S Safe

Summary

Affiliation: Texas A and M University
Country: USA

Publications

  1. pmc The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
    Un Ho Jin
    Institute of Biosciences and Technology, Texas A and M Health Sciences Center, 2121 W, Holcombe Blvd, Houston, TX 77030, USA
    BMC Cancer 14:498. 2014
  2. ncbi request reprint Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target
    Stephen Safe
    Texas A and M University, Veterinary Physiology and Pharmacology, 4466 TAMU, College Station, TX 77843 4466, USA
    Expert Opin Ther Targets 18:759-69. 2014
  3. pmc HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
    K Kim
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX, USA
    Oncogene 32:1616-25. 2013
  4. pmc Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
    K Kim
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77843, USA
    Oncogene 31:1034-44. 2012
  5. pmc Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors
    Satya Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
    PLoS ONE 7:e48208. 2012
  6. ncbi request reprint The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells
    Syng Ook Lee
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843 4466
    Mol Cancer Res 12:527-38. 2014
  7. ncbi request reprint The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells
    Sandeep Sreevalsan
    Corresponding Author Stephen Safe, Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466
    Mol Cancer Ther 12:2483-93. 2013
  8. pmc Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Toxicol Sci 135:1-16. 2013
  9. pmc Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs
    Stephen H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466, USA
    Anticancer Agents Med Chem 12:1211-20. 2012
  10. pmc Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs
    Shruti U Gandhy
    College of Medicine, Texas A and M Health Science Center, Houston, TX 77030, USA
    BMC Cancer 12:564. 2012

Collaborators

Detail Information

Publications75

  1. pmc The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis
    Un Ho Jin
    Institute of Biosciences and Technology, Texas A and M Health Sciences Center, 2121 W, Holcombe Blvd, Houston, TX 77030, USA
    BMC Cancer 14:498. 2014
    ..Aryl hydrocarbon receptor (AHR) ligands show promise as antimetastatic drugs for estrogen receptor (ER)-negative breast cancer...
  2. ncbi request reprint Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target
    Stephen Safe
    Texas A and M University, Veterinary Physiology and Pharmacology, 4466 TAMU, College Station, TX 77843 4466, USA
    Expert Opin Ther Targets 18:759-69. 2014
    ..Sp1 has been the most extensively investigated member of this family, and expression of this protein decreases with age, whereas Sp1 and other family members (Sp3 and Sp4) are highly expressed in tumors and cancer cell lines...
  3. pmc HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer
    K Kim
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX, USA
    Oncogene 32:1616-25. 2013
    ..HOTAIR knockdown in L3.6pL cells inhibited tumor growth in mouse xenograft model, further demonstrating the pro-oncogenic function of HOTAIR in pancreatic cancer...
  4. pmc Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
    K Kim
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX 77843, USA
    Oncogene 31:1034-44. 2012
    ..These results confirm that ZBTB4 functions as a novel tumor-suppressor gene with prognostic significance for breast cancer survival, and the oncogenic miR-17-92/ZBTB4/Sp axis may be a potential therapeutic target...
  5. pmc Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors
    Satya Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX, USA
    PLoS ONE 7:e48208. 2012
    ....
  6. ncbi request reprint The Orphan Nuclear Receptor NR4A1 (Nur77) Regulates Oxidative and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells
    Syng Ook Lee
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843 4466
    Mol Cancer Res 12:527-38. 2014
    ..Mol Cancer Res; 12(4); 527-38. ©2014 AACR. ..
  7. ncbi request reprint The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells
    Sandeep Sreevalsan
    Corresponding Author Stephen Safe, Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466
    Mol Cancer Ther 12:2483-93. 2013
    ..The results show that the anticancer activity of WIN is due, in part, to PP2A-dependent disruption of miR-27a:ZBTB10 and ZBTB10-mediated repression of Sp transcription factors and Sp-regulated genes, including eIF4E...
  8. pmc Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Toxicol Sci 135:1-16. 2013
    ....
  9. pmc Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs
    Stephen H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466, USA
    Anticancer Agents Med Chem 12:1211-20. 2012
    ....
  10. pmc Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs
    Shruti U Gandhy
    College of Medicine, Texas A and M Health Science Center, Houston, TX 77030, USA
    BMC Cancer 12:564. 2012
    ..In this study, we investigated the anticancer activity of curcumin and several synthetic cyclohexanone and piperidine analogs in colon cancer cells...
  11. pmc Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells
    Un Ho Jin
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, TX, USA
    J Pharmacol Exp Ther 343:333-41. 2012
    ..These data indicate that the AHR-active pharmaceuticals are selective AHR modulators, and applications of these drugs for targeting the AHR must be confirmed by studies using the most relevant cell context...
  12. pmc Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters
    Kyounghyun Kim
    Institute of Biosciences and Technology, Texas A and M Health Science Center, MD Anderson Cancer Center, The University of Texas, Houston, USA
    Mol Cancer Ther 11:1852-62. 2012
    ..CDODA-Me induces ZBTB4 in prostate cancer cells through disruption of miR-ZBTB4 interactions, and this results in downregulation of pro-oncogenic Sp transcription factors and Sp-regulated genes...
  13. doi request reprint Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer
    Xinyi Liu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    Mol Cancer Ther 11:1421-31. 2012
    ....
  14. pmc 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice
    Yunpeng Su
    Scott and White Cancer Research Institute, South Airport Road, Temple, Texas 76502, USA
    Breast Cancer Res 9:R56. 2007
    ..CDIM9 has not previously been studied with respect to its effects against basal-like breast cancer. Our goal in the present study was to investigate the anti-basal-like breast tumor activity of CDIM9 in vitro and in vivo...
  15. pmc Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors
    Sudhakar Chintharlapalli
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    BMC Cancer 11:371. 2011
    ....
  16. pmc 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer
    Kathy Vanderlaag
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    BMC Cancer 10:669. 2010
    ..The main purpose of this study was to investigate the pathways of C-DIM-induced cell death...
  17. pmc Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells
    Shu Zhang
    Institute of Biosciences and Technology, Texas A and M Health Science Center, Houston, Texas 77843, USA
    Mol Cancer Ther 11:108-18. 2012
    ....
  18. ncbi request reprint Environmental estrogens: roles in male reproductive tract problems and in breast cancer
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology Texas A and M University, College Station, Texas 77843 4466, USA
    Rev Environ Health 17:253-62. 2002
    ..The results do not preclude an environmental eitology to some of these health problems or to susceptible subpopulations, and these areas require further research and critical scrutiny...
  19. pmc Problems for risk assessment of endocrine-active estrogenic compounds
    Stephen H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Environ Health Perspect 110:925-9. 2002
    ..These results suggest that other receptors, such as the aryl hydrocarbon receptor, that also bind structurally diverse ligands may exhibit unique responses in vivo that are not predicted by standard in vitro bioassays...
  20. ncbi request reprint Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    Chem Res Toxicol 16:807-16. 2003
  21. ncbi request reprint Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    J Mammary Gland Biol Neoplasia 5:295-306. 2000
    ....
  22. ncbi request reprint Endocrine disruptors and human health: is there a problem
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Toxicology 205:3-10. 2004
    ..In contrast, testicular cancer is increasing in most countries, and causal environmental/lifestyle factors for this disease are unknown...
  23. ncbi request reprint Clinical correlates of environmental endocrine disruptors
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843 4466, USA
    Trends Endocrinol Metab 16:139-44. 2005
    ..However, several studies report large differences in sperm count and quality and other endocrine-related problems within countries and regions, but the environmental, dietary and/or lifestyle factors responsible remain unknown...
  24. ncbi request reprint Cyclooxygenase-2 inhibitors decrease vascular endothelial growth factor expression in colon cancer cells by enhanced degradation of Sp1 and Sp4 proteins
    Maen Abdelrahim
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 409, College Station, TX 77843 4466
    Mol Pharmacol 68:317-29. 2005
    ..These results suggest that the antiangiogenic activity of COX-2 inhibitors in colon cancer cells is linked to activation of proteasome-dependent degradation of Sp1 and Sp4 proteins...
  25. ncbi request reprint Sp transcription factor family and its role in cancer
    Stephen Safe
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030 3303, USA
    Eur J Cancer 41:2438-48. 2005
    ..Sp/KLF proteins are also potential targets for cancer chemotherapy...
  26. pmc Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
    Sandeep Sreevalsan
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    Anticancer Res 31:3799-807. 2011
    ..We hypothesized that the anticancer activity of cannabinoids was linked to induction of phosphatases...
  27. pmc Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Building 410, College Station, TX 77843 4466, USA
    Cancer Lett 269:326-38. 2008
    ....
  28. pmc Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    J Mol Endocrinol 41:263-75. 2008
    ....
  29. pmc 3-methylcholanthrene induces differential recruitment of aryl hydrocarbon receptor to human promoters
    Stephen Safe
    Department of Veterinary Physiology and Physiology, Texas A and M University, College Station, Texas 77843 4466, USA
    Toxicol Sci 117:1-3. 2010
    ..TCDD)-dependent AHR bound regions. The results illustrate the complexity of AHR signaling and also demonstrate that compared with TCDD as a reference ligand, 3MC is a selective AHR modulator...
  30. ncbi request reprint Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review)
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Int J Oncol 20:1123-8. 2002
    ..SAhRMs represent a novel class of drugs for treatment of hormone-dependent cancers, and combined therapies of SAhRMs with tamoxifen and other selective ER modulators (SERMs) provides a new approach for treating women with breast cancer...
  31. ncbi request reprint Toxicology of environmental estrogens
    S H Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Reprod Fertil Dev 13:307-15. 2001
    ..For example, BPA inhibits E2-induced responses in the rodent uterus, and HPTE and structurally related compounds are ERalpha agonists and ERbeta antagonists in assays carried out in HepG2 and other cancer cell lines...
  32. ncbi request reprint Methods for xenoestrogen testing
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Toxicol Lett 102:665-70. 1998
    ....
  33. ncbi request reprint Molecular biology of the Ah receptor and its role in carcinogenesis
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843 4466, USA
    Toxicol Lett 120:1-7. 2001
    ..Both TCDD and phytochemicals inhibit estrogen-induced breast and endometrial cancer, and the molecular mechanisms of this common response will be described...
  34. ncbi request reprint Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Toxicol Lett 102:343-7. 1998
    ..Research has also focused on development of AhR-based antiestrogens which inhibit mammary tumor development and growth but do not exhibit prototypical AhR-induced toxic responses...
  35. ncbi request reprint Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture
    E Castro-Rivera
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    J Steroid Biochem Mol Biol 64:287-95. 1998
    ..These results demonstrate that HEC1A endometrial cancer cells are E2-responsive and represent a useful cell culture model for understanding hormone/antihormone-induced endometrial cell responses...
  36. ncbi request reprint Interactions between hormones and chemicals in breast cancer
    S H Safe
    Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Annu Rev Pharmacol Toxicol 38:121-58. 1998
    ..More information is required on the identities and serum levels of both natural and xenoendocrine active compounds, their concentrations in serum, and the mammary gland and levels of these compounds at critical periods of exposure...
  37. pmc Is there an association between exposure to environmental estrogens and breast cancer?
    S H Safe
    Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Environ Health Perspect 105:675-8. 1997
    ..Thus, E2 2-hydroxylase activity and the 16alpha-hydroxyestrone/2-hydroxyestrone metabolite ratio in MCF-7 cells does not predict xenoestrogens or mammary carcinogens...
  38. ncbi request reprint Bisphenol A and related endocrine disruptors
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Toxicol Sci 56:251-2. 2000
    ..Papaconstantinou, Thomas H. Umbreit, Benjamin R. Fisher, Peter L. Goering, Nicholas T. Lappas, and Ken M. Brown (pp. 332-339)...
  39. ncbi request reprint The role of xenoestrogenic compounds in the development of breast cancer
    Stephen Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    Trends Pharmacol Sci 27:447-54. 2006
    ....
  40. ncbi request reprint Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements
    K Yoon
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843-4466, USA
    J Steroid Biochem Mol Biol 78:25-32. 2001
    ....
  41. ncbi request reprint Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins
    M Stoner
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    J Biol Chem 275:22769-79. 2000
    ....
  42. ncbi request reprint Ligand-, cell-, and estrogen receptor subtype (alpha/beta)-dependent activation at GC-rich (Sp1) promoter elements
    B Saville
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843 4466, USA
    J Biol Chem 275:5379-87. 2000
    ....
  43. ncbi request reprint Regulation of constitutive gene expression through interactions of Sp1 protein with the nuclear aryl hydrocarbon receptor complex
    F Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Biochemistry 38:11490-500. 1999
    ..These studies show that regulation of basal expression of some genes by Sp1 may also require interactions with AhR-Arnt...
  44. ncbi request reprint Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes
    M Wormke
    Department of Veterinary Physiology and Pharmacology, and Department of Biochemistry and Biophysics, Texas A and M University, 77843 4466, College Station, TX, USA
    FEBS Lett 478:109-12. 2000
    ..Thus, TCDD-induced degradation of ERalpha may contribute to the antiestrogenic activity of AhR agonists and this pathway may be involved in AhR-mediated disruption of other endocrine responses...
  45. ncbi request reprint Functional synergy between the transcription factor Sp1 and the estrogen receptor
    W Porter
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Mol Endocrinol 11:1569-80. 1997
    ..Thus, the results illustrate a new estrogen-dependent transactivation pathway that involves ER-protein interactions and is ERE-independent...
  46. ncbi request reprint Transcriptional activation of E2F1 gene expression by 17beta-estradiol in MCF-7 cells is regulated by NF-Y-Sp1/estrogen receptor interactions
    W Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Mol Endocrinol 13:1373-87. 1999
    ..This represents a unique trans-acting protein complex in which ligand-dependent transactivation by the ER is independent of direct ER interactions with promoter elements...
  47. ncbi request reprint Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1
    R Duan
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843-4466, USA
    J Biol Chem 276:11590-8. 2001
    ....
  48. ncbi request reprint Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective aryl hydrocarbon receptor modulator
    A McDougal
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843, USA
    Cancer Res 61:3902-7. 2001
    ....
  49. ncbi request reprint Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis
    C Qin
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843-4466, USA
    Clin Cancer Res 7:818-23. 2001
    ..This study shows the biological importance of ARNT splice variants in the behavior of human breast cancer and suggests that the breast cell lines in which the splice variant was discovered may be useful models for further investigation...
  50. pmc Effect of transient expression of the oestrogen receptor on constitutive and inducible CYP1A1 in Hs578T human breast cancer cells
    W L Wang
    Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Br J Cancer 73:316-22. 1996
    ..These results suggest that basal and inducible CAT activity in Hs578T cells transiently transfected with pRNH11c is modulated differentially by ER domains that are present in the N- and C-terminal regions of the ER...
  51. ncbi request reprint Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex
    T A Nguyen
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas, 77843 4466, USA
    Arch Biochem Biophys 367:250-7. 1999
    ..These results confirmed functional and physical interactions of AhR/Arnt with ERAP 140 and SMRT in breast cancer cells...
  52. ncbi request reprint Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites
    F Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, TX 77843-4466, USA
    J Cell Biochem 84:156-72. 2001
    ..These results show that transcriptional activation of CKB by estrogen is dependent, in part, on ERalpha/Sp1 action which is cell context-dependent...
  53. pmc The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53
    S O Lee
    Institute of BioScience and Technology, Texas A and M Health Science Center, Houston, TX 77843 4466, USA
    Oncogene 31:3265-76. 2012
    ....
  54. ncbi request reprint Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements
    E Castro-Rivera
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843-4466, USA
    J Biol Chem 276:30853-61. 2001
    ....
  55. ncbi request reprint Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells
    C Vyhlidal
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843 4466, USA
    J Mol Endocrinol 29:305-17. 2002
    ..These studies confirm that E2 induces Tf gene expression through a nonconsensus distal ERE...
  56. ncbi request reprint Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk
    W Xie
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843-4466, USA
    J Mol Endocrinol 26:217-28. 2001
    ....
  57. ncbi request reprint Aryl hydrocarbon (Ah) receptor-independent induction of Cyp1a2 gene expression by acenaphthylene and related compounds in B6C3F1 mice
    K Chaloupka
    Texas A and M University, College Station 77843 4466
    Carcinogenesis 15:2835-40. 1994
    ....
  58. ncbi request reprint A comparison of the mouse versus human aryl hydrocarbon (Ah) receptor complex: effects of proteolysis
    X Wang
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466
    Chem Biol Interact 85:79-93. 1992
    ....
  59. doi request reprint Effect of tolfenamic acid on canine cancer cell proliferation, specificity protein (sp) transcription factors, and sp-regulated proteins in canine osteosarcoma, mammary carcinoma, and melanoma cells
    H Wilson
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Texas A and M University, College Station, TX, USA
    J Vet Intern Med 26:977-86. 2012
    ..TA induces proteosome-dependent degradation of transcription factors Sp 1, 3, and 4. These proteins are known to be overexpressed in many human cancers...
  60. ncbi request reprint Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression
    M Merchant
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77843 4466
    Arch Biochem Biophys 298:389-94. 1992
    ..The results suggest that alpha NF and possibly MCDF compete with TCDD for cytosolic Ah receptor binding sites; however, MCDF may also inhibit the induction response by competing for and/or partially inactivating genomic binding sites...
  61. ncbi request reprint Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells
    J E Lee
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, TX 77843-4466, USA
    Biochem Pharmacol 62:1113-24. 2001
    ..These data suggest that resveratrol inhibits CYP1A1 via an AhR-independent post-transcriptional pathway...
  62. ncbi request reprint Transcriptional activation of genes by 17 beta-estradiol through estrogen receptor-Sp1 interactions
    S Safe
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843-4466, USA
    Vitam Horm 62:231-52. 2001
    ....
  63. ncbi request reprint Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses
    C L Wilson
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843 4466, USA
    Toxicol Pathol 26:657-71. 1998
    ....
  64. ncbi request reprint Induction of glutathione S-transferases in genetically inbred male mice by dietary ethoxyquin hydrochloride
    M Makary
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station 77843
    Comp Biochem Physiol C 92:171-4. 1989
    ..GST activity was induced 2.9-fold in Aroclor 1254-responsive (C57BL/6) and 2.8-fold in non-responsive (DBA/2) mice, respectively...
  65. pmc GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway
    Satya S Pathi
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Vet Res Bldg 410, College Station, TX 77843, USA
    Mol Cancer Res 9:195-202. 2011
    ....
  66. pmc The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression
    Xinyi Liu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843 4466, USA
    Mol Cancer Ther 8:1207-17. 2009
    ..TA represents a novel and promising new anticancer drug that targets erbB2 by decreasing transcription of this oncogene...
  67. pmc Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context
    Shu Zhang
    Department of Veterinary Physiology and Pharmacology, Texas AM University, College Station 77843 4466, USA
    Environ Health Perspect 111:1877-82. 2003
    ....
  68. pmc MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells
    Xiangrong Li
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, College Station, Texas 77843 4466, USA
    Endocrinology 151:2462-73. 2010
    ..Thus, miR-27a indirectly regulates E2-responsiveness in MCF-7 cells through suppression of ZBTB10, thereby enhancing expression of ERalpha...
  69. ncbi request reprint Estrogen regulates transcription of the ovine oxytocin receptor gene through GC-rich SP1 promoter elements
    Joann G W Fleming
    Center for Animal Biotechnology and Genomics, Texas A and M University, College Station, 77843 2471, USA
    Endocrinology 147:899-911. 2006
    ..These results support the hypothesis that the antiluteolytic effects of IFNT are mediated by direct inhibition or silencing of ESR1 gene transcription, thereby precluding ESR1/SP1 from stimulating OXTR gene transcription...
  70. ncbi request reprint Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity
    Hans E Purkey
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Chem Biol 11:1719-28. 2004
    ..Four OH-PCB/TTR cocrystal structures provide further insight into inhibitor binding interactions...
  71. ncbi request reprint A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia
    Rooha Contractor
    Department of Blood and Marrow Transplantation, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Res 65:2890-8. 2005
    ..Together, these findings suggest that diindolylmethanes are a new class of compounds that selectively induce apoptosis in AML cells through the modulation of the extracellular signal-regulated kinase and PPARgamma signaling pathways...
  72. ncbi request reprint Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells
    Marina Konopleva
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, Unit 448, 1400 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 5:317-28. 2006
    ....
  73. ncbi request reprint Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways
    Lavanya Reddivari
    Department of Horticultural Sciences, Texas A and M University, College Station, TX 77843, USA
    Carcinogenesis 28:2227-35. 2007
    ....
  74. pmc Endocrine disrupting chemicals research program of the U.S. Environmental Protection Agency: summary of a peer-review report
    Anna K Harding
    Department of Public Health, Oregon State University, Corvallis, Oregon 97331 6406, USA
    Environ Health Perspect 114:1276-82. 2006
    ....
  75. ncbi request reprint Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects
    Paolo Calabro
    Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases, University of Texas Houston Health Science Center, Houston, Tex, USA
    J Vasc Res 42:509-16. 2005
    ....

Research Grants52

  1. Molecular Mechanisms and Application of Ah Receptor-MicroRNA Interactions
    Stephen H Safe; Fiscal Year: 2010
    ..The proposed research will investigate the AhR-dependent induction of the antimetastatic microRNA-335 and microRNA-205 and delineate their role in the anticarcinogenic activity of SAhRMs. ..
  2. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2007
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  3. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2007
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  4. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2006
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  5. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  6. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2006
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  7. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2006
    ..abstract_text> ..
  8. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2006
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  9. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  10. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2005
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  11. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2005
    ..abstract_text> ..
  12. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2005
    ..abstract_text> ..
  13. NUR77 Agonists: New Targets for Pancreatic Cancer Chemotherapy
    Stephen Safe; Fiscal Year: 2007
    ..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
  14. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2008
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  15. NUR77 Agonists: New Targets for Pancreatic Cancer Chemotherapy
    Stephen H Safe; Fiscal Year: 2010
    ..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
  16. MicroRNAs as Targets for Colon Cancer Chemotherapy
    Stephen H Safe; Fiscal Year: 2010
    ....
  17. NUR77 Agonists: New Targets for Pancreatic Cancer Chemotherapy
    Stephen Safe; Fiscal Year: 2009
    ..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
  18. PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE
    Stephen Safe; Fiscal Year: 2008
    ..To support the research projects, the Program also includes three Research Support Cores (Image Analysis, Analytical Services & Biostatistics, and Field Services) and Administrative, Outreach, and Training Cores. ..
  19. MicroRNAs as Targets for Colon Cancer Chemotherapy
    Stephen Safe; Fiscal Year: 2009
    ....
  20. PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE
    Stephen Safe; Fiscal Year: 2008
    ..An Outreach Core will communicate research results to community groups and students. ..
  21. Colon Cancer Inhibition by a Class of PPARgamma Agonists
    Stephen Safe; Fiscal Year: 2009
    ..The proposed studies will provide mechanistic insights on PPARy-dependent inhibition of colon cancer and identify compounds for future clinical studies. ..
  22. NUR77 Agonists: New Targets for Pancreatic Cancer Chemotherapy
    Stephen Safe; Fiscal Year: 2008
    ..These studies will serve to highlight the potential role of selective Nur77 modulators as a new class of chemotherapeutic drugs for treatment of pancreatic cancer. ..
  23. TOXICOLOGY OF ENVIRONMENT CONTAMINANTS
    Stephen Safe; Fiscal Year: 2007
    ..The proposed training program will continue to provide trainees with a challenging academic and research environment that will prepare them for future careers in academic, industry and government. ..
  24. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  25. PROCEDURES TO ASSESS THE HAZARDS OF A SUPERFUND SITE
    Stephen Safe; Fiscal Year: 2007
    ..To support the research projects, the Program also includes three Research Support Cores (Image Analysis, Analytical Services & Biostatistics, and Field Services) and Administrative, Outreach, and Training Cores. ..
  26. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2005
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  27. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2004
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  28. MECHANISMS OF GROWTH FACTOR/ESTROGEN RECEPTOR CROSSTALK
    Stephen Safe; Fiscal Year: 2000
    ..The effects of AhR agonists will determine impacts of important dietary/environmental endocrine disruptors on these coupled endocrine pathways, which play important roles in development of hormone-dependent cancers. ..
  29. 2, 3, 7, 8--TCDD EFFECTS ON ESTROGENIC RESPONSES
    Stephen Safe; Fiscal Year: 2000
    ..iDREs are important new 5'-promoter sequences which affect hormone-induced transactivation, and functional iDREs in critical E2-regulated genes could serve as important genomic target sequences for antiestrogen chemotherapy. ..
  30. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2000
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  31. 2, 3, 7, 8--TCDD EFFECTS ON ESTROGENIC RESPONSES
    Stephen Safe; Fiscal Year: 1999
    ..iDREs are important new 5'-promoter sequences which affect hormone-induced transactivation, and functional iDREs in critical E2-regulated genes could serve as important genomic target sequences for antiestrogen chemotherapy. ..
  32. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 1999
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  33. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 1999
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  34. MECHANISMS OF GROWTH FACTOR/ESTROGEN RECEPTOR CROSSTALK
    Stephen Safe; Fiscal Year: 1999
    ..The effects of AhR agonists will determine impacts of important dietary/environmental endocrine disruptors on these coupled endocrine pathways, which play important roles in development of hormone-dependent cancers. ..
  35. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2000
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  36. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2001
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  37. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2004
    ..abstract_text> ..
  38. Coactivation of Estrogen Receptor alpha/Sp1
    Stephen Safe; Fiscal Year: 2004
    ..abstract_text> ..
  39. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2004
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  40. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2003
    ..abstract_text> ..
  41. ESTROGEN INDUCED RESPONSES VIA ER/SPL COMPLEXES
    Stephen Safe; Fiscal Year: 2002
    ..These results will ultimately facilitate design of chemotherapeutic approaches which target specific genes. ..
  42. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2003
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  43. Mechanisms of Growth Factor-Estrogen Receptor Crosstalk
    Stephen Safe; Fiscal Year: 2002
    ..abstract_text> ..
  44. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2002
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  45. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  46. MECHANISMS OF GROWTH FACTOR/ESTROGEN RECEPTOR CROSSTALK
    Stephen Safe; Fiscal Year: 2001
    ..The effects of AhR agonists will determine impacts of important dietary/environmental endocrine disruptors on these coupled endocrine pathways, which play important roles in development of hormone-dependent cancers. ..
  47. 2, 3, 7, 8--TCDD EFFECTS ON ESTROGENIC RESPONSES
    Stephen Safe; Fiscal Year: 2001
    ..iDREs are important new 5'-promoter sequences which affect hormone-induced transactivation, and functional iDREs in critical E2-regulated genes could serve as important genomic target sequences for antiestrogen chemotherapy. ..