Premlata Shankar

Summary

Affiliation: Texas Tech University Health Sciences Center
Country: USA

Publications

  1. pmc Long-term engraftment of human natural T regulatory cells in NOD/SCID IL2rγc(null) mice by expression of human IL-2
    Sojan Abraham
    Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 7:e51832. 2012
  2. pmc Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model
    Chunting Ye
    Center of Excellence in Infectious Disease, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Proc Natl Acad Sci U S A 109:21052-7. 2012
  3. pmc Improved siRNA/shRNA functionality by mismatched duplex
    Haoquan Wu
    Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e28580. 2011
  4. pmc Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitis
    Chunting Ye
    Paul L Foster School of Medicine, Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e17889. 2011
  5. pmc Targeting the HIV entry, assembly and release pathways for anti-HIV gene therapy
    Anjali Joshi
    Center of Excellence for Infectious Disease, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Virology 415:95-106. 2011
  6. pmc Lentiviral delivery of short hairpin RNAs
    N Manjunath
    Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Adv Drug Deliv Rev 61:732-45. 2009
  7. doi request reprint Antibody-mediated delivery of siRNAs for anti-HIV therapy
    Sang Soo Kim
    Department of Biomedical Sciences, Center of Excellence for Infectious Diseases, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA
    Methods Mol Biol 721:339-53. 2011
  8. pmc Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice
    Himanshu Garg
    Center of Excellence for Infectious Disease, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, 5001 El Paso Drive, El Paso, Texas 79905, USA
    Virol J 8:34. 2011
  9. pmc Newer gene editing technologies toward HIV gene therapy
    N Manjunath
    Center of Excellence in Infectious Disease, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Viruses 5:2748-66. 2013
  10. pmc Targeted delivery of siRNA to macrophages for anti-inflammatory treatment
    Sang Soo Kim
    Center of Excellence in Infectious Diseases, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Mol Ther 18:993-1001. 2010

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Long-term engraftment of human natural T regulatory cells in NOD/SCID IL2rγc(null) mice by expression of human IL-2
    Sojan Abraham
    Department of Biomedical Sciences, Center of Excellence in Infectious Disease Research, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 7:e51832. 2012
    ..Thus, this novel 'hu-T(Reg) mouse' model offers a pre-clinical platform to study the in vivo function and stability of human nT(Regs) and their ability to modulate autoimmune diseases and GVHD...
  2. pmc Human macrophage and dendritic cell-specific silencing of high-mobility group protein B1 ameliorates sepsis in a humanized mouse model
    Chunting Ye
    Center of Excellence in Infectious Disease, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Proc Natl Acad Sci U S A 109:21052-7. 2012
    ....
  3. pmc Improved siRNA/shRNA functionality by mismatched duplex
    Haoquan Wu
    Center of Excellence in Infectious Disease Research, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e28580. 2011
    ....
  4. pmc Silencing early viral replication in macrophages and dendritic cells effectively suppresses flavivirus encephalitis
    Chunting Ye
    Paul L Foster School of Medicine, Center of Excellence in Infectious Diseases, Texas Tech University Health Sciences Center, El Paso, Texas, United States of America
    PLoS ONE 6:e17889. 2011
    ..These studies suggest that early suppression of viral replication in macrophages and dendritic cells by RVG-9R-mediated siRNA delivery is key to preventing the development of a fatal neurological disease...
  5. pmc Targeting the HIV entry, assembly and release pathways for anti-HIV gene therapy
    Anjali Joshi
    Center of Excellence for Infectious Disease, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Virology 415:95-106. 2011
    ..Finally, the Y164A/R515A double mutant expressed in a lentiviral vector was effective at inhibiting HIV replication in CD34+ hematopoietic stem cell-derived macrophages, demonstrating the therapeutic potential of our approach...
  6. pmc Lentiviral delivery of short hairpin RNAs
    N Manjunath
    Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Adv Drug Deliv Rev 61:732-45. 2009
    ..In this review we describe some of these advances, focusing on the progress made in the development of lentiviral shRNA delivery strategies to combat viral infections...
  7. doi request reprint Antibody-mediated delivery of siRNAs for anti-HIV therapy
    Sang Soo Kim
    Department of Biomedical Sciences, Center of Excellence for Infectious Diseases, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA
    Methods Mol Biol 721:339-53. 2011
    ..Here, we describe details of two antibody-based strategies for systemic delivery of siRNA either specifically to T cells via the CD7 receptor or to multiple immune cell types via LFA-1, present on all leukocytes...
  8. pmc Single amino acid change in gp41 region of HIV-1 alters bystander apoptosis and CD4 decline in humanized mice
    Himanshu Garg
    Center of Excellence for Infectious Disease, Department of Biomedical Sciences, Texas Tech University Health Sciences Center, 5001 El Paso Drive, El Paso, Texas 79905, USA
    Virol J 8:34. 2011
    ..Whether the loss of CD4 cells is a direct consequence of virus infection or bystander apoptosis of uninfected cells is also uncertain...
  9. pmc Newer gene editing technologies toward HIV gene therapy
    N Manjunath
    Center of Excellence in Infectious Disease, Department of Biomedical Sciences, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX 79905, USA
    Viruses 5:2748-66. 2013
    ..Here, we review the applications, limitations and future prospects of novel gene-editing strategies for use as HIV therapy. ..
  10. pmc Targeted delivery of siRNA to macrophages for anti-inflammatory treatment
    Sang Soo Kim
    Center of Excellence in Infectious Diseases, Paul L Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA
    Mol Ther 18:993-1001. 2010
    ..These results demonstrate that RVG-9dR provides a tool for siRNA delivery to macrophages and microglia and that suppression of TNF-alpha can potentially be used to suppress neuroinflammation in vivo...
  11. pmc Targeted delivery of small interfering RNA to human dendritic cells to suppress dengue virus infection and associated proinflammatory cytokine production
    Sandesh Subramanya
    Immune Disease Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Virol 84:2490-501. 2010
    ....

Research Grants5

  1. Targeted delivery of anti HIV sRNAs/shRNAs to T cells
    Premlata Shankar; Fiscal Year: 2009
    ..Finally, we will reconstitute NOD/Lt-scid IL2r?null mice with lentivirus-transduced CD34+ human HSCs and test establishment of long-term HIV resistance. ..
  2. Targeted delivery of anti HIV sRNAs/shRNAs to T cells
    Premlata Shankar; Fiscal Year: 2010
    ..Finally, we will reconstitute NOD/Lt-scid IL2r?null mice with lentivirus-transduced CD34+ human HSCs and test establishment of long-term HIV resistance. ..
  3. RNAi manipulations of DC to enhance HIV immunogenicity
    Premlata Shankar; Fiscal Year: 2010
    ..In addition, the in vivo studies in a preclinical animal model will provide novel insights into the immune correlates of protection. ..
  4. RNAi manipulations of DC to enhance HIV immunogenicity
    Premlata Shankar; Fiscal Year: 2009
    ..In addition, the in vivo studies in a preclinical animal model will provide novel insights into the immune correlates of protection. ..