementation benefited body composition and bone properties in obese rats possibly through enhancing antioxidant capacity and suppressing inflammation...
  8. doi request reprint Fruits and dietary phytochemicals in bone protection
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Nutr Res 32:897-910. 2012
    ....
  9. doi request reprint Dietary polyphenols and mechanisms of osteoarthritis
    Chwan Li Shen
    Department of Pathology and Physiology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Nutr Biochem 23:1367-77. 2012
    ....
  10. doi request reprint Green tea polyphenols and 1-α-OH-vitamin D₃ attenuate chronic inflammation-induced myocardial fibrosis in female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    J Med Food 15:269-77. 2012
    ..In summary, both 1-α-OH-vitamin D₃ administration and GTPs supplementation mitigate myocardial fibrosis through suppression of a chronic inflammation innate immune response...
  11. pmc Effect of green tea and Tai Chi on bone health in postmenopausal osteopenic women: a 6-month randomized placebo-controlled trial
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 23:1541-52. 2012
    ..Tai Chi exercise increased serum parathyroid hormone. GTP supplementation, Tai Chi exercise, and the combination of the two all improved muscle strength in postmenopausal women with osteopenia...
  12. doi request reprint Green tea polyphenols mitigate bone loss of female rats in a chronic inflammation-induced bone loss model
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    J Nutr Biochem 21:968-74. 2010
    ..We conclude that GTP mitigates bone loss in a chronic inflammation-induced bone loss model by reducing oxidative stress-induced damage and inflammation...
  13. pmc Green tea and bone health: Evidence from laboratory studies
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    Pharmacol Res 64:155-61. 2011
    ....
  14. doi request reprint Supplementation with green tea polyphenols improves bone microstructure and quality in aged, orchidectomized rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, 79430, USA
    Calcif Tissue Int 88:455-63. 2011
    ..We conclude that GTP supplementation attenuates trabecular and cortical bone loss through increasing bone formation while suppressing bone resorption due to its antioxidant capacity...
  15. doi request reprint Green tea polyphenols avert chronic inflammation-induced myocardial fibrosis of female rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Inflamm Res 60:665-72. 2011
    ..This study evaluated whether green tea polyphenols (GTP) can avert fibrosis or vascular disruption along with mechanisms in rats with chronic inflammation...
  16. pmc Green tea polyphenols supplementation and Tai Chi exercise for postmenopausal osteopenic women: safety and quality of life report
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
    BMC Complement Altern Med 10:76. 2010
    ..This study was to evaluate the safety of 24 weeks of GTP supplementation combined with TC exercise in postmenopausal osteopenic women, along with effects on quality of life in this population...
  17. doi request reprint Protective actions of green tea polyphenols and alfacalcidol on bone microstructure in female rats with chronic inflammation
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    J Nutr Biochem 22:673-80. 2011
    ..A combination of both showed to sustain bone microarchitecture and strength. We conclude that a protective impact of GTP and alfacalcidol in bone microarchitecture during chronic inflammation may be due to a suppression of TNF-α...
  18. doi request reprint Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 22:327-37. 2011
    ..GTP supplementation sustained microarchitecture and improved bone quality via a decrease in inflammation. Findings suggest a significant role for GTP in skeletal health of patients with chronic inflammation...
  19. pmc Synergistic effects of green tea polyphenols and alphacalcidol on chronic inflammation-induced bone loss in female rats
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX 79430 9097, USA
    Osteoporos Int 21:1841-52. 2010
    ....
  20. pmc Green tea polyphenols and Tai Chi for bone health: designing a placebo-controlled randomized trial
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    BMC Musculoskelet Disord 10:110. 2009
    ....
  21. ncbi request reprint Decreased production of inflammatory mediators in human osteoarthritic chondrocytes by conjugated linoleic acids
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Lipids 39:161-6. 2004
    ..The fact that CLA alone or in combination with other PUFA modulated PGE2 and NO production in human OC cultures suggests that these 18:2 isomers may have the potential to influence OA pathogenesis...
  22. ncbi request reprint Short-term supplementation of COX-2 inhibitor suppresses bone turnover in gonad-intact middle-aged male rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, 79430 9790, USA
    J Bone Miner Metab 24:461-6. 2006
    ..Such action was through modulating local factors and systemic hormones...
  23. ncbi request reprint Improvement of bone quality in gonad-intact middle-aged male rats by long-chain n-3 polyunsaturated fatty acid
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Calcif Tissue Int 80:286-93. 2007
    ....
  24. ncbi request reprint Protective effect of dietary long-chain n-3 polyunsaturated fatty acids on bone loss in gonad-intact middle-aged male rats
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, USA
    Br J Nutr 95:462-8. 2006
    ..These findings indicate a protective action of LC n-3 PUFA on ageing-induced bone loss in gonad-intact middle-aged male rats through a modulation of local factors and systemic calcitrophic hormones...
  25. ncbi request reprint Comparison of the effects of Tai Chi and resistance training on bone metabolism in the elderly: a feasibility study
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Am J Chin Med 35:369-81. 2007
    ..In conclusion, these findings support that TC is beneficial for increasing bone formation in elderly, and long-term application is needed to substantiate the effect of TC as an alternative exercise in promotion of bone health...
  26. ncbi request reprint Protective effect of green tea polyphenols on bone loss in middle-aged female rats
    C L Shen
    Department of Pathology, Texas Tech University Health Sciences Center, BB 198, 3601 4th Street, Lubbock, TX, 79430 9097, USA
    Osteoporos Int 19:979-90. 2008
    ....
  27. doi request reprint Effect of long-chain n-3 polyunsaturated fatty acid on inflammation mediators during osteoblastogenesis
    Chwan Li Shen
    Department of Pathology and Neuroscience, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Med Food 11:105-10. 2008
    ..Our investigation has corroborated that the protective action of EPA on osteoblastogenesis was mediated by the modulation of PGE(2) and the NO pathway...
  28. ncbi request reprint Effects of Tai Chi on gait kinematics, physical function, and pain in elderly with knee osteoarthritis--a pilot study
    Chwan Li Shen
    Department of Pathology, School of Medicine, Texas Tech University Health Sciences Center, Texas 79430, USA
    Am J Chin Med 36:219-32. 2008
    ....
  29. doi request reprint Green tea polyphenols mitigate deterioration of bone microarchitecture in middle-aged female rats
    Chwan Li Shen
    BB 198, 3601 4th Street, Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Bone 44:684-90. 2009
    ....
  30. pmc Green tea and bone metabolism
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 9097, USA
    Nutr Res 29:437-56. 2009
    ..In general, tea and its bioactive components might decrease the risk of fracture by improving bone mineral density and supporting osteoblastic activities while suppressing osteoclastic activities...
  31. ncbi request reprint Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes
    Chwan Li Shen
    Department of Pathology, Texas Tech University, Lubbock, Texas 79409 2141, USA
    J Med Food 8:149-53. 2005
    ..The inhibitory effects of GRE on NO and PGE2 production by sow OC observed in this study suggest an important role for GRE as an anti-arthritic agent...
  32. pmc Novel insights of dietary polyphenols and obesity
    Shu Wang
    Department of Nutritional Sciences, Texas Tech University, Lubbock, TX 79409, USA
    J Nutr Biochem 25:1-18. 2014
    ..Future randomized controlled trials are warranted to reconcile the discrepancies between preclinical efficacies and inconclusive clinic outcomes of these polyphenols. ..
  33. doi request reprint A gel-based proteomic analysis of the effects of green tea polyphenols on ovariectomized rats
    Changxia Shao
    Department of Environmental Toxicology, The Institute of Environmental and Human Health, Texas Tech University, Lubbock, Texas, USA
    Nutrition 27:681-6. 2011
    ..This may lead to understanding the mechanisms of GTPs in promoting bone health...
  34. ncbi request reprint Effects of tai chi exercise on posturography, gait, physical function and quality of life in postmenopausal women with osteopaenia: a randomized clinical study
    Ming Chien Chyu
    Department of Mechanical Engineering, Texas Tech University and Department of Pathology, Texas, USA
    Clin Rehabil 24:1080-90. 2010
    ..to evaluate the effects of tai chi exercise on risk factors for falls in postmenopausal women with osteopaenia through measurements of balance, gait, physical function and quality of life...
  35. pmc Aortic cholesterol accumulation correlates with systemic inflammation but not hepatic and gonadal adipose tissue inflammation in low-density lipoprotein receptor null mice
    Shu Wang
    Nutritional Sciences Program, Texas Tech University, Lubbock, TX, USA Electronic address
    Nutr Res 33:1072-82. 2013
    ..Aortic TC content was positively associated with systemic inflammation but not hepatic and GAT inflammatory status. ..
  36. pmc Tea and bone health: steps forward in translational nutrition
    Chwan Li Shen
    Department of Pathology C LS and M CC and the Laura W Bush Institute for Women s Health C LS, Texas Tech University Health Sciences Center, Lubbock, TX the Department of Mechanical Engineering and the Graduate Healthcare Engineering Option, Texas Tech University, Lubbock, TX M CC and the Department of Environmental Health Science, University of Georgia, Athens, GA J SW
    Am J Clin Nutr 98:1694S-1699S. 2013
    ....
  37. ncbi request reprint Cyclooxygenase-2 regulation of the age-related decline in testosterone biosynthesis
    XingJia Wang
    Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    Endocrinology 146:4202-8. 2005
    ..The present study suggests a novel mechanism in male aging involving COX2 and a potential application of the mechanism to delay the age-related decline in testosterone biosynthesis...
  38. ncbi request reprint Group and home-based tai chi in elderly subjects with knee osteoarthritis: a randomized controlled trial
    Jean Michel Brismee
    Department of Rehabilitation Sciences, School of Allied Health Sciences, Texas Tech University Health Sciences Center, Texas 79430, USA
    Clin Rehabil 21:99-111. 2007
    ..To evaluate the effects of tai chi consisting of group and home-based sessions in elderly subjects with knee osteoarthritis...
  39. ncbi request reprint Effects of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthrotic cartilage explants
    Chwan Li Shen
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, Texas 79409, USA
    J Med Food 6:323-8. 2003
    ..The inhibitory effects of GRE on NO and PGE(2) production by sow osteoarthrotic cartilage explants observed in this study suggest an important role for GRE as an anti-arthritic agent in osteoarthrosis in the sow...
  40. pmc Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios
    Shu Wang
    Department of Nutrition, Texas Tech University, Lubbock, TX 79409, USA Electronic address
    Clin Nutr 33:260-6. 2014
    ..LDL receptor null mice were used to assess the effect of an atherogenic diet with different ω-6:EPA+DHA ratios on weight gain, hepatic and GAT lipid accumulation, and their relationship to atherosclerosis...
  41. ncbi request reprint Effects of Ganoderma lucidum on apoptotic and anti-inflammatory function in HT-29 human colonic carcinoma cells
    Kee Jong Hong
    Department of Pathology, Texas Tech University Health Sciences Center, Lubbock 79430, USA
    Phytother Res 18:768-70. 2004
    ....
  42. pmc Associations between tissue visfatin/nicotinamide, phosphoribosyltransferase (Nampt), retinol binding protein-4, and vaspin concentrations and insulin resistance in morbidly obese subjects
    Zeynep Goktas
    Nutritional Sciences Program, College of Human Science, Texas Tech University, P O Box 41240, Lubbock, TX 79409 1240, USA
    Mediators Inflamm 2013:861496. 2013
    ..In conclusion, the correlations of visfatin/Nampt, vaspin, and RBP-4 with insulin resistance are tissue dependent. ..
  43. pmc Training Self-Administered Acupressure Exercise among Postmenopausal Women with Osteoarthritic Knee Pain: A Feasibility Study and Lessons Learned
    Yan Zhang
    Department of Family and Community Medicine, Texas Tech University Health Sciences Center, 3601 4th Street, STOP 8143, Lubbock, TX 79430, USA
    Evid Based Complement Alternat Med 2012:570431. 2012
    ..Due to the limitations of this study such as small sample size and high attrition rate, acupressure's efficacy needs to be further explored in larger scale studies with more rigorous design...
  44. ncbi request reprint The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression
    XingJia Wang
    Department of Neuropsychiatry, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 190:871-8. 2006
    ..This study suggests that cAMP stimulation of MA-10 cells increases epoxygenase-generated AA metabolites and the co-action of these metabolites with PKA significantly increases StAR gene expression and steroid hormone production...
  45. ncbi request reprint The effect of acute exercise on serum brain-derived neurotrophic factor levels and cognitive function
    Lee T Ferris
    Department of Physiology, Texas Tech University Health Sciences Center Texas Tech University, Lubbock, TX 79409 3011, USA
    Med Sci Sports Exerc 39:728-34. 2007
    ..Previous studies using animals have demonstrated that acute and chronic exercise leads to increases in BDNF in various brain regions...
  46. pmc Effects of bariatric surgery on adipokine-induced inflammation and insulin resistance
    Zeynep Goktas
    Nutritional Sciences Program, College of Human Science, Texas Tech University, Lubbock, TX, USA
    Front Endocrinol (Lausanne) 4:69. 2013
    ..This review article focuses on some of these novel adipokines and discusses their changes after bariatric surgery and their relationship to insulin resistance, fat mass, inflammation, and glucose homeostasis...

Research Grants1

  1. GTP and Tai Chi for Bone Health: a Pilot Study
    Chwan Li Shen; Fiscal Year: 2007
    ..Significance: The study will result in a new alternative rehabilitation treatment with proven anti-osteoporotic benefits for postmenopausal women with low bone mass. ..