Research Topics
| Eva M Sevick-MuracaSummaryAffiliation: Texas A and M University Country: USA Publications
| Collaborators
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Detail Information
Publications
New horizons for imaging lymphatic functionRuchi Sharma
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, One Baylor Plaza, BCM 360, Houston, TX 77030, USA
Ann N Y Acad Sci 1131:13-36. 2008....
Fluorescence-enhanced, near infrared diagnostic imaging with contrast agentsEva M Sevick-Muraca
The Photon Migration Laboratory, Texas A and M University, College Station 77845 3122, USA
Curr Opin Chem Biol 6:642-50. 2002....- Quantifying molecular specificity of alphavbeta3 integrin-targeted optical contrast agents with dynamic optical imagingMichael Gurfinkel
Texas A and M University, Photon Migration Laboratories, College Station, Texas 77843-3012, USA
J Biomed Opt 10:034019. 2005..In vivo pharmacokinetic analysis based on rapid and dynamic optical imaging may be potentially useful for evaluating the presence and turnover rate of disease markers that are potential targets of molecular medicine... - Fluorescence-enhanced optical tomography using referenced measurements of heterogeneous mediaRanadhir Roy
The Photon Migration Laboratories, Texas A and M University, College Station, TX 77843-3573, USA
IEEE Trans Med Imaging 22:824-36. 2003..Furthermore, we demonstrate the performance of the bounding parameter for rejection of background artifacts owing to background tissue heterogeneity... - Quality analysis of in vivo near-infrared fluorescence and conventional gamma images acquired using a dual-labeled tumor-targeting probeJessica P Houston
Texas A and M University, Photon Migration Laboratory, College Station, Texas 77842-3012, USA
J Biomed Opt 10:054010. 2005.... - Fluorescence lifetime spectroscopy of a pH-sensitive dye encapsulated in hydrogel beadsEddy Kuwana
The Photon Migration Laboratories, Texas A and M University, College Station, Texas 77843-3573, USA
Biotechnol Prog 20:1561-6. 2004..When extended to the immobilized fluorophore-enzymatic systems, fluorescence lifetime spectroscopy with multiply scattered light may provide a new ultrasensitive approach for analyte or toxin screening... - Evaluation of ingredient concentration in powders using two-speed photon migration theory and measurementsTianshu Pan
The Photon Migration Laboratories, Department of Chemistry, Texas A and M University, College Station, 77843, USA
J Pharm Sci 95:530-41. 2006.... - Improved excitation light rejection enhances small-animal fluorescent optical imagingKildong Hwang
Texas A and M University, USA
Mol Imaging 4:194-204. 2005.... - Fluorescence-enhanced optical imaging in large tissue volumes using a gain-modulated ICCD cameraAnuradha Godavarty
Department of Chemical Engineering, Texas A and M University, College Station, TX 77843-3122, USA
Phys Med Biol 48:1701-20. 2003.... - Detection of single and multiple targets in tissue phantoms with fluorescence-enhanced optical imaging: feasibility studyAnuradha Godavarty
Photon Migration Laboratories, Texas A and M University, PO Box 30012, College Station, TX 77842-3012, USA
Radiology 235:148-54. 2005..CONCLUSION: It is feasible to detect single or multiple fluorescent targets in tissue phantoms of clinically relevant size by using fluorescence-enhanced optical tomography... - Near-infrared fluorescence optical imaging and tomographyMichael Gurfinkel
Department of Chemical Engineering, Texas A and M University, College Station, TX 77843-3122, USA
Dis Markers 19:107-21. 2003..Finally, a critical evaluation of the limitations and the opportunities for future translation of fluorescence-enhanced optical imaging of deep tissues is presented... - Determination of optical properties in semi-infinite turbid media using imaging measurements of frequency-domain photon migration obtained with an intensified charge-coupled deviceMichael Gurfinkel
Texas A and M University, Photon Migration Laboratories, Department of Chemical Engineering, College Station, Texas 77843-3122, USA
J Biomed Opt 9:1336-46. 2004.... - Validating the assumption to the interference approximation by use of measurements of absorption efficiency and hindered scattering in dense suspensionsYingqing Huang
Photon Migration Laboratories, Texas A and M University, Mailstop 3573, College Station, Texas 77843-3573, USA
Appl Opt 43:814-9. 2004..Furthermore, owing to the accuracy of FDPM absorption measurements, the imaginary refractive indices for both particles and their suspending fluid were determined and were found to compare favorably with literature values... - Sensitivity and depth penetration of continuous wave versus frequency-domain photon migration near-infrared fluorescence contrast-enhanced imagingJessica P Houston
Department of Chemical Engineering, Texas A and M University, College Station, TX 77843-3573, USA
Photochem Photobiol 77:420-30. 2003..5 mW/cm2) and FDPM area collection of 830 nm fluorescent light generated from 3 cm below the phantom surface. The lowered noise floor of FDPM measurements enables greater sensitivity and penetration depth than comparable CW measurements... - Imaging dose-dependent pharmacokinetics of an RGD-fluorescent dye conjugate targeted to alpha v beta 3 receptor expressed in Kaposi's sarcomaSunkuk Kwon
Texas A and M University, TX 77842-3012, USA
Mol Imaging 4:75-87. 2005..5 nmol/mouse, the uptake no longer increased with dose, suggesting integrin receptor saturation. In normal tissues, the PK uptake parameters were not influenced by Cy5.5-c(KRGDf) dose nor by the preadministration of c(KRGDf)... - Near-infrared fluorescence contrast-enhanced imaging with area illumination and area detection: the forward imaging problemAlan B Thompson
Photon Migration Laboratories, Texas A and M University, 3573 TAMU, College Station, Texas 77843-3573, USA
Appl Opt 42:4125-36. 2003..Results also demonstrate that target-to-background ratios of fluorescence yield and fluorescence lifetime significantly affect target detectability... - Near-infrared fluorescence contrast-enhanced imaging with intensified charge-coupled device homodyne detection: measurement precision and accuracyAlan B Thompson
Texas A and M University, Department of Chemical Engineering, 337 Zachry Engineering Center, College Station, Texas 77843-3122, USA
J Biomed Opt 8:111-20. 2003..0 cm from the point source, measurements of fluorescence modulation amplitude and phase exhibit a mean accuracy of 5.4% and 0.30 deg, respectively... - Measurements of FRET in a glucose-sensitive affinity system with frequency-domain lifetime spectroscopyFeng Liang
The Photon Migration Laboratory, Department of Chemistry, Texas A and M University, College Station, USA
Photochem Photobiol 81:1386-94. 2005..09 microM dextran to labeled concanavalin A at a solution concentration of 10.67 microM in the presence of glucose at concentrations ranging from 0 to 224 mg/dL... - Measurement of low-dose active pharmaceutical ingredient in a pharmaceutical blend using frequency-domain photon migrationTianshu Pan
Department of Chemical Engineering, Texas A and M University, College Station, TX 77843-3122, USA
J Pharm Sci 93:635-45. 2004..Evolution of homogeneity within the blending process assessed through FDPM measurements was fit to the first-order model of particle blending further evidencing applicability for monitoring powder-blending processes... - Volume of pharmaceutical powders probed by frequency-domain photon migration measurements of multiply scattered lightTianshu Pan
Department of Chemical Engineering, Texas A and M University, College Station 77843-3122, USA
Anal Chem 74:4228-34. 2002..8 and 1.5 cm3 at modulated frequencies of 50 and 100 MHz, respectively. Experimental measurements in lactose powder confirm the predictions... - Fluorescence lifetime spectroscopy in multiply scattering media with dyes exhibiting multiexponential decay kineticsEddy Kuwana
Department of Chemistry, Texas A and M University, College Station, Texas 77843-3122, USA
Biophys J 83:1165-76. 2002..Our results suggest the high sensitivity of phase-modulation measurements in scattering solutions may provide greater opportunities for fluorescence lifetime spectroscopy... - Three-dimensional fluorescence lifetime tomographyAnuradha Godavarty
Department of Computer Science, University of Vermont, Burlington, Vermont 05405, USA
Med Phys 32:992-1000. 2005..1:1) contrasts at target depths of 1.4-2 cm. The Bayesian tomography algorithm was employed to obtain three-dimensional images of lifetime and absorption owing to the fluorophores... 
Noninvasive quantitative imaging of lymph function in miceSunkuk Kwon
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030 3411, USA
Lymphat Res Biol 5:219-31. 2007..Herein, we present a noninvasive and rapid approach to measure lymphatic function in a rodent model using a near-infrared (NIR) dye to minimize background autofluorescence and maximize tissue penetration...- Radiative transport-based frequency-domain fluorescence tomographyAmit Joshi
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
Phys Med Biol 53:2069-88. 2008..Finally, we demonstrate fluorescence tomography on a realistic computational mouse model to locate nM to microM fluorophore concentration distributions in simulated mouse organs... - Imaging of lymph flow in breast cancer patients after microdose administration of a near-infrared fluorophore: feasibility studyEva M Sevick-Muraca
Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, One Baylor Plaza, BCM 360, Houston, TX 77030, USA
Radiology 246:734-41. 2008.... - A new optical and nuclear dual-labeled imaging agent targeting interleukin 11 receptor alpha-chainWei Wang
Department of Radiology, Division of Molecular Imaging, Baylor College of Medicine, Houston, Texas 77030, USA
Bioconjug Chem 18:397-402. 2007..The cross validation and direct comparison of optical and nuclear imaging of a tumor was achieved using a single injection, and the preliminary results show the conjugate has tumor targeting capabilities in vivo... - Quantitative imaging of lymph functionRuchi Sharma
Division of Molecular Imaging, Department of Radiology, Baylor College of Medicine, Houston, TX 77030, USA
Am J Physiol Heart Circ Physiol 292:H3109-18. 2007..Our results suggest that microgram quantities of NIR optical imaging agents and their conjugates have a potential to image lymph function in patients suffering from lymph-related disorders... - Radiative transport in fluorescence-enhanced frequency domain photon migrationJohn C Rasmussen
Department of Radiology, Baylor College of Medicine, One Baylor Plaza, MS: BCM 360, Houston, Texas 77030, USA
Med Phys 33:4685-700. 2006..This work demonstrates the use of an appropriate RTE solver for deployment in small animal optical tomography... - Three-dimensional, Bayesian image reconstruction from sparse and noisy data sets: near-infrared fluorescence tomographyMargaret J Eppstein
Department of Computer Science, 327 Votey Building, University of Vermont, Burlington, VT 05405, USA
Proc Natl Acad Sci U S A 99:9619-24. 2002..The results demonstrate that, to employ NIR fluorescence-enhanced optical imaging for large volumes, reconstruction approaches must account for the large range of signal-to-noise ratio associated with the measurements... - Application of frequency domain photon migration to particle size analysis and monitoring of pharmaceutical powdersZhigang Sun
Malvern Instruments Inc, 10 Southville Road, Southborough, Massachusetts 01772, USA
Anal Chem 75:1720-5. 2003.... - Near-infrared optical imaging of epidermal growth factor receptor in breast cancer xenograftsShi Ke
Division of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 63:7870-5. 2003..In MDA-MB-468 tumors, our data suggest that EGF-Cy5.5 may be used as a specific NIR contrast agent for noninvasive imaging of EGFr expression and monitoring of responses to molecularly targeted therapy... - Near-infrared optical imaging of integrin alphavbeta3 in human tumor xenograftsWei Wang
Department of Experimental Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Imaging 3:343-51. 2004..Our data suggest that near-infrared fluorescence imaging may be applied to the detection of tumors expressing integrin alphavbeta3 and to the assessment of the optimal biological dose and schedule of targeted therapies... - Three-dimensional fluorescence enhanced optical tomography using referenced frequency-domain photon migration measurements at emission and excitation wavelengthsJangwoen Lee
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana 47907, USA
J Opt Soc Am A Opt Image Sci Vis 19:759-71. 2002..Finally, in light of our results, we demonstrate the method for eliminating the influence of source strength and instrument functions for effective fluorescence-enhanced optical tomography using FDPM...