F Schroeder


Affiliation: Texas A and M University
Country: USA


  1. Martin G, Seeger D, McIntosh A, Chung S, Milligan S, Landrock D, et al. Scp-2/Scp-x ablation in Fabp1 null mice differentially impacts hepatic endocannabinoid level depending on dietary fat. Arch Biochem Biophys. 2018;650:93-102 pubmed publisher
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    Schroeder F, Jolly C, Cho T, Frolov A. Fatty acid binding protein isoforms: structure and function. Chem Phys Lipids. 1998;92:1-25 pubmed
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    Schroeder F, Gallegos A, Atshaves B, Storey S, McIntosh A, Petrescu A, et al. Recent advances in membrane microdomains: rafts, caveolae, and intracellular cholesterol trafficking. Exp Biol Med (Maywood). 2001;226:873-90 pubmed
  4. McIntosh A, Martin G, Huang H, Landrock D, Kier A, Schroeder F. Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation. J Lipid Res. 2018;59:646-657 pubmed publisher
  5. Martin G, Chung S, Landrock D, Landrock K, Dangott L, Peng X, et al. Female Mice are Resistant to Fabp1 Gene Ablation-Induced Alterations in Brain Endocannabinoid Levels. Lipids. 2016;51:1007-20 pubmed publisher
    ..These data show that female mouse brain endocannabinoid levels were unchanged (AEA, 2-AG) or decreased (OEA, PEA, 2-OG) by complete loss of FABP1 (LKO). ..
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    Schroeder F, Frolov A, Starodub O, Atshaves B, Russell W, Petrescu A, et al. Pro-sterol carrier protein-2: role of the N-terminal presequence in structure, function, and peroxisomal targeting. J Biol Chem. 2000;275:25547-55 pubmed
    ..In summary, the data suggest for the first time that the 20-amino acid presequence of pro-SCP-2 alters SCP-2 structure to facilitate peroxisomal targeting mediated by the C-terminal SKL peroxisomal targeting sequence...
  7. Huang H, McIntosh A, Landrock K, Landrock D, Storey S, Martin G, et al. Human FABP1 T94A variant enhances cholesterol uptake. Biochim Biophys Acta. 2015;1851:946-55 pubmed publisher
    ..Thus, the increased HDL- and LDL-mediated NBD-cholesterol uptake by CC hepatocytes may be associated with higher affinity of T94A protein for cholesterol and/or increased total T94A protein level. ..
  8. Martin G, Landrock D, Landrock K, Howles P, Atshaves B, Kier A, et al. Relative contributions of L-FABP, SCP-2/SCP-x, or both to hepatic biliary phenotype of female mice. Arch Biochem Biophys. 2015;588:25-32 pubmed publisher
    ..These data suggested that L-FABP was more important in hepatic retention of bile acids, while SCP-2/SCP-x more broadly affected biliary bile acid and phospholipid levels. ..
  9. Schroeder F, McIntosh A, Martin G, Huang H, Landrock D, Chung S, et al. Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias. Lipids. 2016;51:655-76 pubmed publisher

More Information


  1. Storey S, Huang H, McIntosh A, Martin G, Kier A, Schroeder F. Impact of Fabp1/Scp-2/Scp-x gene ablation (TKO) on hepatic phytol metabolism in mice. J Lipid Res. 2017;58:1153-1165 pubmed publisher
    ..These findings suggested that: 1) SCP-2 and FABP1 both facilitated phytol metabolism after its conversion to phytanic acid; and 2) SCP-2/SCP-x had a greater impact on hepatic phytol metabolism than FABP1. ..
  2. Martin G, Landrock D, Chung S, Dangott L, McIntosh A, Mackie J, et al. Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet. J Lipid Res. 2017;58:2114-2126 pubmed publisher
    ..Thus, pair-fed HFD selectively impacted hepatic ECs more in females, but did not elicit NAFLD in either sex. These effects were modified by LKO consistent with FABP1's ability to impact EC and FA metabolism. ..
  3. McIntosh A, Storey S, Huang H, Kier A, Schroeder F. Sex-dependent impact of Scp-2/Scp-x gene ablation on hepatic phytol metabolism. Arch Biochem Biophys. 2017;635:17-26 pubmed publisher
    ..Thus, the loss of Scp-2/Scp-x contributed to a sex-dependent hepatic accumulation of dietary phytol and BCFA. ..
  4. McIntosh A, Huang H, Storey S, Landrock K, Landrock D, Petrescu A, et al. Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-? activation in cultured human female hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2014;307:G164-76 pubmed publisher
    ..Thus the FABP1 T94A variant represents an altered/reduced function mutation resulting in TG accumulation. ..
  5. Martin G, Atshaves B, Landrock K, Landrock D, Storey S, Howles P, et al. Ablating L-FABP in SCP-2/SCP-x null mice impairs bile acid metabolism and biliary HDL-cholesterol secretion. Am J Physiol Gastrointest Liver Physiol. 2014;307:G1130-43 pubmed publisher
    ..Conversely, SCP-2/SCP-x may function more in formation and biliary secretion of bile acid, with less impact on hepatic uptake or biliary secretion of HDL-cholesterol. ..