Research Topics

Genomes and Genes


Lee A Shapiro


Affiliation: Texas A and M Health Science Center
Country: USA


  1. Nizamutdinov D, Mukherjee S, Deng C, Stauss H, Shapiro L. Gulf War agents pyridostigmine bromide and permethrin cause hypersensitive nociception that is restored after vagus nerve stimulation. Neurotoxicology. 2018;69:93-96 pubmed publisher
    ..Therefore, stimulating the vagus nerve appears to influence nociception. Future studies are need to elucidate possible mechanisms of this effect. ..
  2. Arisi G, Foresti M, Katki K, Shapiro L. Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures. J Neuroinflammation. 2015;12:129 pubmed publisher
    ..Understanding the precise spatial and temporal pattern of cytokines and chemokine changes could provide more viable therapeutic targets to reduce, reverse, or prevent the development of epilepsy following a precipitating injury. ..
  3. Shapiro L, Ng K, Zhou Q, Ribak C. Subventricular zone-derived, newly generated neurons populate several olfactory and limbic forebrain regions. Epilepsy Behav. 2009;14 Suppl 1:74-80 pubmed publisher
    ..In light of the increasing body of evidence for neurogenesis in these and other olfactory, limbic, and striatal structures, we hypothesize that brain regions displaying adult neurogenesis are functionally linked. ..
  4. Tobin R, Mukherjee S, Kain J, Rogers S, Henderson S, Motal H, et al. Traumatic brain injury causes selective, CD74-dependent peripheral lymphocyte activation that exacerbates neurodegeneration. Acta Neuropathol Commun. 2014;2:143 pubmed publisher
    ..Taken together, the data support the hypothesis that neurodegeneration following TBI is dependent upon antigen processing and presentation that requires CD74. ..
  5. Wang F, Wang X, Shapiro L, Cotrina M, Liu W, Wang E, et al. NKCC1 up-regulation contributes to early post-traumatic seizures and increased post-traumatic seizure susceptibility. Brain Struct Funct. 2017;222:1543-1556 pubmed publisher
    ..Our findings identify neuronal up-regulation of NKCC1 and its mediation by TGF?, as a potential and important mechanism in the early post-traumatic seizures, and demonstrate the therapeutic potential of blocking this pathway. ..
  6. Nizamutdinov D, Shapiro L. Overview of Traumatic Brain Injury: An Immunological Context. Brain Sci. 2017;7: pubmed publisher